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Merge branch 'main' of github.com:RYDE-WORK/lnp_ml into main

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RYDE-WORK 2026-02-28 16:50:16 +08:00
commit e925a338b9
6 changed files with 11 additions and 450 deletions
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data/interim/internal_corrected.csv
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@ -1,439 +0,0 @@
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O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC,DSPC,0,0,1,0,17.33731463,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,5.12455904041457,-,0.0210297731298931,0.658450324145507,0.200900368909969,0.111879408982101,0.00774012483253011,77.5%?,0.0342179895228306,0.0342179895228306,-1.0250573081218382
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,5.112590016619249,-,0.00128819081649658,0.393692319023747,0.589452131076946,0.0101812483827002,0.00538611070010966,77.5%?,1.0,1.0,0.4646149359523945
O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H](C)N(CCCCCCCCCCCC)CCCCCCCCCCCC,DSPC,0,0,1,0,15.85660447,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.114394528387108,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.63293083,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,5.272999558563747,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O,DSPC,0,0,1,0,16.2856483,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.28978103552575,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)NCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC,DSPC,0,0,1,0,16.23582504,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.260615499364025,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)CN(CCCCCCCCCCCC)CCCCCCCCCCCC,DSPC,0,0,1,0,15.75702627,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.9788005705762375,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)=O)CO)CCCCCCOC(CCCCC)=O)CCCCC,DSPC,0,0,1,0,16.47477668,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.68213122712422,-,-,-,-,-,-,-,0.0,,
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.686750172980514,-,-,-,-,-,-,-,1.0,1.0,0.4646149359523945
CCCCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,19.33366115,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.98780245,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.9473404437239425,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCN(CCCNC([C@@H](N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)CO)=O)CCCCCCCCCCCCCC,DSPC,0,0,1,0,16.42695266,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.545101659521972,-,0.00318490682025255,0.0608074236431031,0.251089505980848,0.00892095913117615,0.00601048706680474,0.669986717357815,0.0815243428420059,0.0815243428420059,-0.9520895361573071
CCCCCCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)=O)CO)CCCCCCCCCCCCCC,DSPC,0,0,1,0,16.68206611,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.844974178195408,-,-,-,-,-,-,-,0.0,,
O=C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H]([C@H](O)C)N(CCCCCCCCCCCC)CCCCCCCCCCCC,DSPC,0,0,1,0,15.77114057,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,thr,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.331522502500114,-,0.0131160505661734,0.0817206877958181,0.209957462105326,0.0363069917919837,0.0161572104727098,0.642741597267989,0.0248953087459781,0.0248953087459781,-1.0394370942878488
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.16832078,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.4135253017332525,-,0.00151329913495755,0.0471551068594211,0.0476760649180962,0.00182335320536251,0.00763287581452213,0.89419930006764,0.35502103370942,0.35502103370942,-0.5302340606861489
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C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.89554445,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.496359280129911,-,-,-,-,-,-,-,0.0,,
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C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.89554445,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.508769411701737,0.0963955724315343,0.000259669027359828,0.0209585518067849,0.0324510369422159,0.00191021824445882,0.00526970020363582,0.84275525134401,0.95415067884307,0.95415067884307,0.3938945659349633
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CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.33700102,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.9082333604781745,0.00523681863830338,0.000823668079767528,0.00977318183991921,0.0124596675509096,0.00267973433328739,0.00363617950788083,0.965390750049932,0.316498770359056,0.316498770359056,-0.5896527968703137
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.33700102,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.9082333604781745,-,0.010109099822305,0.45796731805265,0.507501663530466,0.0194068402228631,0.00501507837171616,-,0.0817828774610745,0.0817828774610745,-0.5807198479650095
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O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.590361070334383,-,0.00283873189227405,0.901276452952094,0.0938738308613158,0.00141019974741145,0.000600784546904834,-,1.0,1.0,1.8695349995476385
O=C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)[C@H](C)N(CCCCCCCCCC)CCCCCCCCCC,DSPC,0,0,1,0,14.63651378,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.442651256490317,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.97521151,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.530769863411841,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)CN(CCCCCCCCCC)CCCCCCCCCC,DSPC,0,0,1,0,14.88045619,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.48874872297084,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)CN(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.83327693,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.343844382133684,-,-,-,-,-,-,-,0.0,,
O=C(NCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.53889564,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.301494223781961,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.27376909,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.596939379038152,-,-,-,-,-,-,-,0.0,,
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O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC,DSPC,0,0,1,0,15.06368788,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.403665809777363,0.0159262664008309,0.00726471746994425,0.0644691443511897,0.0154248397225439,0.00666778094817397,0.00618426236554005,0.884062988741777,0.163983867672707,0.163983867672707,-0.8248996899319107
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CCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.40770989,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.168208681201016,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.93089479,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.697749367281185,-,-,-,-,-,-,-,0.0,,
O=C(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC,DSPC,0,0,1,0,16.38737682,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.2112383136936,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.61200662,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.27999390910873,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,17.2554924,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.611152257665639,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.391561,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,5.1422481808981475,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC,DSPC,0,0,1,0,16.63400342,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.515354881665727,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC,DSPC,0,0,1,0,17.25637024,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.57532934397707,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC,DSPC,0,0,1,0,17.79833258,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.451896454476337,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,17.2554924,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.925077405734609,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.391561,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.829912458665998,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC,DSPC,0,0,1,0,16.63400342,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.421728001525434,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC,DSPC,0,0,1,0,17.25637024,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.775756486563625,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC,DSPC,0,0,1,0,17.79833258,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,8.862341963516347,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.55042057,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,5.5506312951620265,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)O,DSPC,0,0,1,0,14.34229222,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.47597224751641,-,-,-,-,-,-,-,0.0,,
CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)O,DSPC,0,0,1,0,15.30473405,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.563722996073918,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCC)O)O,DSPC,0,0,1,0,16.11614863,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.275554390163365,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCCCC)O)O,DSPC,0,0,1,0,16.80938411,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.35709336812867,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O,DSPC,0,0,1,0,17.32727581,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.473579765600494,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CCCCCCOC(CCCCCCC)=O,DSPC,0,0,1,0,17.03239796,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.5612182984589085,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.71577453,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.695924549256556,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCCCCN(CC(O)CCCCCC)CC(O)CCCCCC)=O)N(CC(CCCCCC)O)CC(CCCCCC)O,DSPC,0,0,1,0,14.72351388,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.857484114602081,-,-,-,-,-,-,-,0.0,,
CCCCCCCCC(CN([C@H](C(NCCCCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CO)CC(CCCCCCCC)O)O,DSPC,0,0,1,0,15.6246954,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.483228515182849,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)=O)N(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O,DSPC,0,0,1,0,16.38850868,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.426521874560433,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O,DSPC,0,0,1,0,17.04402965,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.412919498116252,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O,DSPC,0,0,1,0,17.53558149,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.69866052907543,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.95535314,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.9459189793765646,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.97521151,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.450269224770129,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O,DSPC,0,0,1,0,17.46731585,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.659658371272161,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.8769168,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,5.139321635057579,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O,DSPC,0,0,1,0,18.04309994,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.283448621312786,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O,DSPC,0,0,1,0,17.76093253,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.1455128487965,-,-,-,-,-,-,-,0.0,,
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,18.07661492,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.3551691805039985,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCC,DSPC,0,0,1,0,18.15212729,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,6.632923618509176,-,-,-,-,-,-,-,0.0,,
O=C(C(CCCCCCCC)CCCCCC)OCCCCCC[N+](CC)(CC)CC.[Br-],DSPC,0,0,1,0,12.69438691,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,TEA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.762173934797756,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.16832078,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.240751047315928,0.0111914004572023,0.00227125491616379,0.00877931935589419,0.0082437061808303,0.00401873844514775,0.00849693826019724,0.956998642384564,0.596141429580998,0.596141429580998,-0.1583174611704737
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OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=O,DSPC,0,0,1,0,15.66191374,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DBU,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.647271362006727,-,-,-,-,-,-,-,0.0,,
OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.541058240520847,0.0155523974922323,0.00129152518305059,0.446962380102849,0.0407067099579296,0.00170625578284345,0.00421830607343662,0.489562425407659,1.0,1.0,0.4646149359523945
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.379899373657707,0.0165979002447495,0.00361970146585138,0.310566371988181,0.0118953898978584,0.00727497963461814,0.00647222326114303,0.643573433507598,1.0,1.0,0.4646149359523945
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.83323084,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.1751562049585145,0.127270779777207,0.0355651632001246,0.0965373529640882,0.0454740204097531,0.0338026797538366,0.0465840928565864,0.614765911038405,0.0505010966098528,0.0505010966098528,-0.999941399550668
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.95682792,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.416186486320586,0.0275897803818406,0.0140220813902507,0.0611423332934752,0.0248626002542061,0.0133347505104052,0.0187510241318683,0.840297430037954,0.11103838626238,0.11103838626238,-0.9065655454256818
C=CCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)=O,DSPC,0,0,1,0,18.01719192,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.445588116163626,0.0250376334304389,0.00337885545037859,0.0517009582142691,0.0430146012578083,0.00350252056656834,0.00406753936383155,0.869297891716705,0.594087846809013,0.594087846809013,-0.1614850137062924
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O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.382151626862033,0.0281381236661192,0.00268792352252722,0.218417144486954,0.0369503427520482,0.00199553488006137,0.00289937744032574,0.708911553251965,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.83044719,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.199605072879594,0.0747106900577881,0.0465999615731367,0.107994265529626,0.0501322770872438,0.0448116344718523,0.0485065251769853,0.627244646103368,0.0685266977729659,0.0685266977729659,-0.9721377777766667
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O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.3651347670036635,0.0896852170263435,0.00316402812450449,0.145700011838927,0.0181473232698177,0.0048727657230144,0.00676784889254742,0.731662805124845,1.0,1.0,0.4646149359523945
O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCCCCCC,DSPC,0,0,1,0,17.93964861,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.27430221608671,0.0441668582339066,0.00173504332049564,0.0552287456296669,0.0103338721124601,0.00424436496446174,0.00798306414101548,0.876308051597994,0.118006736161235,0.118006736161235,-0.8958172012665345
O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C,DSPC,0,0,1,0,17.66483929,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.322011202263895,0.014374943627672,0.00199135248489222,0.0891563599260395,0.0109943655858212,0.00408170887074953,0.00721565797781185,0.872185611527014,0.120117219447052,0.120117219447052,-0.8925618824281657
C=CCCCCCCCCC(OCCCCCCN(CCOCCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.93091393,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.589955020181611,0.159505299591344,0.00863892692709962,0.059163494819016,0.0251436766117119,0.0207012928199433,0.0319161553971728,0.694931153833713,0.19624671777719,0.19624671777719,-0.775135797258418
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.461068842013835,0.18227458966528,0.00260059752378256,0.10140002712747,0.0194272464327483,0.00394998811850684,0.00708234329707097,0.683265207835141,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.16832078,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.897839799950911,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.87291972,32.96703297,21.97802198,43.95604396,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.667205576907544,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.34369997,41.32231405,16.52892562,41.32231405,0.826446281,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.786658062033468,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,11.12329906,27.02702703,32.43243243,37.83783784,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.520374534283375,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.602904588,25.0,40.0,30.0,5.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.2162671661789055,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.22342652,38.46153846,21.97802198,38.46153846,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.634728988229636,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.21412129,40.0,34.28571429,22.85714286,2.857142857,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.378896741664954,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.29890072,34.65346535,39.6039604,24.75247525,0.99009901,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.661550519424199,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.62419529,41.86046512,37.20930233,18.60465116,2.325581395,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.552612935249416,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.26075368,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,5.021245473208271,0.0189024787568605,0.00542838949966448,0.0161874266221436,0.00564673685028802,0.0063903753402389,0.0111802988958026,0.936264294035002,0.0913658402077254,0.0913658402077254,-0.9369095003865034
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.59373115,37.83783784,37.83783784,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.484470400750307,0.220192249542946,0.000764987158036526,0.00117389921248248,0.000355328494502401,0.000727082388944626,0.00146163086877099,0.775324822334317,0.909323670538887,0.909323670538887,0.3247510642635732
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.02523135,35.8974359,41.02564103,20.51282051,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.474947598938117,0.0634606467339624,0.00208550415241484,0.000693953783467295,0.000703971489002912,0.00107462659382075,0.00306678394465369,0.928914513302678,0.68813569412733,0.68813569412733,-0.016420738077667085
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.01459482,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.414493824811383,0.0115671522937999,0.000329262998462127,0.000782715410474643,0.000454168201139608,0.00050928396392566,0.0365052454816706,0.949852171650527,1.45919493888772,1.45919493888772,1.172901016723797
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.50825332,52.83018868,26.41509434,18.86792453,1.886792453,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.573163389853005,0.0289504727873473,0.000587630380490671,0.00098172979734669,0.000247631664832521,0.000530890620697785,0.00148666967519347,0.967214975074092,1.18732779204068,1.18732779204068,0.7535590344336197
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.02959744,50.90909091,29.09090909,18.18181818,1.818181818,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.424367475163407,0.01918176556647,0.0010650954164724,0.0022206234626453,0.00126505200881015,0.0010329415925789,0.00258134917445057,0.972653172778573,0.519739549496667,0.519739549496667,-0.2761636820795619
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.0526464,43.24324324,32.43243243,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.646312129319266,0.0173760673957131,0.000550323482827711,0.00231355504088989,0.000799250291024724,0.00171157517792979,0.00187915335599706,0.975370075255618,0.641975082983608,0.641975082983608,-0.08762125790960282
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.87880561,39.02439024,39.02439024,19.51219512,2.43902439,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.627909672957581,0.031425165165133,0.00121897501467252,0.00336392108926765,0.00273184674446895,0.00365496097119473,0.00253008289994281,0.95507504811532,0.292484943880311,0.292484943880311,-0.6266929678315919
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.72896002,41.02564103,30.76923077,25.64102564,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.6141299273595635,0.00243290161785256,0.00374029360494432,0.00771109158226845,0.00256075951190699,0.0024473081411263,0.00398520450059787,0.977122441041304,0.29000081469118,0.29000081469118,-0.6305246174829606
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.2936051730729785,0.0291199872991734,0.000702410023626044,0.0253755412996204,0.0176881988849176,0.000962484515645204,0.00126799370807735,0.92488338426894,1.0,1.0,0.4646149359523945
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.98993052,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.596835549198034,0.0642873127295256,0.000194616801396495,0.00548703707264694,0.0163820187916684,0.000849254927099769,0.000518055392084143,0.912281704285579,0.772854925639995,0.772854925639995,0.11425459688882487
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.26769266,37.83783784,37.83783784,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.284827171296749,0.000820324065776298,6.77505055763446e-05,0.00130838737685328,0.00203458073148474,0.00044026025400656,0.00179231955954145,0.993536377506761,0.647354606156059,0.647354606156059,-0.07932360246622268
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,12.69845587,35.8974359,41.02564103,20.51282051,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.355939299910563,0.000606683031689403,0.000350488437662207,0.00200552330636915,0.00341592792036262,0.00135658595795651,0.00484812686613966,0.98741666447982,0.429472560198128,0.429472560198128,-0.4153961662793264
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.73864775,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.210051369934071,0.0506054803736383,0.000934742670841204,0.00195746112246746,0.00131704918881155,0.00229254534633995,0.00362188526923176,0.93927083602867,0.295296757118666,0.295296757118666,-0.622355881313871
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.22254695,52.83018868,26.41509434,18.86792453,1.886792453,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.19614876167715,0.000394517913167851,0.000925918583325644,0.00219111536287718,0.00192843383777798,0.00141208216065332,0.00279803133939282,0.990349900802805,0.423957111788814,0.423957111788814,-0.4239034798551084
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,16.73562869,50.90909091,29.09090909,18.18181818,1.818181818,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.324000197151533,0.0149763371723649,9.09516394922477e-05,0.00865819492777344,0.00337158611087041,0.000870833891384162,0.00234291805381448,0.9696891782043,0.799987755503576,0.799987755503576,0.1561056803760758
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.73441264,43.24324324,32.43243243,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.638604962074329,0.00412763242238728,0.000587351434637121,0.00125519721482213,0.00156835329887146,0.00151910105091065,0.00332452673735467,0.987617837841017,0.519710678404319,0.519710678404319,-0.27620821434922566
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.55362203,39.02439024,39.02439024,19.51219512,2.43902439,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.465448242812954,0.001908149535057,0.00051106883667359,0.00195557181028906,0.00222543526142979,0.00102554934782431,0.0036709617373884,0.988703263471338,0.559906246507883,0.559906246507883,-0.21420848616098725
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.4082575,41.02564103,30.76923077,25.64102564,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.439351701293151,0.0164941051995163,0.00133624924425635,0.0136411729141475,0.0068725438331318,0.00281561744256348,0.00565863059250302,0.953181680773882,0.404416041627467,0.404416041627467,-0.4540446395817048
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.348211286179151,0.25310386523031,0.000588156076259717,0.140706646889545,0.17621759673582,0.00218337900345845,0.000839731767209391,0.426360624297398,1.0,1.0,0.4646149359523945
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.98993052,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.574298522321004,0.0173152888243317,0.00170643426094864,0.0181271736370668,0.0103847448319841,0.00234708518590686,0.00464250497463967,0.945476768285122,0.880302275630684,0.880302275630684,0.27998696013855723
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.54771521,32.96703297,21.97802198,43.95604396,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.530015512387331,0.0022188818222417,0.00151967168045253,0.0265741083102934,0.00935341146520975,0.00161955884356527,0.00594450434134348,0.952769863536894,0.693395601815244,0.693395601815244,-0.008307583759119837
