lnp_ml/data/interim/internal.csv
2026-03-02 14:51:54 +08:00

276 KiB

1smilesHelper_lipid_IDHelper_lipid_ID_DOPEHelper_lipid_ID_DOTAPHelper_lipid_ID_DSPCHelper_lipid_ID_MDOACationic_Lipid_to_mRNA_weight_ratioCationic_Lipid_Mol_RatioPhospholipid_Mol_RatioCholesterol_Mol_RatioPEG_Lipid_Mol_RatioPurityMix_typeCargo_typeCargo_type_mRNACargo_type_pDNACargo_type_siRNATarget_or_delivered_geneModel_typeModel_type_A549Model_type_BDMCModel_type_BMDMModel_type_HBEC_ALIModel_type_HEK293TModel_type_HeLaModel_type_IGROV1Model_type_MouseModel_type_RAW264p7Delivery_targetDelivery_target_bodyDelivery_target_dendritic_cellDelivery_target_generic_cellDelivery_target_liverDelivery_target_lungDelivery_target_lung_epitheliumDelivery_target_macrophageDelivery_target_muscleDelivery_target_spleenRoute_of_administrationRoute_of_administration_in_vitroRoute_of_administration_intramuscularRoute_of_administration_intratrachealRoute_of_administration_intravenousBatch_or_individual_or_barcodedBatch_or_individual_or_barcoded_BarcodedBatch_or_individual_or_barcoded_IndividualValue_nameFormulation_IDCationic_Lipid_Mass_RatioPhospholipid_Mass_RatioCholesterol_Mass_RatioPEG_Lipid_Mass_RatioAmineTailLipid_nameLibrary_IDExperiment_IDExperimenter_IDExperiment_weightGoalscreen_idSourceSample_weightCommentAmine_numberFull_SMILESAmine_SMILESTail_lengthNum_tailsKetoneIsocyanideIs_cyclicFormulationBatch_or_individualRandom_id4CR_Lipid_nameAldehydeCarboxylic_acidAmine_nameTail_nameLinkerMolWtTail_countNum tailsCommon_nameEsterDisulfideTotal_radianceForm_commentmolecular_weightsplit_name_for_normalizationEncapsulation_Efficiency_EE<50Encapsulation_Efficiency_50<=EE<80Encapsulation_Efficiency_80<EE<=100PDI_0_0to0_2PDI_0_2to0_3PDI_0_3to0_4PDI_0_4to0_5toxicsizeBiodistribution_lymph_nodesBiodistribution_heartBiodistribution_liverBiodistribution_spleenBiodistribution_lungBiodistribution_kidneyBiodistribution_musclequantified_total_luminescenceunnormalized_deliveryquantified_delivery
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82O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCCDSPC001016.6340034250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5153548816657270.00.00.00.00.00.00.00.0
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87O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCCDSPC001016.6340034250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.4217280015254340.00.00.00.00.00.00.00.0
88O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCDSPC001017.2563702450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.7757564865636250.00.00.00.00.00.00.00.0
89O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCCDSPC001017.7983325850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001008.8623419635163470.00.00.00.00.00.00.00.0
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91OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)ODSPC001014.3422922250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101004.475972247516410.00.00.00.00.00.00.00.0
92CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)ODSPC001015.3047340550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5637229960739180.00.00.00.00.00.00.00.0
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102O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=ODSPC001017.5355814950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.698660529075430.00.00.00.00.00.00.00.0
103O=C(CCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=ODSPC001016.9553531450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001004.94591897937656460.00.00.00.00.00.00.00.0
104O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCCDSPC001013.9752115150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencealaChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001004.4502692247701290.00.00.00.00.00.00.00.0
105O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=ODSPC001017.4673158550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010004.6596583712721610.00.00.00.00.00.00.00.0
106O=C(CCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=ODSPC001016.876916850.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010005.1393216350575790.00.00.00.00.00.00.00.0
107O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=ODSPC001018.0430999450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.2834486213127860.00.00.00.00.00.00.00.0
108O=C(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=ODSPC001017.7609325350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceglyChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010004.14551284879650.00.00.00.00.00.00.00.0
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110O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCCDSPC001018.1521272950.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001006.6329236185091760.00.00.00.00.00.00.00.0
111O=C(C(CCCCCCCC)CCCCCC)OCCCCCC[N+](CC)(CC)CC.[Br-]DSPC001012.6943869150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceTEAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001004.7621739347977560.00.00.00.00.00.00.00.0
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119C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODOPE100017.9899305250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4627998446963640.01220023327497470.0005910910035853450.001139755933748260.001767661820400170.001186287756211570.0008145121805598940.982300458030521.587128447163311.587128447163311.2259922362734261
120C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODOPE100017.9899305250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.04.4627998446963640.00.00559090767477880.8645475423261110.1215039789215080.007299140125687630.001058430951914690.00.7623859425294130.7623859425294131.2354638394013375
121O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.1966002629264480.03907638542783160.001649940098442520.06611924249156160.02062099305498160.001973476930542320.001604542852447980.8689554191441921.01.00.38802190219888055
122O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.1966002629264480.00.003843163634960110.8512558674941990.1372104001666040.007011090926596470.0006794777776411090.01.01.01.8695349995476385
123O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCC)=O)CCCCCCCCCDSPC001017.6778865150.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.4019518034811510.00.00.00.00.00.00.00.0
124O=C(CCCCCCCCC)OCCCCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)CO)=ODSPC001017.8691509550.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.4214877035547950.00.00.00.00.00.00.00.0
125OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)ODSPC001017.6128587350.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110004.5775934182178570.00.00.00.00.00.00.00.0
126OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=ODSPC001015.6619137450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDBUChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.6472713620067270.00.00.00.00.00.00.00.0
127OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=ODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5410582405208470.01555239749223230.001291525183050590.4469623801028490.04070670995792960.001706255782843450.004218306073436620.4895624254076591.04.047182918074154.73706835052163
128O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3798993736577070.01659790024474950.003619701465851380.3105663719881810.01189538989785840.007274979634618140.006472223261143030.6435734335075981.01.00.38802190219888055
129C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODSPC001017.8332308450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.17515620495851450.1272707797772070.03556516320012460.09653735296408820.04547402040975310.03380267975383660.04658409285658640.6147659110384050.05050109660985280.0505010966098528-0.9671362699547936
130C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=ODSPC001017.9568279250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.4161864863205860.02758978038184060.01402208139025070.06114233329347520.02486260025420610.01333475051040520.01875102413186830.8402974300379540.111038386262380.11103838626238-0.8807353246775064
131C=CCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)=ODSPC001018.0171919250.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4455881161636260.02503763343043890.003378855450378590.05170095821426910.04301460125780830.003502520566568340.004067539363831550.8692978917167050.5940878468090130.594087846809013-0.19131017455153912
132CCCCCCCCCCCC(OCCCCCCN(CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001018.2816135650.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.3810261343402980.007748844284906290.002059211835880780.03666444032502920.01139254241213470.002251300461763640.004145414028259560.9357382466520260.9036917887034430.9036917887034430.2505674416217897
133O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.6710024450.010.038.51.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3821516268620330.02813812366611920.002687923522527220.2184171444869540.03695034275204820.001995534880061370.002899377440325740.7089115532519651.01.00.38802190219888055
134CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001017.8304471948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.1996050728795930.07471069005778810.04659996157313670.1079942655296260.05013227708724380.04481163447185230.04850652517698530.6272446461033680.06852669777296590.0685266977729659-0.9414094990897005
135CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=ODSPC001017.9479509548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3337550860001820.01096509733410360.005003018363333050.02095166074894360.009288769741069860.004983545051506910.006137338777205840.9426705699838370.6241124121020860.624112412102086-0.14845806079238213
136CCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCC)=O)=ODSPC001017.6472811648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceserChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.33309896105045760.03120319393112190.006655727145858570.03039550968454310.0164834041335030.007036565603897330.01082705844464550.8973985410564310.3962477984376630.396247798437663-0.4736744378197291
137O=C([C@H](CO)N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2DSPC001015.2140102248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10001000.04.8652240913223980.1139937587958150.0736400905586490.1559995104937890.0891819127455180.07780089334883440.08548002202777950.4039038120296150.03310420542716130.0331042054271613-0.991965723861604
138O=C([C@H](CO)N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)N(CC1)CCN1C2=NC=CC=N2DSPC001014.96496648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010005.1772790381709810.00.00.00.00.00.00.00.0
139O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3278344055904550.07916813099890920.004382362383997030.2074507250090390.02000573241763190.004355016928862320.006875862774429370.6777621694871311.01.00.38802190219888055
140O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2DSPC001014.0114343548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.8267124559353270.0518549914164530.05280024881614130.1311773333373990.06083493671349250.06763164233899370.0910801242861020.5446207230914190.00589767682753020.0058976768275302-1.0307958367096368
141O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2DSPC001014.9813100548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01001000.04.6131383556372680.03494046569397910.0321707595703410.1079897875472480.04106448719226550.03761816773876980.04872957701124750.6974867552461490.00938217477428710.0093821747742871-1.025822638898096
142O=C([C@H](CO)N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)N(CC1)CCN1C2=NC=CC=N2DSPC001013.7222064848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.453183828990210.00.00.00.00.00.00.00.0
143O=C(CCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2DSPC001014.2701261648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010005.2564531624493380.00.00.00.00.00.00.00.0
144O=C(CCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2DSPC001015.1989806548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceppChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.8683033855184590.03532817757399170.003071827369604910.0347164074883130.01241831478969630.004930001761156310.007143497162066550.9023917738551710.2910156337809080.291015633780908-0.6238654779555869
145O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2602826397655310.02630129130834460.001042219185528390.173963315757520.02312524845930150.002184212268911950.002504937971849710.7708787750485441.01.00.38802190219888055
146O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4008483889144690.1421040279892060.002877147992659220.2151342048639430.02431521845661930.006197044804490070.004054514572316690.6053178413207651.01.00.38802190219888055
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282OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.9222284748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.85437127162159050.0010.0010.86470.13020.00250.00070.00.250.25-0.13183383852538677
283O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3148178849804320.00090.00070.91160.08440.00180.00060.01.01.01.8695349995476385
