lnp_ml/data/interim/internal_corrected.csv
2026-01-19 18:57:55 +08:00

284 KiB

1smilesHelper_lipid_IDHelper_lipid_ID_DOPEHelper_lipid_ID_DOTAPHelper_lipid_ID_DSPCHelper_lipid_ID_MDOACationic_Lipid_to_mRNA_weight_ratioCationic_Lipid_Mol_RatioPhospholipid_Mol_RatioCholesterol_Mol_RatioPEG_Lipid_Mol_RatioPurityMix_typeCargo_typeCargo_type_mRNACargo_type_pDNACargo_type_siRNATarget_or_delivered_geneModel_typeModel_type_A549Model_type_BDMCModel_type_BMDMModel_type_HBEC_ALIModel_type_HEK293TModel_type_HeLaModel_type_IGROV1Model_type_MouseModel_type_RAW264p7Delivery_targetDelivery_target_bodyDelivery_target_dendritic_cellDelivery_target_generic_cellDelivery_target_liverDelivery_target_lungDelivery_target_lung_epitheliumDelivery_target_macrophageDelivery_target_muscleDelivery_target_spleenRoute_of_administrationRoute_of_administration_in_vitroRoute_of_administration_intramuscularRoute_of_administration_intratrachealRoute_of_administration_intravenousBatch_or_individual_or_barcodedBatch_or_individual_or_barcoded_BarcodedBatch_or_individual_or_barcoded_IndividualValue_nameFormulation_IDCationic_Lipid_Mass_RatioPhospholipid_Mass_RatioCholesterol_Mass_RatioPEG_Lipid_Mass_RatioAmineTailLipid_nameLibrary_IDExperiment_IDExperimenter_IDExperiment_weightGoalscreen_idSourceSample_weightCommentAmine_numberFull_SMILESAmine_SMILESTail_lengthNum_tailsKetoneIsocyanideIs_cyclicFormulationBatch_or_individualRandom_id4CR_Lipid_nameAldehydeCarboxylic_acidAmine_nameTail_nameLinkerMolWtTail_countNum tailsCommon_nameEsterDisulfideTotal_radianceForm_commentmolecular_weightsplit_name_for_normalizationEncapsulation_Efficiency_EE<50Encapsulation_Efficiency_50<=EE<80Encapsulation_Efficiency_80<EE<=100PDI_0_0to0_2PDI_0_2to0_3PDI_0_3to0_4PDI_0_4to0_5toxicsizeBiodistribution_lymph_nodesBiodistribution_heartBiodistribution_liverBiodistribution_spleenBiodistribution_lungBiodistribution_kidneyBiodistribution_musclequantified_total_luminescenceunnormalized_deliveryquantified_delivery
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75O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)CN(CCCCCCCC)CCCCCCCCDSPC001013.8332769350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.3438443821336840.000.00.00.00.00.00.0
76O=C(NCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCCDSPC001013.5388956450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.3014942237819610.000.00.00.00.00.00.0
77O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=ODSPC001018.2737690950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.5969393790381520.000.00.00.00.00.00.0
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79O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCCDSPC001015.0636878850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4036658097773630.01592626640083090.007264717469944250.06446914435118970.01542483972254390.00666778094817390.006184262365540.8840629887417770.1639838676727070.163983867672707-0.6273685605189503
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81O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCCDSPC001015.9117665150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001000.04.2853780596180760.00952025723585670.004247871121988890.02704948029587920.00951147065788180.00569809581675410.00864159943836190.9353312254332770.222812475742140.22281247574214-0.5671454450317258
82O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCCDSPC001015.9117665150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01001000.04.2853780596180760.00.005774017873322590.7811233297408650.2023862888534940.00852464019685450.00219172333546330.00.236886988352550.23688698835255-0.16682580237138014
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85CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001018.1683207850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.491217305912060.03076905432531170.0008038468935280310.00327375890943850.00440309874760960.00131506681420970.00341198428561480.9560231900242871.143705006411171.143705006411170.37557645585614496
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87O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.5738858959483250.00305704097815130.001004917793202090.01657732595741030.01177102714129670.0020869712985650.00287252217431470.962630194657061.01.00.2284649826936687
88O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.5738858959483250.00.003300408326120470.5453988019752740.4461922510443120.00323782528214890.00187071337214380.01.01.01.8695349995476385
89O=C(CN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=ODSPC001017.7975645750.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.7890423186070250.000.00.00.00.00.00.0
90CCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=ODSPC001017.4077098950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.1682086812010160.000.00.00.00.00.00.0
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92O=C(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCCDSPC001016.3873768250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001004.21123831369360.000.00.00.00.00.00.0
93CCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=ODSPC001017.6120066250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.279993909108730.000.00.00.00.00.00.0
94O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.255492450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.6111522576656390.000.00.00.00.00.00.0
95CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=ODSPC001018.39156150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010005.14224818089814750.000.00.00.00.00.00.0
96O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCCDSPC001016.6340034250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5153548816657270.000.00.00.00.00.00.0
97O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCDSPC001017.2563702450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.575329343977070.000.00.00.00.00.00.0
98O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCCDSPC001017.7983325850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001005.4518964544763370.000.00.00.00.00.00.0
99O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.255492450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.9250774057346090.000.00.00.00.00.00.0
100CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=ODSPC001018.39156150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.8299124586659980.000.00.00.00.00.00.0
101O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCCDSPC001016.6340034250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.4217280015254340.000.00.00.00.00.00.0
102O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCDSPC001017.2563702450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.7757564865636250.000.00.00.00.00.00.0
103O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCCDSPC001017.7983325850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001008.8623419635163470.000.00.00.00.00.00.0
104CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=ODSPC001018.5504205750.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101005.55063129516202650.000.00.00.00.00.00.0
105OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)ODSPC001014.3422922250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.475972247516410.000.00.00.00.00.00.0
106CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)ODSPC001015.3047340550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5637229960739180.000.00.00.00.00.00.0
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109O=C(CCCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=ODSPC001017.3272758150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.4735797656004940.000.00.00.00.00.00.0
110O=C(CCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CCCCCCOC(CCCCCCC)=ODSPC001017.0323979650.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.56121829845890850.000.00.00.00.00.00.0
111O=C(CCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=ODSPC001016.7157745350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.6959245492565560.000.00.00.00.00.00.0
112OC[C@@H](C(NCCCCCCN(CC(O)CCCCCC)CC(O)CCCCCC)=O)N(CC(CCCCCC)O)CC(CCCCCC)ODSPC001014.7235138850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.8574841146020810.000.00.00.00.00.00.0
113CCCCCCCCC(CN([C@H](C(NCCCCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CO)CC(CCCCCCCC)O)ODSPC001015.624695450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.4832285151828490.000.00.00.00.00.00.0
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255O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4441794998959660.04122365538926410.003906632314769250.1215170801438590.01881772679213660.00482332620655520.00736318860597740.8023483905474391.01.00.2284649826936687
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315O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3757570216602860.00190.90770.00330.08180.00.0030.00231.01.01.8695349995476385
316O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3477610649.07.541.52.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9437829871084150.05420.31460.00140.03780.59130.00060.00011.141.140.37178362382589436
317O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10008.63033050334.2518.7545.02.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3956829611213670.030.08370.0020.02610.85630.00130.00060.780.780.0032499752001711128
318O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10005.74637555922.030.045.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.2640873368091950.01560.01380.00250.01040.95320.00310.00140.320.32-0.4676541313771421
319O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.1573402549.028.020.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5130548970802860.000.00.00.00.00.00.0
320O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10009.81205171844.6124.8927.942.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4704952826614890.0090.01780.00170.09480.87620.00030.00041.051.050.27965021166946363
321O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10007.89369762932.1124.8940.442.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2890886390146120.03430.16970.00130.0270.76660.00090.00030.460.46-0.3243354902449163
322O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.0867591749.018.7531.251.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.96842344528694650.000.00.00.00.00.00.0
323O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.1351297742.1318.7538.131.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9060152449661530.01280.0280.00060.02080.93780.00.00.930.930.15680566212755587
324O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.4384851145.6113.6438.192.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5250441415088070.06350.20190.00090.0830.65020.00030.00021.51.50.7403172724516178
325O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.4474839544.57.545.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.45201900649391650.0110.39720.00160.05360.53520.00090.00051.451.450.6891320434758229
326O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.5716909549.030.020.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.868303385518460.000.00.00.00.00.00.0
327O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10008.00994101934.530.032.53.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.34769395559337650.01650.04270.00350.06160.87280.00280.00.420.42-0.3652836734255523
328O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10009.30114235239.3624.8934.191.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.6298627985784630.02460.12450.00150.08950.75760.00230.00.440.44-0.3448095818352343
329O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10006.52577364324.030.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7326835062870510.0060.02050.00080.01770.95380.00.00120.440.44-0.3448095818352343
330O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3176593246.57.545.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.813809051099420.0730.03730.00.01490.87480.00.01.011.010.23870202848882768
331O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.0188828846.377.544.211.92PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7068238397145910.01450.11650.00070.0190.84770.00110.00041.941.941.190747287438613
332O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3056283448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.737951297221910.03430.16970.00130.0270.76660.00090.00031.91.91.149799104257977