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,16.03951812,41.32231405,16.52892562,41.32231405,0.826446281,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.640537329825382,0.0191565810814788,0.00120917820488213,0.00564887782228727,0.00368324602436162,0.00270413188019715,0.00625226385441887,0.961345721132374,0.702078866162311,0.702078866162311,0.005085933354948288
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,10.8033785,27.02702703,32.43243243,37.83783784,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.2431955089544555,0.0191175904912105,0.0046774627841674,0.0253721583259607,0.0153479247605493,0.0105242912643767,0.0240873946993884,0.900873177674347,0.168910555827937,0.168910555827937,-0.8173005106963921
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,9.298704135,25.0,40.0,30.0,5.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.822697998516666,0.00783638212803346,0.00315432464612104,0.0156004284210389,0.0122536904537434,0.00649575798551451,0.014293561001533,0.940365855364016,0.26946434750834,0.26946434750834,-0.6622011291820169
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.90666525,38.46153846,21.97802198,38.46153846,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.291292751611072,-,-,-,-,-,-,-,0.0,,
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.89035919,40.0,34.28571429,22.85714286,2.857142857,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.388753955423308,0.0457836478243602,0.00256820195313693,0.0933595380902435,0.040121791020458,0.00303459231576053,0.00719748271402532,0.807934746082015,0.638042293066864,0.638042293066864,-0.09368739697327609
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,12.97231927,34.65346535,39.6039604,24.75247525,0.99009901,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.500031867864786,0.00367784574047392,0.00111977791364668,0.0109807451773001,0.00533981749985873,0.0035253353907892,0.00945759694134628,0.965898881336585,0.664597706735618,0.664597706735618,-0.05272695016115616
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.30278396,41.86046512,37.20930233,18.60465116,2.325581395,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.578518154990665,0.00602415700375336,0.00352191807012307,0.0129438874596237,0.0112365957475355,0.00705054455561779,0.0163551166761144,0.942867780487232,0.387412476367661,0.387412476367661,-0.48027182019083947
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DOPE,1,0,0,0,14.78083639,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.373742415086184,0.00132025329631253,0.000860633620224201,0.00503931327076771,0.0029913613071963,0.00270028184029275,0.0088532339643477,0.978234922700859,1.0,1.0,0.4646149359523945
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.434619084793052,0.00770185399584477,0.00244833711322221,0.0462111239750686,0.0198642411939162,0.00381226904350308,0.00922041774380283,0.910741756934642,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,11.7812451,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.485936098064394,0.00448668985970796,0.00155299888410839,0.00808200908228358,0.00771278024096098,0.00385266053622471,0.00536687174407294,0.968945989652641,1.22295554827804,1.22295554827804,0.8085131327805288
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.01459482,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.73444252169223,0.00221922165343577,0.00134658478491355,0.00928071520245763,0.0103471897935628,0.00308928870366618,0.00305991935175966,0.970657080510204,2.4848301850992,2.4848301850992,2.75489399469468
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.379899373657707,0.0165979002447495,0.00361970146585138,0.310566371988181,0.0118953898978584,0.00727497963461814,0.00647222326114303,0.643573433507598,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.26075368,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.7140245909001735,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.85564,30.9,36.3,25.9,6.9,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.002960000420248,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,12.10629825,33.7,32.2,28.8,5.4,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,3.9917579734469997,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,8.076607527,21.5,44.3,27.4,6.7,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.150252194160397,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.262126773,28.5,36.9,23.3,11.4,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,3.9384701754429945,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.14390228,47.0,40.4,5.7,6.8,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.139158578011894,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.465333240800292,0.0929588198875335,0.00109661539851913,0.0103406974639253,0.00262333547972377,0.00257373980843396,0.00319533888859958,0.887211453073265,2.49616154919077,2.49616154919077,2.7723720781458008
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.95064466,41.0,39.5,16.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.25063580654847,0.00217929592656579,0.00233573351378476,0.00718449647353577,0.00718369422949875,0.00471157922942054,0.00408542775852615,0.972319772868668,1.71461830076508,1.71461830076508,1.5668792525462236
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,11.40653622,31.3333,31.3333,31.3333,6.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.188896879163323,0.0142737392382439,0.00348189340868737,0.00880858320276677,0.0038525568856599,0.00593274588142816,0.00610316587084082,0.957547315512373,0.645718762121967,0.645718762121967,-0.08184681311498729
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.77836699,50.0,23.5,23.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.343935283551159,0.0065593281978378,0.00138907609400551,0.00613919753007927,0.00613411120238244,0.00366825953495706,0.00406194129869205,0.972048086142046,1.35219591573978,1.35219591573978,1.0078601760398935
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.200348974,22.0,22.0,50.0,6.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.057161771094385,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.72417162,27.0,27.0,41.0,5.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.102973888920155,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.092439729,16.0,39.5,41.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.127940511650616,0.0097349353786325,0.00823434520879355,0.0380775286515883,0.0189007253206434,0.0281939358827934,0.0273826912679074,0.869475838289641,0.161929321885153,0.161929321885153,-0.8280687278728707
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.93804335,39.5,16.0,41.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.116269119637892,0.00176070173692806,0.00134882241229812,0.00721447825021801,0.00277771416530431,0.00258248336542972,0.00338400053115958,0.980931799538662,0.834918279031508,0.834918279031508,0.2099843308438277
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.312676556539088,0.0122849683487715,0.00187692747865846,0.313004652084084,0.0267625511357853,0.00478000951875277,0.00400214034383056,0.637288751090117,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.5612182984589085,0.00230427148121394,0.00151653786120671,0.00981883965091339,0.0195498469521307,0.00278714514326426,0.00256552165624032,0.961457837255031,3.54213716664653,3.54213716664653,4.385739099273481
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.95064466,41.0,39.5,16.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.2756934238792645,0.00339636246099529,0.00439836397767252,0.00922438120812044,0.0070906355917358,0.00777777401057153,0.0070228258793507,0.961089656871554,1.60048193764837,1.60048193764837,1.3908294086580206
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.77836699,50.0,23.5,23.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.300138475201197,0.0251900613139205,0.0263858529561065,0.0690244086529141,0.0290319859464883,0.0512059292322219,0.0395084822769767,0.759653279621372,0.244442812501583,0.244442812501583,-0.7007956420217016
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.93804335,39.5,16.0,41.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.035478809355064,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.07835597,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.314416735011824,0.00832740543716945,0.00279899792781369,0.0133506530995165,0.00590470004845411,0.00800781451355169,0.00611088774111073,0.955499541232384,1.4036171732161,1.4036171732161,1.0871749895142324
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,12.46964291,32.3,32.3,32.3,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.122932019074013,0.00935369123549862,0.00681432683334856,0.0266295187790274,0.0091342786879667,0.0148394527045059,0.0109795829907811,0.922249148768872,0.807897092094877,0.807897092094877,0.168305451195249
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.23312059,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.214347354616797,0.00175971204953205,0.0023945553766021,0.00864096914216858,0.00287247113967731,0.00354165273920712,0.00438932700137801,0.976401312551435,2.1807873939408,2.1807873939408,2.28592263046752
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.297557478047431,0.0163588203416613,0.0050349858804786,0.141665503002976,0.0268932928836599,0.0108166459136593,0.00842178986187252,0.790808962115693,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.623991940228679,0.0114998638575461,0.00130788860611426,0.00505223783079306,0.0046933168158669,0.00183202266239377,0.00287251942980201,0.972742150797484,1.19732008331576,1.19732008331576,0.768971662548154
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.47398367,41.5,40.5,16.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.261975403606051,0.0120973279883405,0.00779128029381303,0.0260350268299895,0.0160802201335602,0.0156019499205845,0.0170739234476819,0.90532027138603,0.213285375768679,0.213285375768679,-0.7488544878005475
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.72570651,40.5,16.0,41.5,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.168678699274804,0.00644850088058007,0.00798921970887525,0.0221223520376599,0.0111631004951633,0.0106463671035197,0.00996963598739929,0.931660823786802,0.29077874869216,0.29077874869216,-0.6293246917477433
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.63764671,41.5,40.5,16.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.40562108352751,0.0088141667427258,0.00585903666298478,0.0157870816204507,0.010986042994209,0.00978368783097364,0.0102623946891479,0.938507589459508,0.370029347989408,0.370029347989408,-0.507084458632374
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.89020107,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.402441819416474,0.154933534385178,0.00229861102597737,0.00525615721273492,0.00408539799683711,0.0022876287732977,0.00287249757879639,0.828266173027179,1.34933481107146,1.34933481107146,1.003447059865073
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.91076362,42.0,40.5,16.5,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.607168188650764,0.0408588610755303,0.0177373482989948,0.0425327283385076,0.0277718677406049,0.0276871974121274,0.0218927074965806,0.821519289637654,0.158736230637426,0.158736230637426,-0.8329939173596629
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.86872188,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.4277167605909975,0.00307921600642319,0.00224989559352084,0.00599370029233814,0.00443157985269048,0.00263031532778781,0.00293093049696406,0.978684362430275,1.27822314397057,1.27822314397057,0.8937607377335357
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CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.573473099244837,0.00689869445402741,0.00600089779665737,0.0191135089301672,0.00620664286397134,0.00981653359048003,0.0097967903769499,0.942166931987747,0.749333285576466,0.749333285576466,0.07797359977185479
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CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,8.877221176,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.829113417472866,0.00517423746484337,0.00420818785762778,0.0136338012801862,0.00389526355348657,0.0081026937251479,0.00825574629036951,0.956730069828339,1.02766134878372,1.02766134878372,0.5072812344232112
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.07835597,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.4595662121293,0.025369932029363,0.00629969301959379,0.0185849502075566,0.00668329267445478,0.00984673129800659,0.00995848867776924,0.923256912093256,0.773367707896157,0.773367707896157,0.11504553882600273
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.306031912,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.528073135603124,0.00974026247143072,0.00459547921939943,0.0155882894773368,0.00424301614179951,0.00735125258984654,0.00918675243548622,0.949294947664701,0.925634770529548,0.925634770529548,0.34991015054061214
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,6.950074466,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.730921391293652,0.0307398296858454,0.00502448817507942,0.0144391987292623,0.00475975114719379,0.00732990645958348,0.00864531856689022,0.929061507236145,0.282355212986546,0.282355212986546,-0.6423175899395637
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.3578620076745835,0.0575651939642587,0.00224327504140443,0.293214190330324,0.103801109257072,0.00316596887134689,0.00243404296405076,0.537576219571543,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.23312059,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.1515122352784415,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.0693509,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.2656332579940335,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.52014814,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.431173877940127,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.89020107,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.436396441739405,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.50369223,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.5666372362713075,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.844529643,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.765586907393996,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.23312059,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.149936935645806,0.0412282002133458,0.00282906106065428,0.0100452919302821,0.00294646346634102,0.0035555046437446,0.00510039590268196,0.93429508278295,2.31132936702855,2.31132936702855,2.4872773377263835
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.0693509,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.244200317766478,0.0307672106546614,0.0492440442693678,0.143087600825361,0.0409904333145751,0.0410729694241231,0.0628737572688051,0.631963984243106,0.159668526820479,0.159668526820479,-0.8315558953918857
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.52014814,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.430459592195472,0.0144382835185698,0.030629687100469,0.0904231657039977,0.0327120644783899,0.0374915496460484,0.0408664371206098,0.753438812431916,0.342029093157046,0.342029093157046,-0.5502735033632513
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.89020107,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.560277417097355,0.064087583051715,0.00731756531038673,0.0186036957891068,0.0053871458118381,0.00655845861152129,0.0086069303650773,0.889438621060355,2.14638048731397,2.14638048731397,2.232851633855025
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.50369223,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.667205576907544,0.00310349569550498,0.00416831577034203,0.0115025538737423,0.00349250282837259,0.00500126547712412,0.00690260249517487,0.965829263859739,3.35844880423818,3.35844880423818,4.1024086457439415
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.844529643,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.713127327493184,0.00089376253365906,0.00183788568066981,0.0054363636464257,0.00195410248071216,0.00225811087193407,0.00383533887250888,0.98378443591409,3.24722414573894,3.24722414573894,3.9308499660154896
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.359653205696989,0.0828383439279835,0.00565653685524585,0.157248489872984,0.00928479521934879,0.00688752099561758,0.00841921269728692,0.729665100431533,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.86872188,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.634728988229636,0.00818072805535472,0.00273349879854757,0.0119346096951512,0.0075308964437597,0.00591367796700706,0.00578329104170321,0.957923297998477,0.213428398303373,0.213428398303373,-0.7486338824280105
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,11.15051107,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.7140245909001735,0.0160361616147136,0.00185083446366488,0.00730973501824061,0.00349956550575257,0.00416153151105757,0.00426975100661699,0.962872420879954,0.319359456002154,0.319359456002154,-0.58524032702172
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,8.327596879,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.822697998516666,0.0208671125611406,0.0200298903914976,0.0765668274895919,0.0297655881927753,0.0442427715485906,0.0417155046265625,0.766812305189841,0.0431568482237034,0.0431568482237034,-1.011269549025132
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.548282323781043,0.235642631118293,0.00357683071882224,0.268183756367962,0.0537803810677977,0.0056567696761597,0.00550191880428196,0.427657712246684,1.0,1.0,0.4646149359523945
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.41834022,50.0,7.5,41.5,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.892602227184663,0.0004,0.0007,0.8627,0.1335,0.0019,0.0008,0,0.33,0.33,0.08164550420240263
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.34376213,50.0,29.0,20.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.935911747900319,0.0015,0.0017,0.585,0.3856,0.0215,0.0046,0,0.09,0.09,-0.5587925239809655
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.47881241,45.5,7.5,45.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.657762636107262,0.0008,0.0009,0.9399,0.0565,0.0012,0.0006,0,0.26,0.26,-0.10514892068441307
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.58994389,50.0,17.75,30.25,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.6520537718869415,0.0009,0.0008,0.8853,0.11,0.0021,0.0009,0,0.31,0.31,0.028275668520455245
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.356515817,38.0,30.0,30.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.522874943261261,0.0008,0.0012,0.7508,0.2416,0.0048,0.0008,0,0.12,0.12,-0.4787377704580445
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.211083767,38.0,16.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.802380355275797,0.0003,0.0007,0.8979,0.0985,0.0022,0.0005,0,0.45,0.45,0.40186451829408665
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.891852481,38.0,23.0,38.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.721173861744398,0.0003,0.0009,0.9061,0.0898,0.0024,0.0005,0,0.3,0.3,0.0015907506794815506
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.59856338,45.96,24.83,26.71,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.599152113662528,0.0006,0.0011,0.8386,0.1563,0.0028,0.0007,0,0.36,0.36,0.16170025772532357
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.516252746,44.58,19.33,33.08,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.539030383483547,0.0011,0.0009,0.9163,0.0784,0.0025,0.0008,0,0.24,0.24,-0.15851875636636045
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.79855736,50.0,7.5,39.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.602165676967792,0.0007,0.0007,0.9622,0.0349,0.001,0.0005,0,0.91,0.91,1.6293707389788754
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.789158454,42.5,30.0,24.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.506454213048934,0.0013,0.0022,0.7003,0.2848,0.009,0.0025,0,0.1,0.1,-0.5321076061399918
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.924427289,44.71,13.58,39.21,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.543294782270004,0.0006,0.0008,0.9464,0.0496,0.0015,0.0011,0,0.56,0.56,0.6953986145447971
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.213203287,41.46,24.83,32.21,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.600157644164547,0.0006,0.0011,0.9277,0.0684,0.0014,0.0008,0,0.44,0.44,0.37517960045311294
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.766920469,38.0,14.0,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.380775852772229,0.0005,0.001,0.9807,0.0157,0.0015,0.0006,0,0.46,0.46,0.42854943613506036
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.9150442,50.0,27.0,20.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.490881039585964,0.0013,0.001,0.7257,0.2649,0.0061,0.0009,0,0.13,0.13,-0.4520528526170708
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.33144164,47.24,11.19,38.87,2.71,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.627909672957581,0.0073,0.0639,0.7768,0.1461,0.0042,0.0016,0,1.3,1.3,2.670082534776849
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.92222847,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.8543712716215905,0.001,0.001,0.8647,0.1302,0.0025,0.0007,0,0.25,0.25,-0.13183383852538677
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.314817884980432,0.0009,0.0007,0.9116,0.0844,0.0018,0.0006,0,1.0,1.0,1.8695349995476385
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.42041204,49.0,7.5,41.5,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.534747721691546,0.0013,0.0021,0.5194,0.4632,0.0111,0.0029,0,0.5,0.5,0.535289107498955
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,15.70987342,34.25,18.75,45.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.191168746857641,0.0011,0.0011,0.7685,0.2222,0.0053,0.0018,0,0.15,0.15,-0.3986830169351235
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,11.2192693,22.0,30.0,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.151039905898646,0.0028,0.0014,0.4022,0.5806,0.0101,0.003,0,0.05,0.05,-0.6655321953448602
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.76101632,49.0,28.0,20.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.154184562578117,0.001,0.0012,0.5862,0.3912,0.0188,0.0017,0,0.16,0.16,-0.37199809909414977
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.31421044,44.61,24.89,27.94,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.155753190350744,0.0041,0.0015,0.5886,0.3825,0.0211,0.0022,0,0.13,0.13,-0.4520528526170708
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,14.60470229,32.11,24.89,40.44,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.104294893075269,0.0017,0.0016,0.5892,0.3913,0.0129,0.0033,0,0.05,0.05,-0.6655321953448602
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.00750041,49.0,18.75,31.25,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.516338972281476,0.0111,0.0048,0.1796,0.7293,0.0671,0.0082,0,0.14,0.14,-0.4253679347760971
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.77390107,42.13,18.75,38.13,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.33204826486764,0.0167,0.0049,0.2598,0.6793,0.0289,0.0104,0,0.15,0.15,-0.3986830169351235
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.21646499,45.61,13.64,38.19,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.365643155423357,0.0042,0.0015,0.3443,0.6172,0.0298,0.003,0,0.2,0.2,-0.2652584277302551
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.27353562,44.5,7.5,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.436751534363128,0.0067,0.0013,0.5909,0.385,0.0142,0.0019,0,0.22,0.22,-0.21188859204830776
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.27759176,49.0,30.0,20.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.151039905898646,0.0122,0.0028,0.2395,0.6818,0.0594,0.0044,0,0.08,0.08,-0.5854774418219391
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,14.75114553,34.5,30.0,32.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.248495242049359,0.0029,0.0024,0.3338,0.6429,0.0151,0.0029,0,0.07,0.07,-0.6121623596629128
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,16.61008,39.36,24.89,34.19,1.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.384523514872469,0.0141,0.0106,0.3243,0.5845,0.0592,0.0073,0,0.14,0.14,-0.4253679347760971
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,12.46688772,24.0,30.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.796616650559047,0.0064,0.0026,0.3777,0.6006,0.0093,0.0034,0,0.1,0.1,-0.5321076061399918
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.37981918,46.5,7.5,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.516338972281476,0.0024,0.0028,0.4642,0.5174,0.0093,0.0039,0,0.81,0.81,1.362521560569139
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,16.04448224,37.36,29.94,31.71,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.370712874773608,0.033,0.008,0.1094,0.8115,0.0325,0.0056,0,0.11,0.11,-0.5054226882990182
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.34728513,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.623010104116422,0.0087,0.0033,0.2348,0.7393,0.011,0.003,0,0.36,0.36,0.16170025772532357
