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Author SHA1 Message Date
RYDE-WORK
ead579b25c Fallback 2026-02-28 18:29:07 +08:00
RYDE-WORK
74fd012f13 尝试切换学习率策略为线性预热+余弦退火 2026-02-28 17:51:40 +08:00
RYDE-WORK
a7db8ffc15 缩小d_model/num_heads/n_attn_layers/hidden_dim或者增大正则化后,欠拟合,恢复默认参数 2026-02-28 17:32:49 +08:00
RYDE-WORK
e3f9d9e9db 统一所有脚本参数统计方式 2026-02-28 17:08:22 +08:00
RYDE-WORK
985f3a1bb0 加载模型时显式weight_only=False 2026-02-28 16:49:34 +08:00
RYDE-WORK
c8c33c1c75 撤回正则化更改 2026-02-28 16:48:45 +08:00
RYDE-WORK
bbc7c88f99 增大benchmark时的固定dropout和weight decay 2026-02-28 16:17:40 +08:00
RYDE-WORK
70b7a4c62a 移除旧版函数参数,以及抑制chemprop/torch影响终端输出查看的过多warning 2026-02-28 15:55:47 +08:00
RYDE-WORK
7c69d47238 微调阶段rdkit缓存共享 2026-02-28 15:40:29 +08:00
RYDE-WORK
f952033b09 Reuse cacje 2026-02-28 15:35:10 +08:00
RYDE-WORK
13b357ce05 增加5-fold训练的并行功能 2026-02-28 14:09:00 +08:00
RYDE-WORK
48de4d5d37 增加超参搜索范围 2026-02-28 13:57:31 +08:00
RYDE-WORK
9e4800b77e 内外部数据LNP四组分比例统一为百分比数,可电离脂质与mRNA比例的搜索范围与四组分解耦 2026-02-28 11:52:55 +08:00
RYDE-WORK
60e082af55 多任务微调时默认不加载预训练时quantified_delivery的预测头参数 2026-02-28 11:13:39 +08:00
RYDE-WORK
c52b82786d 对backbone与预测头采用分层学习率,缓解预训练任务数与任务定义都不一致的问题 2026-02-28 11:11:27 +08:00
13 changed files with 507 additions and 741 deletions
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5
Makefile
View File

@ -15,6 +15,7 @@ EPOCHS_PER_TRIAL_FLAG = $(if $(EPOCHS_PER_TRIAL),--epochs-per-trial $(EPOCHS_PER
MIN_STRATUM_FLAG = $(if $(MIN_STRATUM_COUNT),--min-stratum-count $(MIN_STRATUM_COUNT),) MIN_STRATUM_FLAG = $(if $(MIN_STRATUM_COUNT),--min-stratum-count $(MIN_STRATUM_COUNT),)
OUTPUT_DIR_FLAG = $(if $(OUTPUT_DIR),--output-dir $(OUTPUT_DIR),) OUTPUT_DIR_FLAG = $(if $(OUTPUT_DIR),--output-dir $(OUTPUT_DIR),)
USE_SWA_FLAG = $(if $(USE_SWA),--use-swa,) USE_SWA_FLAG = $(if $(USE_SWA),--use-swa,)
PARALLEL_FLAG = $(if $(PARALLEL),--parallel,)
INIT_PRETRAIN_FLAG = $(if $(NO_PRETRAIN),,--init-from-pretrain $(or $(INIT_PRETRAIN),models/pretrain_delivery.pt)) INIT_PRETRAIN_FLAG = $(if $(NO_PRETRAIN),,--init-from-pretrain $(or $(INIT_PRETRAIN),models/pretrain_delivery.pt))
################################################################################# #################################################################################
@ -91,10 +92,12 @@ benchmark: requirements
# INIT_PRETRAIN 预训练权重路径 (默认: models/pretrain_delivery.pt) # INIT_PRETRAIN 预训练权重路径 (默认: models/pretrain_delivery.pt)
# NO_PRETRAIN=1 禁用预训练权重 # NO_PRETRAIN=1 禁用预训练权重
# USE_SWA=1 启用 SWA (final train 阶段) # USE_SWA=1 启用 SWA (final train 阶段)
# PARALLEL=1 并行运行外层 fold (nested CV 阶段，需足够 GPU 显存)
# #
# 使用示例: # 使用示例:
# make pretrain # make pretrain
# make train DEVICE=cuda N_TRIALS=30 USE_SWA=1 INIT_PRETRAIN=models/pretrain_delivery.pt # make train DEVICE=cuda N_TRIALS=30 USE_SWA=1 INIT_PRETRAIN=models/pretrain_delivery.pt
# make train DEVICE=cuda PARALLEL=1
## Pretrain on external data (delivery only) ## Pretrain on external data (delivery only)
@ -109,7 +112,7 @@ pretrain: requirements
train: requirements train: requirements
$(PYTHON_INTERPRETER) -m lnp_ml.modeling.nested_cv_optuna \ $(PYTHON_INTERPRETER) -m lnp_ml.modeling.nested_cv_optuna \
$(DEVICE_FLAG) $(MPNN_FLAG) $(SEED_FLAG) $(INIT_PRETRAIN_FLAG) \ $(DEVICE_FLAG) $(MPNN_FLAG) $(SEED_FLAG) $(INIT_PRETRAIN_FLAG) \
$(N_TRIALS_FLAG) $(EPOCHS_PER_TRIAL_FLAG) $(MIN_STRATUM_FLAG) $(OUTPUT_DIR_FLAG) $(N_TRIALS_FLAG) $(EPOCHS_PER_TRIAL_FLAG) $(MIN_STRATUM_FLAG) $(OUTPUT_DIR_FLAG) $(PARALLEL_FLAG)
$(PYTHON_INTERPRETER) -m lnp_ml.modeling.final_train_optuna_cv \ $(PYTHON_INTERPRETER) -m lnp_ml.modeling.final_train_optuna_cv \
$(DEVICE_FLAG) $(MPNN_FLAG) $(SEED_FLAG) $(INIT_PRETRAIN_FLAG) \ $(DEVICE_FLAG) $(MPNN_FLAG) $(SEED_FLAG) $(INIT_PRETRAIN_FLAG) \
$(N_TRIALS_FLAG) $(EPOCHS_PER_TRIAL_FLAG) $(MIN_STRATUM_FLAG) $(OUTPUT_DIR_FLAG) $(USE_SWA_FLAG) $(N_TRIALS_FLAG) $(EPOCHS_PER_TRIAL_FLAG) $(MIN_STRATUM_FLAG) $(OUTPUT_DIR_FLAG) $(USE_SWA_FLAG)

27
app/api.py
View File

@ -31,17 +31,17 @@ from app.optimize import (
# ============ Pydantic Models ============ # ============ Pydantic Models ============
class CompRangesRequest(BaseModel): class CompRangesRequest(BaseModel):
"""组分范围配置""" """组分范围配置（mol 比例为百分数 0-100）"""
weight_ratio_min: float = Field(default=0.05, ge=0.01, le=0.50, description="阳离子脂质/mRNA 重量比最小值") weight_ratio_min: float = Field(default=5.0, ge=1.0, le=50.0, description="阳离子脂质/mRNA 重量比最小值")
weight_ratio_max: float = Field(default=0.30, ge=0.01, le=0.50, description="阳离子脂质/mRNA 重量比最大值") weight_ratio_max: float = Field(default=30.0, ge=1.0, le=50.0, description="阳离子脂质/mRNA 重量比最大值")
cationic_mol_min: float = Field(default=0.05, ge=0.00, le=1.00, description="阳离子脂质 mol 比例最小值") cationic_mol_min: float = Field(default=5.0, ge=0.0, le=100.0, description="阳离子脂质 mol 比例最小值 (%)")
cationic_mol_max: float = Field(default=0.80, ge=0.00, le=1.00, description="阳离子脂质 mol 比例最大值") cationic_mol_max: float = Field(default=80.0, ge=0.0, le=100.0, description="阳离子脂质 mol 比例最大值 (%)")
phospholipid_mol_min: float = Field(default=0.00, ge=0.00, le=1.00, description="磷脂 mol 比例最小值") phospholipid_mol_min: float = Field(default=0.0, ge=0.0, le=100.0, description="磷脂 mol 比例最小值 (%)")
phospholipid_mol_max: float = Field(default=0.80, ge=0.00, le=1.00, description="磷脂 mol 比例最大值") phospholipid_mol_max: float = Field(default=80.0, ge=0.0, le=100.0, description="磷脂 mol 比例最大值 (%)")
cholesterol_mol_min: float = Field(default=0.00, ge=0.00, le=1.00, description="胆固醇 mol 比例最小值") cholesterol_mol_min: float = Field(default=0.0, ge=0.0, le=100.0, description="胆固醇 mol 比例最小值 (%)")
cholesterol_mol_max: float = Field(default=0.80, ge=0.00, le=1.00, description="胆固醇 mol 比例最大值") cholesterol_mol_max: float = Field(default=80.0, ge=0.0, le=100.0, description="胆固醇 mol 比例最大值 (%)")
peg_mol_min: float = Field(default=0.00, ge=0.00, le=0.20, description="PEG 脂质 mol 比例最小值") peg_mol_min: float = Field(default=0.0, ge=0.0, le=20.0, description="PEG 脂质 mol 比例最小值 (%)")
peg_mol_max: float = Field(default=0.05, ge=0.00, le=0.20, description="PEG 脂质 mol 比例最大值") peg_mol_max: float = Field(default=5.0, ge=0.0, le=20.0, description="PEG 脂质 mol 比例最大值 (%)")
def to_comp_ranges(self) -> CompRanges: def to_comp_ranges(self) -> CompRanges:
"""转换为 CompRanges 对象""" """转换为 CompRanges 对象"""
@ -87,7 +87,8 @@ class OptimizeRequest(BaseModel):
top_k: int = Field(default=20, ge=1, le=100, description="Number of top formulations to return") top_k: int = Field(default=20, ge=1, le=100, description="Number of top formulations to return")
num_seeds: Optional[int] = Field(default=None, ge=1, le=500, description="Number of seed points from first iteration (default: top_k * 5)") num_seeds: Optional[int] = Field(default=None, ge=1, le=500, description="Number of seed points from first iteration (default: top_k * 5)")
top_per_seed: int = Field(default=1, ge=1, le=10, description="Number of local best to keep per seed in refinement") top_per_seed: int = Field(default=1, ge=1, le=10, description="Number of local best to keep per seed in refinement")
step_sizes: Optional[List[float]] = Field(default=None, description="Step sizes for each iteration (default: [0.10, 0.02, 0.01])") step_sizes: Optional[List[float]] = Field(default=None, description="Mol ratio step sizes for each iteration (default: [10, 2, 1])")
wr_step_sizes: Optional[List[float]] = Field(default=None, description="Weight ratio step sizes for each iteration (default: [5, 2, 1])")
comp_ranges: Optional[CompRangesRequest] = Field(default=None, description="组分范围配置（默认使用标准范围）") comp_ranges: Optional[CompRangesRequest] = Field(default=None, description="组分范围配置（默认使用标准范围）")
routes: Optional[List[str]] = Field(default=None, description="给药途径列表 (default: ['intravenous', 'intramuscular'])") routes: Optional[List[str]] = Field(default=None, description="给药途径列表 (default: ['intravenous', 'intramuscular'])")
scoring_weights: Optional[ScoringWeightsRequest] = Field(default=None, description="评分权重配置（默认仅按 biodist 排序）") scoring_weights: Optional[ScoringWeightsRequest] = Field(default=None, description="评分权重配置（默认仅按 biodist 排序）")
@ -290,7 +291,6 @@ async def optimize_formulation(request: OptimizeRequest):
scoring_weights = request.scoring_weights.to_scoring_weights() scoring_weights = request.scoring_weights.to_scoring_weights()
try: try:
# 执行优化（层级搜索策略）
results = optimize( results = optimize(
smiles=request.smiles, smiles=request.smiles,
organ=request.organ, organ=request.organ,
@ -300,6 +300,7 @@ async def optimize_formulation(request: OptimizeRequest):
num_seeds=request.num_seeds, num_seeds=request.num_seeds,
top_per_seed=request.top_per_seed, top_per_seed=request.top_per_seed,
step_sizes=request.step_sizes, step_sizes=request.step_sizes,
wr_step_sizes=request.wr_step_sizes,
comp_ranges=comp_ranges, comp_ranges=comp_ranges,
routes=request.routes, routes=request.routes,
scoring_weights=scoring_weights, scoring_weights=scoring_weights,

111
app/app.py
View File

@ -144,6 +144,7 @@ def call_optimize_api(
num_seeds: int = None, num_seeds: int = None,
top_per_seed: int = 1, top_per_seed: int = 1,
step_sizes: list = None, step_sizes: list = None,
wr_step_sizes: list = None,
comp_ranges: dict = None, comp_ranges: dict = None,
routes: list = None, routes: list = None,
scoring_weights: dict = None, scoring_weights: dict = None,
@ -156,6 +157,7 @@ def call_optimize_api(
"num_seeds": num_seeds, "num_seeds": num_seeds,
"top_per_seed": top_per_seed, "top_per_seed": top_per_seed,
"step_sizes": step_sizes, "step_sizes": step_sizes,
"wr_step_sizes": wr_step_sizes,
"comp_ranges": comp_ranges, "comp_ranges": comp_ranges,
"routes": routes, "routes": routes,
"scoring_weights": scoring_weights, "scoring_weights": scoring_weights,
@ -354,48 +356,75 @@ def main():
use_custom_steps = st.checkbox( use_custom_steps = st.checkbox(