333O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC00109.48098659348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3027128279541560.04550.3240.00110.0730.55510.00120.01.01.00.2284649826936687
334O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001017.8855161548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7630282706036710.02537016899819310.009852095920987010.3079495376464530.6223008936382440.01746805222837240.01705925156775050.00.0
335O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001017.9439052848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5845592320839670.00894763570081520.001829037731791440.4304163199538470.5497304827920460.0075788685661330.00149765525536680.00.00195320598425320.0019532059842532-0.793744670428099
336O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001018.329169748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.58272005715050.00757568328250180.002205108735396760.7280256151258690.2364467768847450.02264299233535590.00310382363613180.00.00114820997105430.0011482099710543-0.7958927956755514
337O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001018.3810919848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.68886774500965850.00599960547383450.001874719224079340.587253637128080.3938422240908620.00908706069367490.00194275338946930.00.00055858767810530.0005585876781053-0.7974661979200065
338O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1DSPC001019.0310345848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3743724157370220.02071243542549990.007678071734895950.5603318525237880.37971898365440.02060039605243440.01095826060898120.00.00014895806806180.0001489580680618-0.7985592911689305
339O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1DSPC001019.0734961848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5675721555727730.00845259582042460.001706003899546990.8077742570872370.1721718606327810.00851123850670420.00138404405330580.00.00524607123399610.0052460712339961-0.7849576865630203
340O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001017.8855161548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7630282706036710.01429654611639660.002730993690581160.29518748134450.1967905105974680.00567584660232590.00900724719724330.4763113744514850.00332036058888080.0033203605888808-0.7918405284817481
341O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001017.9439052848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5845592320839670.04262585033347260.0008871270421757570.1020996047435990.0571963487718580.00222434780081790.00162961025671660.793337111051360.04651954265664690.0465195426566469-0.7476173279676349
342O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001018.329169748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.58272005715050.01826489125928050.0004628676766682480.0830730774622890.04296086169302040.00195825764287220.0009234236249690.8523566206409010.05092095220374640.0509209522037464-0.7431115848579443
343O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001018.3810919848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.68886774500965850.00689080696037130.0006295478739985480.0213943149436290.0424487771630220.00198708372142950.00248444060475970.924165028732790.0162012629724280.016201262972428-0.7786542897234137
344O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1DSPC001019.0310345848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3743724157370220.01169326763754750.001037390277643260.05250711359109410.02154775991938750.00368874758435240.00400972460855570.9055159963814190.0061044617937550.006104461793755-0.7889904313284827
345O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1DSPC001019.0734961848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5675721555727730.02379119812584130.000672072030559790.183348810143480.04664426840444730.00188246389345950.00095364834470790.7427075390575040.05504888227319850.0550488822731985-0.7388858039419247
346O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8249121448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGLNChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5725436831609980.00071499725924950.0006615521426571720.1259433207785540.8019661628740890.06931465030975980.00139931663568970.00.01273734387781320.0127373438778132-0.764967287060561
347O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9108191848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceBIMChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3585020896269240.00147233862420230.001074054729631310.9014301683351020.09231591340926670.00310160866776490.00060591623403220.00.07634346211405440.0763434621140544-0.5952348831288257
348O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8135726248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescence3FLAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3962992939606010.00110223184180450.001617974261335870.9633222017177950.03219957761778040.00129202117564390.00046599338563980.00.3803760879232580.3803760879232580.21607368094058316
349O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.3514385529058580.00061802522712850.002081914199617060.00520107649990860.0187802521865080.9666711457246690.00664758616216930.00.02898868126049620.0289886812604962-0.7216007267742771
350O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2DSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceIZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5449954629520210.00423798522906650.003606059858827060.01321633083593380.1827688636347740.7890786218947970.0070921385466010.00.00333873262999930.0033387326299993-0.7900474039572776
351O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8088437448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePYChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.2370008626236240.01234833106850720.004307192492523660.04298744650705880.7519786052371790.1740738148281350.01430460986659650.00.00050909567679020.0005090956767902-0.7975982669188943