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.375757021660286,0.0019,0.0023,0.9077,0.0818,0.0033,0.003,0,1.0,1.0,1.8695349995476385
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O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.630330503,34.25,18.75,45.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.395682961121367,0.03,0.0006,0.0837,0.0261,0.002,0.0013,0.8563,0.78,0.78,0.12527553001915628
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,5.746375559,22.0,30.0,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.264087336809195,0.0156,0.0014,0.0138,0.0104,0.0025,0.0031,0.9532,0.32,0.32,-0.584252318750342
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.15734025,49.0,28.0,20.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.513054897080286,,,,,,,,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.812051718,44.61,24.89,27.94,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.470495282661489,0.009,0.0004,0.0178,0.0948,0.0017,0.0003,0.8762,1.05,1.05,0.5417375282099487
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,7.893697629,32.11,24.89,40.44,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.289088639014612,0.0343,0.0003,0.1697,0.027,0.0013,0.0009,0.7666,0.46,0.46,-0.3683090604291903
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.08675917,49.0,18.75,31.25,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.9684234452869465,,,,,,,,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.13512977,42.13,18.75,38.13,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.906015244966153,0.0128,0,0.028,0.0208,0.0006,0,0.9378,0.93,0.93,0.35664330679181877
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.43848511,45.61,13.64,38.19,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.525044141508807,0.0635,0.0002,0.2019,0.083,0.0009,0.0003,0.6502,1.5,1.5,1.2358408585279361
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.44748395,44.5,7.5,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.4520190064939165,0.011,0.0005,0.3972,0.0536,0.0016,0.0009,0.5352,1.45,1.45,1.1587182662703819
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.57169095,49.0,30.0,20.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.86830338551846,,,,,,,,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.009941019,34.5,30.0,32.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.3476939555933765,0.0165,0,0.0427,0.0616,0.0035,0.0028,0.8728,0.42,0.42,-0.4300071342352337
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.301142352,39.36,24.89,34.19,1.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.629862798578463,0.0246,0,0.1245,0.0895,0.0015,0.0023,0.7576,0.44,0.44,-0.399158097332212
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,6.525773643,24.0,30.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.732683506287051,0.006,0.0012,0.0205,0.0177,0.0008,0,0.9538,0.44,0.44,-0.399158097332212
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.31765932,46.5,7.5,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.81380905109942,0.073,0,0.0373,0.0149,0,0,0.8748,1.01,1.01,0.4800394544039054
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.01888288,46.37,7.5,44.21,1.92,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.706823839714591,0.0145,0.0004,0.1165,0.019,0.0007,0.0011,0.8477,1.94,1.94,1.9145196703944125
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.30562834,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.73795129722191,0.0343,0.0003,0.1697,0.027,0.0013,0.0009,0.7666,1.9,1.9,1.8528215965883692
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,9.480986593,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.302712827954156,0.0455,0,0.324,0.073,0.0011,0.0012,0.5551,1.0,1.0,0.4646149359523945
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,17.88551615,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.763028270603671,0.0253701689981931,0.00985209592098701,0.307949537646453,0.622300893638244,0.0174680522283724,0.0170592515677505,-,0.0,,
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,17.94390528,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.584559232083967,0.00894763570081526,0.00182903773179144,0.430416319953847,0.549730482792046,0.00757886856613304,0.0014976552553668,-,0.0019532059842532,0.0019532059842532,-0.793744670428099
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,18.3291697,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.5827200571505,0.00757568328250189,0.00220510873539676,0.728025615125869,0.236446776884745,0.0226429923353559,0.00310382363613184,-,0.0011482099710543,0.0011482099710543,-0.7958927956755514
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,18.38109198,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.6888677450096585,0.00599960547383456,0.00187471922407934,0.58725363712808,0.393842224090862,0.00908706069367491,0.00194275338946932,-,0.0005585876781053,0.0005585876781053,-0.7974661979200065
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,19.03103458,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.374372415737022,0.0207124354254999,0.00767807173489595,0.560331852523788,0.3797189836544,0.0206003960524344,0.0109582606089812,-,0.0001489580680618,0.0001489580680618,-0.7985592911689305
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,19.07349618,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.567572155572773,0.0084525958204246,0.00170600389954699,0.807774257087237,0.172171860632781,0.00851123850670424,0.00138404405330582,-,0.0052460712339961,0.0052460712339961,-0.7849576865630203
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,17.88551615,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.763028270603671,0.0142965461163966,0.00273099369058116,0.2951874813445,0.196790510597468,0.00567584660232592,0.00900724719724339,0.476311374451485,0.0033203605888808,0.0033203605888808,-1.0727154128818024
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,17.94390528,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.584559232083967,0.0426258503334726,0.000887127042175757,0.102099604743599,0.057196348771858,0.00222434780081794,0.00162961025671667,0.79333711105136,0.0465195426566469,0.0465195426566469,-1.006082754792359
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,18.3291697,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.5827200571505,0.0182648912592805,0.000462867676668248,0.083073077462289,0.0429608616930204,0.00195825764287227,0.000923423624969053,0.852356620640901,0.0509209522037464,0.0509209522037464,-0.9992937925151699
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,18.38109198,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.6888677450096585,0.0068908069603713,0.000629547873998548,0.021394314943629,0.042448777163022,0.00198708372142952,0.00248444060475972,0.92416502873279,0.016201262972428,0.016201262972428,-1.0528472412330891
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,19.03103458,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.374372415737022,0.0116932676375475,0.00103739027764326,0.0525071135910941,0.0215477599193875,0.00368874758435242,0.00400972460855577,0.905515996381419,0.006104461793755,0.006104461793755,-1.068421070841257
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,19.07349618,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.567572155572773,0.0237911981258413,0.00067207203055979,0.18334881014348,0.0466442684044473,0.00188246389345958,0.000953648344707904,0.742707539057504,0.0550488822731985,0.0550488822731985,-0.9929266591628888
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.82491214,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GLN,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.572543683160998,0.000714997259249526,0.000661552142657172,0.125943320778554,0.801966162874089,0.0693146503097598,0.00139931663568972,-,0.0127373438778132,0.0127373438778132,-0.764967287060561
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.91081918,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,BIM,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.358502089626924,0.00147233862420237,0.00107405472963131,0.901430168335102,0.0923159134092667,0.00310160866776492,0.000605916234032228,-,0.0763434621140544,0.0763434621140544,-0.5952348831288257
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81357262,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,3FLA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.396299293960601,0.00110223184180453,0.00161797426133587,0.963322201717795,0.0321995776177804,0.00129202117564397,0.000465993385639812,-,0.380376087923258,0.380376087923258,0.21607368094058316
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.58547122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.351438552905858,0.00061802522712851,0.00208191419961706,0.00520107649990865,0.018780252186508,0.966671145724669,0.00664758616216931,-,0.0289886812604962,0.0289886812604962,-0.7216007267742771
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,IZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.544995462952021,0.00423798522906651,0.00360605985882706,0.0132163308359338,0.182768863634774,0.789078621894797,0.00709213854660109,-,0.0033387326299993,0.0033387326299993,-0.7900474039572776
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.80884374,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PY,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.237000862623624,0.0123483310685072,0.00430719249252366,0.0429874465070588,0.751978605237179,0.174073814828135,0.0143046098665965,-,0.0005090956767902,0.0005090956767902,-0.7975982669188943
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.790487251761845,0.00153513483125764,0.00147931904743739,0.82338319944907,0.169033483447006,0.00378262362292623,0.000786239602302501,-,0.306009500746919,0.306009500746919,0.017627054049161966
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,17.10338647,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.842058839093973,0.00164287085070931,0.000659195379539964,0.94017588697419,0.0550751037989028,0.00183173459161262,0.000615208405045708,-,0.504231824712829,0.504231824712829,0.5465816969768794
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.82491214,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,GLN,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.572543683160998,0.0204881792124896,0.00996076677576078,0.024515683125648,0.0206076067733214,0.0213656753332114,0.0146396167476402,0.888422472031929,0.0035574041476412,0.0035574041476412,-1.0723497846072114
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.91081918,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,BIM,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.358502089626924,0.0789442718629389,0.000859220559164078,0.352513414289749,0.0167725689541561,0.00207992092629201,0.000939235620822743,0.547891367786878,0.128034152082589,0.128034152082589,-0.8803503950765449
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81357262,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,3FLA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.396299293960601,0.020589791219893,0.00221295822133462,0.77006639472807,0.0336156368936998,0.00141982059640497,0.000804331444027444,0.17129106689657,0.352623838360951,0.352623838360951,-0.5339316190745824
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.58547122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,1.0,4.351438552905858,0.0518701933925729,0.031230151711712,0.196119602463562,0.0891250765615729,0.225998436967717,0.183312147304902,0.222344391597961,0.0006916766953858,0.0006916766953858,-1.0767700312036428
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,IZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.544995462952021,0.0318134391856252,0.0195739470918212,0.0658637908929555,0.0405146823853727,0.0383355214778253,0.0445803960220688,0.759318222944331,0.0007826107131428,0.0007826107131428,-1.0766297698601666
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.80884374,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PY,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.237000862623624,0.0496007240706346,0.0248050760368446,0.125156740550784,0.0913290655906173,0.0605654916232193,0.0647609529825488,0.583781949145352,0.000319594239126,0.000319594239126,-1.077343950474849
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.790487251761845,0.0660465509749711,0.000704686244275338,0.176882938102508,0.134254150019803,0.00301700767902668,0.00146559050061717,0.617629076478799,0.391796497651864,0.391796497651864,-0.473509678471839
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,17.10338647,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.842058839093973,0.180962520579808,0.000840183131263393,0.0600498448220066,0.0139903797423045,0.00230022430813273,0.00221494849849946,0.739641898917986,0.515169720881209,0.515169720881209,-0.2832124226594992
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.07758774,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.48897339158558,0.000136174132145422,0.00212452688507234,0.811633900204502,0.179761878637886,0.00385751556458306,0.00248600457581157,-,0.767759892635294,0.767759892635294,1.24980418110703
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.50454535,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ALA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.675628649636653,0.00268100351583557,0.00240431632025112,0.142040711181502,0.523320437165769,0.324868931367264,0.00468460044937817,-,0.0241897161135915,0.0241897161135915,-0.7344067258409619
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.59671966,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,SER,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.737600973168581,0.00157432110064945,0.00176844882817444,0.053765469363115,0.438156626388713,0.500533090562106,0.00420204375724176,-,0.0189624719731265,0.0189624719731265,-0.7483555838832638
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.07758774,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.48897339158558,0.0550309639531662,0.00234353835896855,0.320198252727196,0.282656133384496,0.0064798077198827,0.00202476215621646,0.331266541700075,1.20135127285815,1.20135127285815,0.775189578295967
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.50454535,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ALA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.675628649636653,0.0418659426619505,0.0219153925677162,0.21668759621254,0.199875450362037,0.113029824089051,0.0495629458661235,0.357062848240582,0.0027707272238572,0.0027707272238572,-1.0735631958798397
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.59671966,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,SER,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.737600973168581,0.0234118812216689,0.0071462713755353,0.0426958781226752,0.0464078935005845,0.0346044033846598,0.0235967118628926,0.822136960531984,0.0055457738057274,0.0055457738057274,-1.0692828201592537
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.16930088,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,TZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,5.001930853466109,0.00767358537807448,0.00233215653996207,0.0713684727707158,0.307444763898641,0.0172788380976704,0.00511228295653041,0.588789900358405,0.0063917829512014,0.0063917829512014,-1.0679778917918028
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.579236803961587,0.00833063062779389,0.00173987762429209,0.156651961849343,0.112205138324295,0.00895304009765426,0.00427289873828259,0.707846452738339,0.269390835357988,0.269390835357988,-0.6623145181339684
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.15847938,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,3F,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.484131857611035,0.0158311033527607,0.00109353847138243,0.0200990623529318,0.00589717673503959,0.00332080816189693,0.00297802720282806,0.95078028372316,0.0070114291767852,0.0070114291767852,-1.06702211732781
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81395289,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PYR,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,5.0755487449389,0.0138253404297663,0.00670375922221507,0.064918033729737,0.0310082272870404,0.0307691214666871,0.0156091189056244,0.83716639895893,0.0111434256880136,0.0111434256880136,-1.060648711684908
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.402809173856411,0.0144051248882893,0.000525788660297221,0.125667067331117,0.214373546599095,0.00410880851120861,0.00177167337754258,0.639147990632451,0.176512628889736,0.176512628889736,-0.8055746790752468
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.16930088,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,TZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,5.001930853466109,0.00115119797114568,0.0003959818507672,0.0538124209539168,0.93604524664705,0.00736502972190904,0.00123012285521143,-,0.0261518819859255,0.0261518819859255,-0.7291707023316024
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.579236803961587,0.0010942059599737,0.000714578151988552,0.367034511120116,0.62078160479883,0.0079478856978032,0.00242721427128835,-,0.970510173989973,0.970510173989973,1.7908416411254202
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.15847938,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,3F,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.484131857611035,0.0376230130625874,0.00236009027623813,0.247039705692743,0.697452972603375,0.0104681865382628,0.00505603182679352,-,0.0013884403431976,0.0013884403431976,-0.7952517429011965
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81395289,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PYR,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,5.0755487449389,0.00873826813676438,0.00145112475939544,0.193065080283125,0.778197018798523,0.014433213681334,0.00411529434085825,-,0.165721665234437,0.165721665234437,-0.35672988242469916
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.402809173856411,0.00532422079532615,0.00061084449763591,0.522469676271313,0.459778984209221,0.00966894873803684,0.00214732548846694,-,0.161020662402855,0.161020662402855,-0.3692744698577941
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.36945365,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.584763376210429,0.0318391346416656,0.000341552225113717,0.113678281409446,0.242279767731552,0.00387550619454475,0.000871625110337537,0.60711413268734,0.649833386251602,0.649833386251602,-0.07550020353412855
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.746322465743975,0.0548193142492001,0.000263362025026913,0.0902956804122817,0.160837629010128,0.00315355508353847,0.000739500993108033,0.689890958226717,1.16375238999006,1.16375238999006,0.7171951120404622
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O,DSPC,0,0,1,0,16.87346518,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,HIS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.651385609785055,0.0172566765287249,0.00318344365411915,0.0712890876960715,0.171965068058214,0.0218135302099503,0.0115493777455846,0.702942816107335,0.00327405282427,0.00327405282427,-1.0727868403787713
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.36945365,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.584763376210429,0.000599963927151076,0.000397997752734626,0.420976508827142,0.560178394908249,0.017044159994242,0.000802974590480822,-,0.25255828640642,0.25255828640642,-0.1250070722684871
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.746322465743975,0.000524374578838527,0.00061514916196369,0.547432124587029,0.435435317287124,0.015309113403191,0.000683920981854007,-,0.568394489552276,0.568394489552276,0.7177992409467366
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O,DSPC,0,0,1,0,16.87346518,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,HIS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.651385609785055,0.00171983501988967,0.00189561016704693,0.0120716635806003,0.711278646835123,0.270438826106656,0.00259541829068387,-,0.0112897234542117,0.0112897234542117,-0.7688302502674332
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.36945365,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.484733632866144,0.0047850951415261,0.000675911772575438,0.46069265034102,0.522359359837259,0.0109775121699624,0.00050947073765779,-,0.773205414607926,0.773205414607926,1.2643355117511204
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.633757642840004,0.00198911414189635,0.00126811595413123,0.543867583730296,0.438842770521552,0.0129988635137729,0.00103355213835123,-,1.98493053910539,1.98493053910539,4.497814051056962
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.0333911,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.609759638321899,0.00125031423153586,0.0004860362025215,0.538249539726811,0.445414640899446,0.0137801694455006,0.000819299494184621,-,0.291137444797345,0.291137444797345,-0.022058905064912687
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=O,DSPC,0,0,1,0,16.68738808,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,CYS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.392884144674663,0.00226285185388551,0.000562872305858137,0.731364439797527,0.256932619347553,0.00825451238600619,0.000622704309170273,-,1.82872279459479,1.82872279459479,4.080974968218046
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O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.633757642840004,0.0374610013402809,0.0005350551106764,0.260855439538844,0.469905543128085,0.00469334055693451,0.000912093945676405,0.225637526379503,1.69276100831231,1.69276100831231,1.5331654314724417
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.0333911,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.609759638321899,0.0836645231428707,0.000419599806684375,0.0235684307001288,0.0712275212970175,0.00119681308497475,0.00178295859414992,0.818140153374174,0.426058290183635,0.426058290183635,-0.4206625133630252
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O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.71419039,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.904756125442696,0.0248552898268163,0.0125192728735768,0.0725307642598596,0.0355254691282667,0.0214395648154144,0.0248745799236939,0.808255059172372,0.0741845243461588,0.0741845243461588,-0.9634108527393006
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.34728513,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.733211535868976,0.0883917007893502,0.00174599838911923,0.0536405332414895,0.100118671210748,0.00771990063396103,0.00639776118235737,0.741985434552974,0.528035509086713,0.528035509086713,-0.2633675639025965
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,18.70678989,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.858726543710496,0.0175679405294797,0.00960173891174304,0.0903179131752613,0.0388184937379254,0.0182497546285787,0.0249045868533177,0.800539572163694,0.125181510399577,0.125181510399577,-0.8847504575040614
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.62870578,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.765586907393996,0.00159278655447388,0.00186611160196327,0.488795918944862,0.485247409700546,0.018616198181097,0.00388157501705755,-,0.352570746370957,0.352570746370957,0.14187535545424673
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.61880246,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.82374330878754,0.000875415234709484,0.00127375854285246,0.683377837104949,0.304003257921165,0.00820355561270421,0.00226617558361995,-,0.943420561172443,0.943420561172443,1.7185532318874628
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.58547122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.433313679041901,0.000602190120987361,0.000576528881915898,0.00566197423128506,0.0161763859347042,0.971683265119797,0.00529965571131053,-,0.0305789310371634,0.0305789310371634,-0.7173571583105779
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,17.70929826,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.356324137321509,0.00187378052819512,0.00157654975652554,0.0163863796216318,0.0648246159165097,0.905280007427939,0.0100586667491993,-,0.003875136361479,0.003875136361479,-0.7886160150068647
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.17273956,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.440767129696482,0.00301049906217731,9.21592223531261e-05,0.00380096827414773,0.0130323481002541,0.97657327492354,0.00349075041752818,-,0.0274401441027376,0.0274401441027376,-0.7257329854571254
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=O,DSPC,0,0,1,0,18.38469122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.349632566862877,0.00273989274094748,0.00161018393061426,0.0112824839963327,0.0583352940699212,0.919247401685963,0.00678474357622127,-,0.0081601896883771,0.0081601896883771,-0.7771813854096181
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=O,DSPC,0,0,1,0,18.90345652,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.662778498608405,0.00349315451118928,0.00171298178399312,0.037797325974731,0.242816837972913,0.706569889763285,0.00760980999388795,-,0.0136767051395404,0.0136767051395404,-0.7624606092513427