"自定义迭代步长", "自定义迭代步长",
value=False, value=False,
help="默认步长为 [0.10, 0.02, 0.01]，共3轮逐步精细化搜索。将某轮步长设为0可减少迭代轮数。", help="默认 mol ratio 步长 [10, 2, 1]（百分数），weight ratio 步长 [5, 2, 1]，共3轮。将某轮步长设为0可减少迭代轮数。",
) )
if use_custom_steps: if use_custom_steps:
st.caption("**Mol ratio 步长 (%)**")
col1, col2, col3 = st.columns(3) col1, col2, col3 = st.columns(3)
with col1: with col1:
step1 = st.number_input( step1 = st.number_input(
"第1轮步长", "第1轮 mol 步长",
min_value=0.01, max_value=0.20, value=0.10, min_value=1, max_value=20, value=10,
step=0.01, format="%.2f", step=1,
help="第1轮为全局粗搜索，步长必须大于0", help="第1轮为全局粗搜索",
key="mol_step1",
) )
with col2: with col2:
step2 = st.number_input( step2 = st.number_input(
"第2轮步长", "第2轮 mol 步长",
min_value=0.00, max_value=0.10, value=0.02, min_value=0, max_value=10, value=2,
step=0.01, format="%.2f", step=1,
help="设为0则只进行1轮搜索", help="设为0则只进行1轮搜索",
key="mol_step2",
) )
with col3: with col3:
step3 = st.number_input( step3 = st.number_input(
"第3轮步长", "第3轮 mol 步长",
min_value=0.00, max_value=0.05, value=0.01, min_value=0, max_value=5, value=1,
step=0.01, format="%.2f", step=1,
help="设为0则只进行2轮搜索", help="设为0则只进行2轮搜索",
key="mol_step3",
) )
# 根据步长值构建实际的 step_sizes 列表 st.caption("**Weight ratio 步长**")
# step2 为 0 → 只保留 [step1]（1轮） col1, col2, col3 = st.columns(3)
# step3 为 0 → 只保留 [step1, step2]（2轮） with col1:
# 都不为 0 → [step1, step2, step3]（3轮） wr_step1 = st.number_input(
if step2 == 0.0: "第1轮 WR 步长",
step_sizes = [step1] min_value=1.0, max_value=10.0, value=5.0,
elif step3 == 0.0: step=1.0, format="%.1f",
step_sizes = [step1, step2] key="wr_step1",
else: )
step_sizes = [step1, step2, step3] with col2:
wr_step2 = st.number_input(
"第2轮 WR 步长",
min_value=0.0, max_value=5.0, value=2.0,
step=0.5, format="%.1f",
key="wr_step2",
)
with col3:
wr_step3 = st.number_input(
"第3轮 WR 步长",
min_value=0.0, max_value=2.0, value=1.0,
step=0.5, format="%.1f",
key="wr_step3",
)
# 显示实际迭代轮数提示 if step2 == 0:
st.caption(f"📌 实际迭代轮数: {len(step_sizes)} 轮，步长: {step_sizes}") step_sizes = [float(step1)]
wr_step_sizes_val = [wr_step1]
elif step3 == 0:
step_sizes = [float(step1), float(step2)]
wr_step_sizes_val = [wr_step1, wr_step2]
else:
step_sizes = [float(step1), float(step2), float(step3)]
wr_step_sizes_val = [wr_step1, wr_step2, wr_step3]
st.caption(f"📌 实际迭代轮数: {len(step_sizes)} 轮，mol步长: {step_sizes}，WR步长: {wr_step_sizes_val}")
else: else:
step_sizes = None # 使用默认值 step_sizes = None
wr_step_sizes_val = None
st.markdown("**组分范围限制**") st.markdown("**组分范围限制**")
use_custom_ranges = st.checkbox( use_custom_ranges = st.checkbox(
@ -408,37 +437,37 @@ def main():
st.caption("阳离子脂质/mRNA 重量比") st.caption("阳离子脂质/mRNA 重量比")
col1, col2 = st.columns(2) col1, col2 = st.columns(2)
with col1: with col1:
weight_ratio_min = st.number_input("最小", min_value=0.01, max_value=0.50, value=0.05, step=0.01, format="%.2f", key="wr_min") weight_ratio_min = st.number_input("最小", min_value=1.0, max_value=50.0, value=5.0, step=1.0, format="%.1f", key="wr_min")
with col2: with col2:
weight_ratio_max = st.number_input("最大", min_value=0.01, max_value=0.50, value=0.30, step=0.01, format="%.2f", key="wr_max") weight_ratio_max = st.number_input("最大", min_value=1.0, max_value=50.0, value=30.0, step=1.0, format="%.1f", key="wr_max")
st.caption("阳离子脂质 mol 比例") st.caption("阳离子脂质 mol 比例 (%)")
col1, col2 = st.columns(2) col1, col2 = st.columns(2)
with col1: with col1:
cationic_mol_min = st.number_input("最小", min_value=0.00, max_value=1.00, value=0.05, step=0.05, format="%.2f", key="cat_min") cationic_mol_min = st.number_input("最小", min_value=0.0, max_value=100.0, value=5.0, step=5.0, format="%.1f", key="cat_min")
with col2: with col2:
cationic_mol_max = st.number_input("最大", min_value=0.00, max_value=1.00, value=0.80, step=0.05, format="%.2f", key="cat_max") cationic_mol_max = st.number_input("最大", min_value=0.0, max_value=100.0, value=80.0, step=5.0, format="%.1f", key="cat_max")
st.caption("磷脂 mol 比例") st.caption("磷脂 mol 比例 (%)")
col1, col2 = st.columns(2) col1, col2 = st.columns(2)
with col1: with col1:
phospholipid_mol_min = st.number_input("最小", min_value=0.00, max_value=1.00, value=0.00, step=0.05, format="%.2f", key="phos_min") phospholipid_mol_min = st.number_input("最小", min_value=0.0, max_value=100.0, value=0.0, step=5.0, format="%.1f", key="phos_min")
with col2: with col2:
phospholipid_mol_max = st.number_input("最大", min_value=0.00, max_value=1.00, value=0.80, step=0.05, format="%.2f", key="phos_max") phospholipid_mol_max = st.number_input("最大", min_value=0.0, max_value=100.0, value=80.0, step=5.0, format="%.1f", key="phos_max")
st.caption("胆固醇 mol 比例") st.caption("胆固醇 mol 比例 (%)")
col1, col2 = st.columns(2) col1, col2 = st.columns(2)
with col1: with col1:
cholesterol_mol_min = st.number_input("最小", min_value=0.00, max_value=1.00, value=0.00, step=0.05, format="%.2f", key="chol_min") cholesterol_mol_min = st.number_input("最小", min_value=0.0, max_value=100.0, value=0.0, step=5.0, format="%.1f", key="chol_min")
with col2: with col2:
cholesterol_mol_max = st.number_input("最大", min_value=0.00, max_value=1.00, value=0.80, step=0.05, format="%.2f", key="chol_max") cholesterol_mol_max = st.number_input("最大", min_value=0.0, max_value=100.0, value=80.0, step=5.0, format="%.1f", key="chol_max")
st.caption("PEG 脂质 mol 比例") st.caption("PEG 脂质 mol 比例 (%)")
col1, col2 = st.columns(2) col1, col2 = st.columns(2)
with col1: with col1:
peg_mol_min = st.number_input("最小", min_value=0.00, max_value=0.20, value=0.00, step=0.01, format="%.2f", key="peg_min") peg_mol_min = st.number_input("最小", min_value=0.0, max_value=20.0, value=0.0, step=1.0, format="%.1f", key="peg_min")
with col2: with col2:
peg_mol_max = st.number_input("最大", min_value=0.00, max_value=0.20, value=0.05, step=0.01, format="%.2f", key="peg_max") peg_mol_max = st.number_input("最大", min_value=0.0, max_value=20.0, value=5.0, step=1.0, format="%.1f", key="peg_max")
comp_ranges = { comp_ranges = {
"weight_ratio_min": weight_ratio_min, "weight_ratio_min": weight_ratio_min,
@ -453,13 +482,12 @@ def main():
"peg_mol_max": peg_mol_max, "peg_mol_max": peg_mol_max,
} }
# 简单验证
min_sum = cationic_mol_min + phospholipid_mol_min + cholesterol_mol_min + peg_mol_min min_sum = cationic_mol_min + phospholipid_mol_min + cholesterol_mol_min + peg_mol_min
max_sum = cationic_mol_max + phospholipid_mol_max + cholesterol_mol_max + peg_mol_max max_sum = cationic_mol_max + phospholipid_mol_max + cholesterol_mol_max + peg_mol_max
if min_sum > 1.0 or max_sum < 1.0: if min_sum > 100.0 or max_sum < 100.0:
st.warning("⚠️ 当前范围设置可能无法生成有效配方（mol 比例需加起来为 100%）") st.warning("⚠️ 当前范围设置可能无法生成有效配方（mol 比例需加起来为 100%）")
else: else:
comp_ranges = None # 使用默认值 comp_ranges = None
st.markdown("**评分/排序权重**") st.markdown("**评分/排序权重**")
use_custom_scoring = st.checkbox( use_custom_scoring = st.checkbox(
@ -575,6 +603,7 @@ def main():
num_seeds=num_seeds, num_seeds=num_seeds,
top_per_seed=top_per_seed, top_per_seed=top_per_seed,
step_sizes=step_sizes, step_sizes=step_sizes,
wr_step_sizes=wr_step_sizes_val,
comp_ranges=comp_ranges, comp_ranges=comp_ranges,
routes=selected_routes, routes=selected_routes,
scoring_weights=scoring_weights, scoring_weights=scoring_weights,

153
app/optimize.py
View File

@ -44,22 +44,22 @@ AVAILABLE_ORGANS = ["lymph_nodes", "heart", "liver", "spleen", "lung", "kidney",
@dataclass @dataclass
class CompRanges: class CompRanges:
"""组分参数范围配置""" """组分参数范围配置（mol 比例为百分数 0-100）"""
# 阳离子脂质/mRNA 重量比 # 阳离子脂质/mRNA 重量比
weight_ratio_min: float = 0.05 weight_ratio_min: float = 5.0
weight_ratio_max: float = 0.30 weight_ratio_max: float = 30.0
# 阳离子脂质 mol 比例 # 阳离子脂质 mol 比例 (%)
cationic_mol_min: float = 0.05 cationic_mol_min: float = 5.0
cationic_mol_max: float = 0.80 cationic_mol_max: float = 80.0
# 磷脂 mol 比例 # 磷脂 mol 比例 (%)
phospholipid_mol_min: float = 0.00 phospholipid_mol_min: float = 0.0
phospholipid_mol_max: float = 0.80 phospholipid_mol_max: float = 80.0
# 胆固醇 mol 比例 # 胆固醇 mol 比例 (%)
cholesterol_mol_min: float = 0.00 cholesterol_mol_min: float = 0.0
cholesterol_mol_max: float = 0.80 cholesterol_mol_max: float = 80.0
# PEG 脂质 mol 比例 # PEG 脂质 mol 比例 (%)
peg_mol_min: float = 0.00 peg_mol_min: float = 0.0
peg_mol_max: float = 0.05 peg_mol_max: float = 5.0
def to_dict(self) -> Dict: def to_dict(self) -> Dict:
"""转换为字典""" """转换为字典"""
@ -94,10 +94,10 @@ class CompRanges:
min_sum = self.cationic_mol_min + self.phospholipid_mol_min + self.cholesterol_mol_min + self.peg_mol_min min_sum = self.cationic_mol_min + self.phospholipid_mol_min + self.cholesterol_mol_min + self.peg_mol_min
max_sum = self.cationic_mol_max + self.phospholipid_mol_max + self.cholesterol_mol_max + self.peg_mol_max max_sum = self.cationic_mol_max + self.phospholipid_mol_max + self.cholesterol_mol_max + self.peg_mol_max
if min_sum > 1.0: if min_sum > 100.0:
return f"mol比例最小值之和({min_sum:.2f})超过100%，无法生成有效配方" return f"mol比例最小值之和({min_sum:.1f}%)超过100%，无法生成有效配方"
if max_sum < 1.0: if max_sum < 100.0:
return f"mol比例最大值之和({max_sum:.2f})不足100%，无法生成有效配方" return f"mol比例最大值之和({max_sum:.1f}%)不足100%，无法生成有效配方"
return None return None
@ -109,11 +109,14 @@ class CompRanges:
# 默认组分范围 # 默认组分范围
DEFAULT_COMP_RANGES = CompRanges() DEFAULT_COMP_RANGES = CompRanges()
# 最小 step size # PEG 最小 step size (百分数)
MIN_STEP_SIZE = 0.01 MIN_STEP_SIZE = 1
# 迭代策略：每个迭代的 step_size # 迭代策略：mol ratio 的 step_size (百分数)
ITERATION_STEP_SIZES = [0.10, 0.02, 0.01] MOL_STEP_SIZES = [10, 2, 1]
# 迭代策略：weight ratio 的 step_size（与 mol ratio 解耦）
WR_STEP_SIZES = [5, 2, 1]
# Helper lipid 选项（不包含 DOTAP） # Helper lipid 选项（不包含 DOTAP）
HELPER_LIPID_OPTIONS = ["DOPE", "DSPC"] HELPER_LIPID_OPTIONS = ["DOPE", "DSPC"]
@ -343,51 +346,46 @@ def generate_grid_values(
def generate_initial_grid( def generate_initial_grid(
step_size: float, mol_step: float,
wr_step: float,