284O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.4204120449.07.541.52.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5347477216915450.00130.00210.51940.46320.01110.00290.00.50.50.535289107498955
285O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001015.7098734234.2518.7545.02.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.191168746857640.00110.00110.76850.22220.00530.00180.00.150.15-0.3986830169351235
286O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001011.219269322.030.045.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.1510399058986460.00280.00140.40220.58060.01010.0030.00.050.05-0.6655321953448602
287O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.7610163249.028.020.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.1541845625781170.0010.00120.58620.39120.01880.00170.00.160.16-0.37199809909414977
288O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3142104444.6124.8927.942.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.1557531903507440.00410.00150.58860.38250.02110.00220.00.130.13-0.4520528526170708
289O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001014.6047022932.1124.8940.442.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.1042948930752680.00170.00160.58920.39130.01290.00330.00.050.05-0.6655321953448602
290O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.0075004149.018.7531.251.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5163389722814760.01110.00480.17960.72930.06710.00820.00.140.14-0.4253679347760971
291O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.7739010742.1318.7538.131.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.332048264867640.01670.00490.25980.67930.02890.01040.00.150.15-0.3986830169351235
292O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.2164649945.6113.6438.192.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3656431554233570.00420.00150.34430.61720.02980.0030.00.20.2-0.2652584277302551
293O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.2735356244.57.545.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4367515343631280.00670.00130.59090.3850.01420.00190.00.220.22-0.21188859204830776
294O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.2775917649.030.020.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.1510399058986460.01220.00280.23950.68180.05940.00440.00.080.08-0.5854774418219391
295O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001014.7511455334.530.032.53.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.24849524204935850.00290.00240.33380.64290.01510.00290.00.070.07-0.6121623596629128
296O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001016.6100839.3624.8934.191.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3845235148724690.01410.01060.32430.58450.05920.00730.00.140.14-0.4253679347760971
297O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001012.4668877224.030.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7966166505590460.00640.00260.37770.60060.00930.00340.00.10.1-0.5321076061399918
298O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3798191846.57.545.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5163389722814760.00240.00280.46420.51740.00930.00390.00.810.811.362521560569139
299O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001016.0444822437.3629.9431.711.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3707128747736080.0330.0080.10940.81150.03250.00560.00.110.11-0.5054226882990182
300O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6230101041164220.00870.00330.23480.73930.0110.0030.00.360.360.16170025772532357
301O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC001014.34303148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3757570216602860.00190.00230.90770.08180.00330.0030.01.01.01.8695349995476385
302O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3477610649.07.541.52.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9437829871084150.05420.00010.31460.03780.00140.00060.59131.141.140.5878348176473546
303O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10008.63033050334.2518.7545.02.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3956829611213670.030.00060.08370.02610.0020.00130.85630.780.780.07403017792270697
304O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10005.74637555922.030.045.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.2640873368091950.01560.00140.01380.01040.00250.00310.95320.320.32-0.5824979728365652
305O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.1573402549.028.020.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular10010004.5130548970802860.00.00.00.00.00.00.00.0
306O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10009.81205171844.6124.8927.942.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.4704952826614890.0090.00040.01780.09480.00170.00030.87621.051.050.45938365771619283
307O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10007.89369762932.1124.8940.442.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2890886390146120.03430.00030.16970.0270.00130.00090.76660.460.46-0.38268505738809105
308O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.0867591749.018.7531.251.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.96842344528694650.00.00.00.00.00.00.00.0
309O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.1351297742.1318.7538.131.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9060152449661530.01280.00.0280.02080.00060.00.93780.930.930.28811544447464355
310O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.4384851145.6113.6438.192.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5250441415088060.06350.00020.20190.0830.00090.00030.65021.51.51.1016394573720025
311O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.4474839544.57.545.03.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.45201900649391650.0110.00050.39720.05360.00160.00090.53521.451.451.0302777018546903
312O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100010.5716909549.030.020.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.8683033855184590.00.00.00.00.00.00.00.0
313O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10008.00994101934.530.032.53.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.34769395559337650.01650.00.04270.06160.00350.00280.87280.420.42-0.43977446180194085
314O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10009.30114235239.3624.8934.191.56PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.04.6298627985784630.02460.00.12450.08950.00150.00230.75760.440.44-0.41122975959501595
315O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE10006.52577364324.030.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7326835062870510.0060.00120.02050.01770.00080.00.95380.440.44-0.41122975959501595
