lnp_ml/data/interim/internal_corrected.csv

285 KiB

1smilesHelper_lipid_IDHelper_lipid_ID_DOPEHelper_lipid_ID_DOTAPHelper_lipid_ID_DSPCHelper_lipid_ID_MDOACationic_Lipid_to_mRNA_weight_ratioCationic_Lipid_Mol_RatioPhospholipid_Mol_RatioCholesterol_Mol_RatioPEG_Lipid_Mol_RatioPurityMix_typeCargo_typeCargo_type_mRNACargo_type_pDNACargo_type_siRNATarget_or_delivered_geneModel_typeModel_type_A549Model_type_BDMCModel_type_BMDMModel_type_HBEC_ALIModel_type_HEK293TModel_type_HeLaModel_type_IGROV1Model_type_MouseModel_type_RAW264p7Delivery_targetDelivery_target_bodyDelivery_target_dendritic_cellDelivery_target_generic_cellDelivery_target_liverDelivery_target_lungDelivery_target_lung_epitheliumDelivery_target_macrophageDelivery_target_muscleDelivery_target_spleenRoute_of_administrationRoute_of_administration_in_vitroRoute_of_administration_intramuscularRoute_of_administration_intratrachealRoute_of_administration_intravenousBatch_or_individual_or_barcodedBatch_or_individual_or_barcoded_BarcodedBatch_or_individual_or_barcoded_IndividualValue_nameFormulation_IDCationic_Lipid_Mass_RatioPhospholipid_Mass_RatioCholesterol_Mass_RatioPEG_Lipid_Mass_RatioAmineTailLipid_nameLibrary_IDExperiment_IDExperimenter_IDExperiment_weightGoalscreen_idSourceSample_weightCommentAmine_numberFull_SMILESAmine_SMILESTail_lengthNum_tailsKetoneIsocyanideIs_cyclicFormulationBatch_or_individualRandom_id4CR_Lipid_nameAldehydeCarboxylic_acidAmine_nameTail_nameLinkerMolWtTail_countNum tailsCommon_nameEsterDisulfideTotal_radianceForm_commentmolecular_weightsplit_name_for_normalizationEncapsulation_Efficiency_EE<50Encapsulation_Efficiency_50<=EE<80Encapsulation_Efficiency_80<EE<=100PDI_0_0to0_2PDI_0_2to0_3PDI_0_3to0_4PDI_0_4to0_5toxicsizeBiodistribution_lymph_nodesBiodistribution_heartBiodistribution_liverBiodistribution_spleenBiodistribution_lungBiodistribution_kidneyBiodistribution_musclequantified_total_luminescenceunnormalized_deliveryquantified_delivery
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55O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.391357962102766-0.0002312984681692620.1958287288494910.01261858331178570.0005049221714932090.001093153520632430.7897233136784281.01.00.4646149359523945
56O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.391357962102766-0.005154479393153040.9625743550100240.03041573014516430.0009180388433166050.000937396608342438-1.01.01.8695349995476385
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75O=C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)CN(CCCCCCCCCC)CCCCCCCCCCDSPC001014.8804561950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.48874872297084-------0.0
76O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)CN(CCCCCCCC)CCCCCCCCDSPC001013.8332769350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.343844382133684-------0.0
77O=C(NCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCCDSPC001013.5388956450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.301494223781961-------0.0
78O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=ODSPC001018.2737690950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.596939379038152-------0.0
79O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=ODSPC001018.2737690950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10001005.596939379038152-------0.0
80O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCCDSPC001015.0636878850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4036658097773630.01592626640083090.007264717469944250.06446914435118970.01542483972254390.006667780948173970.006184262365540050.8840629887417770.1639838676727070.163983867672707-0.8248996899319107
81O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCCDSPC001015.0636878850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.04.403665809777363-0.01107680668203140.6792381455962640.2899824390814820.01511043628511070.00459217235511197-0.08648249177213720.0864824917721372-0.5681789657875123
82O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCCDSPC001015.9117665150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001000.04.2853780596180760.009520257235856790.004247871121988890.02704948029587920.009511470657881850.005698095816754160.008641599438361940.9353312254332770.222812475742140.22281247574214-0.7341593948675438
83O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCCDSPC001015.9117665150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01001000.04.285378059618076-0.005774017873322590.7811233297408650.2023862888534940.008524640196854520.00219172333546338-0.236886988352550.23688698835255-0.16682580237138014
84CCCCCCCCCCCCCCOC(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCCCCCCCC)=O)=ODSPC001018.1103353750.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.0106352940962555-------0.0
85CCCCCCCCCCCCCCOC(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCCCCCCCC)=O)=ODSPC001018.1103353750.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10001005.0106352940962555-------0.0
86CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001018.1683207850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.491217305912060.03076905432531170.0008038468935280310.003273758909438590.004403098747609620.001315066814209770.003411984285614880.9560231900242871.143705006411171.143705006411170.6862729882487519
87CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001018.1683207850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.49121730591206-0.01030060572695740.2292081940924220.7357796434298650.01822284009705240.00648871665370264-0.1461011328434690.146101132843469-0.40908711190961344
88O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.5738858959483250.003057040978151310.001004917793202090.01657732595741030.01177102714129670.002086971298565030.002872522174314770.962630194657061.01.00.4646149359523945
89O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.573885895948325-0.003300408326120470.5453988019752740.4461922510443120.003237825282148990.00187071337214386-1.01.01.8695349995476385
90O=C(CN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=ODSPC001017.7975645750.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.789042318607025-------0.0
91CCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=ODSPC001017.4077098950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.168208681201016-------0.0
92CCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCC)=O)=ODSPC001017.9308947950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010004.697749367281185-------0.0
93O=C(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCCDSPC001016.3873768250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001004.2112383136936-------0.0
94CCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=ODSPC001017.6120066250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.27999390910873-------0.0
95O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.255492450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.611152257665639-------0.0
96CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=ODSPC001018.39156150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010005.1422481808981475-------0.0
97O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCCDSPC001016.6340034250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.515354881665727-------0.0
98O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCDSPC001017.2563702450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.57532934397707-------0.0
99O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCCDSPC001017.7983325850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.451896454476337-------0.0
100O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.255492450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.925077405734609-------0.0
101CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=ODSPC001018.39156150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.829912458665998-------0.0
102O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCCDSPC001016.6340034250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.421728001525434-------0.0
103O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCDSPC001017.2563702450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.775756486563625-------0.0
104O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCCDSPC001017.7983325850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001008.862341963516347-------0.0
105CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=ODSPC001018.5504205750.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101005.5506312951620265-------0.0
106OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)ODSPC001014.3422922250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.47597224751641-------0.0
107CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)ODSPC001015.3047340550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.563722996073918-------0.0
108CCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCC)O)ODSPC001016.1161486350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.275554390163365-------0.0
109CCCCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCCCC)O)ODSPC001016.8093841150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.35709336812867-------0.0
110O=C(CCCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=ODSPC001017.3272758150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.473579765600494-------0.0
111O=C(CCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CCCCCCOC(CCCCCCC)=ODSPC001017.0323979650.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.5612182984589085-------0.0
112O=C(CCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=ODSPC001016.7157745350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.695924549256556-------0.0
113OC[C@@H](C(NCCCCCCN(CC(O)CCCCCC)CC(O)CCCCCC)=O)N(CC(CCCCCC)O)CC(CCCCCC)ODSPC001014.7235138850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.857484114602081-------0.0
114CCCCCCCCC(CN([C@H](C(NCCCCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CO)CC(CCCCCCCC)O)ODSPC001015.624695450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.483228515182849-------0.0
115OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)=O)N(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)ODSPC001016.3885086850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.426521874560433-------0.0
116OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)ODSPC001017.0440296550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.412919498116252-------0.0
117O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=ODSPC001017.5355814950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.69866052907543-------0.0
118O=C(CCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=ODSPC001016.9553531450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001004.9459189793765646-------0.0
119O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCCDSPC001013.9752115150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001004.450269224770129-------0.0
120O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=ODSPC001017.4673158550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010004.659658371272161-------0.0
121O=C(CCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=ODSPC001016.876916850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010005.139321635057579-------0.0
122O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=ODSPC001018.0430999450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.283448621312786-------0.0
123O=C(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=ODSPC001017.7609325350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010004.1455128487965-------0.0
124C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODSPC001018.0766149250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.3551691805039985-------0.0
125O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCCDSPC001018.1521272950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001006.632923618509176-------0.0
126O=C(C(CCCCCCCC)CCCCCC)OCCCCCC[N+](CC)(CC)CC.[Br-]DSPC001012.6943869150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceTEAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.762173934797756-------0.0
127CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001018.1683207850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2407510473159280.01119140045720230.002271254916163790.008779319355894190.00824370618083030.004018738445147750.008496938260197240.9569986423845640.5961414295809980.596141429580998-0.1583174611704737
128CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001018.1683207850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.240751047315928-0.005317331064861590.691565257509890.285080034958930.01603124880666270.00200612765965623-0.1766024244886840.176602424488684-0.3276946657499996
129C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODSPC001017.8955444550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2533406270458360.02105842488329370.0009316401176148860.03003151705042590.01603606006602870.0020604957531820.005193484572538040.9246883775569170.5077419681356950.507741968135695-0.2946693735871433
130C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODSPC001017.8955444550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.253340627045836-0.005339347869841050.5978448016834090.3742789853378980.01993014730781450.00260671780103763-0.1778601370068110.177860137006811-0.3243384702286213