comp_ranges: CompRanges = None, comp_ranges: CompRanges = None,
) -> List[Tuple[float, float, float, float, float]]: ) -> List[Tuple[float, float, float, float, float]]:
""" """
生成初始搜索网格（满足 mol ratio 和为 1 的约束）。 生成初始搜索网格（满足 mol ratio 和为 100% 的约束）。
Args: Args:
step_size: 搜索步长 mol_step: mol ratio 搜索步长 (百分数)
wr_step: weight ratio 搜索步长
comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES） comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES）
Returns: Returns:
List of (cationic_ratio, cationic_mol, phospholipid_mol, cholesterol_mol, peg_mol) List of (weight_ratio, cationic_mol, phospholipid_mol, cholesterol_mol, peg_mol)
""" """
if comp_ranges is None: if comp_ranges is None:
comp_ranges = DEFAULT_COMP_RANGES comp_ranges = DEFAULT_COMP_RANGES
grid = [] grid = []
# Cationic_Lipid_to_mRNA_weight_ratio
weight_ratios = np.arange( weight_ratios = np.arange(
comp_ranges.weight_ratio_min, comp_ranges.weight_ratio_min,
comp_ranges.weight_ratio_max + 0.001, comp_ranges.weight_ratio_max + 0.001,
step_size wr_step
) )
# PEG: 单独处理，范围很小，始终用最小步长
peg_values = np.arange( peg_values = np.arange(
comp_ranges.peg_mol_min, comp_ranges.peg_mol_min,
comp_ranges.peg_mol_max + 0.001, comp_ranges.peg_mol_max + 0.001,
MIN_STEP_SIZE MIN_STEP_SIZE
) )
# 其他三个 mol ratio 需要满足和为 1 - PEG
mol_step = step_size
for weight_ratio in weight_ratios: for weight_ratio in weight_ratios:
for peg in peg_values: for peg in peg_values:
remaining = 1.0 - peg remaining = 100.0 - peg
# 生成满足约束的组合
cationic_max = min(comp_ranges.cationic_mol_max, remaining) + 0.001 cationic_max = min(comp_ranges.cationic_mol_max, remaining) + 0.001
for cationic_mol in np.arange(comp_ranges.cationic_mol_min, cationic_max, mol_step): for cationic_mol in np.arange(comp_ranges.cationic_mol_min, cationic_max, mol_step):
phospholipid_max = min(comp_ranges.phospholipid_mol_max, remaining - cationic_mol) + 0.001 phospholipid_max = min(comp_ranges.phospholipid_mol_max, remaining - cationic_mol) + 0.001
for phospholipid_mol in np.arange(comp_ranges.phospholipid_mol_min, phospholipid_max, mol_step): for phospholipid_mol in np.arange(comp_ranges.phospholipid_mol_min, phospholipid_max, mol_step):
cholesterol_mol = remaining - cationic_mol - phospholipid_mol cholesterol_mol = remaining - cationic_mol - phospholipid_mol
# 检查约束
if (comp_ranges.cholesterol_mol_min <= cholesterol_mol <= comp_ranges.cholesterol_mol_max): if (comp_ranges.cholesterol_mol_min <= cholesterol_mol <= comp_ranges.cholesterol_mol_max):
grid.append(( grid.append((
round(weight_ratio, 4), round(weight_ratio, 4),
@ -402,7 +400,8 @@ def generate_initial_grid(
def generate_refined_grid( def generate_refined_grid(
seeds: List[Formulation], seeds: List[Formulation],
step_size: float, mol_step: float,
wr_step: float,
radius: int = 2, radius: int = 2,
comp_ranges: CompRanges = None, comp_ranges: CompRanges = None,
) -> List[Tuple[float, float, float, float, float]]: ) -> List[Tuple[float, float, float, float, float]]:
@ -411,7 +410,8 @@ def generate_refined_grid(
Args: Args:
seeds: 种子配方列表 seeds: 种子配方列表
step_size: 步长 mol_step: mol ratio 步长 (百分数)
wr_step: weight ratio 步长
radius: 扩展半径 radius: 扩展半径
comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES） comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES）
@ -424,35 +424,31 @@ def generate_refined_grid(
grid_set = set() grid_set = set()
for seed in seeds: for seed in seeds:
# Weight ratio
weight_ratios = generate_grid_values( weight_ratios = generate_grid_values(
seed.cationic_lipid_to_mrna_ratio, step_size, seed.cationic_lipid_to_mrna_ratio, wr_step,
comp_ranges.weight_ratio_min, comp_ranges.weight_ratio_max, radius comp_ranges.weight_ratio_min, comp_ranges.weight_ratio_max, radius
) )
# PEG (始终用最小步长)
peg_values = generate_grid_values( peg_values = generate_grid_values(
seed.peg_lipid_mol_ratio, MIN_STEP_SIZE, seed.peg_lipid_mol_ratio, MIN_STEP_SIZE,
comp_ranges.peg_mol_min, comp_ranges.peg_mol_max, radius comp_ranges.peg_mol_min, comp_ranges.peg_mol_max, radius
) )
# Mol ratios
cationic_mols = generate_grid_values( cationic_mols = generate_grid_values(
seed.cationic_lipid_mol_ratio, step_size, seed.cationic_lipid_mol_ratio, mol_step,
comp_ranges.cationic_mol_min, comp_ranges.cationic_mol_max, radius comp_ranges.cationic_mol_min, comp_ranges.cationic_mol_max, radius
) )
phospholipid_mols = generate_grid_values( phospholipid_mols = generate_grid_values(
seed.phospholipid_mol_ratio, step_size, seed.phospholipid_mol_ratio, mol_step,
comp_ranges.phospholipid_mol_min, comp_ranges.phospholipid_mol_max, radius comp_ranges.phospholipid_mol_min, comp_ranges.phospholipid_mol_max, radius
) )
for weight_ratio in weight_ratios: for weight_ratio in weight_ratios:
for peg in peg_values: for peg in peg_values:
remaining = 1.0 - peg remaining = 100.0 - peg
for cationic_mol in cationic_mols: for cationic_mol in cationic_mols:
for phospholipid_mol in phospholipid_mols: for phospholipid_mol in phospholipid_mols:
cholesterol_mol = remaining - cationic_mol - phospholipid_mol cholesterol_mol = remaining - cationic_mol - phospholipid_mol
# 检查约束
if (comp_ranges.cationic_mol_min <= cationic_mol <= comp_ranges.cationic_mol_max and if (comp_ranges.cationic_mol_min <= cationic_mol <= comp_ranges.cationic_mol_max and
comp_ranges.phospholipid_mol_min <= phospholipid_mol <= comp_ranges.phospholipid_mol_max and comp_ranges.phospholipid_mol_min <= phospholipid_mol <= comp_ranges.phospholipid_mol_max and
comp_ranges.cholesterol_mol_min <= cholesterol_mol <= comp_ranges.cholesterol_mol_max and comp_ranges.cholesterol_mol_min <= cholesterol_mol <= comp_ranges.cholesterol_mol_max and
@ -677,7 +673,8 @@ def select_top_k(
def generate_single_seed_grid( def generate_single_seed_grid(
seed: Formulation, seed: Formulation,
step_size: float, mol_step: float,
wr_step: float,
radius: int = 2, radius: int = 2,
comp_ranges: CompRanges = None, comp_ranges: CompRanges = None,
) -> List[Tuple[float, float, float, float, float]]: ) -> List[Tuple[float, float, float, float, float]]:
@ -686,7 +683,8 @@ def generate_single_seed_grid(
Args: Args:
seed: 种子配方 seed: 种子配方
step_size: 步长 mol_step: mol ratio 步长 (百分数)
wr_step: weight ratio 步长
radius: 扩展半径 radius: 扩展半径
comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES） comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES）
@ -698,35 +696,31 @@ def generate_single_seed_grid(
grid_set = set() grid_set = set()
# Weight ratio
weight_ratios = generate_grid_values( weight_ratios = generate_grid_values(
seed.cationic_lipid_to_mrna_ratio, step_size, seed.cationic_lipid_to_mrna_ratio, wr_step,
comp_ranges.weight_ratio_min, comp_ranges.weight_ratio_max, radius comp_ranges.weight_ratio_min, comp_ranges.weight_ratio_max, radius
) )
# PEG (始终用最小步长)
peg_values = generate_grid_values( peg_values = generate_grid_values(
seed.peg_lipid_mol_ratio, MIN_STEP_SIZE, seed.peg_lipid_mol_ratio, MIN_STEP_SIZE,
comp_ranges.peg_mol_min, comp_ranges.peg_mol_max, radius comp_ranges.peg_mol_min, comp_ranges.peg_mol_max, radius
) )
# Mol ratios
cationic_mols = generate_grid_values( cationic_mols = generate_grid_values(
seed.cationic_lipid_mol_ratio, step_size, seed.cationic_lipid_mol_ratio, mol_step,
comp_ranges.cationic_mol_min, comp_ranges.cationic_mol_max, radius comp_ranges.cationic_mol_min, comp_ranges.cationic_mol_max, radius
) )
phospholipid_mols = generate_grid_values( phospholipid_mols = generate_grid_values(
seed.phospholipid_mol_ratio, step_size, seed.phospholipid_mol_ratio, mol_step,
comp_ranges.phospholipid_mol_min, comp_ranges.phospholipid_mol_max, radius comp_ranges.phospholipid_mol_min, comp_ranges.phospholipid_mol_max, radius
) )
for weight_ratio in weight_ratios: for weight_ratio in weight_ratios:
for peg in peg_values: for peg in peg_values:
remaining = 1.0 - peg remaining = 100.0 - peg
for cationic_mol in cationic_mols: for cationic_mol in cationic_mols:
for phospholipid_mol in phospholipid_mols: for phospholipid_mol in phospholipid_mols:
cholesterol_mol = remaining - cationic_mol - phospholipid_mol cholesterol_mol = remaining - cationic_mol - phospholipid_mol
# 检查约束
if (comp_ranges.cationic_mol_min <= cationic_mol <= comp_ranges.cationic_mol_max and if (comp_ranges.cationic_mol_min <= cationic_mol <= comp_ranges.cationic_mol_max and
comp_ranges.phospholipid_mol_min <= phospholipid_mol <= comp_ranges.phospholipid_mol_max and comp_ranges.phospholipid_mol_min <= phospholipid_mol <= comp_ranges.phospholipid_mol_max and
comp_ranges.cholesterol_mol_min <= cholesterol_mol <= comp_ranges.cholesterol_mol_max and comp_ranges.cholesterol_mol_min <= cholesterol_mol <= comp_ranges.cholesterol_mol_max and
@ -751,6 +745,7 @@ def optimize(
num_seeds: Optional[int] = None, num_seeds: Optional[int] = None,
top_per_seed: int = 1, top_per_seed: int = 1,
step_sizes: Optional[List[float]] = None, step_sizes: Optional[List[float]] = None,
wr_step_sizes: Optional[List[float]] = None,
comp_ranges: Optional[CompRanges] = None, comp_ranges: Optional[CompRanges] = None,
routes: Optional[List[str]] = None, routes: Optional[List[str]] = None,
scoring_weights: Optional[ScoringWeights] = None, scoring_weights: Optional[ScoringWeights] = None,
@ -772,7 +767,8 @@ def optimize(
top_k: 最终返回的最优配方数 top_k: 最终返回的最优配方数
num_seeds: 第一次迭代后保留的种子点数量（默认为 top_k * 5） num_seeds: 第一次迭代后保留的种子点数量（默认为 top_k * 5）
top_per_seed: 每个种子点的邻域搜索后保留的局部最优点数量 top_per_seed: 每个种子点的邻域搜索后保留的局部最优点数量
step_sizes: 每轮迭代的步长列表（默认为 [0.10, 0.02, 0.01]） step_sizes: mol ratio 每轮迭代的步长列表 (百分数，默认 [10, 2, 1])
wr_step_sizes: weight ratio 每轮迭代的步长列表 (默认 [5, 2, 1])
comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES） comp_ranges: 组分范围配置（默认使用 DEFAULT_COMP_RANGES）
routes: 给药途径列表（默认使用 ROUTE_OPTIONS） routes: 给药途径列表（默认使用 ROUTE_OPTIONS）
scoring_weights: 评分权重配置（默认仅按 biodist 排序） scoring_weights: 评分权重配置（默认仅按 biodist 排序）