316O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3176593246.57.545.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8138090510994190.0730.00.03730.01490.00.00.87481.011.010.40229425330234303
317O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.0188828846.377.544.211.92PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7068238397145910.01450.00040.11650.0190.00070.00110.84771.941.941.7296229059243498
318O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100011.3056283448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.737951297221910.03430.00030.16970.0270.00130.00090.76661.91.91.6725335015104998
319O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCODSPC00109.48098659348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCrtlChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3027128279541560.04550.00.3240.0730.00110.00120.55511.01.00.38802190219888055
320O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001017.8855161548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7630282706036710.02537016899819310.009852095920987010.3079495376464530.6223008936382440.01746805222837240.01705925156775050.00.0
321O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001017.9439052848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5845592320839670.008947635700815260.001829037731791440.4304163199538470.5497304827920460.007578868566133040.00149765525536680.00.00195320598425320.0019532059842532-0.793744670428099
322O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001018.329169748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.58272005715050.007575683282501890.002205108735396760.7280256151258690.2364467768847450.02264299233535590.003103823636131840.00.00114820997105430.0011482099710543-0.7958927956755514
323O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001018.3810919848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6888677450096580.005999605473834560.001874719224079340.587253637128080.3938422240908620.009087060693674910.001942753389469320.00.00055858767810530.0005585876781053-0.7974661979200065
324O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1DSPC001019.0310345848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3743724157370220.02071243542549990.007678071734895950.5603318525237880.37971898365440.02060039605243440.01095826060898120.00.00014895806806180.0001489580680618-0.7985592911689305
325O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1DSPC001019.0734961848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5675721555727730.00845259582042460.001706003899546990.8077742570872370.1721718606327810.008511238506704240.001384044053305820.00.00524607123399610.0052460712339961-0.7849576865630203
326O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001017.8855161548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7630282706036710.01429654611639660.002730993690581160.29518748134450.1967905105974680.005675846602325920.009007247197243390.4763113744514850.00332036058888080.0033203605888808-1.0344742729359027
327O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001017.9439052848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5845592320839670.04262585033347260.0008871270421757570.1020996047435990.0571963487718580.002224347800817940.001629610256716670.793337111051360.04651954265664690.0465195426566469-0.972818883550547
328O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1DSPC001018.329169748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.58272005715050.01826489125928050.0004628676766682480.0830730774622890.04296086169302040.001958257642872270.0009234236249690530.8523566206409010.05092095220374640.0509209522037464-0.9665370373099135
329O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1DSPC001018.3810919848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6888677450096580.00689080696037130.0006295478739985480.0213943149436290.0424487771630220.001987083721429520.002484440604759720.924165028732790.0162012629724280.016201262972428-1.0160901968011615
330O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1DSPC001019.0310345848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3743724157370220.01169326763754750.001037390277643260.05250711359109410.02154775991938750.003688747584352420.004009724608555770.9055159963814190.0061044617937550.006104461793755-1.0305007059455489
331O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1DSPC001019.0734961848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceMLChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5675721555727730.02379119812584130.000672072030559790.183348810143480.04664426840444730.001882463893459580.0009536483447079040.7427075390575040.05504888227319850.0550488822731985-0.9606455105817374
332O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8249121448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGLNChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5725436831609980.0007149972592495260.0006615521426571720.1259433207785540.8019661628740890.06931465030975980.001399316635689720.00.01273734387781320.0127373438778132-0.764967287060561
333O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9108191848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceBIMChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3585020896269240.001472338624202370.001074054729631310.9014301683351020.09231591340926670.003101608667764920.0006059162340322280.00.07634346211405440.0763434621140544-0.5952348831288257
334O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8135726248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescence3FLAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.39629929396060.001102231841804530.001617974261335870.9633222017177950.03219957761778040.001292021175643970.0004659933856398120.00.3803760879232580.3803760879232580.21607368094058316
335O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.3514385529058580.000618025227128510.002081914199617060.005201076499908650.0187802521865080.9666711457246690.006647586162169310.00.02898868126049620.0289886812604962-0.7216007267742771
336O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2DSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceIZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5449954629520210.004237985229066510.003606059858827060.01321633083593380.1827688636347740.7890786218947970.007092138546601090.00.00333873262999930.0033387326299993-0.7900474039572776
337O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8088437448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePYChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.2370008626236240.01234833106850720.004307192492523660.04298744650705880.7519786052371790.1740738148281350.01430460986659650.00.00050909567679020.0005090956767902-0.7975982669188943