352O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7904872517618450.00153513483125760.001479319047437390.823383199449070.1690334834470060.00378262362292620.00078623960230250.00.3060095007469190.3060095007469190.017627054049161966
353O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100017.1033864748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.8420588390939730.00164287085070930.0006591953795399640.940175886974190.05507510379890280.00183173459161260.00061520840504570.00.5042318247128290.5042318247128290.5465816969768794
354O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8249121448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceGLNChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5725436831609980.02048817921248960.009960766775760780.0245156831256480.02060760677332140.02136567533321140.01463961674764020.8884224720319290.00355740414764120.0035574041476412-0.7915978659051004
355O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9108191848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceBIMChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3585020896269240.07894427186293890.0008592205591640780.3525134142897490.01677256895415610.0020799209262920.00093923562082270.5478913677868780.1280341520825890.128034152082589-0.6641704490008483
356O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8135726248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescence3FLAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3962992939606010.0205897912198930.002212958221334620.770066394728070.03361563689369980.00141982059640490.00080433144402740.171291066896570.3526238383609510.352623838360951-0.4342569586456501
357O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110001.04.3514385529058580.05187019339257290.0312301517117120.1961196024635620.08912507656157290.2259984369677170.1833121473049020.2223443915979610.00069167669538580.0006916766953858-0.7945315242216187
358O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2DSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceIZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5449954629520210.03181343918562520.01957394709182120.06586379089295550.04051468238537270.03833552147782530.04458039602206880.7593182229443310.00078261071314280.0007826107131428-0.7944384346512071
359O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8088437448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePYChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2370008626236240.04960072407063460.02480507603684460.1251567405507840.09132906559061730.06056549162321930.06476095298254880.5837819491453520.0003195942391260.000319594239126-0.7949124267360493
360O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7904872517618450.06604655097497110.0007046862442753380.1768829381025080.1342541500198030.00301700767902660.00146559050061710.6176290764787990.3917964976518640.391796497651864-0.3941557279377265
361O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100017.1033864748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8420588390939730.1809625205798080.0008401831312633930.06004984482200660.01399037974230450.00230022430813270.00221494849849940.7396418989179860.5151697208812090.515169720881209-0.2678579943282088
362O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.0775877448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.488973391585580.00013617413214540.002124526885072340.8116339002045020.1797618786378860.0038575155645830.00248600457581150.00.7677598926352940.7677598926352941.24980418110703
363O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5045453548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceALAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6756286496366530.00268100351583550.002404316320251120.1420407111815020.5233204371657690.3248689313672640.00468460044937810.00.02418971611359150.0241897161135915-0.7344067258409619
364O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5967196648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceSERChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7376009731685810.00157432110064940.001768448828174440.0537654693631150.4381566263887130.5005330905621060.00420204375724170.00.01896247197312650.0189624719731265-0.7483555838832638
365O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.0775877448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.488973391585580.05503096395316620.002343538358968550.3201982527271960.2826561333844960.00647980771988270.00202476215621640.3312665417000751.201351272858151.201351272858150.434589202809912
366O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5045453548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceALAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6756286496366530.04186594266195050.02191539256771620.216687596212540.1998754503620370.1130298240890510.04956294586612350.3570628482405820.00277072722385720.0027707272238572-0.7924031906745775
367O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5967196648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceSERChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7376009731685810.02341188122166890.00714627137553530.04269587812267520.04640789350058450.03460440338465980.02359671186289260.8221369605319840.00554577380572740.0055457738057274-0.7895623627803471
368O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1693008848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceTZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.05.0019308534661090.00767358537807440.002332156539962070.07136847277071580.3074447638986410.01727883809767040.00511228295653040.5887899003584050.00639178295120140.0063917829512014-0.7886962993438131
369O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5792368039615870.00833063062779380.001739877624292090.1566519618493430.1122051383242950.00895304009765420.00427289873828250.7078464527383390.2693908353579880.269390835357988-0.5194629649866438
370O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1584793848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescence3FChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4841318576110350.01583110335276070.001093538471382430.02009906235293180.00589717673503950.00332080816189690.0029780272028280.950780283723160.00701142917678520.0070114291767852-0.7880619646650031