@ -781,49 +777,52 @@ def optimize(
Returns: Returns:
最终 top-k 配方列表 最终 top-k 配方列表
""" """
# 默认 num_seeds 为 top_k * 5
if num_seeds is None: if num_seeds is None:
num_seeds = top_k * 5 num_seeds = top_k * 5
# 默认步长
if step_sizes is None: if step_sizes is None:
step_sizes = ITERATION_STEP_SIZES step_sizes = MOL_STEP_SIZES
if wr_step_sizes is None:
wr_step_sizes = WR_STEP_SIZES
# 两组步长长度必须一致
if len(wr_step_sizes) != len(step_sizes):
raise ValueError(
f"step_sizes ({len(step_sizes)}) 和 wr_step_sizes ({len(wr_step_sizes)}) 长度不一致"
)
# 默认组分范围
if comp_ranges is None: if comp_ranges is None:
comp_ranges = DEFAULT_COMP_RANGES comp_ranges = DEFAULT_COMP_RANGES
# 默认给药途径
if routes is None: if routes is None:
routes = ROUTE_OPTIONS routes = ROUTE_OPTIONS
# 默认评分权重
if scoring_weights is None: if scoring_weights is None:
scoring_weights = DEFAULT_SCORING_WEIGHTS scoring_weights = DEFAULT_SCORING_WEIGHTS
# 评分函数（用于 Formulation 对象排序）
def _score(f: Formulation) -> float: def _score(f: Formulation) -> float:
return compute_formulation_score(f, organ, scoring_weights) return compute_formulation_score(f, organ, scoring_weights)
logger.info(f"Starting optimization for organ: {organ}") logger.info(f"Starting optimization for organ: {organ}")
logger.info(f"SMILES: {smiles}") logger.info(f"SMILES: {smiles}")
logger.info(f"Strategy: num_seeds={num_seeds}, top_per_seed={top_per_seed}, top_k={top_k}") logger.info(f"Strategy: num_seeds={num_seeds}, top_per_seed={top_per_seed}, top_k={top_k}")
logger.info(f"Step sizes: {step_sizes}") logger.info(f"Mol step sizes: {step_sizes}, WR step sizes: {wr_step_sizes}")
logger.info(f"Routes: {routes}") logger.info(f"Routes: {routes}")
logger.info(f"Scoring weights: biodist={scoring_weights.biodist_weight}, delivery={scoring_weights.delivery_weight}, size={scoring_weights.size_weight}") logger.info(f"Scoring weights: biodist={scoring_weights.biodist_weight}, delivery={scoring_weights.delivery_weight}, size={scoring_weights.size_weight}")
logger.info(f"Comp ranges: {comp_ranges.to_dict()}") logger.info(f"Comp ranges: {comp_ranges.to_dict()}")
seeds = None seeds = None
for iteration, step_size in enumerate(step_sizes): for iteration, (mol_step, wr_step) in enumerate(zip(step_sizes, wr_step_sizes)):
logger.info(f"\n{'='*60}") logger.info(f"\n{'='*60}")
logger.info(f"Iteration {iteration + 1}/{len(step_sizes)}, step_size={step_size}") logger.info(f"Iteration {iteration + 1}/{len(step_sizes)}, mol_step={mol_step}, wr_step={wr_step}")
logger.info(f"{'='*60}") logger.info(f"{'='*60}")
if seeds is None: if seeds is None:
# ==================== 第一次迭代：全局稀疏搜索 ==================== # ==================== 第一次迭代：全局稀疏搜索 ====================
logger.info("Generating initial grid (global sparse search)...") logger.info("Generating initial grid (global sparse search)...")
grid = generate_initial_grid(step_size, comp_ranges) grid = generate_initial_grid(mol_step, wr_step, comp_ranges)
logger.info(f"Grid size: {len(grid)} comp combinations") logger.info(f"Grid size: {len(grid)} comp combinations")
@ -853,8 +852,7 @@ def optimize(
all_local_best = [] all_local_best = []
for seed_idx, seed in enumerate(seeds): for seed_idx, seed in enumerate(seeds):
# 为当前种子点生成邻域网格 local_grid = generate_single_seed_grid(seed, mol_step, wr_step, radius=2, comp_ranges=comp_ranges)
local_grid = generate_single_seed_grid(seed, step_size, radius=2, comp_ranges=comp_ranges)
if len(local_grid) == 0: if len(local_grid) == 0:
# 如果没有新的网格点，保留原种子 # 如果没有新的网格点，保留原种子
@ -946,7 +944,8 @@ def main(
top_k: int = typer.Option(20, "--top-k", "-k", help="Number of top formulations to return"), top_k: int = typer.Option(20, "--top-k", "-k", help="Number of top formulations to return"),
num_seeds: Optional[int] = typer.Option(None, "--num-seeds", "-n", help="Number of seed points from first iteration (default: top_k * 5)"), num_seeds: Optional[int] = typer.Option(None, "--num-seeds", "-n", help="Number of seed points from first iteration (default: top_k * 5)"),
top_per_seed: int = typer.Option(1, "--top-per-seed", "-t", help="Number of local best to keep per seed"), top_per_seed: int = typer.Option(1, "--top-per-seed", "-t", help="Number of local best to keep per seed"),
step_sizes: Optional[str] = typer.Option(None, "--step-sizes", "-S", help="Comma-separated step sizes (e.g., '0.10,0.02,0.01')"), step_sizes: Optional[str] = typer.Option(None, "--step-sizes", "-S", help="Mol ratio step sizes, comma-separated (e.g., '10,2,1')"),
wr_step_sizes: Optional[str] = typer.Option(None, "--wr-step-sizes", help="Weight ratio step sizes, comma-separated (e.g., '5,2,1')"),
batch_size: int = typer.Option(256, "--batch-size", "-b", help="Prediction batch size"), batch_size: int = typer.Option(256, "--batch-size", "-b", help="Prediction batch size"),
device: str = typer.Option("cuda" if torch.cuda.is_available() else "cpu", "--device", "-d", help="Device"), device: str = typer.Option("cuda" if torch.cuda.is_available() else "cpu", "--device", "-d", help="Device"),
): ):
@ -961,7 +960,7 @@ def main(
示例: 示例:
python -m app.optimize --smiles "CC(C)..." --organ liver python -m app.optimize --smiles "CC(C)..." --organ liver
python -m app.optimize -s "CC(C)..." -o spleen -k 10 -n 30 -t 2 python -m app.optimize -s "CC(C)..." -o spleen -k 10 -n 30 -t 2
python -m app.optimize -s "CC(C)..." -o liver -S "0.10,0.05,0.02" python -m app.optimize -s "CC(C)..." -o liver -S "10,2,1" --wr-step-sizes "5,2,1"
""" """
# 验证器官 # 验证器官
if organ not in AVAILABLE_ORGANS: if organ not in AVAILABLE_ORGANS:
@ -977,12 +976,19 @@ def main(
logger.error(f"Invalid step sizes format: {step_sizes}") logger.error(f"Invalid step sizes format: {step_sizes}")
raise typer.Exit(1) raise typer.Exit(1)
parsed_wr_step_sizes = None
if wr_step_sizes:
try:
parsed_wr_step_sizes = [float(s.strip()) for s in wr_step_sizes.split(",")]
except ValueError:
logger.error(f"Invalid wr step sizes format: {wr_step_sizes}")
raise typer.Exit(1)
# 加载模型 # 加载模型
logger.info(f"Loading model from {model_path}") logger.info(f"Loading model from {model_path}")
device = torch.device(device) device = torch.device(device)
model = load_model(model_path, device) model = load_model(model_path, device)
# 执行优化（层级搜索策略）
results = optimize( results = optimize(
smiles=smiles, smiles=smiles,
organ=organ, organ=organ,
@ -992,6 +998,7 @@ def main(
num_seeds=num_seeds, num_seeds=num_seeds,
top_per_seed=top_per_seed, top_per_seed=top_per_seed,
step_sizes=parsed_step_sizes, step_sizes=parsed_step_sizes,
wr_step_sizes=parsed_wr_step_sizes,
batch_size=batch_size, batch_size=batch_size,
) )

439
data/interim/internal_corrected.csv
View File

@ -1,439 +0,0 @@
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O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC,DSPC,0,0,1,0,17.33731463,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,5.12455904041457,-,0.0210297731298931,0.658450324145507,0.200900368909969,0.111879408982101,0.00774012483253011,77.5%?,0.0342179895228306,0.0342179895228306,-1.0250573081218382
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,5.112590016619249,-,0.00128819081649658,0.393692319023747,0.589452131076946,0.0101812483827002,0.00538611070010966,77.5%?,1.0,1.0,0.4646149359523945
O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H](C)N(CCCCCCCCCCCC)CCCCCCCCCCCC,DSPC,0,0,1,0,15.85660447,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.114394528387108,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.63293083,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,5.272999558563747,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O,DSPC,0,0,1,0,16.2856483,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.28978103552575,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)NCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC,DSPC,0,0,1,0,16.23582504,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.260615499364025,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)CN(CCCCCCCCCCCC)CCCCCCCCCCCC,DSPC,0,0,1,0,15.75702627,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.9788005705762375,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)=O)CO)CCCCCCOC(CCCCC)=O)CCCCC,DSPC,0,0,1,0,16.47477668,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.68213122712422,-,-,-,-,-,-,-,0.0,,
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.686750172980514,-,-,-,-,-,-,-,1.0,1.0,0.4646149359523945
CCCCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,19.33366115,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.98780245,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.9473404437239425,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCN(CCCNC([C@@H](N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)CO)=O)CCCCCCCCCCCCCC,DSPC,0,0,1,0,16.42695266,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.545101659521972,-,0.00318490682025255,0.0608074236431031,0.251089505980848,0.00892095913117615,0.00601048706680474,0.669986717357815,0.0815243428420059,0.0815243428420059,-0.9520895361573071
CCCCCCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)=O)CO)CCCCCCCCCCCCCC,DSPC,0,0,1,0,16.68206611,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.844974178195408,-,-,-,-,-,-,-,0.0,,
O=C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H]([C@H](O)C)N(CCCCCCCCCCCC)CCCCCCCCCCCC,DSPC,0,0,1,0,15.77114057,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,thr,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.331522502500114,-,0.0131160505661734,0.0817206877958181,0.209957462105326,0.0363069917919837,0.0161572104727098,0.642741597267989,0.0248953087459781,0.0248953087459781,-1.0394370942878488