O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCN,DSPC,0,0,1,0,18.38469122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,1,0,0,0,0,0,1,,4.405498990859024,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=O,DSPC,0,0,1,0,16.89527599,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,,4.815106909815019,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.89527599,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.562053894914463,0.00241700650155169,0.00189161759954923,0.0117804592312353,0.0588098364115177,0.918016488291877,0.0070845919642692,-,0.288385322760908,0.288385322760908,-0.029402920107978105
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.89527599,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.667205576907544,0.00146771264056884,0.000853267380299107,0.00521853383313367,0.0984194458399351,0.890752405611161,0.00328863469490281,-,0.174730948641107,0.174730948641107,-0.3326886836733955
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,17.94799221,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.701389043728634,0.00256320924432886,0.00193796271600952,0.0128146756680969,0.0418402586947232,0.934553052894321,0.00629084078252029,-,0.0492674291707299,0.0492674291707299,-0.6674870545840368
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,18.38469122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.460491174618648,0.00101051612937229,0.00153512067382825,0.00950098551353592,0.161931963893941,0.822835993399315,0.00318542039000704,-,0.105055900803977,0.105055900803977,-0.5186159763833679
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O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,17.18453431,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.684905154006945,0.0025903109842197,0.00122267327648511,0.0959380417500791,0.558064631213231,0.339326541744348,0.00285780103163663,-,0.0836567108446898,0.0836567108446898,-0.5757195389760648
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,18.58497913,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.695924549256556,0.00270162630925447,0.000571977156802491,0.072649821877092,0.283620916967858,0.638520904456637,0.00193475323235631,-,0.108372702997361,0.108372702997361,-0.5097651169808466
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=O,DSPC,0,0,1,0,16.82518306,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,LYS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,1,0,0,0,1,0,0,,4.202899968776446,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,14.52948326,43.25,25.0,30.0,1.75,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,0.0,5.029784112935016,0.000951862951033406,0.000642237882584555,0.00747953132811133,0.295137112679544,0.692754163229738,0.0030350919289883,-,0.19435393861906,0.19435393861906,-0.2803248961378029
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,11.10169345,30.0,25.0,42.5,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.833102254034098,0.00529626249319983,0.00246267213977097,0.0289260006923807,0.563065088278535,0.393847703229461,0.00640227316665243,-,0.049072760763369,0.049072760763369,-0.6680065256297026
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.72804315,38.075,17.975,41.825,2.125,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,,4.93014804318357,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.39261658,37.0,25.0,37.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,5.146912912388804,0.000759366167023555,0.000694817987152034,0.00466364025695932,0.212680085653105,0.777593147751606,0.00360894218415418,-,0.201238755105862,0.201238755105862,-0.2619528199077537
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.51039532,38.5,20.5,38.5,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.684905154006945,0.00157535225652128,0.00592927130077556,0.00900517890128691,0.366135503933579,0.613833328839362,0.00352136476847493,-,0.149329656900936,0.149329656900936,-0.40047182198750214
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.48290639,45.0,9.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.869839484130799,0.00147117555088917,0.000927103843315829,0.00585237061645294,0.136146016514374,0.851575135737455,0.00402819773751327,-,0.31219703699332,0.31219703699332,0.034138443686487704
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,14.13138042,41.2,22.35,34.325,2.125,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,0.0,4.901564199041894,0.00315707422768752,0.0025689389054212,0.0146712017391132,0.327849346901905,0.646061693847123,0.0056917443787501,-,0.158541375998041,0.158541375998041,-0.3758904252594646
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.11942242,41.825,14.975,41.825,1.375,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,,5.039546637590676,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,14.79492927,45.0,22.5,30.0,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.9141243937154115,0.00113350028034128,0.000566939752127873,0.00680706926467914,0.502661298625749,0.486733894218144,0.00209729785895866,-,0.145448415448628,0.145448415448628,-0.4108288829150842
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,12.55393718,34.325,21.725,41.825,2.125,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,0.0,4.814620410170298,0.001692878443667,0.000820135726038303,0.00868136575507882,0.408928448915581,0.577101122031978,0.00277604912765729,-,0.113760366510672,0.113760366510672,-0.495388181160095
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.93959861,45.0,7.5,45.0,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.527640983478854,0.00506334343919377,0.004281344333051,0.0165771717732586,0.226890591170162,0.736348900590883,0.0108386486934518,-,0.0547343765642327,0.0547343765642327,-0.6528985503803821
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.59337013,45.0,15.75,37.5,1.75,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.810557015713042,0.00141112235558708,0.000749767156842064,0.00637541161251223,0.138880841494329,0.847648476304751,0.00493438107597822,-,0.294154433878409,0.294154433878409,-0.0140080944893819
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,11.66031337,30.0,24.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,5.167639042905921,0.00199236267032557,0.000827577235394216,0.008719084857644,0.192132365846187,0.792330257640873,0.0039983517495764,-,0.151793984465988,0.151793984465988,-0.3938957841268362
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.66358165,37.5,15.0,45.0,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.618086411254637,0.00271480786609193,0.00181664538344774,0.00938513027274936,0.132547184736695,0.849509595736892,0.0040266360041233,-,0.0950036114384557,0.0950036114384557,-0.5454404279666308
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.26186294,45.0,24.0,30.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,,5.098035484377089,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.27611859,45.0,11.382,42.618,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.680277658474897,0.00152924607683628,0.00192508702614222,0.0105762053188716,0.167270255683968,0.810875386281306,0.00782381961287527,-,0.278754923842637,0.278754923842637,-0.05510156049896443
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.11001923,45.0,13.445,40.445,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.924350925499243,0.000999438616070677,0.00125158481927741,0.00771842730472846,0.249469737208587,0.735450494958472,0.00511031709286499,-,0.286455906115286,0.286455906115286,-0.03455155257492116
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.85662691,45.0,16.405,37.595,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.924350925499243,0.00141338619768439,0.00124322063420737,0.0100450891793794,0.235894751086175,0.745556785166654,0.00584676773589971,-,0.264336417833639,0.264336417833639,-0.09357722532293417
1 smiles Helper_lipid_ID Helper_lipid_ID_DOPE Helper_lipid_ID_DOTAP Helper_lipid_ID_DSPC Helper_lipid_ID_MDOA Cationic_Lipid_to_mRNA_weight_ratio Cationic_Lipid_Mol_Ratio Phospholipid_Mol_Ratio Cholesterol_Mol_Ratio PEG_Lipid_Mol_Ratio Purity Mix_type Cargo_type Cargo_type_mRNA Cargo_type_pDNA Cargo_type_siRNA Target_or_delivered_gene Model_type Model_type_A549 Model_type_BDMC Model_type_BMDM Model_type_HBEC_ALI Model_type_HEK293T Model_type_HeLa Model_type_IGROV1 Model_type_Mouse Model_type_RAW264p7 Delivery_target Delivery_target_body Delivery_target_dendritic_cell Delivery_target_generic_cell Delivery_target_liver Delivery_target_lung Delivery_target_lung_epithelium Delivery_target_macrophage Delivery_target_muscle Delivery_target_spleen Route_of_administration Route_of_administration_in_vitro Route_of_administration_intramuscular Route_of_administration_intratracheal Route_of_administration_intravenous Batch_or_individual_or_barcoded Batch_or_individual_or_barcoded_Barcoded Batch_or_individual_or_barcoded_Individual Value_name Formulation_ID Cationic_Lipid_Mass_Ratio Phospholipid_Mass_Ratio Cholesterol_Mass_Ratio PEG_Lipid_Mass_Ratio Amine Tail Lipid_name Library_ID Experiment_ID Experimenter_ID Experiment_weight Goal screen_id Source Sample_weight Comment Amine_number Full_SMILES Amine_SMILES Tail_length Num_tails Ketone Isocyanide Is_cyclic Formulation Batch_or_individual Random_id 4CR_Lipid_name Aldehyde Carboxylic_acid Amine_name Tail_name Linker MolWt Tail_count Num tails Common_name Ester Disulfide Total_radiance Form_comment molecular_weight split_name_for_normalization Encapsulation_Efficiency_EE<50 Encapsulation_Efficiency_50<=EE<80 Encapsulation_Efficiency_80<EE<=100 PDI_0_0to0_2 PDI_0_2to0_3 PDI_0_3to0_4 PDI_0_4to0_5 toxic size Biodistribution_lymph_nodes Biodistribution_heart Biodistribution_liver Biodistribution_spleen Biodistribution_lung Biodistribution_kidney Biodistribution_muscle quantified_total_luminescence unnormalized_delivery quantified_delivery
2 OC(CC(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)(CC(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)C(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O DSPC 0 0 1 0 19.35326347 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence citric acid Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 5.01396308418893 - 0.141974553073968 0.351788837480042 0.21590174472742 0.201831859522378 0.0885030051961923 77.5%? 0.148451427756917 0.148451427756917 -0.8488577305397192
3 OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O DSPC 0 0 1 0 19.19352646 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence citric acid Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.346658490836091 - 0.118429962362459 0.359442163877919 0.207462553548735 0.206757503800386 0.107907816410501 77.5%? 0.141461295642972 0.141461295642972 -0.8596396727167236
4 O=C(CN(CCCCCCCCCCCC)CCCCCCCCCCCC)NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.44559484 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 6.892641641172089 - - - - - - - 0.0
5 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCCCC DSPC 0 0 1 0 15.24245185 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 5.2699178920263385 - 0.124916929794055 0.369468729447656 0.195055730208631 0.225094433177121 0.0854641773725367 77.5%? 0.156358397802496 0.156358397802496 -0.8366616100033615
6 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCCCC DSPC 0 0 1 0 15.24245185 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.345103280569283 - - - - - - - 0.0
7 O=C(CN(CCCCCCCC)CCCCCCCC)NCCCN(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.38607591 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.281930018135596 - 0.150136519605605 0.355001041089 0.229550847405215 0.174081272090009 0.0912303198101713 77.5%? 0.152341943264804 0.152341943264804 -0.8428567977159901
8 CCCCCCCCN([C@H](C(NCCCN(CCCCCCCC)CCCCCCCC)=O)CO)CCCCCCCC DSPC 0 0 1 0 13.70858688 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.6061696863211745 - 0.135258733819858 0.336501144772348 0.220509705752364 0.219041309358291 0.0886891062971386 77.5%? 0.158669313943658 0.158669313943658 -0.8330971331374368
9 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.40770989 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.60816569496789 - 0.104670582084173 0.315839166696278 0.253250862525529 0.232520638852651 0.0937187498413698 77.5%? 0.159094240395848 0.159094240395848 -0.8324417045472029
10 CCCCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CO)CCCCCCCCCCCC DSPC 0 0 1 0 15.96782216 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.378645926514404 - 0.12522501256674 0.335948007662315 0.256499891314685 0.184909383618406 0.0974177048378551 77.5%? 0.158517890991896 0.158517890991896 -0.8333306957487803
11 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.6210435351443815 - 0.018637540697442 0.856266507625458 0.0685481607764484 0.037483843171047 0.0190639477296046 77.5%? 1.0 1.0 0.4646149359523945
12 O=C(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.2554924 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.310127759130018 - - - - - - - 0.0
13 O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O DSPC 0 0 1 0 16.95535314 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.35696520407851 - - - - - - - 0.0
14 O=C(CN(CCCCCCCCCC)CCCCCCCCCC)NCCCN(CCCCCCCCCC)CCCCCCCCCC DSPC 0 0 1 0 14.51030189 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.175309921045206 - - - - - - - 0.0
15 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.11860943 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.447697327163527 - - - - - - - 0.0
16 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 16.80841018 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.381651564343798 - - - - - - - 0.0
17 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCC DSPC 0 0 1 0 14.7769988 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.250350662548819 - - - - - - - 0.0
18 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.33731463 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.386765389021055 - - - - - - - 0.0
19 O=C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H](C)N(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.55151343 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.391729410135267 - - - - - - - 0.0
20 O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O DSPC 0 0 1 0 16.95535314 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.844974178195408 - 0.00630203002731954 0.185980624705068 0.790574355089574 0.0148193516556036 0.00232363852243453 77.5%? 2.42642874788244 2.42642874788244 2.664812590100213
21 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.11860943 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 5.19295685089021 - 0.00474168484136008 0.800367351971756 0.180650022354306 0.00984951126906641 0.00439142956351233 77.5%? 0.287207020238001 0.287207020238001 -0.6348339108922395
22 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 16.80841018 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 5.394990253808298 - 0.00302211757671521 0.318679912693443 0.664215585884173 0.0128029348785811 0.00127944896708776 77.5%? 0.514539131213174 0.514539131213174 -0.28418507685649314
23 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCC DSPC 0 0 1 0 14.7769988 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.509649984130679 - 0.00312543572304221 0.147942119682821 0.821649165313096 0.0234407679228166 0.00384251135822455 77.5%? 0.239971111848379 0.239971111848379 -0.7076930249451995
24 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.33731463 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 5.12455904041457 - 0.0210297731298931 0.658450324145507 0.200900368909969 0.111879408982101 0.00774012483253011 77.5%? 0.0342179895228306 0.0342179895228306 -1.0250573081218382
25 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 5.112590016619249 - 0.00128819081649658 0.393692319023747 0.589452131076946 0.0101812483827002 0.00538611070010966 77.5%? 1.0 1.0 0.4646149359523945
26 O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H](C)N(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.85660447 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.114394528387108 - - - - - - - 0.0
27 O=C(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.63293083 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 5.272999558563747 - - - - - - - 0.0
28 O=C(CN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O DSPC 0 0 1 0 16.2856483 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.28978103552575 - - - - - - - 0.0
29 O=C(CN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)NCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC DSPC 0 0 1 0 16.23582504 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.260615499364025 - - - - - - - 0.0
30 O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)CN(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.75702627 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.9788005705762375 - - - - - - - 0.0
31 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)=O)CO)CCCCCCOC(CCCCC)=O)CCCCC DSPC 0 0 1 0 16.47477668 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.68213122712422 - - - - - - - 0.0
32 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.686750172980514 - - - - - - - 1.0 1.0 0.4646149359523945
33 CCCCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 19.33366115 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 - - - - - - - 0.0
34 CCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.98780245 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.9473404437239425 - - - - - - - 0.0
35 CCCCCCCCCCCCCCN(CCCNC([C@@H](N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)CO)=O)CCCCCCCCCCCCCC DSPC 0 0 1 0 16.42695266 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.545101659521972 - 0.00318490682025255 0.0608074236431031 0.251089505980848 0.00892095913117615 0.00601048706680474 0.669986717357815 0.0815243428420059 0.0815243428420059 -0.9520895361573071
36 CCCCCCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)=O)CO)CCCCCCCCCCCCCC DSPC 0 0 1 0 16.68206611 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.844974178195408 - - - - - - - 0.0
37 O=C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H]([C@H](O)C)N(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.77114057 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence thr Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.331522502500114 - 0.0131160505661734 0.0817206877958181 0.209957462105326 0.0363069917919837 0.0161572104727098 0.642741597267989 0.0248953087459781 0.0248953087459781 -1.0394370942878488
38 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.4135253017332525 - 0.00151329913495755 0.0471551068594211 0.0476760649180962 0.00182335320536251 0.00763287581452213 0.89419930006764 0.35502103370942 0.35502103370942 -0.5302340606861489
39 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.509649984130679 - 0.00235961766437825 0.513627015742916 0.0879412499947796 0.00175822838354556 0.00311254749811917 0.391201340716262 1.0 1.0 0.4646149359523945
40 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.496359280129911 - - - - - - - 0.0
41 CCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCC)CCCCCCCC)=O)CO)CCCCCCCC DSPC 0 0 1 0 14.13296737 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.170425586627436 - - - - - - - 0.0
42 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.445353484534206 - - - - - - - 0.0
43 CCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCC DSPC 0 0 1 0 15.1299087 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.166510173022286 - - - - - - - 0.0
44 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 17.04310679 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.673109168996284 - - - - - - - 0.0
45 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)=O)CO)CCCCCCOC(CCCCC)=O)CCCCC DSPC 0 0 1 0 16.72728505 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.7572902340489245 - - - - - - - 0.0
46 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.332573750954351 - 0.000230328920605394 0.0259372790881254 0.0734981485145439 0.000576894596302152 0.000867946038939987 0.898889402841483 0.486446282346577 0.486446282346577 -0.32751694342632615
47 O=C(CCN(CCCNC([C@@H](NCCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.332573750954351 - 0.00183814880222334 0.508470854676458 0.479298868566087 0.00664368457868438 0.00374844337654761 - 0.0806697533656258 0.0806697533656258 -0.5836902104683951
48 O=C(CCN(CCCNC([C@@H](NCCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 14.7050121 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.577079305821566 - 0.00446051681777838 0.0286140231457339 0.01484311836534 0.00629790100652696 0.01599114503205 0.929793295632571 0.0275210452544693 0.0275210452544693 -1.035387022165446
49 OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O DSPC 0 0 1 0 14.7050121 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.577079305821566 - 0.0104002218216073 0.139229779861971 0.807246421461676 0.041233674188 0.00188990266674509 - 0.0040656278842911 0.0040656278842911 -0.7881076899433005
50 O=C(CCN([C@H](C(NCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 16.11494914 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.7535901911063645 - 0.00711911642710361 0.153280595121264 0.136743424441396 0.0628412485834964 0.0734141937722642 0.566601421654476 0.0027486514420013 0.0027486514420013 -1.0735972467102965
51 O=C(CCN([C@H](C(NCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 16.11494914 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.7535901911063645 - 0.106975953776871 0.247623902989694 0.292657465739291 0.229416263063982 0.123326414430162 - 0.001042320755636 0.001042320755636 -0.7961753601769197
52 O=C(CN(CC(O)CCCCCC)CC(O)CCCCCC)NCCCN(CC(O)CCCCCC)CC(O)CCCCCC DSPC 0 0 1 0 14.05354178 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.789157022101107 - 0.0386975655052687 0.153034034478582 0.0799184464451532 0.0414429326981307 0.0607210626185958 0.626185958254269 0.0073827728841294 0.0073827728841294 -1.0664493375412318
53 O=C(CN(CC(O)CCCCCC)CC(O)CCCCCC)NCCCN(CC(O)CCCCCC)CC(O)CCCCCC DSPC 0 0 1 0 14.05354178 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 1 0 0 0 0.0 4.639571612705423 - 0.135531713474282 0.541180183023036 0.178510571158094 0.0949195329757021 0.0498579993688861 - 0.004009461265808 0.004009461265808 -0.7882575701032632
54 O=C(CN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 15.91058453 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.639571612705423 - - - - - - - 0.0
55 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.391357962102766 - 0.000231298468169262 0.195828728849491 0.0126185833117857 0.000504922171493209 0.00109315352063243 0.789723313678428 1.0 1.0 0.4646149359523945
56 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.391357962102766 - 0.00515447939315304 0.962574355010024 0.0304157301451643 0.000918038843316605 0.000937396608342438 - 1.0 1.0 1.8695349995476385
57 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.45295097301058 - - - - - - - 0.0
58 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 4.45295097301058 - - - - - - - 0.0
59 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.508769411701737 0.0963955724315343 0.000259669027359828 0.0209585518067849 0.0324510369422159 0.00191021824445882 0.00526970020363582 0.84275525134401 0.95415067884307 0.95415067884307 0.3938945659349633
60 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.508769411701737 - 0.00301852406237983 0.561715155652109 0.427466534539213 0.00675382930885143 0.00104595643744612 - 0.469108231863161 0.469108231863161 0.4528546780295592
61 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.424367475163407 0.00431198097235812 0.000818950238891083 0.0696322838846972 0.0220758004851341 0.00177157151502323 0.00255208415951453 0.898837328744382 0.673380628639453 0.673380628639453 -0.039179716064767986
62 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.424367475163407 - 0.00336772556852765 0.856457049453334 0.133858740361315 0.00483749939645135 0.00147898522037143 - 0.274077344076178 0.274077344076178 -0.06758364367522034
63 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.570475216191205 0.0465123735855303 0.000498926332937811 0.165458883776434 0.0565565738614754 0.00106294680997165 0.00247840641808945 0.727431889215561 1.0 1.0 0.4646149359523945
64 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.570475216191205 - 0.00167236193574396 0.848665421605967 0.144098339320739 0.00370843762360476 0.00185543951394526 - 1.0 1.0 1.8695349995476385
65 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.570268133978827 0.0297656858896609 0.000244336475601744 0.00951547807887942 0.00817695885320599 0.000472306069630483 0.00458791238707824 0.947237322245943 0.549425262386022 0.549425262386022 -0.23037489945875103
66 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.570268133978827 - 0.00411439872497652 0.670601694270008 0.311096989874152 0.00850379747404768 0.00568311965681539 - 0.0620258136097327 0.0620258136097327 -0.6334414105302022
67 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.33731463 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 - - - - - - - 0.0
68 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 17.04310679 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.311727053457954 - - - - - - - 0.0