131O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCCDSPC001018.1521272950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001008.664405571096625-------0.0
132CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODOPE100018.2607536850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.4981416132295680.002242227406158350.0009624222466655620.002872198927993670.003224511768646070.002066618906268620.003334095855940760.9852979248883270.7928585570604830.7928585570604830.14510923508307877
133CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODOPE100018.2607536850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.498141613229568-0.006572307019470910.5562973979050010.4041381642287110.02966244542059420.00332968542622302-0.209480411571820.20948041157182-0.2399600273409918
134C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODOPE100017.9899305250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4627998446963650.01220023327497470.0005910910035853450.001139755933748260.001767661820400170.001186287756211570.0008145121805598940.982300458030521.587128447163311.587128447163311.3702322926201322
135C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODOPE100017.9899305250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.04.462799844696365-0.00559090767477880.8645475423261110.1215039789215080.007299140125687630.00105843095191469-0.7623859425294130.7623859425294131.2354638394013375
136O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.1966002629264480.03907638542783160.001649940098442520.06611924249156160.02062099305498160.001973476930542320.001604542852447980.8689554191441921.01.00.4646149359523945
137O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.196600262926448-0.003843163634960110.8512558674941990.1372104001666040.007011090926596470.000679477777641109-1.01.01.8695349995476385
138O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCC)=O)CCCCCCCCCDSPC001017.6778865150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.401951803481151-------0.0
139O=C(CCCCCCCCC)OCCCCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)CO)=ODSPC001017.8691509550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.421487703554795-------0.0
140OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)ODSPC001017.6128587350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.577593418217857-------0.0
141OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=ODSPC001015.6619137450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDBUChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.647271362006727-------0.0
142OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=ODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5410582405208470.01555239749223230.001291525183050590.4469623801028490.04070670995792960.001706255782843450.004218306073436620.4895624254076591.01.00.4646149359523945
143O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3798993736577070.01659790024474950.003619701465851380.3105663719881810.01189538989785840.007274979634618140.006472223261143030.6435734335075981.01.00.4646149359523945
144C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODSPC001017.8332308450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.17515620495851450.1272707797772070.03556516320012460.09653735296408820.04547402040975310.03380267975383660.04658409285658640.6147659110384050.05050109660985280.0505010966098528-0.999941399550668
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146C=CCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)=ODSPC001018.0171919250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4455881161636260.02503763343043890.003378855450378590.05170095821426910.04301460125780830.003502520566568340.004067539363831550.8692978917167050.5940878468090130.594087846809013-0.1614850137062924
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148O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3821516268620330.02813812366611920.002687923522527220.2184171444869540.03695034275204820.001995534880061370.002899377440325740.7089115532519651.01.00.4646149359523945
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150CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001017.9479509548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3337550860001820.01096509733410360.005003018363333050.02095166074894360.009288769741069860.004983545051506910.006137338777205840.9426705699838370.6241124121020860.624112412102086-0.11517356757013285
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154O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3278344055904550.07916813099890920.004382362383997030.2074507250090390.02000573241763190.004355016928862320.006875862774429370.6777621694871311.01.00.4646149359523945
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168O=C(OCCCCCCN([C@H](C(NCCOCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=CDSPC001017.743927648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.26941769029122750.02739333632936680.00254811370838070.04898896602472620.009103952599865310.005538630371376590.005707316390042810.9007196845762420.2825115115592150.282511511559215-0.6420765069177559
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170O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.779123493111530.08972660596205160.001396134825272670.2567720562789090.1911865122631010.003381609255283120.002973443901567730.4545636375138151.01.00.4646149359523945
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178CC(CNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CDSPC001017.7353531148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.224056168743758-------0.0
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318O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6230101041164220.00870.00330.23480.73930.0110.00300.360.360.16170025772532357
319O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3757570216602860.00190.00230.90770.08180.00330.00301.01.01.8695349995476385
320O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3477610649.07.541.52.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9437829871084150.05420.00010.31460.03780.00140.00060.59131.141.140.680558194273546
321O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10008.63033050334.2518.7545.02.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3956829611213670.030.00060.08370.02610.0020.00130.85630.780.780.12527553001915628
322O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10005.74637555922.030.045.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.2640873368091950.01560.00140.01380.01040.00250.00310.95320.320.32-0.584252318750342
323O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.1573402549.028.020.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5130548970802860.0