371O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8139528948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePYRChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.05.07554874493890.01382534042976630.006703759222215070.0649180337297370.03100822728704040.03076912146668710.01560911890562440.837166398958930.01114342568801360.0111434256880136-0.7838320209139149
372O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4028091738564110.01440512488828930.0005257886602972210.1256670673311170.2143735465990950.00410880851120860.00177167337754250.6391479906324510.1765126288897360.176512628889736-0.6145428102854165
373O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1693008848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceTZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.05.0019308534661090.00115119797114560.00039598185076720.05381242095391680.936045246647050.0073650297219090.00123012285521140.00.02615188198592550.0261518819859255-0.7291707023316024
374O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5792368039615870.00109420595997370.0007145781519885520.3670345111201160.620781604798830.00794788569780320.00242721427128830.00.9705101739899730.9705101739899731.7908416411254202
375O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1584793848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescence3FChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4841318576110350.03762301306258740.002360090276238130.2470397056927430.6974529726033750.01046818653826280.00505603182679350.00.00138844034319760.0013884403431976-0.7952517429011965
376O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8139528948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePYRChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.05.07554874493890.00873826813676430.001451124759395440.1930650802831250.7781970187985230.0144332136813340.00411529434085820.00.1657216652344370.165721665234437-0.35672988242469916
377O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4028091738564110.00532422079532610.000610844497635910.5224696762713130.4597789842092210.00966894873803680.00214732548846690.00.1610206624028550.161020662402855-0.3692744698577941
378O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5847633762104290.03183913464166560.0003415522251137170.1136782814094460.2422797677315520.00387550619454470.00087162511033750.607114132687340.6498333862516020.649833386251602-0.130002183394141
379O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7463224657439750.05481931424920010.0002633620250269130.09029568041228170.1608376290101280.00315355508353840.0007395009931080.6898909582267171.163752389990061.163752389990060.3960990542331664
380O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=ODSPC001016.8734651848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceHISChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.6513856097850550.01725667652872490.003183443654119150.07128908769607150.1719650680582140.02181353020995030.01154937774558460.7029428161073350.003274052824270.00327405282427-0.7918879339524474
381O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5847633762104290.0005999639271510.0003979977527346260.4209765088271420.5601783949082490.0170441599942420.00080297459048080.00.252558286406420.25255828640642-0.1250070722684871
382O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7463224657439750.00052437457883850.000615149161963690.5474321245870290.4354353172871240.0153091134031910.0006839209818540.00.5683944895522760.5683944895522760.7177992409467366
383O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=ODSPC001016.8734651848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceHISChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6513856097850550.00171983501988960.001895610167046930.01207166358060030.7112786468351230.2704388261066560.00259541829068380.00.01128972345421170.0112897234542117-0.7688302502674332
384O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4847336328661440.00478509514152610.0006759117725754380.460692650341020.5223593598372590.01097751216996240.00050947073765770.00.7732054146079260.7732054146079261.2643355117511204
385O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6337576428400040.00198911414189630.001268115954131230.5438675837302960.4388427705215520.01299886351377290.00103355213835120.01.984930539105391.984930539105394.497814051056962
386O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001018.033391148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6097596383218990.00125031423153580.00048603620252150.5382495397268110.4454146408994460.01378016944550060.00081929949418460.00.2911374447973450.291137444797345-0.022058905064912687
387O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001016.6873880848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3928841446746630.00226285185388550.0005628723058581370.7313644397975270.2569326193475530.00825451238600610.00062270430917020.01.828722794594791.828722794594794.080974968218046
388O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4847336328661440.04429234588340680.000554526503313330.1064598812950740.1925269407339640.00311682882196990.00062304206880890.6524264346934630.6724315389024460.672431538902446-0.10686835103687269
389O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6337576428400040.03746100134028090.00053505511067640.2608554395388440.4699055431280850.00469334055693450.00091209394567640.2256375263795031.692761008312311.692761008312310.9376475994130317
390O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001018.033391148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6097596383218990.08366452314287070.0004195998066843750.02356843070012880.07122752129701750.00119681308497470.00178295859414990.8181401533741740.4260582901836350.426058290183635-0.35908177402052893
391O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001016.6873880848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3928841446746630.05129907354328090.0006721896554912440.1873439724836810.2321874364332340.00314791870850820.00146679734452720.5238826118312781.307840951139471.307840951139470.543603174137674