69 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.9082333604781745 0.00523681863830338 0.000823668079767528 0.00977318183991921 0.0124596675509096 0.00267973433328739 0.00363617950788083 0.965390750049932 0.316498770359056 0.316498770359056 -0.5896527968703137
70 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.9082333604781745 - 0.010109099822305 0.45796731805265 0.507501663530466 0.0194068402228631 0.00501507837171616 - 0.0817828774610745 0.0817828774610745 -0.5807198479650095
71 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.590361070334383 0.00631834763893091 0.000504819647616299 0.140779687268235 0.0297514168337676 0.000617892126006545 0.0011394500617625 0.820888386423681 1.0 1.0 0.4646149359523945
72 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.590361070334383 - 0.00283873189227405 0.901276452952094 0.0938738308613158 0.00141019974741145 0.000600784546904834 - 1.0 1.0 1.8695349995476385
73 O=C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)[C@H](C)N(CCCCCCCCCC)CCCCCCCCCC DSPC 0 0 1 0 14.63651378 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.442651256490317 - - - - - - - 0.0
74 O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.97521151 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.530769863411841 - - - - - - - 0.0
75 O=C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)CN(CCCCCCCCCC)CCCCCCCCCC DSPC 0 0 1 0 14.88045619 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.48874872297084 - - - - - - - 0.0
76 O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)CN(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.83327693 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.343844382133684 - - - - - - - 0.0
77 O=C(NCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.53889564 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.301494223781961 - - - - - - - 0.0
78 O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.27376909 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.596939379038152 - - - - - - - 0.0
79 O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.27376909 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 1 0 0 5.596939379038152 - - - - - - - 0.0
80 O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC DSPC 0 0 1 0 15.06368788 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.403665809777363 0.0159262664008309 0.00726471746994425 0.0644691443511897 0.0154248397225439 0.00666778094817397 0.00618426236554005 0.884062988741777 0.163983867672707 0.163983867672707 -0.8248996899319107
81 O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC DSPC 0 0 1 0 15.06368788 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.403665809777363 - 0.0110768066820314 0.679238145596264 0.289982439081482 0.0151104362851107 0.00459217235511197 - 0.0864824917721372 0.0864824917721372 -0.5681789657875123
82 O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC DSPC 0 0 1 0 15.91176651 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.285378059618076 0.00952025723585679 0.00424787112198889 0.0270494802958792 0.00951147065788185 0.00569809581675416 0.00864159943836194 0.935331225433277 0.22281247574214 0.22281247574214 -0.7341593948675438
83 O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC DSPC 0 0 1 0 15.91176651 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.285378059618076 - 0.00577401787332259 0.781123329740865 0.202386288853494 0.00852464019685452 0.00219172333546338 - 0.23688698835255 0.23688698835255 -0.16682580237138014
84 CCCCCCCCCCCCCCOC(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.11033537 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.0106352940962555 - - - - - - - 0.0
85 CCCCCCCCCCCCCCOC(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.11033537 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 1 0 0 5.0106352940962555 - - - - - - - 0.0
86 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.49121730591206 0.0307690543253117 0.000803846893528031 0.00327375890943859 0.00440309874760962 0.00131506681420977 0.00341198428561488 0.956023190024287 1.14370500641117 1.14370500641117 0.6862729882487519
87 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.49121730591206 - 0.0103006057269574 0.229208194092422 0.735779643429865 0.0182228400970524 0.00648871665370264 - 0.146101132843469 0.146101132843469 -0.40908711190961344
88 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.573885895948325 0.00305704097815131 0.00100491779320209 0.0165773259574103 0.0117710271412967 0.00208697129856503 0.00287252217431477 0.96263019465706 1.0 1.0 0.4646149359523945
89 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.573885895948325 - 0.00330040832612047 0.545398801975274 0.446192251044312 0.00323782528214899 0.00187071337214386 - 1.0 1.0 1.8695349995476385
90 O=C(CN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.79756457 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.789042318607025 - - - - - - - 0.0
91 CCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.40770989 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.168208681201016 - - - - - - - 0.0
92 CCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.93089479 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.697749367281185 - - - - - - - 0.0
93 O=C(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 16.38737682 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.2112383136936 - - - - - - - 0.0
94 CCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.27999390910873 - - - - - - - 0.0
95 O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.2554924 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.611152257665639 - - - - - - - 0.0
96 CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.391561 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.1422481808981475 - - - - - - - 0.0
97 O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC DSPC 0 0 1 0 16.63400342 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.515354881665727 - - - - - - - 0.0
98 O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC DSPC 0 0 1 0 17.25637024 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.57532934397707 - - - - - - - 0.0
99 O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC DSPC 0 0 1 0 17.79833258 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.451896454476337 - - - - - - - 0.0
100 O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.2554924 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.925077405734609 - - - - - - - 0.0
101 CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.391561 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.829912458665998 - - - - - - - 0.0
102 O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC DSPC 0 0 1 0 16.63400342 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.421728001525434 - - - - - - - 0.0
103 O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC DSPC 0 0 1 0 17.25637024 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.775756486563625 - - - - - - - 0.0
104 O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC DSPC 0 0 1 0 17.79833258 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 8.862341963516347 - - - - - - - 0.0
105 CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.55042057 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 5.5506312951620265 - - - - - - - 0.0
106 OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)O DSPC 0 0 1 0 14.34229222 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.47597224751641 - - - - - - - 0.0
107 CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)O DSPC 0 0 1 0 15.30473405 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.563722996073918 - - - - - - - 0.0
108 CCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCC)O)O DSPC 0 0 1 0 16.11614863 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.275554390163365 - - - - - - - 0.0
109 CCCCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCCCC)O)O DSPC 0 0 1 0 16.80938411 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.35709336812867 - - - - - - - 0.0
110 O=C(CCCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.32727581 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.473579765600494 - - - - - - - 0.0
111 O=C(CCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CCCCCCOC(CCCCCCC)=O DSPC 0 0 1 0 17.03239796 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.5612182984589085 - - - - - - - 0.0
112 O=C(CCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.71577453 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.695924549256556 - - - - - - - 0.0
113 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCC)CC(O)CCCCCC)=O)N(CC(CCCCCC)O)CC(CCCCCC)O DSPC 0 0 1 0 14.72351388 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.857484114602081 - - - - - - - 0.0
114 CCCCCCCCC(CN([C@H](C(NCCCCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CO)CC(CCCCCCCC)O)O DSPC 0 0 1 0 15.6246954 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.483228515182849 - - - - - - - 0.0
115 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)=O)N(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O DSPC 0 0 1 0 16.38850868 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.426521874560433 - - - - - - - 0.0
116 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O DSPC 0 0 1 0 17.04402965 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.412919498116252 - - - - - - - 0.0
117 O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.53558149 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.69866052907543 - - - - - - - 0.0
118 O=C(CCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.95535314 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.9459189793765646 - - - - - - - 0.0
119 O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.97521151 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.450269224770129 - - - - - - - 0.0
120 O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.46731585 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.659658371272161 - - - - - - - 0.0
121 O=C(CCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.8769168 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.139321635057579 - - - - - - - 0.0
122 O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O DSPC 0 0 1 0 18.04309994 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.283448621312786 - - - - - - - 0.0
123 O=C(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O DSPC 0 0 1 0 17.76093253 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.1455128487965 - - - - - - - 0.0
124 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 18.07661492 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.3551691805039985 - - - - - - - 0.0
125 O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCC DSPC 0 0 1 0 18.15212729 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 6.632923618509176 - - - - - - - 0.0
126 O=C(C(CCCCCCCC)CCCCCC)OCCCCCC[N+](CC)(CC)CC.[Br-] DSPC 0 0 1 0 12.69438691 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence TEA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.762173934797756 - - - - - - - 0.0
127 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.240751047315928 0.0111914004572023 0.00227125491616379 0.00877931935589419 0.0082437061808303 0.00401873844514775 0.00849693826019724 0.956998642384564 0.596141429580998 0.596141429580998 -0.1583174611704737
128 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.240751047315928 - 0.00531733106486159 0.69156525750989 0.28508003495893 0.0160312488066627 0.00200612765965623 - 0.176602424488684 0.176602424488684 -0.3276946657499996
129 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.253340627045836 0.0210584248832937 0.000931640117614886 0.0300315170504259 0.0160360600660287 0.002060495753182 0.00519348457253804 0.924688377556917 0.507741968135695 0.507741968135695 -0.2946693735871433
130 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.253340627045836 - 0.00533934786984105 0.597844801683409 0.374278985337898 0.0199301473078145 0.00260671780103763 - 0.177860137006811 0.177860137006811 -0.3243384702286213
131 O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCC DSPC 0 0 1 0 18.15212729 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 8.664405571096625 - - - - - - - 0.0
132 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.498141613229568 0.00224222740615835 0.000962422246665562 0.00287219892799367 0.00322451176864607 0.00206661890626862 0.00333409585594076 0.985297924888327 0.792858557060483 0.792858557060483 0.14510923508307877
133 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.498141613229568 - 0.00657230701947091 0.556297397905001 0.404138164228711 0.0296624454205942 0.00332968542622302 - 0.20948041157182 0.20948041157182 -0.2399600273409918
134 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.462799844696365 0.0122002332749747 0.000591091003585345 0.00113975593374826 0.00176766182040017 0.00118628775621157 0.000814512180559894 0.98230045803052 1.58712844716331 1.58712844716331 1.3702322926201322
135 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.462799844696365 - 0.0055909076747788 0.864547542326111 0.121503978921508 0.00729914012568763 0.00105843095191469 - 0.762385942529413 0.762385942529413 1.2354638394013375
136 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.196600262926448 0.0390763854278316 0.00164994009844252 0.0661192424915616 0.0206209930549816 0.00197347693054232 0.00160454285244798 0.868955419144192 1.0 1.0 0.4646149359523945
137 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.196600262926448 - 0.00384316363496011 0.851255867494199 0.137210400166604 0.00701109092659647 0.000679477777641109 - 1.0 1.0 1.8695349995476385
138 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCC)=O)CCCCCCCCC DSPC 0 0 1 0 17.67788651 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.401951803481151 - - - - - - - 0.0
139 O=C(CCCCCCCCC)OCCCCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)CO)=O DSPC 0 0 1 0 17.86915095 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.421487703554795 - - - - - - - 0.0
140 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)O DSPC 0 0 1 0 17.61285873 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.577593418217857 - - - - - - - 0.0
141 OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=O DSPC 0 0 1 0 15.66191374 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DBU Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.647271362006727 - - - - - - - 0.0
142 OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.541058240520847 0.0155523974922323 0.00129152518305059 0.446962380102849 0.0407067099579296 0.00170625578284345 0.00421830607343662 0.489562425407659 1.0 1.0 0.4646149359523945
143 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.379899373657707 0.0165979002447495 0.00361970146585138 0.310566371988181 0.0118953898978584 0.00727497963461814 0.00647222326114303 0.643573433507598 1.0 1.0 0.4646149359523945
144 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.83323084 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.1751562049585145 0.127270779777207 0.0355651632001246 0.0965373529640882 0.0454740204097531 0.0338026797538366 0.0465840928565864 0.614765911038405 0.0505010966098528 0.0505010966098528 -0.999941399550668
145 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.95682792 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.416186486320586 0.0275897803818406 0.0140220813902507 0.0611423332934752 0.0248626002542061 0.0133347505104052 0.0187510241318683 0.840297430037954 0.11103838626238 0.11103838626238 -0.9065655454256818
146 C=CCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)=O DSPC 0 0 1 0 18.01719192 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.445588116163626 0.0250376334304389 0.00337885545037859 0.0517009582142691 0.0430146012578083 0.00350252056656834 0.00406753936383155 0.869297891716705 0.594087846809013 0.594087846809013 -0.1614850137062924
147 CCCCCCCCCCCC(OCCCCCCN(CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.28161356 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.381026134340298 0.00774884428490629 0.00205921183588078 0.0366644403250292 0.0113925424121347 0.00225130046176364 0.00414541402825956 0.935738246652026 0.903691788703443 0.903691788703443 0.31606415773481983
148 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.382151626862033 0.0281381236661192 0.00268792352252722 0.218417144486954 0.0369503427520482 0.00199553488006137 0.00289937744032574 0.708911553251965 1.0 1.0 0.4646149359523945
149 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.83044719 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.199605072879594 0.0747106900577881 0.0465999615731367 0.107994265529626 0.0501322770872438 0.0448116344718523 0.0485065251769853 0.627244646103368 0.0685266977729659 0.0685266977729659 -0.9721377777766667
150 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.94795095 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.333755086000182 0.0109650973341036 0.00500301836333305 0.0209516607489436 0.00928876974106986 0.00498354505150691 0.00613733877720584 0.942670569983837 0.624112412102086 0.624112412102086 -0.11517356757013285
151 CCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.64728116 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.333098961050458 0.0312031939311219 0.00665572714585857 0.0303955096845431 0.016483404133503 0.00703656560389733 0.0108270584446455 0.897398541056431 0.396247798437663 0.396247798437663 -0.4666437613614608
152 O=C([C@H](CO)N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 15.21401022 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 0.0 4.865224091322398 0.113993758795815 0.073640090558649 0.155999510493789 0.089181912745518 0.0778008933488344 0.0854800220277795 0.403903812029615 0.0331042054271613 0.0331042054271613 -1.0267752664553031
153 O=C([C@H](CO)N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.964966 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.177279038170981 - - - - - - - 0.0
154 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.327834405590455 0.0791681309989092 0.00438236238399703 0.207450725009039 0.0200057324176319 0.00435501692886232 0.00687586277442937 0.677762169487131 1.0 1.0 0.4646149359523945
155 O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.01143435 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.826712455935327 0.051854991416453 0.0528002488161413 0.131177333337399 0.0608349367134925 0.0676316423389937 0.091080124286102 0.544620723091419 0.0058976768275302 0.0058976768275302 -1.06874002669396
156 O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.98131005 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.613138355637268 0.0349404656939791 0.032170759570341 0.107989787547248 0.0410644871922655 0.0376181677387698 0.0487295770112475 0.697486755246149 0.0093821747742871 0.0093821747742871 -1.0633653564065595
157 O=C([C@H](CO)N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 13.72220648 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.45318382899021 - - - - - - - 0.0
158 O=C(CCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.27012616 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.256453162449338 - - - - - - - 0.0
159 O=C(CCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 15.19898065 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.86830338551846 0.0353281775739917 0.00307182736960491 0.034716407488313 0.0124183147896963 0.00493000176115631 0.00714349716206655 0.902391773855171 0.291015633780908 0.291015633780908 -0.6289593079055151
160 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.260282639765531 0.0263012913083446 0.00104221918552839 0.17396331575752 0.0231252484593015 0.00218421226891195 0.00250493797184971 0.770878775048544 1.0 1.0 0.4646149359523945
161 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.400848388914469 0.142104027989206 0.00287714799265922 0.215134204863943 0.0243152184566193 0.00619704480449007 0.00405451457231669 0.605317841320765 1.0 1.0 0.4646149359523945
162 CCCCCCCCCCCC(OCCCCCCN(CCN(C)CCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.06597416 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.3551691805039985 0.0696417285874694 0.0029599268608454 0.0569405498935433 0.0189535946790038 0.00628554949471398 0.00620455647115851 0.839014094013266 1.46543205325214 1.46543205325214 1.1825214652836151
163 O=C(OCCCCCCN([C@H](C(NCCN(C)CCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.80021894 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.318154558079471 0.0260251149767627 0.00751090805185066 0.0532899531021804 0.0511794000344704 0.0152455710134586 0.0158624088727893 0.830886643948488 0.594741863231617 0.594741863231617 -0.16047622486848778
164 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.518849479521564 0.235642631118293 0.00357683071882224 0.268183756367962 0.0537803810677977 0.0056567696761597 0.00550191880428196 0.427657712246684 1.0 1.0 0.4646149359523945
165 CCCCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCOC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)=O DSPC 0 0 1 0 17.89376817 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.605170185988092 0.00991904799330563 0.00800736011391533 0.0452217049389508 0.0197202047147262 0.0164331186633441 0.0158205463682553 0.884878017207502 0.0777961107519447 0.0777961107519447 -0.9578401546237735
166 O=C(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCOC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.61561565 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.886582645426277 - - - - - - - 0.0
167 CCCCCCCCCCCC(OCCCCCCN(CCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.01340623 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.190175207928333 - - - - - - - 0.0
168 O=C(OCCCCCCN([C@H](C(NCCOCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.7439276 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.2694176902912275 0.0273933363293668 0.0025481137083807 0.0489889660247262 0.00910395259986531 0.00553863037137659 0.00570731639004281 0.900719684576242 0.282511511559215 0.282511511559215 -0.6420765069177559
169 O=C(CCCCCCCCCCC)OCCCCCCN(CCOCCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O DSPC 0 0 1 0 18.18802872 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.561949483533528 0.0107761878140537 0.0018907931479914 0.00906874325536026 0.00817364202148832 0.00369121050409089 0.00412231341943734 0.962277109837578 1.03869430459932 1.03869430459932 0.5242990374784536
170 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.77912349311153 0.0897266059620516 0.00139613482527267 0.256772056278909 0.191186512263101 0.00338160925528312 0.00297344390156773 0.454563637513815 1.0 1.0 0.4646149359523945
171 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.8896653 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.422808628394115 - 0.00393259539867672 0.698404256940233 0.29082082024119 0.00482745799593445 0.00201486942396601 - 0.150267764477171 0.150267764477171 -0.3979684896277195
172 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.24735173134728 - 0.0193985055782088 0.642311593152982 0.297952931923085 0.0232690994142363 0.0170678699314884 - 0.0138284395356039 0.0138284395356039 -0.7620557072620823
173 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.776599301615622 - 0.00374237304524464 0.388696129733584 0.542462789676973 0.0600826887673663 0.00501601877683173 - 0.0757788640374704 0.0757788640374704 -0.5967415084575073
174 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.59784341060163 - 0.00454633850545055 0.547957057084188 0.42844914578143 0.0150324705651762 0.00401498806375593 - 0.0747683143174281 0.0747683143174281 -0.5994381520828621
175 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.37981918 46.5 7.5 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.784988612563928 - 0.00648649184357099 0.353238786148937 0.611732175774514 0.0204133713900616 0.00812917484291689 - 0.231046253558505 0.231046253558505 -0.18241175518238087
176 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.684905154006945 - 0.00209231248329155 0.858334702447977 0.133879376324869 0.0038743559198132 0.0018192528240494 - 1.0 1.0 1.8695349995476385
177 CC(CNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)C DSPC 0 0 1 0 18.00540724 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.583231278469338 - - - - - - - 0.0
178 CC(CNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)C DSPC 0 0 1 0 17.73535311 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.224056168743758 - - - - - - - 0.0
179 O=C(CCCCC(OCCCCCCN(CCCNC([C@@H](N(CCCCCCOC(CCCCC(OCCCC(F)(F)F)=O)=O)CCCCCCOC(CCCCC(OCCCC(F)(F)F)=O)=O)CO)=O)CCCCCCOC(CCCCC(OCCCC(F)(F)F)=O)=O)=O)OCCCC(F)(F)F DSPC 0 0 1 0 18.72527826 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.972587226458726 - - - - - - - 0.0
180 O=C(OCCCCCCCCN(CCCNC([C@@H](N(CCCCCCCCOC(CCCCCCCCC)=O)CCCCCCCCOC(CCCCCCCCC)=O)CO)=O)CCCCCCCCOC(CCCCCCCCC)=O)CCCCCCCCC DSPC 0 0 1 0 17.8896653 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.363226005210164 0.0302618004269707 0.0170318389360463 0.0852511261606349 0.0321310738618372 0.020553836096385 0.0249767617646758 0.78979356275345 0.103578477209434 0.103578477209434 -0.9180720959090577