324O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10009.81205171844.6124.8927.942.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4704952826614890.0090.00040.01780.09480.00170.00030.87621.051.050.5417375282099487
325O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10007.89369762932.1124.8940.442.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2890886390146120.03430.00030.16970.0270.00130.00090.76660.460.46-0.3683090604291903
326O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.0867591749.018.7531.251.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.96842344528694650.0
327O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.1351297742.1318.7538.131.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9060152449661530.012800.0280.02080.000600.93780.930.930.35664330679181877
328O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.4384851145.6113.6438.192.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5250441415088070.06350.00020.20190.0830.00090.00030.65021.51.51.2358408585279361
329O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.4474839544.57.545.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.45201900649391650.0110.00050.39720.05360.00160.00090.53521.451.451.1587182662703819
330O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.5716909549.030.020.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.868303385518460.0
331O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10008.00994101934.530.032.53.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.34769395559337650.016500.04270.06160.00350.00280.87280.420.42-0.4300071342352337
332O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10009.30114235239.3624.8934.191.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.6298627985784630.024600.12450.08950.00150.00230.75760.440.44-0.399158097332212
333O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10006.52577364324.030.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7326835062870510.0060.00120.02050.01770.000800.95380.440.44-0.399158097332212
334O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3176593246.57.545.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.813809051099420.07300.03730.0149000.87481.011.010.4800394544039054
335O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.0188828846.377.544.211.92PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7068238397145910.01450.00040.11650.0190.00070.00110.84771.941.941.9145196703944125
336O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3056283448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.737951297221910.03430.00030.16970.0270.00130.00090.76661.91.91.8528215965883692
337O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC00109.48098659348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3027128279541560.045500.3240.0730.00110.00120.55511.01.00.4646149359523945
338O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001017.8855161548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7630282706036710.02537016899819310.009852095920987010.3079495376464530.6223008936382440.01746805222837240.0170592515677505-0.0
339O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001017.9439052848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5845592320839670.008947635700815260.001829037731791440.4304163199538470.5497304827920460.007578868566133040.0014976552553668-0.00195320598425320.0019532059842532-0.793744670428099
340O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001018.329169748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.58272005715050.007575683282501890.002205108735396760.7280256151258690.2364467768847450.02264299233535590.00310382363613184-0.00114820997105430.0011482099710543-0.7958927956755514
341O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001018.3810919848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.68886774500965850.005999605473834560.001874719224079340.587253637128080.3938422240908620.009087060693674910.00194275338946932-0.00055858767810530.0005585876781053-0.7974661979200065
342O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1DSPC001019.0310345848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3743724157370220.02071243542549990.007678071734895950.5603318525237880.37971898365440.02060039605243440.0109582606089812-0.00014895806806180.0001489580680618-0.7985592911689305
343O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1DSPC001019.0734961848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5675721555727730.00845259582042460.001706003899546990.8077742570872370.1721718606327810.008511238506704240.00138404405330582-0.00524607123399610.0052460712339961-0.7849576865630203
344O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001017.8855161548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7630282706036710.01429654611639660.002730993690581160.29518748134450.1967905105974680.005675846602325920.009007247197243390.4763113744514850.00332036058888080.0033203605888808-1.0727154128818024
345O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001017.9439052848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5845592320839670.04262585033347260.0008871270421757570.1020996047435990.0571963487718580.002224347800817940.001629610256716670.793337111051360.04651954265664690.0465195426566469-1.006082754792359
346O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001018.329169748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.58272005715050.01826489125928050.0004628676766682480.0830730774622890.04296086169302040.001958257642872270.0009234236249690530.8523566206409010.05092095220374640.0509209522037464-0.9992937925151699
347O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001018.3810919848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.68886774500965850.00689080696037130.0006295478739985480.0213943149436290.0424487771630220.001987083721429520.002484440604759720.924165028732790.0162012629724280.016201262972428-1.0528472412330891
348O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1DSPC001019.0310345848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3743724157370220.01169326763754750.001037390277643260.05250711359109410.02154775991938750.003688747584352420.004009724608555770.9055159963814190.0061044617937550.006104461793755-1.068421070841257
349O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1DSPC001019.0734961848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5675721555727730.02379119812584130.000672072030559790.183348810143480.04664426840444730.001882463893459580.0009536483447079040.7427075390575040.05504888227319850.0550488822731985-0.9929266591628888