392O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001017.7875976748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7512598918599860.0040579970298420.002250472241821050.7192702087504140.2572086997206850.01387181782144650.00334080443579040.01.251606109420241.251606109420242.540943835364252
393O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.3172977448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6662652853479020.00272982965803780.0001723653525173030.4980480220510360.4791374423060180.01803169597272670.00188064465966410.00.1555371691315050.155537169131505-0.3839071266005448
394O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.7141903948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9047561254426960.00273286200255070.002600550697920030.4311462579180510.503490189514580.05501380280959670.00501633705730220.00.0219853087993660.021985308799366-0.7402891686477768
395O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7332115358689760.00166528576158010.0001768860386207120.2052072250421430.7509160285453820.03927204517105160.00276252944122190.00.1200966909619610.120096690961961-0.478479751420455
396O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001018.7067898948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.8587265437104960.00383743159330310.002489507292141280.5559034224234810.3804456357090310.05156687125668010.0057571317253640.00.05265384122510380.0526538412251038-0.6584504418393717
397O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.3172977448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6662652853479020.05672891570854950.006533482670080080.0648395772855760.3350552774539610.01449556942253920.01437366187417620.5079735155851180.2683113660519180.268311366051918-0.5205680226587145
398O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.7141903948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9047561254426960.02485528982681630.01251927287357680.07253076425985960.03552546912826670.02143956481541440.02487457992369390.8082550591723720.07418452434615880.0741845243461588-0.7192965595198582
399O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7332115358689760.08839170078935020.001745998389119230.05364053324148950.1001186712107480.0077199006339610.00639776118235730.7419854345529740.5280355090867130.528035509086713-0.2546872280231527
400O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001018.7067898948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8587265437104960.01756794052947970.009601738911743040.09031791317526130.03881849373792540.01824975462857870.02490458685331770.8005395721636940.1251815103995770.125181510399577-0.6670907113554655
401O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.6287057848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7655869073939960.00159278655447380.001866111601963270.4887959189448620.4852474097005460.0186161981810970.00388157501705750.00.3525707463709570.3525707463709570.14187535545424673
402O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.6188024648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.04.823743308787540.00087541523470940.001273758542852460.6833778371049490.3040032579211650.00820355561270420.00226617558361990.00.9434205611724430.9434205611724431.7185532318874628
403O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.4333136790419010.00060219012098730.0005765288819158980.0056619742312850.01617638593470420.9716832651197970.00529965571131050.00.03057893103716340.0305789310371634-0.7173571583105779
404O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.7092982648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.3563241373215090.00187378052819510.001576549756525540.01638637962163180.06482461591650970.9052800074279390.01005866674919930.00.0038751363614790.003875136361479-0.7886160150068647
405O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=ODSPC001018.1727395648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.4407671296964820.00301049906217739.21592223531261eNaN050.00380096827414770.01303234810025410.976573274923540.00349075041752810.00.02744014410273760.0274401441027376-0.7257329854571254
406O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=ODSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.3496325668628770.00273989274094740.001610183930614260.01128248399633270.05833529406992120.9192474016859630.00678474357622120.00.00816018968837710.0081601896883771-0.7771813854096181
407O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=ODSPC001018.9034565248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6627784986084050.00349315451118920.001712981783993120.0377973259747310.2428168379729130.7065698897632850.00760980999388790.00.01367670513954040.0136767051395404-0.7624606092513427
408O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCNDSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10000014.4054989908590240.000.00.00.00.00.00.0
409O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110004.8151069098150190.000.00.00.00.00.00.0
410O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.5620538949144630.00241700650155160.001891617599549230.01178045923123530.05880983641151770.9180164882918770.00708459196426920.00.2883853227609080.288385322760908-0.029402920107978105
411O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6672055769075440.00146771264056880.0008532673802991070.00521853383313360.09841944583993510.8907524056111610.00328863469490280.00.1747309486411070.174730948641107-0.3326886836733955
412O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001017.9479922148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.7013890437286340.00256320924432880.001937962716009520.01281467566809690.04184025869472320.9345530528943210.00629084078252020.00.04926742917072990.0492674291707299-0.6674870545840368
413O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.4604911746186480.00101051612937220.001535120673828250.00950098551353590.1619319638939410.8228359933993150.0031854203900070.00.1050559008039770.105055900803977-0.5186159763833679
414O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001019.076471848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.5054603418390790.00282763425766740.001352204283895790.1015503103108280.7013643725797190.189505298029720.00340018053817030.00.07003022223518680.0700302222351868-0.6120817118766197