181 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.3651347670036635 0.0896852170263435 0.00316402812450449 0.145700011838927 0.0181473232698177 0.0048727657230144 0.00676784889254742 0.731662805124845 1.0 1.0 0.4646149359523945
182 O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCCCCCC DSPC 0 0 1 0 17.93964861 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.27430221608671 0.0441668582339066 0.00173504332049564 0.0552287456296669 0.0103338721124601 0.00424436496446174 0.00798306414101548 0.876308051597994 0.118006736161235 0.118006736161235 -0.8958172012665345
183 O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.66483929 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.322011202263895 0.014374943627672 0.00199135248489222 0.0891563599260395 0.0109943655858212 0.00408170887074953 0.00721565797781185 0.872185611527014 0.120117219447052 0.120117219447052 -0.8925618824281657
184 C=CCCCCCCCCC(OCCCCCCN(CCOCCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.93091393 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.589955020181611 0.159505299591344 0.00863892692709962 0.059163494819016 0.0251436766117119 0.0207012928199433 0.0319161553971728 0.694931153833713 0.19624671777719 0.19624671777719 -0.775135797258418
185 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.461068842013835 0.18227458966528 0.00260059752378256 0.10140002712747 0.0194272464327483 0.00394998811850684 0.00708234329707097 0.683265207835141 1.0 1.0 0.4646149359523945
186 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.897839799950911 - - - - - - - 0.0
187 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.87291972 32.96703297 21.97802198 43.95604396 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.667205576907544 - - - - - - - 0.0
188 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.34369997 41.32231405 16.52892562 41.32231405 0.826446281 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.786658062033468 - - - - - - - 0.0
189 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.12329906 27.02702703 32.43243243 37.83783784 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.520374534283375 - - - - - - - 0.0
190 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.602904588 25.0 40.0 30.0 5.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.2162671661789055 - - - - - - - 0.0
191 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.22342652 38.46153846 21.97802198 38.46153846 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.634728988229636 - - - - - - - 0.0
192 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.21412129 40.0 34.28571429 22.85714286 2.857142857 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.378896741664954 - - - - - - - 0.0
193 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.29890072 34.65346535 39.6039604 24.75247525 0.99009901 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.661550519424199 - - - - - - - 0.0
194 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.62419529 41.86046512 37.20930233 18.60465116 2.325581395 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.552612935249416 - - - - - - - 0.0
195 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 5.021245473208271 0.0189024787568605 0.00542838949966448 0.0161874266221436 0.00564673685028802 0.0063903753402389 0.0111802988958026 0.936264294035002 0.0913658402077254 0.0913658402077254 -0.9369095003865034
196 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.59373115 37.83783784 37.83783784 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.484470400750307 0.220192249542946 0.000764987158036526 0.00117389921248248 0.000355328494502401 0.000727082388944626 0.00146163086877099 0.775324822334317 0.909323670538887 0.909323670538887 0.3247510642635732
197 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.02523135 35.8974359 41.02564103 20.51282051 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.474947598938117 0.0634606467339624 0.00208550415241484 0.000693953783467295 0.000703971489002912 0.00107462659382075 0.00306678394465369 0.928914513302678 0.68813569412733 0.68813569412733 -0.016420738077667085
198 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.01459482 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.414493824811383 0.0115671522937999 0.000329262998462127 0.000782715410474643 0.000454168201139608 0.00050928396392566 0.0365052454816706 0.949852171650527 1.45919493888772 1.45919493888772 1.172901016723797
199 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.50825332 52.83018868 26.41509434 18.86792453 1.886792453 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.573163389853005 0.0289504727873473 0.000587630380490671 0.00098172979734669 0.000247631664832521 0.000530890620697785 0.00148666967519347 0.967214975074092 1.18732779204068 1.18732779204068 0.7535590344336197
200 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.02959744 50.90909091 29.09090909 18.18181818 1.818181818 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.424367475163407 0.01918176556647 0.0010650954164724 0.0022206234626453 0.00126505200881015 0.0010329415925789 0.00258134917445057 0.972653172778573 0.519739549496667 0.519739549496667 -0.2761636820795619
201 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.0526464 43.24324324 32.43243243 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.646312129319266 0.0173760673957131 0.000550323482827711 0.00231355504088989 0.000799250291024724 0.00171157517792979 0.00187915335599706 0.975370075255618 0.641975082983608 0.641975082983608 -0.08762125790960282
202 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.87880561 39.02439024 39.02439024 19.51219512 2.43902439 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.627909672957581 0.031425165165133 0.00121897501467252 0.00336392108926765 0.00273184674446895 0.00365496097119473 0.00253008289994281 0.95507504811532 0.292484943880311 0.292484943880311 -0.6266929678315919
203 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.72896002 41.02564103 30.76923077 25.64102564 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.6141299273595635 0.00243290161785256 0.00374029360494432 0.00771109158226845 0.00256075951190699 0.0024473081411263 0.00398520450059787 0.977122441041304 0.29000081469118 0.29000081469118 -0.6305246174829606
204 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.2936051730729785 0.0291199872991734 0.000702410023626044 0.0253755412996204 0.0176881988849176 0.000962484515645204 0.00126799370807735 0.92488338426894 1.0 1.0 0.4646149359523945
205 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.596835549198034 0.0642873127295256 0.000194616801396495 0.00548703707264694 0.0163820187916684 0.000849254927099769 0.000518055392084143 0.912281704285579 0.772854925639995 0.772854925639995 0.11425459688882487
206 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.26769266 37.83783784 37.83783784 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.284827171296749 0.000820324065776298 6.77505055763446e-05 0.00130838737685328 0.00203458073148474 0.00044026025400656 0.00179231955954145 0.993536377506761 0.647354606156059 0.647354606156059 -0.07932360246622268
207 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 12.69845587 35.8974359 41.02564103 20.51282051 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.355939299910563 0.000606683031689403 0.000350488437662207 0.00200552330636915 0.00341592792036262 0.00135658595795651 0.00484812686613966 0.98741666447982 0.429472560198128 0.429472560198128 -0.4153961662793264
208 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.73864775 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.210051369934071 0.0506054803736383 0.000934742670841204 0.00195746112246746 0.00131704918881155 0.00229254534633995 0.00362188526923176 0.93927083602867 0.295296757118666 0.295296757118666 -0.622355881313871
209 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.22254695 52.83018868 26.41509434 18.86792453 1.886792453 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.19614876167715 0.000394517913167851 0.000925918583325644 0.00219111536287718 0.00192843383777798 0.00141208216065332 0.00279803133939282 0.990349900802805 0.423957111788814 0.423957111788814 -0.4239034798551084
210 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 16.73562869 50.90909091 29.09090909 18.18181818 1.818181818 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.324000197151533 0.0149763371723649 9.09516394922477e-05 0.00865819492777344 0.00337158611087041 0.000870833891384162 0.00234291805381448 0.9696891782043 0.799987755503576 0.799987755503576 0.1561056803760758
211 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.73441264 43.24324324 32.43243243 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.638604962074329 0.00412763242238728 0.000587351434637121 0.00125519721482213 0.00156835329887146 0.00151910105091065 0.00332452673735467 0.987617837841017 0.519710678404319 0.519710678404319 -0.27620821434922566
212 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.55362203 39.02439024 39.02439024 19.51219512 2.43902439 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.465448242812954 0.001908149535057 0.00051106883667359 0.00195557181028906 0.00222543526142979 0.00102554934782431 0.0036709617373884 0.988703263471338 0.559906246507883 0.559906246507883 -0.21420848616098725
213 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.4082575 41.02564103 30.76923077 25.64102564 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.439351701293151 0.0164941051995163 0.00133624924425635 0.0136411729141475 0.0068725438331318 0.00281561744256348 0.00565863059250302 0.953181680773882 0.404416041627467 0.404416041627467 -0.4540446395817048
214 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.348211286179151 0.25310386523031 0.000588156076259717 0.140706646889545 0.17621759673582 0.00218337900345845 0.000839731767209391 0.426360624297398 1.0 1.0 0.4646149359523945
215 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.574298522321004 0.0173152888243317 0.00170643426094864 0.0181271736370668 0.0103847448319841 0.00234708518590686 0.00464250497463967 0.945476768285122 0.880302275630684 0.880302275630684 0.27998696013855723
216 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.54771521 32.96703297 21.97802198 43.95604396 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.530015512387331 0.0022188818222417 0.00151967168045253 0.0265741083102934 0.00935341146520975 0.00161955884356527 0.00594450434134348 0.952769863536894 0.693395601815244 0.693395601815244 -0.008307583759119837
217 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 16.03951812 41.32231405 16.52892562 41.32231405 0.826446281 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.640537329825382 0.0191565810814788 0.00120917820488213 0.00564887782228727 0.00368324602436162 0.00270413188019715 0.00625226385441887 0.961345721132374 0.702078866162311 0.702078866162311 0.005085933354948288
218 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 10.8033785 27.02702703 32.43243243 37.83783784 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.2431955089544555 0.0191175904912105 0.0046774627841674 0.0253721583259607 0.0153479247605493 0.0105242912643767 0.0240873946993884 0.900873177674347 0.168910555827937 0.168910555827937 -0.8173005106963921
219 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 9.298704135 25.0 40.0 30.0 5.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.822697998516666 0.00783638212803346 0.00315432464612104 0.0156004284210389 0.0122536904537434 0.00649575798551451 0.014293561001533 0.940365855364016 0.26946434750834 0.26946434750834 -0.6622011291820169
220 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.90666525 38.46153846 21.97802198 38.46153846 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.291292751611072 - - - - - - - 0.0
221 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.89035919 40.0 34.28571429 22.85714286 2.857142857 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.388753955423308 0.0457836478243602 0.00256820195313693 0.0933595380902435 0.040121791020458 0.00303459231576053 0.00719748271402532 0.807934746082015 0.638042293066864 0.638042293066864 -0.09368739697327609
222 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 12.97231927 34.65346535 39.6039604 24.75247525 0.99009901 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.500031867864786 0.00367784574047392 0.00111977791364668 0.0109807451773001 0.00533981749985873 0.0035253353907892 0.00945759694134628 0.965898881336585 0.664597706735618 0.664597706735618 -0.05272695016115616
223 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.30278396 41.86046512 37.20930233 18.60465116 2.325581395 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.578518154990665 0.00602415700375336 0.00352191807012307 0.0129438874596237 0.0112365957475355 0.00705054455561779 0.0163551166761144 0.942867780487232 0.387412476367661 0.387412476367661 -0.48027182019083947
224 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DOPE 1 0 0 0 14.78083639 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.373742415086184 0.00132025329631253 0.000860633620224201 0.00503931327076771 0.0029913613071963 0.00270028184029275 0.0088532339643477 0.978234922700859 1.0 1.0 0.4646149359523945
225 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.434619084793052 0.00770185399584477 0.00244833711322221 0.0462111239750686 0.0198642411939162 0.00381226904350308 0.00922041774380283 0.910741756934642 1.0 1.0 0.4646149359523945
226 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 11.7812451 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.485936098064394 0.00448668985970796 0.00155299888410839 0.00808200908228358 0.00771278024096098 0.00385266053622471 0.00536687174407294 0.968945989652641 1.22295554827804 1.22295554827804 0.8085131327805288
227 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.01459482 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.73444252169223 0.00221922165343577 0.00134658478491355 0.00928071520245763 0.0103471897935628 0.00308928870366618 0.00305991935175966 0.970657080510204 2.4848301850992 2.4848301850992 2.75489399469468
228 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.379899373657707 0.0165979002447495 0.00361970146585138 0.310566371988181 0.0118953898978584 0.00727497963461814 0.00647222326114303 0.643573433507598 1.0 1.0 0.4646149359523945
229 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.7140245909001735 - - - - - - - 0.0
230 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.85564 30.9 36.3 25.9 6.9 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.002960000420248 - - - - - - - 0.0
231 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 12.10629825 33.7 32.2 28.8 5.4 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 3.9917579734469997 - - - - - - - 0.0
232 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 8.076607527 21.5 44.3 27.4 6.7 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.150252194160397 - - - - - - - 0.0
233 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.262126773 28.5 36.9 23.3 11.4 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 3.9384701754429945 - - - - - - - 0.0
234 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.14390228 47.0 40.4 5.7 6.8 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.139158578011894 - - - - - - - 0.0
235 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.465333240800292 0.0929588198875335 0.00109661539851913 0.0103406974639253 0.00262333547972377 0.00257373980843396 0.00319533888859958 0.887211453073265 2.49616154919077 2.49616154919077 2.7723720781458008
236 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.95064466 41.0 39.5 16.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.25063580654847 0.00217929592656579 0.00233573351378476 0.00718449647353577 0.00718369422949875 0.00471157922942054 0.00408542775852615 0.972319772868668 1.71461830076508 1.71461830076508 1.5668792525462236
237 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.40653622 31.3333 31.3333 31.3333 6.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.188896879163323 0.0142737392382439 0.00348189340868737 0.00880858320276677 0.0038525568856599 0.00593274588142816 0.00610316587084082 0.957547315512373 0.645718762121967 0.645718762121967 -0.08184681311498729
238 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.77836699 50.0 23.5 23.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.343935283551159 0.0065593281978378 0.00138907609400551 0.00613919753007927 0.00613411120238244 0.00366825953495706 0.00406194129869205 0.972048086142046 1.35219591573978 1.35219591573978 1.0078601760398935
239 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.200348974 22.0 22.0 50.0 6.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.057161771094385 - - - - - - - 0.0
240 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.72417162 27.0 27.0 41.0 5.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.102973888920155 - - - - - - - 0.0
241 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.092439729 16.0 39.5 41.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.127940511650616 0.0097349353786325 0.00823434520879355 0.0380775286515883 0.0189007253206434 0.0281939358827934 0.0273826912679074 0.869475838289641 0.161929321885153 0.161929321885153 -0.8280687278728707
242 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.93804335 39.5 16.0 41.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.116269119637892 0.00176070173692806 0.00134882241229812 0.00721447825021801 0.00277771416530431 0.00258248336542972 0.00338400053115958 0.980931799538662 0.834918279031508 0.834918279031508 0.2099843308438277
243 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.312676556539088 0.0122849683487715 0.00187692747865846 0.313004652084084 0.0267625511357853 0.00478000951875277 0.00400214034383056 0.637288751090117 1.0 1.0 0.4646149359523945
244 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.5612182984589085 0.00230427148121394 0.00151653786120671 0.00981883965091339 0.0195498469521307 0.00278714514326426 0.00256552165624032 0.961457837255031 3.54213716664653 3.54213716664653 4.385739099273481
245 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.95064466 41.0 39.5 16.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.2756934238792645 0.00339636246099529 0.00439836397767252 0.00922438120812044 0.0070906355917358 0.00777777401057153 0.0070228258793507 0.961089656871554 1.60048193764837 1.60048193764837 1.3908294086580206
246 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.77836699 50.0 23.5 23.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.300138475201197 0.0251900613139205 0.0263858529561065 0.0690244086529141 0.0290319859464883 0.0512059292322219 0.0395084822769767 0.759653279621372 0.244442812501583 0.244442812501583 -0.7007956420217016
247 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.93804335 39.5 16.0 41.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.035478809355064 - - - - - - - 0.0
248 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.07835597 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.314416735011824 0.00832740543716945 0.00279899792781369 0.0133506530995165 0.00590470004845411 0.00800781451355169 0.00611088774111073 0.955499541232384 1.4036171732161 1.4036171732161 1.0871749895142324
249 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 12.46964291 32.3 32.3 32.3 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.122932019074013 0.00935369123549862 0.00681432683334856 0.0266295187790274 0.0091342786879667 0.0148394527045059 0.0109795829907811 0.922249148768872 0.807897092094877 0.807897092094877 0.168305451195249
250 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.214347354616797 0.00175971204953205 0.0023945553766021 0.00864096914216858 0.00287247113967731 0.00354165273920712 0.00438932700137801 0.976401312551435 2.1807873939408 2.1807873939408 2.28592263046752
251 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.297557478047431 0.0163588203416613 0.0050349858804786 0.141665503002976 0.0268932928836599 0.0108166459136593 0.00842178986187252 0.790808962115693 1.0 1.0 0.4646149359523945
252 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.623991940228679 0.0114998638575461 0.00130788860611426 0.00505223783079306 0.0046933168158669 0.00183202266239377 0.00287251942980201 0.972742150797484 1.19732008331576 1.19732008331576 0.768971662548154
253 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.47398367 41.5 40.5 16.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.261975403606051 0.0120973279883405 0.00779128029381303 0.0260350268299895 0.0160802201335602 0.0156019499205845 0.0170739234476819 0.90532027138603 0.213285375768679 0.213285375768679 -0.7488544878005475
254 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.72570651 40.5 16.0 41.5 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.168678699274804 0.00644850088058007 0.00798921970887525 0.0221223520376599 0.0111631004951633 0.0106463671035197 0.00996963598739929 0.931660823786802 0.29077874869216 0.29077874869216 -0.6293246917477433
255 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.63764671 41.5 40.5 16.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.40562108352751 0.0088141667427258 0.00585903666298478 0.0157870816204507 0.010986042994209 0.00978368783097364 0.0102623946891479 0.938507589459508 0.370029347989408 0.370029347989408 -0.507084458632374
256 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.89020107 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.402441819416474 0.154933534385178 0.00229861102597737 0.00525615721273492 0.00408539799683711 0.0022876287732977 0.00287249757879639 0.828266173027179 1.34933481107146 1.34933481107146 1.003447059865073
257 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.91076362 42.0 40.5 16.5 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.607168188650764 0.0408588610755303 0.0177373482989948 0.0425327283385076 0.0277718677406049 0.0276871974121274 0.0218927074965806 0.821519289637654 0.158736230637426 0.158736230637426 -0.8329939173596629
258 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.86872188 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.4277167605909975 0.00307921600642319 0.00224989559352084 0.00599370029233814 0.00443157985269048 0.00263031532778781 0.00293093049696406 0.978684362430275 1.27822314397057 1.27822314397057 0.8937607377335357
259 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.444179499895966 0.0412236553892641 0.00390663231476925 0.121517080143859 0.0188177267921366 0.00482332620655526 0.0073631886059774 0.802348390547439 1.0 1.0 0.4646149359523945
260 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.573473099244837 0.00689869445402741 0.00600089779665737 0.0191135089301672 0.00620664286397134 0.00981653359048003 0.0097967903769499 0.942166931987747 0.749333285576466 0.749333285576466 0.07797359977185479
261 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.88644869 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.688591794127164 0.00886147101476089 0.00436553876298869 0.0150948084008648 0.00476112441477112 0.00826588994437132 0.00836456609804533 0.950286601364198 0.883781845590108 0.883781845590108 0.28535402924280306
262 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 8.877221176 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.829113417472866 0.00517423746484337 0.00420818785762778 0.0136338012801862 0.00389526355348657 0.0081026937251479 0.00825574629036951 0.956730069828339 1.02766134878372 1.02766134878372 0.5072812344232112
263 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.07835597 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.4595662121293 0.025369932029363 0.00629969301959379 0.0185849502075566 0.00668329267445478 0.00984673129800659 0.00995848867776924 0.923256912093256 0.773367707896157 0.773367707896157 0.11504553882600273
264 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.306031912 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.528073135603124 0.00974026247143072 0.00459547921939943 0.0155882894773368 0.00424301614179951 0.00735125258984654 0.00918675243548622 0.949294947664701 0.925634770529548 0.925634770529548 0.34991015054061214
265 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 6.950074466 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.730921391293652 0.0307398296858454 0.00502448817507942 0.0144391987292623 0.00475975114719379 0.00732990645958348 0.00864531856689022 0.929061507236145 0.282355212986546 0.282355212986546 -0.6423175899395637
266 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.3578620076745835 0.0575651939642587 0.00224327504140443 0.293214190330324 0.103801109257072 0.00316596887134689 0.00243404296405076 0.537576219571543 1.0 1.0 0.4646149359523945
267 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.1515122352784415 - - - - - - - 0.0
268 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.0693509 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.2656332579940335 - - - - - - - 0.0
269 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.52014814 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.431173877940127 - - - - - - - 0.0