350O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8249121448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGLNChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5725436831609980.0007149972592495260.0006615521426571720.1259433207785540.8019661628740890.06931465030975980.00139931663568972-0.01273734387781320.0127373438778132-0.764967287060561
351O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9108191848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceBIMChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3585020896269240.001472338624202370.001074054729631310.9014301683351020.09231591340926670.003101608667764920.000605916234032228-0.07634346211405440.0763434621140544-0.5952348831288257
352O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8135726248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescence3FLAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3962992939606010.001102231841804530.001617974261335870.9633222017177950.03219957761778040.001292021175643970.000465993385639812-0.3803760879232580.3803760879232580.21607368094058316
353O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.3514385529058580.000618025227128510.002081914199617060.005201076499908650.0187802521865080.9666711457246690.00664758616216931-0.02898868126049620.0289886812604962-0.7216007267742771
354O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2DSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceIZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5449954629520210.004237985229066510.003606059858827060.01321633083593380.1827688636347740.7890786218947970.00709213854660109-0.00333873262999930.0033387326299993-0.7900474039572776
355O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8088437448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePYChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.2370008626236240.01234833106850720.004307192492523660.04298744650705880.7519786052371790.1740738148281350.0143046098665965-0.00050909567679020.0005090956767902-0.7975982669188943
356O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7904872517618450.001535134831257640.001479319047437390.823383199449070.1690334834470060.003782623622926230.000786239602302501-0.3060095007469190.3060095007469190.017627054049161966
357O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100017.1033864748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.8420588390939730.001642870850709310.0006591953795399640.940175886974190.05507510379890280.001831734591612620.000615208405045708-0.5042318247128290.5042318247128290.5465816969768794
358O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8249121448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceGLNChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5725436831609980.02048817921248960.009960766775760780.0245156831256480.02060760677332140.02136567533321140.01463961674764020.8884224720319290.00355740414764120.0035574041476412-1.0723497846072114
359O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9108191848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceBIMChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3585020896269240.07894427186293890.0008592205591640780.3525134142897490.01677256895415610.002079920926292010.0009392356208227430.5478913677868780.1280341520825890.128034152082589-0.8803503950765449
360O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8135726248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescence3FLAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3962992939606010.0205897912198930.002212958221334620.770066394728070.03361563689369980.001419820596404970.0008043314440274440.171291066896570.3526238383609510.352623838360951-0.5339316190745824
361O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110001.04.3514385529058580.05187019339257290.0312301517117120.1961196024635620.08912507656157290.2259984369677170.1833121473049020.2223443915979610.00069167669538580.0006916766953858-1.0767700312036428
362O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2DSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceIZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5449954629520210.03181343918562520.01957394709182120.06586379089295550.04051468238537270.03833552147782530.04458039602206880.7593182229443310.00078261071314280.0007826107131428-1.0766297698601666
363O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8088437448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePYChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2370008626236240.04960072407063460.02480507603684460.1251567405507840.09132906559061730.06056549162321930.06476095298254880.5837819491453520.0003195942391260.000319594239126-1.077343950474849
364O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7904872517618450.06604655097497110.0007046862442753380.1768829381025080.1342541500198030.003017007679026680.001465590500617170.6176290764787990.3917964976518640.391796497651864-0.473509678471839
365O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100017.1033864748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8420588390939730.1809625205798080.0008401831312633930.06004984482200660.01399037974230450.002300224308132730.002214948498499460.7396418989179860.5151697208812090.515169720881209-0.2832124226594992
366O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.0775877448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.488973391585580.0001361741321454220.002124526885072340.8116339002045020.1797618786378860.003857515564583060.00248600457581157-0.7677598926352940.7677598926352941.24980418110703
367O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5045453548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceALAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6756286496366530.002681003515835570.002404316320251120.1420407111815020.5233204371657690.3248689313672640.00468460044937817-0.02418971611359150.0241897161135915-0.7344067258409619
368O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5967196648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceSERChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7376009731685810.001574321100649450.001768448828174440.0537654693631150.4381566263887130.5005330905621060.00420204375724176-0.01896247197312650.0189624719731265-0.7483555838832638
369O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.0775877448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.488973391585580.05503096395316620.002343538358968550.3201982527271960.2826561333844960.00647980771988270.002024762156216460.3312665417000751.201351272858151.201351272858150.775189578295967