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.16832078,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.4135253017332525,-,0.00151329913495755,0.0471551068594211,0.0476760649180962,0.00182335320536251,0.00763287581452213,0.89419930006764,0.35502103370942,0.35502103370942,-0.5302340606861489
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C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.89554445,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.496359280129911,-,-,-,-,-,-,-,0.0,,
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C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.89554445,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.508769411701737,0.0963955724315343,0.000259669027359828,0.0209585518067849,0.0324510369422159,0.00191021824445882,0.00526970020363582,0.84275525134401,0.95415067884307,0.95415067884307,0.3938945659349633
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CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.33700102,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.9082333604781745,0.00523681863830338,0.000823668079767528,0.00977318183991921,0.0124596675509096,0.00267973433328739,0.00363617950788083,0.965390750049932,0.316498770359056,0.316498770359056,-0.5896527968703137
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.33700102,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.9082333604781745,-,0.010109099822305,0.45796731805265,0.507501663530466,0.0194068402228631,0.00501507837171616,-,0.0817828774610745,0.0817828774610745,-0.5807198479650095
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O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.590361070334383,-,0.00283873189227405,0.901276452952094,0.0938738308613158,0.00141019974741145,0.000600784546904834,-,1.0,1.0,1.8695349995476385
O=C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)[C@H](C)N(CCCCCCCCCC)CCCCCCCCCC,DSPC,0,0,1,0,14.63651378,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.442651256490317,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.97521151,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.530769863411841,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)CN(CCCCCCCCCC)CCCCCCCCCC,DSPC,0,0,1,0,14.88045619,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.48874872297084,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)CN(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.83327693,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.343844382133684,-,-,-,-,-,-,-,0.0,,
O=C(NCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.53889564,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.301494223781961,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.27376909,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.596939379038152,-,-,-,-,-,-,-,0.0,,
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O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC,DSPC,0,0,1,0,15.06368788,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.403665809777363,0.0159262664008309,0.00726471746994425,0.0644691443511897,0.0154248397225439,0.00666778094817397,0.00618426236554005,0.884062988741777,0.163983867672707,0.163983867672707,-0.8248996899319107
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CCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.40770989,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.168208681201016,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.93089479,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.697749367281185,-,-,-,-,-,-,-,0.0,,
O=C(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC,DSPC,0,0,1,0,16.38737682,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.2112383136936,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.61200662,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.27999390910873,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,17.2554924,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.611152257665639,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.391561,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,5.1422481808981475,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC,DSPC,0,0,1,0,16.63400342,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.515354881665727,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC,DSPC,0,0,1,0,17.25637024,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.57532934397707,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC,DSPC,0,0,1,0,17.79833258,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.451896454476337,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,17.2554924,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.925077405734609,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.391561,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.829912458665998,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC,DSPC,0,0,1,0,16.63400342,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.421728001525434,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC,DSPC,0,0,1,0,17.25637024,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.775756486563625,-,-,-,-,-,-,-,0.0,,
O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC,DSPC,0,0,1,0,17.79833258,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,8.862341963516347,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.55042057,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,5.5506312951620265,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)O,DSPC,0,0,1,0,14.34229222,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.47597224751641,-,-,-,-,-,-,-,0.0,,
CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)O,DSPC,0,0,1,0,15.30473405,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.563722996073918,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCC)O)O,DSPC,0,0,1,0,16.11614863,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.275554390163365,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCCCC)O)O,DSPC,0,0,1,0,16.80938411,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.35709336812867,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O,DSPC,0,0,1,0,17.32727581,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.473579765600494,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CCCCCCOC(CCCCCCC)=O,DSPC,0,0,1,0,17.03239796,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.5612182984589085,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.71577453,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.695924549256556,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCCCCN(CC(O)CCCCCC)CC(O)CCCCCC)=O)N(CC(CCCCCC)O)CC(CCCCCC)O,DSPC,0,0,1,0,14.72351388,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.857484114602081,-,-,-,-,-,-,-,0.0,,
CCCCCCCCC(CN([C@H](C(NCCCCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CO)CC(CCCCCCCC)O)O,DSPC,0,0,1,0,15.6246954,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.483228515182849,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)=O)N(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O,DSPC,0,0,1,0,16.38850868,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.426521874560433,-,-,-,-,-,-,-,0.0,,
OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O,DSPC,0,0,1,0,17.04402965,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.412919498116252,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O,DSPC,0,0,1,0,17.53558149,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.69866052907543,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.95535314,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.9459189793765646,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC,DSPC,0,0,1,0,13.97521151,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ala,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.450269224770129,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O,DSPC,0,0,1,0,17.46731585,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.659658371272161,-,-,-,-,-,-,-,0.0,,
O=C(CCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O,DSPC,0,0,1,0,16.8769168,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,5.139321635057579,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O,DSPC,0,0,1,0,18.04309994,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.283448621312786,-,-,-,-,-,-,-,0.0,,
O=C(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O,DSPC,0,0,1,0,17.76093253,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,gly,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.1455128487965,-,-,-,-,-,-,-,0.0,,
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,18.07661492,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.3551691805039985,-,-,-,-,-,-,-,0.0,,
O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCC,DSPC,0,0,1,0,18.15212729,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,6.632923618509176,-,-,-,-,-,-,-,0.0,,
O=C(C(CCCCCCCC)CCCCCC)OCCCCCC[N+](CC)(CC)CC.[Br-],DSPC,0,0,1,0,12.69438691,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,TEA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.762173934797756,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.16832078,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.240751047315928,0.0111914004572023,0.00227125491616379,0.00877931935589419,0.0082437061808303,0.00401873844514775,0.00849693826019724,0.956998642384564,0.596141429580998,0.596141429580998,-0.1583174611704737
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OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=O,DSPC,0,0,1,0,15.66191374,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DBU,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.647271362006727,-,-,-,-,-,-,-,0.0,,
OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.541058240520847,0.0155523974922323,0.00129152518305059,0.446962380102849,0.0407067099579296,0.00170625578284345,0.00421830607343662,0.489562425407659,1.0,1.0,0.4646149359523945