270 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.89020107 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.436396441739405 - - - - - - - 0.0
271 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.50369223 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.5666372362713075 - - - - - - - 0.0
272 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.844529643 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.765586907393996 - - - - - - - 0.0
273 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.149936935645806 0.0412282002133458 0.00282906106065428 0.0100452919302821 0.00294646346634102 0.0035555046437446 0.00510039590268196 0.93429508278295 2.31132936702855 2.31132936702855 2.4872773377263835
274 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.0693509 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.244200317766478 0.0307672106546614 0.0492440442693678 0.143087600825361 0.0409904333145751 0.0410729694241231 0.0628737572688051 0.631963984243106 0.159668526820479 0.159668526820479 -0.8315558953918857
275 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.52014814 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.430459592195472 0.0144382835185698 0.030629687100469 0.0904231657039977 0.0327120644783899 0.0374915496460484 0.0408664371206098 0.753438812431916 0.342029093157046 0.342029093157046 -0.5502735033632513
276 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.89020107 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.560277417097355 0.064087583051715 0.00731756531038673 0.0186036957891068 0.0053871458118381 0.00655845861152129 0.0086069303650773 0.889438621060355 2.14638048731397 2.14638048731397 2.232851633855025
277 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.50369223 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.667205576907544 0.00310349569550498 0.00416831577034203 0.0115025538737423 0.00349250282837259 0.00500126547712412 0.00690260249517487 0.965829263859739 3.35844880423818 3.35844880423818 4.1024086457439415
278 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.844529643 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.713127327493184 0.00089376253365906 0.00183788568066981 0.0054363636464257 0.00195410248071216 0.00225811087193407 0.00383533887250888 0.98378443591409 3.24722414573894 3.24722414573894 3.9308499660154896
279 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.359653205696989 0.0828383439279835 0.00565653685524585 0.157248489872984 0.00928479521934879 0.00688752099561758 0.00841921269728692 0.729665100431533 1.0 1.0 0.4646149359523945
280 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.86872188 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.634728988229636 0.00818072805535472 0.00273349879854757 0.0119346096951512 0.0075308964437597 0.00591367796700706 0.00578329104170321 0.957923297998477 0.213428398303373 0.213428398303373 -0.7486338824280105
281 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.15051107 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.7140245909001735 0.0160361616147136 0.00185083446366488 0.00730973501824061 0.00349956550575257 0.00416153151105757 0.00426975100661699 0.962872420879954 0.319359456002154 0.319359456002154 -0.58524032702172
282 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 8.327596879 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.822697998516666 0.0208671125611406 0.0200298903914976 0.0765668274895919 0.0297655881927753 0.0442427715485906 0.0417155046265625 0.766812305189841 0.0431568482237034 0.0431568482237034 -1.011269549025132
283 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.548282323781043 0.235642631118293 0.00357683071882224 0.268183756367962 0.0537803810677977 0.0056567696761597 0.00550191880428196 0.427657712246684 1.0 1.0 0.4646149359523945
284 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.41834022 50.0 7.5 41.5 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.892602227184663 0.0004 0.0007 0.8627 0.1335 0.0019 0.0008 0 0.33 0.33 0.08164550420240263
285 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.34376213 50.0 29.0 20.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.935911747900319 0.0015 0.0017 0.585 0.3856 0.0215 0.0046 0 0.09 0.09 -0.5587925239809655
286 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.47881241 45.5 7.5 45.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.657762636107262 0.0008 0.0009 0.9399 0.0565 0.0012 0.0006 0 0.26 0.26 -0.10514892068441307
287 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.58994389 50.0 17.75 30.25 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.6520537718869415 0.0009 0.0008 0.8853 0.11 0.0021 0.0009 0 0.31 0.31 0.028275668520455245
288 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.356515817 38.0 30.0 30.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.522874943261261 0.0008 0.0012 0.7508 0.2416 0.0048 0.0008 0 0.12 0.12 -0.4787377704580445
289 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.211083767 38.0 16.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.802380355275797 0.0003 0.0007 0.8979 0.0985 0.0022 0.0005 0 0.45 0.45 0.40186451829408665
290 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.891852481 38.0 23.0 38.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.721173861744398 0.0003 0.0009 0.9061 0.0898 0.0024 0.0005 0 0.3 0.3 0.0015907506794815506
291 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.59856338 45.96 24.83 26.71 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.599152113662528 0.0006 0.0011 0.8386 0.1563 0.0028 0.0007 0 0.36 0.36 0.16170025772532357
292 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.516252746 44.58 19.33 33.08 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.539030383483547 0.0011 0.0009 0.9163 0.0784 0.0025 0.0008 0 0.24 0.24 -0.15851875636636045
293 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.79855736 50.0 7.5 39.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.602165676967792 0.0007 0.0007 0.9622 0.0349 0.001 0.0005 0 0.91 0.91 1.6293707389788754
294 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.789158454 42.5 30.0 24.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.506454213048934 0.0013 0.0022 0.7003 0.2848 0.009 0.0025 0 0.1 0.1 -0.5321076061399918
295 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.924427289 44.71 13.58 39.21 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.543294782270004 0.0006 0.0008 0.9464 0.0496 0.0015 0.0011 0 0.56 0.56 0.6953986145447971
296 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.213203287 41.46 24.83 32.21 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.600157644164547 0.0006 0.0011 0.9277 0.0684 0.0014 0.0008 0 0.44 0.44 0.37517960045311294
297 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.766920469 38.0 14.0 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.380775852772229 0.0005 0.001 0.9807 0.0157 0.0015 0.0006 0 0.46 0.46 0.42854943613506036
298 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.9150442 50.0 27.0 20.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.490881039585964 0.0013 0.001 0.7257 0.2649 0.0061 0.0009 0 0.13 0.13 -0.4520528526170708
299 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.33144164 47.24 11.19 38.87 2.71 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.627909672957581 0.0073 0.0639 0.7768 0.1461 0.0042 0.0016 0 1.3 1.3 2.670082534776849
300 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.92222847 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.8543712716215905 0.001 0.001 0.8647 0.1302 0.0025 0.0007 0 0.25 0.25 -0.13183383852538677
301 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.314817884980432 0.0009 0.0007 0.9116 0.0844 0.0018 0.0006 0 1.0 1.0 1.8695349995476385
302 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.42041204 49.0 7.5 41.5 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.534747721691546 0.0013 0.0021 0.5194 0.4632 0.0111 0.0029 0 0.5 0.5 0.535289107498955
303 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 15.70987342 34.25 18.75 45.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.191168746857641 0.0011 0.0011 0.7685 0.2222 0.0053 0.0018 0 0.15 0.15 -0.3986830169351235
304 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 11.2192693 22.0 30.0 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.151039905898646 0.0028 0.0014 0.4022 0.5806 0.0101 0.003 0 0.05 0.05 -0.6655321953448602
305 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.76101632 49.0 28.0 20.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.154184562578117 0.001 0.0012 0.5862 0.3912 0.0188 0.0017 0 0.16 0.16 -0.37199809909414977
306 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.31421044 44.61 24.89 27.94 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.155753190350744 0.0041 0.0015 0.5886 0.3825 0.0211 0.0022 0 0.13 0.13 -0.4520528526170708
307 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 14.60470229 32.11 24.89 40.44 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.104294893075269 0.0017 0.0016 0.5892 0.3913 0.0129 0.0033 0 0.05 0.05 -0.6655321953448602
308 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.00750041 49.0 18.75 31.25 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.516338972281476 0.0111 0.0048 0.1796 0.7293 0.0671 0.0082 0 0.14 0.14 -0.4253679347760971
309 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.77390107 42.13 18.75 38.13 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.33204826486764 0.0167 0.0049 0.2598 0.6793 0.0289 0.0104 0 0.15 0.15 -0.3986830169351235
310 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.21646499 45.61 13.64 38.19 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.365643155423357 0.0042 0.0015 0.3443 0.6172 0.0298 0.003 0 0.2 0.2 -0.2652584277302551
311 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.27353562 44.5 7.5 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.436751534363128 0.0067 0.0013 0.5909 0.385 0.0142 0.0019 0 0.22 0.22 -0.21188859204830776
312 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.27759176 49.0 30.0 20.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.151039905898646 0.0122 0.0028 0.2395 0.6818 0.0594 0.0044 0 0.08 0.08 -0.5854774418219391
313 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 14.75114553 34.5 30.0 32.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.248495242049359 0.0029 0.0024 0.3338 0.6429 0.0151 0.0029 0 0.07 0.07 -0.6121623596629128
314 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 16.61008 39.36 24.89 34.19 1.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.384523514872469 0.0141 0.0106 0.3243 0.5845 0.0592 0.0073 0 0.14 0.14 -0.4253679347760971
315 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 12.46688772 24.0 30.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.796616650559047 0.0064 0.0026 0.3777 0.6006 0.0093 0.0034 0 0.1 0.1 -0.5321076061399918
316 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.37981918 46.5 7.5 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.516338972281476 0.0024 0.0028 0.4642 0.5174 0.0093 0.0039 0 0.81 0.81 1.362521560569139
317 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 16.04448224 37.36 29.94 31.71 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.370712874773608 0.033 0.008 0.1094 0.8115 0.0325 0.0056 0 0.11 0.11 -0.5054226882990182
318 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.623010104116422 0.0087 0.0033 0.2348 0.7393 0.011 0.003 0 0.36 0.36 0.16170025772532357
319 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.375757021660286 0.0019 0.0023 0.9077 0.0818 0.0033 0.003 0 1.0 1.0 1.8695349995476385
320 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.34776106 49.0 7.5 41.5 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.943782987108415 0.0542 0.0001 0.3146 0.0378 0.0014 0.0006 0.5913 1.14 1.14 0.680558194273546
321 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.630330503 34.25 18.75 45.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.395682961121367 0.03 0.0006 0.0837 0.0261 0.002 0.0013 0.8563 0.78 0.78 0.12527553001915628
322 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 5.746375559 22.0 30.0 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.264087336809195 0.0156 0.0014 0.0138 0.0104 0.0025 0.0031 0.9532 0.32 0.32 -0.584252318750342
323 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.15734025 49.0 28.0 20.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.513054897080286 0.0
324 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.812051718 44.61 24.89 27.94 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.470495282661489 0.009 0.0004 0.0178 0.0948 0.0017 0.0003 0.8762 1.05 1.05 0.5417375282099487
325 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 7.893697629 32.11 24.89 40.44 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.289088639014612 0.0343 0.0003 0.1697 0.027 0.0013 0.0009 0.7666 0.46 0.46 -0.3683090604291903
326 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.08675917 49.0 18.75 31.25 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.9684234452869465 0.0
327 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.13512977 42.13 18.75 38.13 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.906015244966153 0.0128 0 0.028 0.0208 0.0006 0 0.9378 0.93 0.93 0.35664330679181877
328 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.43848511 45.61 13.64 38.19 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.525044141508807 0.0635 0.0002 0.2019 0.083 0.0009 0.0003 0.6502 1.5 1.5 1.2358408585279361
329 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.44748395 44.5 7.5 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.4520190064939165 0.011 0.0005 0.3972 0.0536 0.0016 0.0009 0.5352 1.45 1.45 1.1587182662703819
330 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.57169095 49.0 30.0 20.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.86830338551846 0.0
331 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.009941019 34.5 30.0 32.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.3476939555933765 0.0165 0 0.0427 0.0616 0.0035 0.0028 0.8728 0.42 0.42 -0.4300071342352337
332 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.301142352 39.36 24.89 34.19 1.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.629862798578463 0.0246 0 0.1245 0.0895 0.0015 0.0023 0.7576 0.44 0.44 -0.399158097332212
333 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 6.525773643 24.0 30.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.732683506287051 0.006 0.0012 0.0205 0.0177 0.0008 0 0.9538 0.44 0.44 -0.399158097332212
334 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.31765932 46.5 7.5 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.81380905109942 0.073 0 0.0373 0.0149 0 0 0.8748 1.01 1.01 0.4800394544039054
335 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.01888288 46.37 7.5 44.21 1.92 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.706823839714591 0.0145 0.0004 0.1165 0.019 0.0007 0.0011 0.8477 1.94 1.94 1.9145196703944125
336 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.30562834 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.73795129722191 0.0343 0.0003 0.1697 0.027 0.0013 0.0009 0.7666 1.9 1.9 1.8528215965883692
337 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 9.480986593 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.302712827954156 0.0455 0 0.324 0.073 0.0011 0.0012 0.5551 1.0 1.0 0.4646149359523945
338 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 17.88551615 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.763028270603671 0.0253701689981931 0.00985209592098701 0.307949537646453 0.622300893638244 0.0174680522283724 0.0170592515677505 - 0.0
339 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 17.94390528 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.584559232083967 0.00894763570081526 0.00182903773179144 0.430416319953847 0.549730482792046 0.00757886856613304 0.0014976552553668 - 0.0019532059842532 0.0019532059842532 -0.793744670428099
340 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 18.3291697 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.5827200571505 0.00757568328250189 0.00220510873539676 0.728025615125869 0.236446776884745 0.0226429923353559 0.00310382363613184 - 0.0011482099710543 0.0011482099710543 -0.7958927956755514
341 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 18.38109198 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.6888677450096585 0.00599960547383456 0.00187471922407934 0.58725363712808 0.393842224090862 0.00908706069367491 0.00194275338946932 - 0.0005585876781053 0.0005585876781053 -0.7974661979200065
342 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 19.03103458 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.374372415737022 0.0207124354254999 0.00767807173489595 0.560331852523788 0.3797189836544 0.0206003960524344 0.0109582606089812 - 0.0001489580680618 0.0001489580680618 -0.7985592911689305
343 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 19.07349618 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.567572155572773 0.0084525958204246 0.00170600389954699 0.807774257087237 0.172171860632781 0.00851123850670424 0.00138404405330582 - 0.0052460712339961 0.0052460712339961 -0.7849576865630203
344 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 17.88551615 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.763028270603671 0.0142965461163966 0.00273099369058116 0.2951874813445 0.196790510597468 0.00567584660232592 0.00900724719724339 0.476311374451485 0.0033203605888808 0.0033203605888808 -1.0727154128818024
345 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 17.94390528 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.584559232083967 0.0426258503334726 0.000887127042175757 0.102099604743599 0.057196348771858 0.00222434780081794 0.00162961025671667 0.79333711105136 0.0465195426566469 0.0465195426566469 -1.006082754792359
346 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 18.3291697 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.5827200571505 0.0182648912592805 0.000462867676668248 0.083073077462289 0.0429608616930204 0.00195825764287227 0.000923423624969053 0.852356620640901 0.0509209522037464 0.0509209522037464 -0.9992937925151699
347 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 18.38109198 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.6888677450096585 0.0068908069603713 0.000629547873998548 0.021394314943629 0.042448777163022 0.00198708372142952 0.00248444060475972 0.92416502873279 0.016201262972428 0.016201262972428 -1.0528472412330891
348 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 19.03103458 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.374372415737022 0.0116932676375475 0.00103739027764326 0.0525071135910941 0.0215477599193875 0.00368874758435242 0.00400972460855577 0.905515996381419 0.006104461793755 0.006104461793755 -1.068421070841257
349 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 19.07349618 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.567572155572773 0.0237911981258413 0.00067207203055979 0.18334881014348 0.0466442684044473 0.00188246389345958 0.000953648344707904 0.742707539057504 0.0550488822731985 0.0550488822731985 -0.9929266591628888
350 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.82491214 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GLN Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.572543683160998 0.000714997259249526 0.000661552142657172 0.125943320778554 0.801966162874089 0.0693146503097598 0.00139931663568972 - 0.0127373438778132 0.0127373438778132 -0.764967287060561
351 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.91081918 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence BIM Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.358502089626924 0.00147233862420237 0.00107405472963131 0.901430168335102 0.0923159134092667 0.00310160866776492 0.000605916234032228 - 0.0763434621140544 0.0763434621140544 -0.5952348831288257
352 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81357262 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence 3FLA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.396299293960601 0.00110223184180453 0.00161797426133587 0.963322201717795 0.0321995776177804 0.00129202117564397 0.000465993385639812 - 0.380376087923258 0.380376087923258 0.21607368094058316
353 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.58547122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.351438552905858 0.00061802522712851 0.00208191419961706 0.00520107649990865 0.018780252186508 0.966671145724669 0.00664758616216931 - 0.0289886812604962 0.0289886812604962 -0.7216007267742771
354 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2 DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence IZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.544995462952021 0.00423798522906651 0.00360605985882706 0.0132163308359338 0.182768863634774 0.789078621894797 0.00709213854660109 - 0.0033387326299993 0.0033387326299993 -0.7900474039572776
355 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.80884374 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PY Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.237000862623624 0.0123483310685072 0.00430719249252366 0.0429874465070588 0.751978605237179 0.174073814828135 0.0143046098665965 - 0.0005090956767902 0.0005090956767902 -0.7975982669188943
356 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.790487251761845 0.00153513483125764 0.00147931904743739 0.82338319944907 0.169033483447006 0.00378262362292623 0.000786239602302501 - 0.306009500746919 0.306009500746919 0.017627054049161966
357 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 17.10338647 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.842058839093973 0.00164287085070931 0.000659195379539964 0.94017588697419 0.0550751037989028 0.00183173459161262 0.000615208405045708 - 0.504231824712829 0.504231824712829 0.5465816969768794
358 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.82491214 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence GLN Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.572543683160998 0.0204881792124896 0.00996076677576078 0.024515683125648 0.0206076067733214 0.0213656753332114 0.0146396167476402 0.888422472031929 0.0035574041476412 0.0035574041476412 -1.0723497846072114
359 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.91081918 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence BIM Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.358502089626924 0.0789442718629389 0.000859220559164078 0.352513414289749 0.0167725689541561 0.00207992092629201 0.000939235620822743 0.547891367786878 0.128034152082589 0.128034152082589 -0.8803503950765449
360 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81357262 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence 3FLA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.396299293960601 0.020589791219893 0.00221295822133462 0.77006639472807 0.0336156368936998 0.00141982059640497 0.000804331444027444 0.17129106689657 0.352623838360951 0.352623838360951 -0.5339316190745824
361 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.58547122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 1.0 4.351438552905858 0.0518701933925729 0.031230151711712 0.196119602463562 0.0891250765615729 0.225998436967717 0.183312147304902 0.222344391597961 0.0006916766953858 0.0006916766953858 -1.0767700312036428
362 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2 DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence IZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.544995462952021 0.0318134391856252 0.0195739470918212 0.0658637908929555 0.0405146823853727 0.0383355214778253 0.0445803960220688 0.759318222944331 0.0007826107131428 0.0007826107131428 -1.0766297698601666
363 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.80884374 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PY Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.237000862623624 0.0496007240706346 0.0248050760368446 0.125156740550784 0.0913290655906173 0.0605654916232193 0.0647609529825488 0.583781949145352 0.000319594239126 0.000319594239126 -1.077343950474849
364 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.790487251761845 0.0660465509749711 0.000704686244275338 0.176882938102508 0.134254150019803 0.00301700767902668 0.00146559050061717 0.617629076478799 0.391796497651864 0.391796497651864 -0.473509678471839
365 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 17.10338647 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.842058839093973 0.180962520579808 0.000840183131263393 0.0600498448220066 0.0139903797423045 0.00230022430813273 0.00221494849849946 0.739641898917986 0.515169720881209 0.515169720881209 -0.2832124226594992
366 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.07758774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.48897339158558 0.000136174132145422 0.00212452688507234 0.811633900204502 0.179761878637886 0.00385751556458306 0.00248600457581157 - 0.767759892635294 0.767759892635294 1.24980418110703