370O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5045453548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceALAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6756286496366530.04186594266195050.02191539256771620.216687596212540.1998754503620370.1130298240890510.04956294586612350.3570628482405820.00277072722385720.0027707272238572-1.0735631958798397
371O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5967196648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceSERChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7376009731685810.02341188122166890.00714627137553530.04269587812267520.04640789350058450.03460440338465980.02359671186289260.8221369605319840.00554577380572740.0055457738057274-1.0692828201592537
372O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1693008848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceTZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.05.0019308534661090.007673585378074480.002332156539962070.07136847277071580.3074447638986410.01727883809767040.005112282956530410.5887899003584050.00639178295120140.0063917829512014-1.0679778917918028
373O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5792368039615870.008330630627793890.001739877624292090.1566519618493430.1122051383242950.008953040097654260.004272898738282590.7078464527383390.2693908353579880.269390835357988-0.6623145181339684
374O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1584793848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescence3FChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4841318576110350.01583110335276070.001093538471382430.02009906235293180.005897176735039590.003320808161896930.002978027202828060.950780283723160.00701142917678520.0070114291767852-1.06702211732781
375O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8139528948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePYRChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.05.07554874493890.01382534042976630.006703759222215070.0649180337297370.03100822728704040.03076912146668710.01560911890562440.837166398958930.01114342568801360.0111434256880136-1.060648711684908
376O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4028091738564110.01440512488828930.0005257886602972210.1256670673311170.2143735465990950.004108808511208610.001771673377542580.6391479906324510.1765126288897360.176512628889736-0.8055746790752468
377O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1693008848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceTZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.05.0019308534661090.001151197971145680.00039598185076720.05381242095391680.936045246647050.007365029721909040.00123012285521143-0.02615188198592550.0261518819859255-0.7291707023316024
378O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5792368039615870.00109420595997370.0007145781519885520.3670345111201160.620781604798830.00794788569780320.00242721427128835-0.9705101739899730.9705101739899731.7908416411254202
379O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1584793848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescence3FChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4841318576110350.03762301306258740.002360090276238130.2470397056927430.6974529726033750.01046818653826280.00505603182679352-0.00138844034319760.0013884403431976-0.7952517429011965
380O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8139528948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePYRChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.05.07554874493890.008738268136764380.001451124759395440.1930650802831250.7781970187985230.0144332136813340.00411529434085825-0.1657216652344370.165721665234437-0.35672988242469916
381O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4028091738564110.005324220795326150.000610844497635910.5224696762713130.4597789842092210.009668948738036840.00214732548846694-0.1610206624028550.161020662402855-0.3692744698577941
382O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5847633762104290.03183913464166560.0003415522251137170.1136782814094460.2422797677315520.003875506194544750.0008716251103375370.607114132687340.6498333862516020.649833386251602-0.07550020353412855
383O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7463224657439750.05481931424920010.0002633620250269130.09029568041228170.1608376290101280.003153555083538470.0007395009931080330.6898909582267171.163752389990061.163752389990060.7171951120404622
384O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=ODSPC001016.8734651848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceHISChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.6513856097850550.01725667652872490.003183443654119150.07128908769607150.1719650680582140.02181353020995030.01154937774558460.7029428161073350.003274052824270.00327405282427-1.0727868403787713
385O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5847633762104290.0005999639271510760.0003979977527346260.4209765088271420.5601783949082490.0170441599942420.000802974590480822-0.252558286406420.25255828640642-0.1250070722684871
386O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7463224657439750.0005243745788385270.000615149161963690.5474321245870290.4354353172871240.0153091134031910.000683920981854007-0.5683944895522760.5683944895522760.7177992409467366
387O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=ODSPC001016.8734651848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceHISChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6513856097850550.001719835019889670.001895610167046930.01207166358060030.7112786468351230.2704388261066560.00259541829068387-0.01128972345421170.0112897234542117-0.7688302502674332
388O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4847336328661440.00478509514152610.0006759117725754380.460692650341020.5223593598372590.01097751216996240.00050947073765779-0.7732054146079260.7732054146079261.2643355117511204
389O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6337576428400040.001989114141896350.001268115954131230.5438675837302960.4388427705215520.01299886351377290.00103355213835123-1.984930539105391.984930539105394.497814051056962
390O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001018.033391148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6097596383218990.001250314231535860.00048603620252150.5382495397268110.4454146408994460.01378016944550060.000819299494184621-0.2911374447973450.291137444797345-0.022058905064912687
391O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001016.6873880848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3928841446746630.002262851853885510.0005628723058581370.7313644397975270.2569326193475530.008254512386006190.000622704309170273-1.828722794594791.828722794594794.080974968218046