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.379899373657707,0.0165979002447495,0.00361970146585138,0.310566371988181,0.0118953898978584,0.00727497963461814,0.00647222326114303,0.643573433507598,1.0,1.0,0.4646149359523945
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.83323084,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.1751562049585145,0.127270779777207,0.0355651632001246,0.0965373529640882,0.0454740204097531,0.0338026797538366,0.0465840928565864,0.614765911038405,0.0505010966098528,0.0505010966098528,-0.999941399550668
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.95682792,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.416186486320586,0.0275897803818406,0.0140220813902507,0.0611423332934752,0.0248626002542061,0.0133347505104052,0.0187510241318683,0.840297430037954,0.11103838626238,0.11103838626238,-0.9065655454256818
C=CCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)=O,DSPC,0,0,1,0,18.01719192,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.445588116163626,0.0250376334304389,0.00337885545037859,0.0517009582142691,0.0430146012578083,0.00350252056656834,0.00406753936383155,0.869297891716705,0.594087846809013,0.594087846809013,-0.1614850137062924
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O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.382151626862033,0.0281381236661192,0.00268792352252722,0.218417144486954,0.0369503427520482,0.00199553488006137,0.00289937744032574,0.708911553251965,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,17.83044719,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.199605072879594,0.0747106900577881,0.0465999615731367,0.107994265529626,0.0501322770872438,0.0448116344718523,0.0485065251769853,0.627244646103368,0.0685266977729659,0.0685266977729659,-0.9721377777766667
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O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.3651347670036635,0.0896852170263435,0.00316402812450449,0.145700011838927,0.0181473232698177,0.0048727657230144,0.00676784889254742,0.731662805124845,1.0,1.0,0.4646149359523945
O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCCCCCC,DSPC,0,0,1,0,17.93964861,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.27430221608671,0.0441668582339066,0.00173504332049564,0.0552287456296669,0.0103338721124601,0.00424436496446174,0.00798306414101548,0.876308051597994,0.118006736161235,0.118006736161235,-0.8958172012665345
O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C,DSPC,0,0,1,0,17.66483929,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.322011202263895,0.014374943627672,0.00199135248489222,0.0891563599260395,0.0109943655858212,0.00408170887074953,0.00721565797781185,0.872185611527014,0.120117219447052,0.120117219447052,-0.8925618824281657
C=CCCCCCCCCC(OCCCCCCN(CCOCCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O,DSPC,0,0,1,0,17.93091393,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.589955020181611,0.159505299591344,0.00863892692709962,0.059163494819016,0.0251436766117119,0.0207012928199433,0.0319161553971728,0.694931153833713,0.19624671777719,0.19624671777719,-0.775135797258418
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.461068842013835,0.18227458966528,0.00260059752378256,0.10140002712747,0.0194272464327483,0.00394998811850684,0.00708234329707097,0.683265207835141,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,18.16832078,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.897839799950911,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.87291972,32.96703297,21.97802198,43.95604396,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.667205576907544,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.34369997,41.32231405,16.52892562,41.32231405,0.826446281,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.786658062033468,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,11.12329906,27.02702703,32.43243243,37.83783784,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.520374534283375,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.602904588,25.0,40.0,30.0,5.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.2162671661789055,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.22342652,38.46153846,21.97802198,38.46153846,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,4.634728988229636,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.21412129,40.0,34.28571429,22.85714286,2.857142857,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.378896741664954,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.29890072,34.65346535,39.6039604,24.75247525,0.99009901,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.661550519424199,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.62419529,41.86046512,37.20930233,18.60465116,2.325581395,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.552612935249416,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.26075368,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,5.021245473208271,0.0189024787568605,0.00542838949966448,0.0161874266221436,0.00564673685028802,0.0063903753402389,0.0111802988958026,0.936264294035002,0.0913658402077254,0.0913658402077254,-0.9369095003865034
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.59373115,37.83783784,37.83783784,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.484470400750307,0.220192249542946,0.000764987158036526,0.00117389921248248,0.000355328494502401,0.000727082388944626,0.00146163086877099,0.775324822334317,0.909323670538887,0.909323670538887,0.3247510642635732
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.02523135,35.8974359,41.02564103,20.51282051,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.474947598938117,0.0634606467339624,0.00208550415241484,0.000693953783467295,0.000703971489002912,0.00107462659382075,0.00306678394465369,0.928914513302678,0.68813569412733,0.68813569412733,-0.016420738077667085
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.01459482,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.414493824811383,0.0115671522937999,0.000329262998462127,0.000782715410474643,0.000454168201139608,0.00050928396392566,0.0365052454816706,0.949852171650527,1.45919493888772,1.45919493888772,1.172901016723797
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.50825332,52.83018868,26.41509434,18.86792453,1.886792453,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.573163389853005,0.0289504727873473,0.000587630380490671,0.00098172979734669,0.000247631664832521,0.000530890620697785,0.00148666967519347,0.967214975074092,1.18732779204068,1.18732779204068,0.7535590344336197
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.02959744,50.90909091,29.09090909,18.18181818,1.818181818,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.424367475163407,0.01918176556647,0.0010650954164724,0.0022206234626453,0.00126505200881015,0.0010329415925789,0.00258134917445057,0.972653172778573,0.519739549496667,0.519739549496667,-0.2761636820795619
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.0526464,43.24324324,32.43243243,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.646312129319266,0.0173760673957131,0.000550323482827711,0.00231355504088989,0.000799250291024724,0.00171157517792979,0.00187915335599706,0.975370075255618,0.641975082983608,0.641975082983608,-0.08762125790960282
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.87880561,39.02439024,39.02439024,19.51219512,2.43902439,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.627909672957581,0.031425165165133,0.00121897501467252,0.00336392108926765,0.00273184674446895,0.00365496097119473,0.00253008289994281,0.95507504811532,0.292484943880311,0.292484943880311,-0.6266929678315919
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.72896002,41.02564103,30.76923077,25.64102564,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.6141299273595635,0.00243290161785256,0.00374029360494432,0.00771109158226845,0.00256075951190699,0.0024473081411263,0.00398520450059787,0.977122441041304,0.29000081469118,0.29000081469118,-0.6305246174829606
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.2936051730729785,0.0291199872991734,0.000702410023626044,0.0253755412996204,0.0176881988849176,0.000962484515645204,0.00126799370807735,0.92488338426894,1.0,1.0,0.4646149359523945
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.98993052,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.596835549198034,0.0642873127295256,0.000194616801396495,0.00548703707264694,0.0163820187916684,0.000849254927099769,0.000518055392084143,0.912281704285579,0.772854925639995,0.772854925639995,0.11425459688882487
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.26769266,37.83783784,37.83783784,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.284827171296749,0.000820324065776298,6.77505055763446e-05,0.00130838737685328,0.00203458073148474,0.00044026025400656,0.00179231955954145,0.993536377506761,0.647354606156059,0.647354606156059,-0.07932360246622268
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,12.69845587,35.8974359,41.02564103,20.51282051,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.355939299910563,0.000606683031689403,0.000350488437662207,0.00200552330636915,0.00341592792036262,0.00135658595795651,0.00484812686613966,0.98741666447982,0.429472560198128,0.429472560198128,-0.4153961662793264
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.73864775,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.210051369934071,0.0506054803736383,0.000934742670841204,0.00195746112246746,0.00131704918881155,0.00229254534633995,0.00362188526923176,0.93927083602867,0.295296757118666,0.295296757118666,-0.622355881313871