367 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.50454535 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ALA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.675628649636653 0.00268100351583557 0.00240431632025112 0.142040711181502 0.523320437165769 0.324868931367264 0.00468460044937817 - 0.0241897161135915 0.0241897161135915 -0.7344067258409619
368 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.59671966 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence SER Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.737600973168581 0.00157432110064945 0.00176844882817444 0.053765469363115 0.438156626388713 0.500533090562106 0.00420204375724176 - 0.0189624719731265 0.0189624719731265 -0.7483555838832638
369 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.07758774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.48897339158558 0.0550309639531662 0.00234353835896855 0.320198252727196 0.282656133384496 0.0064798077198827 0.00202476215621646 0.331266541700075 1.20135127285815 1.20135127285815 0.775189578295967
370 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.50454535 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ALA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.675628649636653 0.0418659426619505 0.0219153925677162 0.21668759621254 0.199875450362037 0.113029824089051 0.0495629458661235 0.357062848240582 0.0027707272238572 0.0027707272238572 -1.0735631958798397
371 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.59671966 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence SER Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.737600973168581 0.0234118812216689 0.0071462713755353 0.0426958781226752 0.0464078935005845 0.0346044033846598 0.0235967118628926 0.822136960531984 0.0055457738057274 0.0055457738057274 -1.0692828201592537
372 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.16930088 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence TZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 5.001930853466109 0.00767358537807448 0.00233215653996207 0.0713684727707158 0.307444763898641 0.0172788380976704 0.00511228295653041 0.588789900358405 0.0063917829512014 0.0063917829512014 -1.0679778917918028
373 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.579236803961587 0.00833063062779389 0.00173987762429209 0.156651961849343 0.112205138324295 0.00895304009765426 0.00427289873828259 0.707846452738339 0.269390835357988 0.269390835357988 -0.6623145181339684
374 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.15847938 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence 3F Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.484131857611035 0.0158311033527607 0.00109353847138243 0.0200990623529318 0.00589717673503959 0.00332080816189693 0.00297802720282806 0.95078028372316 0.0070114291767852 0.0070114291767852 -1.06702211732781
375 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81395289 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PYR Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 5.0755487449389 0.0138253404297663 0.00670375922221507 0.064918033729737 0.0310082272870404 0.0307691214666871 0.0156091189056244 0.83716639895893 0.0111434256880136 0.0111434256880136 -1.060648711684908
376 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.402809173856411 0.0144051248882893 0.000525788660297221 0.125667067331117 0.214373546599095 0.00410880851120861 0.00177167337754258 0.639147990632451 0.176512628889736 0.176512628889736 -0.8055746790752468
377 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.16930088 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence TZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 5.001930853466109 0.00115119797114568 0.0003959818507672 0.0538124209539168 0.93604524664705 0.00736502972190904 0.00123012285521143 - 0.0261518819859255 0.0261518819859255 -0.7291707023316024
378 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.579236803961587 0.0010942059599737 0.000714578151988552 0.367034511120116 0.62078160479883 0.0079478856978032 0.00242721427128835 - 0.970510173989973 0.970510173989973 1.7908416411254202
379 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.15847938 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence 3F Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.484131857611035 0.0376230130625874 0.00236009027623813 0.247039705692743 0.697452972603375 0.0104681865382628 0.00505603182679352 - 0.0013884403431976 0.0013884403431976 -0.7952517429011965
380 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81395289 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PYR Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 5.0755487449389 0.00873826813676438 0.00145112475939544 0.193065080283125 0.778197018798523 0.014433213681334 0.00411529434085825 - 0.165721665234437 0.165721665234437 -0.35672988242469916
381 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.402809173856411 0.00532422079532615 0.00061084449763591 0.522469676271313 0.459778984209221 0.00966894873803684 0.00214732548846694 - 0.161020662402855 0.161020662402855 -0.3692744698577941
382 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.584763376210429 0.0318391346416656 0.000341552225113717 0.113678281409446 0.242279767731552 0.00387550619454475 0.000871625110337537 0.60711413268734 0.649833386251602 0.649833386251602 -0.07550020353412855
383 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.746322465743975 0.0548193142492001 0.000263362025026913 0.0902956804122817 0.160837629010128 0.00315355508353847 0.000739500993108033 0.689890958226717 1.16375238999006 1.16375238999006 0.7171951120404622
384 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O DSPC 0 0 1 0 16.87346518 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence HIS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.651385609785055 0.0172566765287249 0.00318344365411915 0.0712890876960715 0.171965068058214 0.0218135302099503 0.0115493777455846 0.702942816107335 0.00327405282427 0.00327405282427 -1.0727868403787713
385 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.584763376210429 0.000599963927151076 0.000397997752734626 0.420976508827142 0.560178394908249 0.017044159994242 0.000802974590480822 - 0.25255828640642 0.25255828640642 -0.1250070722684871
386 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.746322465743975 0.000524374578838527 0.00061514916196369 0.547432124587029 0.435435317287124 0.015309113403191 0.000683920981854007 - 0.568394489552276 0.568394489552276 0.7177992409467366
387 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O DSPC 0 0 1 0 16.87346518 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence HIS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.651385609785055 0.00171983501988967 0.00189561016704693 0.0120716635806003 0.711278646835123 0.270438826106656 0.00259541829068387 - 0.0112897234542117 0.0112897234542117 -0.7688302502674332
388 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.484733632866144 0.0047850951415261 0.000675911772575438 0.46069265034102 0.522359359837259 0.0109775121699624 0.00050947073765779 - 0.773205414607926 0.773205414607926 1.2643355117511204
389 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.633757642840004 0.00198911414189635 0.00126811595413123 0.543867583730296 0.438842770521552 0.0129988635137729 0.00103355213835123 - 1.98493053910539 1.98493053910539 4.497814051056962
390 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.0333911 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.609759638321899 0.00125031423153586 0.0004860362025215 0.538249539726811 0.445414640899446 0.0137801694455006 0.000819299494184621 - 0.291137444797345 0.291137444797345 -0.022058905064912687
391 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=O DSPC 0 0 1 0 16.68738808 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence CYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.392884144674663 0.00226285185388551 0.000562872305858137 0.731364439797527 0.256932619347553 0.00825451238600619 0.000622704309170273 - 1.82872279459479 1.82872279459479 4.080974968218046
392 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.484733632866144 0.0442923458834068 0.00055452650331333 0.106459881295074 0.192526940733964 0.00311682882196998 0.000623042068808978 0.652426434693463 0.672431538902446 0.672431538902446 -0.04064364128082843
393 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.633757642840004 0.0374610013402809 0.0005350551106764 0.260855439538844 0.469905543128085 0.00469334055693451 0.000912093945676405 0.225637526379503 1.69276100831231 1.69276100831231 1.5331654314724417
394 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.0333911 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.609759638321899 0.0836645231428707 0.000419599806684375 0.0235684307001288 0.0712275212970175 0.00119681308497475 0.00178295859414992 0.818140153374174 0.426058290183635 0.426058290183635 -0.4206625133630252
395 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=O DSPC 0 0 1 0 16.68738808 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence CYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.392884144674663 0.0512990735432809 0.000672189655491244 0.187343972483681 0.232187436433234 0.00314791870850824 0.00146679734452725 0.523882611831278 1.30784095113947 1.30784095113947 0.9394447790505344
396 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC([C@@H](N)CS)=O DSPC 0 0 1 0 17.78759767 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence CYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.751259891859986 0.00405799702984203 0.00225047224182105 0.719270208750414 0.257208699720685 0.0138718178214465 0.00334080443579049 - 1.25160610942024 1.25160610942024 2.540943835364252
397 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.31729774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.666265285347902 0.00272982965803786 0.000172365352517303 0.498048022051036 0.479137442306018 0.0180316959727267 0.00188064465966415 - 0.155537169131505 0.155537169131505 -0.3839071266005448
398 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.71419039 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.904756125442696 0.00273286200255075 0.00260055069792003 0.431146257918051 0.50349018951458 0.0550138028095967 0.00501633705730229 - 0.021985308799366 0.021985308799366 -0.7402891686477768
399 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.733211535868976 0.00166528576158017 0.000176886038620712 0.205207225042143 0.750916028545382 0.0392720451710516 0.00276252944122191 - 0.120096690961961 0.120096690961961 -0.478479751420455
400 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 18.70678989 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.858726543710496 0.00383743159330312 0.00248950729214128 0.555903422423481 0.380445635709031 0.0515668712566801 0.00575713172536402 - 0.0526538412251038 0.0526538412251038 -0.6584504418393717
401 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.31729774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.666265285347902 0.0567289157085495 0.00653348267008008 0.064839577285576 0.335055277453961 0.0144955694225392 0.0143736618741762 0.507973515585118 0.268311366051918 0.268311366051918 -0.6639795475568999
402 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.71419039 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.904756125442696 0.0248552898268163 0.0125192728735768 0.0725307642598596 0.0355254691282667 0.0214395648154144 0.0248745799236939 0.808255059172372 0.0741845243461588 0.0741845243461588 -0.9634108527393006
403 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.733211535868976 0.0883917007893502 0.00174599838911923 0.0536405332414895 0.100118671210748 0.00771990063396103 0.00639776118235737 0.741985434552974 0.528035509086713 0.528035509086713 -0.2633675639025965
404 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 18.70678989 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.858726543710496 0.0175679405294797 0.00960173891174304 0.0903179131752613 0.0388184937379254 0.0182497546285787 0.0249045868533177 0.800539572163694 0.125181510399577 0.125181510399577 -0.8847504575040614
405 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.62870578 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.765586907393996 0.00159278655447388 0.00186611160196327 0.488795918944862 0.485247409700546 0.018616198181097 0.00388157501705755 - 0.352570746370957 0.352570746370957 0.14187535545424673
406 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.61880246 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.82374330878754 0.000875415234709484 0.00127375854285246 0.683377837104949 0.304003257921165 0.00820355561270421 0.00226617558361995 - 0.943420561172443 0.943420561172443 1.7185532318874628
407 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.58547122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.433313679041901 0.000602190120987361 0.000576528881915898 0.00566197423128506 0.0161763859347042 0.971683265119797 0.00529965571131053 - 0.0305789310371634 0.0305789310371634 -0.7173571583105779
408 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.70929826 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.356324137321509 0.00187378052819512 0.00157654975652554 0.0163863796216318 0.0648246159165097 0.905280007427939 0.0100586667491993 - 0.003875136361479 0.003875136361479 -0.7886160150068647
409 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.17273956 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.440767129696482 0.00301049906217731 9.21592223531261e-05 0.00380096827414773 0.0130323481002541 0.97657327492354 0.00349075041752818 - 0.0274401441027376 0.0274401441027376 -0.7257329854571254
410 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=O DSPC 0 0 1 0 18.38469122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.349632566862877 0.00273989274094748 0.00161018393061426 0.0112824839963327 0.0583352940699212 0.919247401685963 0.00678474357622127 - 0.0081601896883771 0.0081601896883771 -0.7771813854096181
411 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=O DSPC 0 0 1 0 18.90345652 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.662778498608405 0.00349315451118928 0.00171298178399312 0.037797325974731 0.242816837972913 0.706569889763285 0.00760980999388795 - 0.0136767051395404 0.0136767051395404 -0.7624606092513427
412 O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCN DSPC 0 0 1 0 18.38469122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 0 0 1 4.405498990859024 - - - - - - - 0.0
413 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=O DSPC 0 0 1 0 16.89527599 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 4.815106909815019 - - - - - - - 0.0
414 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.89527599 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.562053894914463 0.00241700650155169 0.00189161759954923 0.0117804592312353 0.0588098364115177 0.918016488291877 0.0070845919642692 - 0.288385322760908 0.288385322760908 -0.029402920107978105
415 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.89527599 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.667205576907544 0.00146771264056884 0.000853267380299107 0.00521853383313367 0.0984194458399351 0.890752405611161 0.00328863469490281 - 0.174730948641107 0.174730948641107 -0.3326886836733955
416 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 17.94799221 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.701389043728634 0.00256320924432886 0.00193796271600952 0.0128146756680969 0.0418402586947232 0.934553052894321 0.00629084078252029 - 0.0492674291707299 0.0492674291707299 -0.6674870545840368
417 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 18.38469122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.460491174618648 0.00101051612937229 0.00153512067382825 0.00950098551353592 0.161931963893941 0.822835993399315 0.00318542039000704 - 0.105055900803977 0.105055900803977 -0.5186159763833679
418 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 19.0764718 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.505460341839079 0.00282763425766742 0.00135220428389579 0.101550310310828 0.701364372579719 0.18950529802972 0.00340018053817036 - 0.0700302222351868 0.0700302222351868 -0.6120817118766197
419 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 17.18453431 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.684905154006945 0.0025903109842197 0.00122267327648511 0.0959380417500791 0.558064631213231 0.339326541744348 0.00285780103163663 - 0.0836567108446898 0.0836567108446898 -0.5757195389760648
420 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 18.58497913 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.695924549256556 0.00270162630925447 0.000571977156802491 0.072649821877092 0.283620916967858 0.638520904456637 0.00193475323235631 - 0.108372702997361 0.108372702997361 -0.5097651169808466
421 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=O DSPC 0 0 1 0 16.82518306 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence LYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 1 0 0 4.202899968776446 - - - - - - - 0.0
422 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 14.52948326 43.25 25.0 30.0 1.75 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 0.0 5.029784112935016 0.000951862951033406 0.000642237882584555 0.00747953132811133 0.295137112679544 0.692754163229738 0.0030350919289883 - 0.19435393861906 0.19435393861906 -0.2803248961378029
423 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 11.10169345 30.0 25.0 42.5 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.833102254034098 0.00529626249319983 0.00246267213977097 0.0289260006923807 0.563065088278535 0.393847703229461 0.00640227316665243 - 0.049072760763369 0.049072760763369 -0.6680065256297026
424 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.72804315 38.075 17.975 41.825 2.125 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 4.93014804318357 - - - - - - - 0.0
425 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.39261658 37.0 25.0 37.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 5.146912912388804 0.000759366167023555 0.000694817987152034 0.00466364025695932 0.212680085653105 0.777593147751606 0.00360894218415418 - 0.201238755105862 0.201238755105862 -0.2619528199077537
426 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.51039532 38.5 20.5 38.5 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.684905154006945 0.00157535225652128 0.00592927130077556 0.00900517890128691 0.366135503933579 0.613833328839362 0.00352136476847493 - 0.149329656900936 0.149329656900936 -0.40047182198750214
427 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.48290639 45.0 9.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.869839484130799 0.00147117555088917 0.000927103843315829 0.00585237061645294 0.136146016514374 0.851575135737455 0.00402819773751327 - 0.31219703699332 0.31219703699332 0.034138443686487704
428 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 14.13138042 41.2 22.35 34.325 2.125 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 0.0 4.901564199041894 0.00315707422768752 0.0025689389054212 0.0146712017391132 0.327849346901905 0.646061693847123 0.0056917443787501 - 0.158541375998041 0.158541375998041 -0.3758904252594646
429 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.11942242 41.825 14.975 41.825 1.375 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 5.039546637590676 - - - - - - - 0.0
430 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 14.79492927 45.0 22.5 30.0 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.9141243937154115 0.00113350028034128 0.000566939752127873 0.00680706926467914 0.502661298625749 0.486733894218144 0.00209729785895866 - 0.145448415448628 0.145448415448628 -0.4108288829150842
431 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 12.55393718 34.325 21.725 41.825 2.125 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 0.0 4.814620410170298 0.001692878443667 0.000820135726038303 0.00868136575507882 0.408928448915581 0.577101122031978 0.00277604912765729 - 0.113760366510672 0.113760366510672 -0.495388181160095
432 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.93959861 45.0 7.5 45.0 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.527640983478854 0.00506334343919377 0.004281344333051 0.0165771717732586 0.226890591170162 0.736348900590883 0.0108386486934518 - 0.0547343765642327 0.0547343765642327 -0.6528985503803821
433 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.59337013 45.0 15.75 37.5 1.75 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.810557015713042 0.00141112235558708 0.000749767156842064 0.00637541161251223 0.138880841494329 0.847648476304751 0.00493438107597822 - 0.294154433878409 0.294154433878409 -0.0140080944893819
434 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 11.66031337 30.0 24.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 5.167639042905921 0.00199236267032557 0.000827577235394216 0.008719084857644 0.192132365846187 0.792330257640873 0.0039983517495764 - 0.151793984465988 0.151793984465988 -0.3938957841268362
435 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.66358165 37.5 15.0 45.0 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.618086411254637 0.00271480786609193 0.00181664538344774 0.00938513027274936 0.132547184736695 0.849509595736892 0.0040266360041233 - 0.0950036114384557 0.0950036114384557 -0.5454404279666308
436 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.26186294 45.0 24.0 30.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 5.098035484377089 - - - - - - - 0.0
437 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.27611859 45.0 11.382 42.618 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.680277658474897 0.00152924607683628 0.00192508702614222 0.0105762053188716 0.167270255683968 0.810875386281306 0.00782381961287527 - 0.278754923842637 0.278754923842637 -0.05510156049896443
438 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.11001923 45.0 13.445 40.445 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.924350925499243 0.000999438616070677 0.00125158481927741 0.00771842730472846 0.249469737208587 0.735450494958472 0.00511031709286499 - 0.286455906115286 0.286455906115286 -0.03455155257492116
439 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.85662691 45.0 16.405 37.595 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.924350925499243 0.00141338619768439 0.00124322063420737 0.0100450891793794 0.235894751086175 0.745556785166654 0.00584676773589971 - 0.264336417833639 0.264336417833639 -0.09357722532293417

14
lnp_ml/modeling/benchmark.py
View File

@ -284,12 +284,12 @@ def main(
data_dir: Path = PROCESSED_DATA_DIR / "benchmark",
output_dir: Path = MODELS_DIR / "benchmark",
# 模型参数
d_model: int = 256,
num_heads: int = 8,
n_attn_layers: int = 4,
d_model: int = 128,
num_heads: int = 4,
n_attn_layers: int = 2,
fusion_strategy: str = "attention",
head_hidden_dim: int = 128,
dropout: float = 0.3,
head_hidden_dim: int = 64,
dropout: float = 0.1,
# MPNN 参数
use_mpnn: bool = False,
mpnn_checkpoint: Optional[str] = None,
@ -298,7 +298,7 @@ def main(
# 训练参数
batch_size: int = 64,
lr: float = 1e-4,
weight_decay: float = 1e-3,
weight_decay: float = 1e-5,
epochs: int = 50,
patience: int = 10,
# 设备
@ -521,7 +521,7 @@ def test(
continue
# 加载模型
checkpoint = torch.load(model_path, map_location=device)
checkpoint = torch.load(model_path, map_location=device, weights_only=False)
config = checkpoint["config"]
use_mpnn = config.get("use_mpnn", False)

2
lnp_ml/modeling/final_train_optuna_cv.py
View File

@ -453,7 +453,7 @@ def main(
if init_from_pretrain is not None:
if init_from_pretrain.exists():
logger.info(f"Loading pretrain weights from {init_from_pretrain}")
checkpoint = torch.load(init_from_pretrain, map_location="cpu")
checkpoint = torch.load(init_from_pretrain, map_location="cpu", weights_only=False)
pretrain_state_dict = checkpoint["model_state_dict"]
pretrain_config = checkpoint.get("config", {})
logger.success(f"Loaded pretrain checkpoint (d_model={pretrain_config.get('d_model')})")

2
lnp_ml/modeling/nested_cv_optuna.py
View File

@ -744,7 +744,7 @@ def main(
if init_from_pretrain is not None:
if init_from_pretrain.exists():
logger.info(f"Loading pretrain weights from {init_from_pretrain}")
checkpoint = torch.load(init_from_pretrain, map_location="cpu")
checkpoint = torch.load(init_from_pretrain, map_location="cpu", weights_only=False)
pretrain_state_dict = checkpoint["model_state_dict"]
pretrain_config = checkpoint.get("config", {})
logger.success(f"Loaded pretrain checkpoint (d_model={pretrain_config.get('d_model')})")

2
lnp_ml/modeling/predict.py
View File

@ -38,7 +38,7 @@ def load_model(
自动根据 checkpoint 的 config.use_mpnn 选择模型类型。
"""
checkpoint = torch.load(model_path, map_location=device)
checkpoint = torch.load(model_path, map_location=device, weights_only=False)
config = checkpoint["config"]
use_mpnn = config.get("use_mpnn", False)

2
lnp_ml/modeling/pretrain.py
View File

@ -392,7 +392,7 @@ def test(
# 加载模型
logger.info(f"Loading pretrain model from {model_path}")
checkpoint = torch.load(model_path, map_location=device_obj)
checkpoint = torch.load(model_path, map_location=device_obj, weights_only=False)
config = checkpoint["config"]
# 解析 MPNN 配置