338O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7904872517618440.001535134831257640.001479319047437390.823383199449070.1690334834470060.003782623622926230.0007862396023025010.00.3060095007469190.3060095007469190.017627054049161966
339O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100017.1033864748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.8420588390939730.001642870850709310.0006591953795399640.940175886974190.05507510379890280.001831734591612620.0006152084050457080.00.5042318247128290.5042318247128290.5465816969768794
340O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8249121448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceGLNChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5725436831609980.02048817921248960.009960766775760780.0245156831256480.02060760677332140.02136567533321140.01463961674764020.8884224720319290.00355740414764120.0035574041476412-1.0341359560461585
341O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9108191848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceBIMChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3585020896269240.07894427186293890.0008592205591640780.3525134142897490.01677256895415610.002079920926292010.0009392356208227430.5478913677868780.1280341520825890.128034152082589-0.8564783709716817
342O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8135726248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescence3FLAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.39629929396060.0205897912198930.002212958221334620.770066394728070.03361563689369980.001419820596404970.0008043314440274440.171291066896570.3526238383609510.352623838360951-0.5359360852935553
343O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110001.04.3514385529058580.05187019339257290.0312301517117120.1961196024635620.08912507656157290.2259984369677170.1833121473049020.2223443915979610.00069167669538580.0006916766953858-1.0382260228827003
344O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2DSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceIZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5449954629520210.03181343918562520.01957394709182120.06586379089295550.04051468238537270.03833552147782530.04458039602206880.7593182229443310.00078261071314280.0007826107131428-1.0380962386598327
345O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8088437448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePYChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.2370008626236240.04960072407063460.02480507603684460.1251567405507840.09132906559061730.06056549162321930.06476095298254880.5837819491453520.0003195942391260.000319594239126-1.0387570720282182
346O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7904872517618440.06604655097497110.0007046862442753380.1768829381025080.1342541500198030.003017007679026680.001465590500617170.6176290764787990.3917964976518640.391796497651864-0.4800274905879333
347O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODOPE100017.1033864748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8420588390939730.1809625205798080.0008401831312633930.06004984482200660.01399037974230450.002300224308132730.002214948498499460.7396418989179860.5151697208812090.515169720881209-0.3039448947184272
348O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.0775877448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.488973391585580.0001361741321454220.002124526885072340.8116339002045020.1797618786378860.003857515564583060.002486004575811570.00.7677598926352940.7677598926352941.24980418110703
349O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5045453548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceALAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6756286496366530.002681003515835570.002404316320251120.1420407111815020.5233204371657690.3248689313672640.004684600449378170.00.02418971611359150.0241897161135915-0.7344067258409619
350O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5967196648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceSERChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7376009731685810.001574321100649450.001768448828174440.0537654693631150.4381566263887130.5005330905621060.004202043757241760.00.01896247197312650.0189624719731265-0.7483555838832638
351O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.0775877448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOHChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.488973391585580.05503096395316620.002343538358968550.3201982527271960.2826561333844960.00647980771988270.002024762156216460.3312665417000751.201351272858151.201351272858150.6753975083349388
352O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5045453548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceALAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6756286496366530.04186594266195050.02191539256771620.216687596212540.1998754503620370.1130298240890510.04956294586612350.3570628482405820.00277072722385720.0027707272238572-1.035258728972282
353O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5967196648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceSERChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7376009731685810.02341188122166890.00714627137553530.04269587812267520.04640789350058450.03460440338465980.02359671186289260.8221369605319840.00554577380572740.0055457738057274-1.0312980850577906
354O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1693008848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceTZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.05.0019308534661090.007673585378074480.002332156539962070.07136847277071580.3074447638986410.01727883809767040.005112282956530410.5887899003584050.00639178295120140.0063917829512014-1.0300906311016962
355O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5792368039615870.008330630627793890.001739877624292090.1566519618493430.1122051383242950.008953040097654260.004272898738282590.7078464527383390.2693908353579880.269390835357988-0.6547291495189385
356O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1584793848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescence3FChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4841318576110350.01583110335276070.001093538471382430.02009906235293180.005897176735039590.003320808161896930.002978027202828060.950780283723160.00701142917678520.0070114291767852-1.0292062502525494