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.22254695,52.83018868,26.41509434,18.86792453,1.886792453,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.19614876167715,0.000394517913167851,0.000925918583325644,0.00219111536287718,0.00192843383777798,0.00141208216065332,0.00279803133939282,0.990349900802805,0.423957111788814,0.423957111788814,-0.4239034798551084
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,16.73562869,50.90909091,29.09090909,18.18181818,1.818181818,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.324000197151533,0.0149763371723649,9.09516394922477e-05,0.00865819492777344,0.00337158611087041,0.000870833891384162,0.00234291805381448,0.9696891782043,0.799987755503576,0.799987755503576,0.1561056803760758
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.73441264,43.24324324,32.43243243,21.62162162,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.638604962074329,0.00412763242238728,0.000587351434637121,0.00125519721482213,0.00156835329887146,0.00151910105091065,0.00332452673735467,0.987617837841017,0.519710678404319,0.519710678404319,-0.27620821434922566
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.55362203,39.02439024,39.02439024,19.51219512,2.43902439,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.465448242812954,0.001908149535057,0.00051106883667359,0.00195557181028906,0.00222543526142979,0.00102554934782431,0.0036709617373884,0.988703263471338,0.559906246507883,0.559906246507883,-0.21420848616098725
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.4082575,41.02564103,30.76923077,25.64102564,2.564102564,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.439351701293151,0.0164941051995163,0.00133624924425635,0.0136411729141475,0.0068725438331318,0.00281561744256348,0.00565863059250302,0.953181680773882,0.404416041627467,0.404416041627467,-0.4540446395817048
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.348211286179151,0.25310386523031,0.000588156076259717,0.140706646889545,0.17621759673582,0.00218337900345845,0.000839731767209391,0.426360624297398,1.0,1.0,0.4646149359523945
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,17.98993052,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.574298522321004,0.0173152888243317,0.00170643426094864,0.0181271736370668,0.0103847448319841,0.00234708518590686,0.00464250497463967,0.945476768285122,0.880302275630684,0.880302275630684,0.27998696013855723
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.54771521,32.96703297,21.97802198,43.95604396,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.530015512387331,0.0022188818222417,0.00151967168045253,0.0265741083102934,0.00935341146520975,0.00161955884356527,0.00594450434134348,0.952769863536894,0.693395601815244,0.693395601815244,-0.008307583759119837
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,16.03951812,41.32231405,16.52892562,41.32231405,0.826446281,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.640537329825382,0.0191565810814788,0.00120917820488213,0.00564887782228727,0.00368324602436162,0.00270413188019715,0.00625226385441887,0.961345721132374,0.702078866162311,0.702078866162311,0.005085933354948288
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,10.8033785,27.02702703,32.43243243,37.83783784,2.702702703,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.2431955089544555,0.0191175904912105,0.0046774627841674,0.0253721583259607,0.0153479247605493,0.0105242912643767,0.0240873946993884,0.900873177674347,0.168910555827937,0.168910555827937,-0.8173005106963921
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,9.298704135,25.0,40.0,30.0,5.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.822697998516666,0.00783638212803346,0.00315432464612104,0.0156004284210389,0.0122536904537434,0.00649575798551451,0.014293561001533,0.940365855364016,0.26946434750834,0.26946434750834,-0.6622011291820169
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.90666525,38.46153846,21.97802198,38.46153846,1.098901099,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,5.291292751611072,-,-,-,-,-,-,-,0.0,,
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,13.89035919,40.0,34.28571429,22.85714286,2.857142857,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.388753955423308,0.0457836478243602,0.00256820195313693,0.0933595380902435,0.040121791020458,0.00303459231576053,0.00719748271402532,0.807934746082015,0.638042293066864,0.638042293066864,-0.09368739697327609
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,12.97231927,34.65346535,39.6039604,24.75247525,0.99009901,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.500031867864786,0.00367784574047392,0.00111977791364668,0.0109807451773001,0.00533981749985873,0.0035253353907892,0.00945759694134628,0.965898881336585,0.664597706735618,0.664597706735618,-0.05272695016115616
C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O,DOPE,1,0,0,0,14.30278396,41.86046512,37.20930233,18.60465116,2.325581395,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.578518154990665,0.00602415700375336,0.00352191807012307,0.0129438874596237,0.0112365957475355,0.00705054455561779,0.0163551166761144,0.942867780487232,0.387412476367661,0.387412476367661,-0.48027182019083947
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DOPE,1,0,0,0,14.78083639,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.373742415086184,0.00132025329631253,0.000860633620224201,0.00503931327076771,0.0029913613071963,0.00270028184029275,0.0088532339643477,0.978234922700859,1.0,1.0,0.4646149359523945
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.434619084793052,0.00770185399584477,0.00244833711322221,0.0462111239750686,0.0198642411939162,0.00381226904350308,0.00922041774380283,0.910741756934642,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DSPC,0,0,1,0,11.7812451,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.485936098064394,0.00448668985970796,0.00155299888410839,0.00808200908228358,0.00771278024096098,0.00385266053622471,0.00536687174407294,0.968945989652641,1.22295554827804,1.22295554827804,0.8085131327805288
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.01459482,54.90196078,23.52941176,19.60784314,1.960784314,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.73444252169223,0.00221922165343577,0.00134658478491355,0.00928071520245763,0.0103471897935628,0.00308928870366618,0.00305991935175966,0.970657080510204,2.4848301850992,2.4848301850992,2.75489399469468
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.67100244,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.379899373657707,0.0165979002447495,0.00361970146585138,0.310566371988181,0.0118953898978584,0.00727497963461814,0.00647222326114303,0.643573433507598,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,18.26075368,50.0,10.0,38.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.7140245909001735,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.85564,30.9,36.3,25.9,6.9,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.002960000420248,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,12.10629825,33.7,32.2,28.8,5.4,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,,3.9917579734469997,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,8.076607527,21.5,44.3,27.4,6.7,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,4.150252194160397,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.262126773,28.5,36.9,23.3,11.4,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,,3.9384701754429945,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.14390228,47.0,40.4,5.7,6.8,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,,4.139158578011894,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.465333240800292,0.0929588198875335,0.00109661539851913,0.0103406974639253,0.00262333547972377,0.00257373980843396,0.00319533888859958,0.887211453073265,2.49616154919077,2.49616154919077,2.7723720781458008
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.95064466,41.0,39.5,16.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.25063580654847,0.00217929592656579,0.00233573351378476,0.00718449647353577,0.00718369422949875,0.00471157922942054,0.00408542775852615,0.972319772868668,1.71461830076508,1.71461830076508,1.5668792525462236
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,11.40653622,31.3333,31.3333,31.3333,6.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.188896879163323,0.0142737392382439,0.00348189340868737,0.00880858320276677,0.0038525568856599,0.00593274588142816,0.00610316587084082,0.957547315512373,0.645718762121967,0.645718762121967,-0.08184681311498729
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.77836699,50.0,23.5,23.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.343935283551159,0.0065593281978378,0.00138907609400551,0.00613919753007927,0.00613411120238244,0.00366825953495706,0.00406194129869205,0.972048086142046,1.35219591573978,1.35219591573978,1.0078601760398935
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.200348974,22.0,22.0,50.0,6.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.057161771094385,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.72417162,27.0,27.0,41.0,5.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,0,1,0,0,,4.102973888920155,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.092439729,16.0,39.5,41.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.127940511650616,0.0097349353786325,0.00823434520879355,0.0380775286515883,0.0189007253206434,0.0281939358827934,0.0273826912679074,0.869475838289641,0.161929321885153,0.161929321885153,-0.8280687278728707
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.93804335,39.5,16.0,41.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.116269119637892,0.00176070173692806,0.00134882241229812,0.00721447825021801,0.00277771416530431,0.00258248336542972,0.00338400053115958,0.980931799538662,0.834918279031508,0.834918279031508,0.2099843308438277