392O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4847336328661440.04429234588340680.000554526503313330.1064598812950740.1925269407339640.003116828821969980.0006230420688089780.6524264346934630.6724315389024460.672431538902446-0.04064364128082843
393O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6337576428400040.03746100134028090.00053505511067640.2608554395388440.4699055431280850.004693340556934510.0009120939456764050.2256375263795031.692761008312311.692761008312311.5331654314724417
394O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001018.033391148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6097596383218990.08366452314287070.0004195998066843750.02356843070012880.07122752129701750.001196813084974750.001782958594149920.8181401533741740.4260582901836350.426058290183635-0.4206625133630252
395O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001016.6873880848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3928841446746630.05129907354328090.0006721896554912440.1873439724836810.2321874364332340.003147918708508240.001466797344527250.5238826118312781.307840951139471.307840951139470.9394447790505344
396O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001017.7875976748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7512598918599860.004057997029842030.002250472241821050.7192702087504140.2572086997206850.01387181782144650.00334080443579049-1.251606109420241.251606109420242.540943835364252
397O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.3172977448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6662652853479020.002729829658037860.0001723653525173030.4980480220510360.4791374423060180.01803169597272670.00188064465966415-0.1555371691315050.155537169131505-0.3839071266005448
398O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.7141903948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9047561254426960.002732862002550750.002600550697920030.4311462579180510.503490189514580.05501380280959670.00501633705730229-0.0219853087993660.021985308799366-0.7402891686477768
399O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7332115358689760.001665285761580170.0001768860386207120.2052072250421430.7509160285453820.03927204517105160.00276252944122191-0.1200966909619610.120096690961961-0.478479751420455
400O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001018.7067898948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.8587265437104960.003837431593303120.002489507292141280.5559034224234810.3804456357090310.05156687125668010.00575713172536402-0.05265384122510380.0526538412251038-0.6584504418393717
401O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.3172977448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6662652853479020.05672891570854950.006533482670080080.0648395772855760.3350552774539610.01449556942253920.01437366187417620.5079735155851180.2683113660519180.268311366051918-0.6639795475568999
402O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.7141903948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9047561254426960.02485528982681630.01251927287357680.07253076425985960.03552546912826670.02143956481541440.02487457992369390.8082550591723720.07418452434615880.0741845243461588-0.9634108527393006
403O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7332115358689760.08839170078935020.001745998389119230.05364053324148950.1001186712107480.007719900633961030.006397761182357370.7419854345529740.5280355090867130.528035509086713-0.2633675639025965
404O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001018.7067898948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8587265437104960.01756794052947970.009601738911743040.09031791317526130.03881849373792540.01824975462857870.02490458685331770.8005395721636940.1251815103995770.125181510399577-0.8847504575040614
405O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.6287057848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7655869073939960.001592786554473880.001866111601963270.4887959189448620.4852474097005460.0186161981810970.00388157501705755-0.3525707463709570.3525707463709570.14187535545424673
406O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.6188024648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.04.823743308787540.0008754152347094840.001273758542852460.6833778371049490.3040032579211650.008203555612704210.00226617558361995-0.9434205611724430.9434205611724431.7185532318874628
407O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.4333136790419010.0006021901209873610.0005765288819158980.005661974231285060.01617638593470420.9716832651197970.00529965571131053-0.03057893103716340.0305789310371634-0.7173571583105779
408O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.7092982648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.3563241373215090.001873780528195120.001576549756525540.01638637962163180.06482461591650970.9052800074279390.0100586667491993-0.0038751363614790.003875136361479-0.7886160150068647
409O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=ODSPC001018.1727395648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.4407671296964820.003010499062177319.21592223531261e-050.003800968274147730.01303234810025410.976573274923540.00349075041752818-0.02744014410273760.0274401441027376-0.7257329854571254
410O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=ODSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.3496325668628770.002739892740947480.001610183930614260.01128248399633270.05833529406992120.9192474016859630.00678474357622127-0.00816018968837710.0081601896883771-0.7771813854096181
411O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=ODSPC001018.9034565248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6627784986084050.003493154511189280.001712981783993120.0377973259747310.2428168379729130.7065698897632850.00760980999388795-0.01367670513954040.0136767051395404-0.7624606092513427
412O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCNDSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10000014.405498990859024-------0.0
413O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110004.815106909815019-------0.0
414O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.5620538949144630.002417006501551690.001891617599549230.01178045923123530.05880983641151770.9180164882918770.0070845919642692-0.2883853227609080.288385322760908-0.029402920107978105
415O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6672055769075440.001467712640568840.0008532673802991070.005218533833133670.09841944583993510.8907524056111610.00328863469490281-0.1747309486411070.174730948641107-0.3326886836733955
416O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001017.9479922148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.7013890437286340.002563209244328860.001937962716009520.01281467566809690.04184025869472320.9345530528943210.00629084078252029-0.04926742917072990.0492674291707299-0.6674870545840368