357O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8139528948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePYRChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular01010000.05.07554874493890.01382534042976630.006703759222215070.0649180337297370.03100822728704040.03076912146668710.01560911890562440.837166398958930.01114342568801360.0111434256880136-1.023308919755896
358O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.402809173856410.01440512488828930.0005257886602972210.1256670673311170.2143735465990950.004108808511208610.001771673377542580.6391479906324510.1765126288897360.176512628889736-0.7872881867764152
359O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1693008848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceTZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.05.0019308534661090.001151197971145680.00039598185076720.05381242095391680.936045246647050.007365029721909040.001230122855211430.00.02615188198592550.0261518819859255-0.7291707023316024
360O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.005478648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5792368039615870.00109420595997370.0007145781519885520.3670345111201160.620781604798830.00794788569780320.002427214271288350.00.9705101739899730.9705101739899731.7908416411254202
361O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001017.1584793848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescence3FChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4841318576110350.03762301306258740.002360090276238130.2470397056927430.6974529726033750.01046818653826280.005056031826793520.00.00138844034319760.0013884403431976-0.7952517429011965
362O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.8139528948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePYRChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.05.07554874493890.008738268136764380.001451124759395440.1930650802831250.7781970187985230.0144332136813340.004115294340858250.00.1657216652344370.165721665234437-0.35672988242469916
363O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.9952245148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.402809173856410.005324220795326150.000610844497635910.5224696762713130.4597789842092210.009668948738036840.002147325488466940.00.1610206624028550.161020662402855-0.3692744698577941
364O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.5847633762104290.03183913464166560.0003415522251137170.1136782814094460.2422797677315520.003875506194544750.0008716251103375370.607114132687340.6498333862516020.649833386251602-0.11174818341388475
365O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7463224657439750.05481931424920010.0002633620250269130.09029568041228170.1608376290101280.003153555083538470.0007395009931080330.6898909582267171.163752389990061.163752389990060.6217350625958049
366O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=ODSPC001016.8734651848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceHISChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00101000.04.6513856097850540.01725667652872490.003183443654119150.07128908769607150.1719650680582140.02181353020995030.01154937774558460.7029428161073350.003274052824270.00327405282427-1.0345403650034368
367O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.5847633762104290.0005999639271510760.0003979977527346260.4209765088271420.5601783949082490.0170441599942420.0008029745904808220.00.252558286406420.25255828640642-0.1250070722684871
368O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7463224657439750.0005243745788385270.000615149161963690.5474321245870290.4354353172871240.0153091134031910.0006839209818540070.00.5683944895522760.5683944895522760.7177992409467366
369O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=ODSPC001016.8734651848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceHISChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6513856097850540.001719835019889670.001895610167046930.01207166358060030.7112786468351230.2704388261066560.002595418290683870.00.01128972345421170.0112897234542117-0.7688302502674332
370O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.4847336328661440.00478509514152610.0006759117725754380.460692650341020.5223593598372590.01097751216996240.000509470737657790.00.7732054146079260.7732054146079261.2643355117511204
371O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6337576428400040.001989114141896350.001268115954131230.5438675837302960.4388427705215520.01299886351377290.001033552138351230.01.984930539105391.984930539105394.497814051056962
372O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001018.033391148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6097596383218990.001250314231535860.00048603620252150.5382495397268110.4454146408994460.01378016944550060.0008192994941846210.00.2911374447973450.291137444797345-0.022058905064912687
373O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001016.6873880848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.3928841446746630.002262851853885510.0005628723058581370.7313644397975270.2569326193475530.008254512386006190.0006227043091702730.01.828722794594791.828722794594794.080974968218046
374O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.3694536548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.4847336328661440.04429234588340680.000554526503313330.1064598812950740.1925269407339640.003116828821969980.0006230420688089780.6524264346934630.6724315389024460.672431538902446-0.07949530652163618
375O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.3588986548.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6337576428400040.03746100134028090.00053505511067640.2608554395388440.4699055431280850.004693340556934510.0009120939456764050.2256375263795031.692761008312311.692761008312311.3767547363410753
376O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001018.033391148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceOZChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6097596383218990.08366452314287070.0004195998066843750.02356843070012880.07122752129701750.001196813084974750.001782958594149920.8181401533741740.4260582901836350.426058290183635-0.431127857343191
377O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001016.6873880848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.3928841446746630.05129907354328090.0006721896554912440.1873439724836810.2321874364332340.003147918708508240.001466797344527250.5238826118312781.307840951139471.307840951139470.8273833160675146
378O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC([C@@H](N)CS)=ODSPC001017.7875976748.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceCYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7512598918599860.004057997029842030.002250472241821050.7192702087504140.2572086997206850.01387181782144650.003340804435790490.01.251606109420241.251606109420242.540943835364252