415O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001017.1845343148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6849051540069450.00259031098421970.001222673276485110.09593804175007910.5580646312132310.3393265417443480.00285780103163660.00.08365671084468980.0836567108446898-0.5757195389760648
416O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001018.5849791348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6959245492565560.00270162630925440.0005719771568024910.0726498218770920.2836209169678580.6385209044566370.00193475323235630.00.1083727029973610.108372702997361-0.5097651169808466
417O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=ODSPC001016.8251830648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceLYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10001004.2028999687764460.000.00.00.00.00.00.0
418O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.5294832643.2525.030.01.75PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.05.0297841129350160.00095186295103340.0006422378825845550.00747953132811130.2951371126795440.6927541632297380.00303509192898830.00.194353938619060.19435393861906-0.2803248961378029
419O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001011.1016934530.025.042.52.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8331022540340980.00529626249319980.002462672139770970.02892600069238070.5630650882785350.3938477032294610.00640227316665240.00.0490727607633690.049072760763369-0.6680065256297026
420O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.7280431538.07517.97541.8252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100104.930148043183570.000.00.00.00.00.00.0
421O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.3926165837.025.037.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.05.1469129123888040.00075936616702350.0006948179871520340.00466364025695930.2126800856531050.7775931477516060.00360894218415410.00.2012387551058620.201238755105862-0.2619528199077537
422O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.5103953238.520.538.52.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6849051540069450.00157535225652120.005929271300775560.00900517890128690.3661355039335790.6138333288393620.00352136476847490.00.1493296569009360.149329656900936-0.40047182198750214
423O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.4829063945.09.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8698394841307990.00147117555088910.0009271038433158290.00585237061645290.1361460165143740.8515751357374550.00402819773751320.00.312197036993320.312197036993320.034138443686487704
424O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.1313804241.222.3534.3252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.04.9015641990418940.00315707422768750.00256893890542120.01467120173911320.3278493469019050.6460616938471230.00569174437875010.00.1585413759980410.158541375998041-0.3758904252594646
425O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.1194224241.82514.97541.8251.375PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101005.0395466375906760.000.00.00.00.00.00.0
426O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.7949292745.022.530.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.91412439371541150.00113350028034120.0005669397521278730.00680706926467910.5026612986257490.4867338942181440.00209729785895860.00.1454484154486280.145448415448628-0.4108288829150842
427O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001012.5539371834.32521.72541.8252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.04.8146204101702980.0016928784436670.0008201357260383030.00868136575507880.4089284489155810.5771011220319780.00277604912765720.00.1137603665106720.113760366510672-0.495388181160095
428O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.9395986145.07.545.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.5276409834788540.00506334343919370.0042813443330510.01657717177325860.2268905911701620.7363489005908830.01083864869345180.00.05473437656423270.0547343765642327-0.6528985503803821
429O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.5933701345.015.7537.51.75PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8105570157130420.0014111223555870.0007497671568420640.00637541161251220.1388808414943290.8476484763047510.00493438107597820.00.2941544338784090.294154433878409-0.0140080944893819
430O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001011.6603133730.024.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.05.1676390429059210.00199236267032550.0008275772353942160.0087190848576440.1921323658461870.7923302576408730.00399835174957640.00.1517939844659880.151793984465988-0.3938957841268362
431O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.6635816537.515.045.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6180864112546370.00271480786609190.001816645383447740.00938513027274930.1325471847366950.8495095957368920.00402663600412330.00.09500361143845570.0950036114384557-0.5454404279666308
432O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.2618629445.024.030.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101005.0980354843770890.000.00.00.00.00.00.0
433O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.2761185945.011.38242.6181.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6802776584748970.00152924607683620.001925087026142220.01057620531887160.1672702556839680.8108753862813060.00782381961287520.00.2787549238426370.278754923842637-0.05510156049896443
434O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.1100192345.013.44540.4451.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9243509254992430.00099943861607060.001251584819277410.00771842730472840.2494697372085870.7354504949584720.00511031709286490.00.2864559061152860.286455906115286-0.03455155257492116
435O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.8566269145.016.40537.5951.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9243509254992430.00141338619768430.001243220634207370.01004508917937940.2358947510861750.7455567851666540.00584676773589970.00.2643364178336390.264336417833639-0.09357722532293417