417O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.4604911746186480.001010516129372290.001535120673828250.009500985513535920.1619319638939410.8228359933993150.00318542039000704-0.1050559008039770.105055900803977-0.5186159763833679
418O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001019.076471848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.5054603418390790.002827634257667420.001352204283895790.1015503103108280.7013643725797190.189505298029720.00340018053817036-0.07003022223518680.0700302222351868-0.6120817118766197
419O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001017.1845343148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6849051540069450.00259031098421970.001222673276485110.09593804175007910.5580646312132310.3393265417443480.00285780103163663-0.08365671084468980.0836567108446898-0.5757195389760648
420O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001018.5849791348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6959245492565560.002701626309254470.0005719771568024910.0726498218770920.2836209169678580.6385209044566370.00193475323235631-0.1083727029973610.108372702997361-0.5097651169808466
421O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=ODSPC001016.8251830648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceLYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10001004.202899968776446-------0.0
422O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.5294832643.2525.030.01.75PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.05.0297841129350160.0009518629510334060.0006422378825845550.007479531328111330.2951371126795440.6927541632297380.0030350919289883-0.194353938619060.19435393861906-0.2803248961378029
423O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001011.1016934530.025.042.52.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8331022540340980.005296262493199830.002462672139770970.02892600069238070.5630650882785350.3938477032294610.00640227316665243-0.0490727607633690.049072760763369-0.6680065256297026
424O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.7280431538.07517.97541.8252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100104.93014804318357-------0.0
425O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.3926165837.025.037.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.05.1469129123888040.0007593661670235550.0006948179871520340.004663640256959320.2126800856531050.7775931477516060.00360894218415418-0.2012387551058620.201238755105862-0.2619528199077537
426O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.5103953238.520.538.52.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6849051540069450.001575352256521280.005929271300775560.009005178901286910.3661355039335790.6138333288393620.00352136476847493-0.1493296569009360.149329656900936-0.40047182198750214
427O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.4829063945.09.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8698394841307990.001471175550889170.0009271038433158290.005852370616452940.1361460165143740.8515751357374550.00402819773751327-0.312197036993320.312197036993320.034138443686487704
428O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.1313804241.222.3534.3252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.04.9015641990418940.003157074227687520.00256893890542120.01467120173911320.3278493469019050.6460616938471230.0056917443787501-0.1585413759980410.158541375998041-0.3758904252594646
429O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.1194224241.82514.97541.8251.375PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101005.039546637590676-------0.0
430O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.7949292745.022.530.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.91412439371541150.001133500280341280.0005669397521278730.006807069264679140.5026612986257490.4867338942181440.00209729785895866-0.1454484154486280.145448415448628-0.4108288829150842
431O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001012.5539371834.32521.72541.8252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.04.8146204101702980.0016928784436670.0008201357260383030.008681365755078820.4089284489155810.5771011220319780.00277604912765729-0.1137603665106720.113760366510672-0.495388181160095
432O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.9395986145.07.545.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.5276409834788540.005063343439193770.0042813443330510.01657717177325860.2268905911701620.7363489005908830.0108386486934518-0.05473437656423270.0547343765642327-0.6528985503803821
433O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.5933701345.015.7537.51.75PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8105570157130420.001411122355587080.0007497671568420640.006375411612512230.1388808414943290.8476484763047510.00493438107597822-0.2941544338784090.294154433878409-0.0140080944893819
434O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001011.6603133730.024.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.05.1676390429059210.001992362670325570.0008275772353942160.0087190848576440.1921323658461870.7923302576408730.0039983517495764-0.1517939844659880.151793984465988-0.3938957841268362
435O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.6635816537.515.045.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6180864112546370.002714807866091930.001816645383447740.009385130272749360.1325471847366950.8495095957368920.0040266360041233-0.09500361143845570.0950036114384557-0.5454404279666308
436O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.2618629445.024.030.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101005.098035484377089-------0.0
437O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.2761185945.011.38242.6181.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6802776584748970.001529246076836280.001925087026142220.01057620531887160.1672702556839680.8108753862813060.00782381961287527-0.2787549238426370.278754923842637-0.05510156049896443
438O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.1100192345.013.44540.4451.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9243509254992430.0009994386160706770.001251584819277410.007718427304728460.2494697372085870.7354504949584720.00511031709286499-0.2864559061152860.286455906115286-0.03455155257492116
439O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.8566269145.016.40537.5951.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9243509254992430.001413386197684390.001243220634207370.01004508917937940.2358947510861750.7455567851666540.00584676773589971-0.2643364178336390.264336417833639-0.09357722532293417