379O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.3172977448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6662652853479020.002729829658037860.0001723653525173030.4980480220510360.4791374423060180.01803169597272670.001880644659664150.00.1555371691315050.155537169131505-0.3839071266005448
380O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.7141903948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9047561254426960.002732862002550750.002600550697920030.4311462579180510.503490189514580.05501380280959670.005016337057302290.00.0219853087993660.021985308799366-0.7402891686477768
381O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7332115358689750.001665285761580170.0001768860386207120.2052072250421430.7509160285453820.03927204517105160.002762529441221910.00.1200966909619610.120096690961961-0.478479751420455
382O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001018.7067898948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.8587265437104960.003837431593303120.002489507292141280.5559034224234810.3804456357090310.05156687125668010.005757131725364020.00.05265384122510380.0526538412251038-0.6584504418393717
383O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.3172977448.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.6662652853479020.05672891570854950.006533482670080080.0648395772855760.3350552774539610.01449556942253920.01437366187417620.5079735155851180.2683113660519180.268311366051918-0.6562698060131026
384O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001018.7141903948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.9047561254426960.02485528982681630.01251927287357680.07253076425985960.03552546912826670.02143956481541440.02487457992369390.8082550591723720.07418452434615880.0741845243461588-0.9333344503561898
385O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001019.3472851348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.7332115358689750.08839170078935020.001745998389119230.05364053324148950.1001186712107480.007719900633961030.006397761182357370.7419854345529740.5280355090867130.528035509086713-0.28558239006925334
386O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001018.7067898948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intramuscular0100Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular00110000.04.8587265437104960.01756794052947970.009601738911743040.09031791317526130.03881849373792540.01824975462857870.02490458685331770.8005395721636940.1251815103995770.125181510399577-0.8605497613389135
387O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=ODSPC001017.6287057848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceDOPChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.7655869073939960.001592786554473880.001866111601963270.4887959189448620.4852474097005460.0186161981810970.003881575017057550.00.3525707463709570.3525707463709570.14187535545424673
388O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=ODSPC001017.6188024648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePBAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous01010000.04.823743308787540.0008754152347094840.001273758542852460.6833778371049490.3040032579211650.008203555612704210.002266175583619950.00.9434205611724430.9434205611724431.7185532318874628
389O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=ODSPC001016.5854712248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.4333136790419010.0006021901209873610.0005765288819158980.005661974231285060.01617638593470420.9716832651197970.005299655711310530.00.03057893103716340.0305789310371634-0.7173571583105779
390O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=ODSPC001017.7092982648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.3563241373215090.001873780528195120.001576549756525540.01638637962163180.06482461591650970.9052800074279390.01005866674919930.00.0038751363614790.003875136361479-0.7886160150068647
391O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=ODSPC001018.1727395648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.4407671296964810.003010499062177319.21592223531261e-050.003800968274147730.01303234810025410.976573274923540.003490750417528180.00.02744014410273760.0274401441027376-0.7257329854571254
392O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=ODSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.3496325668628770.002739892740947480.001610183930614260.01128248399633270.05833529406992120.9192474016859630.006784743576221270.00.00816018968837710.0081601896883771-0.7771813854096181
393O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=ODSPC001018.9034565248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6627784986084050.003493154511189280.001712981783993120.0377973259747310.2428168379729130.7065698897632850.007609809993887950.00.01367670513954040.0136767051395404-0.7624606092513427
394O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCNDSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10000014.4054989908590240.00.00.00.00.00.00.00.0
395O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceGABAChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110004.8151069098150190.00.00.00.00.00.00.00.0
396O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.5620538949144630.002417006501551690.001891617599549230.01178045923123530.05880983641151770.9180164882918770.00708459196426920.00.2883853227609080.288385322760908-0.029402920107978105
397O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.8952759948.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6672055769075440.001467712640568840.0008532673802991070.005218533833133670.09841944583993510.8907524056111610.003288634694902810.00.1747309486411070.174730948641107-0.3326886836733955
398O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001017.9479922148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101001.04.7013890437286340.002563209244328860.001937962716009520.01281467566809690.04184025869472320.9345530528943210.006290840782520290.00.04926742917072990.0492674291707299-0.6674870545840368
399O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001018.3846912248.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.4604911746186480.001010516129372290.001535120673828250.009500985513535920.1619319638939410.8228359933993150.003185420390007040.00.1050559008039770.105055900803977-0.5186159763833679
400O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001019.076471848.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.5054603418390790.002827634257667420.001352204283895790.1015503103108280.7013643725797190.189505298029720.003400180538170360.00.07003022223518680.0700302222351868-0.6120817118766197
401O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001017.1845343148.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6849051540069450.00259031098421970.001222673276485110.09593804175007910.5580646312132310.3393265417443480.002857801031636630.00.08365671084468980.0836567108446898-0.5757195389760648
402O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001018.5849791348.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110001.04.6959245492565560.002701626309254470.0005719771568024910.0726498218770920.2836209169678580.6385209044566370.001934753232356310.00.1083727029973610.108372702997361-0.5097651169808466
403O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=ODSPC001016.8251830648.510.040.01.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescenceLYSChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous10001004.2028999687764460.00.00.00.00.00.00.00.0
404O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.5294832643.2525.030.01.75PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.05.0297841129350160.0009518629510334060.0006422378825845550.007479531328111330.2951371126795440.6927541632297380.00303509192898830.00.194353938619060.19435393861906-0.2803248961378029
405O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001011.1016934530.025.042.52.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8331022540340980.005296262493199830.002462672139770970.02892600069238070.5630650882785350.3938477032294610.006402273166652430.00.0490727607633690.049072760763369-0.6680065256297026
406O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.7280431538.07517.97541.8252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100104.9301480431835690.00.00.00.00.00.00.00.0
407O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.3926165837.025.037.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.05.1469129123888030.0007593661670235550.0006948179871520340.004663640256959320.2126800856531050.7775931477516060.003608942184154180.00.2012387551058620.201238755105862-0.2619528199077537
408O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.5103953238.520.538.52.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6849051540069450.001575352256521280.005929271300775560.009005178901286910.3661355039335790.6138333288393620.003521364768474930.00.1493296569009360.149329656900936-0.40047182198750214
409O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.4829063945.09.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8698394841307990.001471175550889170.0009271038433158290.005852370616452940.1361460165143740.8515751357374550.004028197737513270.00.312197036993320.312197036993320.034138443686487704
410O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.1313804241.222.3534.3252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.04.9015641990418940.003157074227687520.00256893890542120.01467120173911320.3278493469019050.6460616938471230.00569174437875010.00.1585413759980410.158541375998041-0.3758904252594646
411O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.1194224241.82514.97541.8251.375PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101005.0395466375906760.00.00.00.00.00.00.00.0
412O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001014.7949292745.022.530.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.91412439371541150.001133500280341280.0005669397521278730.006807069264679140.5026612986257490.4867338942181440.002097297858958660.00.1454484154486280.145448415448628-0.4108288829150842
413O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001012.5539371834.32521.72541.8252.125PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00100100.04.8146204101702980.0016928784436670.0008201357260383030.008681365755078820.4089284489155810.5771011220319780.002776049127657290.00.1137603665106720.113760366510672-0.495388181160095
414O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.9395986145.07.545.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.5276409834788540.005063343439193770.0042813443330510.01657717177325860.2268905911701620.7363489005908830.01083864869345180.00.05473437656423270.0547343765642327-0.6528985503803821
415O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.5933701345.015.7537.51.75PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.8105570157130420.001411122355587080.0007497671568420640.006375411612512230.1388808414943290.8476484763047510.004934381075978220.00.2941544338784090.294154433878409-0.0140080944893819
416O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001011.6603133730.024.045.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.05.167639042905920.001992362670325570.0008275772353942160.0087190848576440.1921323658461870.7923302576408730.00399835174957640.00.1517939844659880.151793984465988-0.3938957841268362
417O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001013.6635816537.515.045.02.5PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101000.04.6180864112546370.002714807866091930.001816645383447740.009385130272749360.1325471847366950.8495095957368920.00402663600412330.00.09500361143845570.0950036114384557-0.5454404279666308
418O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.2618629445.024.030.01.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00101005.0980354843770890.00.00.00.00.00.00.00.0
419O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.2761185945.011.38242.6181.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.6802776584748960.001529246076836280.001925087026142220.01057620531887160.1672702556839680.8108753862813060.007823819612875270.00.2787549238426370.278754923842637-0.05510156049896443
420O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001016.1100192345.013.44540.4451.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9243509254992430.0009994386160706770.001251584819277410.007718427304728460.2494697372085870.7354504949584720.005110317092864990.00.2864559061152860.286455906115286-0.03455155257492116
421O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=ODSPC001015.8566269145.016.40537.5951.0PureMicrofluidicmRNA100FFLMouse000000010body100000000intravenous0001Individual01luminescencePREChinese_Academy_of_SciencesChinese_Academy_of_SciencesccchinamaxChinese_Academy_of_SciencesinternalChinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous00110000.04.9243509254992430.001413386197684390.001243220634207370.01004508917937940.2358947510861750.7455567851666540.005846767735899710.00.2643364178336390.264336417833639-0.09357722532293417