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.312676556539088,0.0122849683487715,0.00187692747865846,0.313004652084084,0.0267625511357853,0.00478000951875277,0.00400214034383056,0.637288751090117,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.5612182984589085,0.00230427148121394,0.00151653786120671,0.00981883965091339,0.0195498469521307,0.00278714514326426,0.00256552165624032,0.961457837255031,3.54213716664653,3.54213716664653,4.385739099273481
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,13.95064466,41.0,39.5,16.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.2756934238792645,0.00339636246099529,0.00439836397767252,0.00922438120812044,0.0070906355917358,0.00777777401057153,0.0070228258793507,0.961089656871554,1.60048193764837,1.60048193764837,1.3908294086580206
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.77836699,50.0,23.5,23.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.300138475201197,0.0251900613139205,0.0263858529561065,0.0690244086529141,0.0290319859464883,0.0512059292322219,0.0395084822769767,0.759653279621372,0.244442812501583,0.244442812501583,-0.7007956420217016
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.93804335,39.5,16.0,41.0,3.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.035478809355064,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.07835597,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.314416735011824,0.00832740543716945,0.00279899792781369,0.0133506530995165,0.00590470004845411,0.00800781451355169,0.00611088774111073,0.955499541232384,1.4036171732161,1.4036171732161,1.0871749895142324
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,12.46964291,32.3,32.3,32.3,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.122932019074013,0.00935369123549862,0.00681432683334856,0.0266295187790274,0.0091342786879667,0.0148394527045059,0.0109795829907811,0.922249148768872,0.807897092094877,0.807897092094877,0.168305451195249
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.23312059,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,0,1,0,0,0.0,4.214347354616797,0.00175971204953205,0.0023945553766021,0.00864096914216858,0.00287247113967731,0.00354165273920712,0.00438932700137801,0.976401312551435,2.1807873939408,2.1807873939408,2.28592263046752
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.297557478047431,0.0163588203416613,0.0050349858804786,0.141665503002976,0.0268932928836599,0.0108166459136593,0.00842178986187252,0.790808962115693,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.623991940228679,0.0114998638575461,0.00130788860611426,0.00505223783079306,0.0046933168158669,0.00183202266239377,0.00287251942980201,0.972742150797484,1.19732008331576,1.19732008331576,0.768971662548154
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.47398367,41.5,40.5,16.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.261975403606051,0.0120973279883405,0.00779128029381303,0.0260350268299895,0.0160802201335602,0.0156019499205845,0.0170739234476819,0.90532027138603,0.213285375768679,0.213285375768679,-0.7488544878005475
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.72570651,40.5,16.0,41.5,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.168678699274804,0.00644850088058007,0.00798921970887525,0.0221223520376599,0.0111631004951633,0.0106463671035197,0.00996963598739929,0.931660823786802,0.29077874869216,0.29077874869216,-0.6293246917477433
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.63764671,41.5,40.5,16.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.40562108352751,0.0088141667427258,0.00585903666298478,0.0157870816204507,0.010986042994209,0.00978368783097364,0.0102623946891479,0.938507589459508,0.370029347989408,0.370029347989408,-0.507084458632374
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.89020107,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.402441819416474,0.154933534385178,0.00229861102597737,0.00525615721273492,0.00408539799683711,0.0022876287732977,0.00287249757879639,0.828266173027179,1.34933481107146,1.34933481107146,1.003447059865073
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.91076362,42.0,40.5,16.5,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.607168188650764,0.0408588610755303,0.0177373482989948,0.0425327283385076,0.0277718677406049,0.0276871974121274,0.0218927074965806,0.821519289637654,0.158736230637426,0.158736230637426,-0.8329939173596629
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.86872188,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.4277167605909975,0.00307921600642319,0.00224989559352084,0.00599370029233814,0.00443157985269048,0.00263031532778781,0.00293093049696406,0.978684362430275,1.27822314397057,1.27822314397057,0.8937607377335357
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CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,17.98206341,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.573473099244837,0.00689869445402741,0.00600089779665737,0.0191135089301672,0.00620664286397134,0.00981653359048003,0.0097967903769499,0.942166931987747,0.749333285576466,0.749333285576466,0.07797359977185479
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CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,8.877221176,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.829113417472866,0.00517423746484337,0.00420818785762778,0.0136338012801862,0.00389526355348657,0.0081026937251479,0.00825574629036951,0.956730069828339,1.02766134878372,1.02766134878372,0.5072812344232112
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,14.07835597,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.4595662121293,0.025369932029363,0.00629969301959379,0.0185849502075566,0.00668329267445478,0.00984673129800659,0.00995848867776924,0.923256912093256,0.773367707896157,0.773367707896157,0.11504553882600273
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,9.306031912,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.528073135603124,0.00974026247143072,0.00459547921939943,0.0155882894773368,0.00424301614179951,0.00735125258984654,0.00918675243548622,0.949294947664701,0.925634770529548,0.925634770529548,0.34991015054061214
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,6.950074466,41.0,40.0,16.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.730921391293652,0.0307398296858454,0.00502448817507942,0.0144391987292623,0.00475975114719379,0.00732990645958348,0.00864531856689022,0.929061507236145,0.282355212986546,0.282355212986546,-0.6423175899395637
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.3578620076745835,0.0575651939642587,0.00224327504140443,0.293214190330324,0.103801109257072,0.00316596887134689,0.00243404296405076,0.537576219571543,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.23312059,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.1515122352784415,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.0693509,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.2656332579940335,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.52014814,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.431173877940127,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.89020107,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.436396441739405,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.50369223,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.5666372362713075,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.844529643,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,,4.765586907393996,-,-,-,-,-,-,-,0.0,,
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.23312059,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.149936935645806,0.0412282002133458,0.00282906106065428,0.0100452919302821,0.00294646346634102,0.0035555046437446,0.00510039590268196,0.93429508278295,2.31132936702855,2.31132936702855,2.4872773377263835
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.0693509,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.244200317766478,0.0307672106546614,0.0492440442693678,0.143087600825361,0.0409904333145751,0.0410729694241231,0.0628737572688051,0.631963984243106,0.159668526820479,0.159668526820479,-0.8315558953918857
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.52014814,40.0,16.0,41.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.430459592195472,0.0144382835185698,0.030629687100469,0.0904231657039977,0.0327120644783899,0.0374915496460484,0.0408664371206098,0.753438812431916,0.342029093157046,0.342029093157046,-0.5502735033632513
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,15.89020107,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.560277417097355,0.064087583051715,0.00731756531038673,0.0186036957891068,0.0053871458118381,0.00655845861152129,0.0086069303650773,0.889438621060355,2.14638048731397,2.14638048731397,2.232851633855025
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,10.50369223,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.667205576907544,0.00310349569550498,0.00416831577034203,0.0115025538737423,0.00349250282837259,0.00500126547712412,0.00690260249517487,0.965829263859739,3.35844880423818,3.35844880423818,4.1024086457439415
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,7.844529643,40.5,16.5,41.5,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.713127327493184,0.00089376253365906,0.00183788568066981,0.0054363636464257,0.00195410248071216,0.00225811087193407,0.00383533887250888,0.98378443591409,3.24722414573894,3.24722414573894,3.9308499660154896
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.359653205696989,0.0828383439279835,0.00565653685524585,0.157248489872984,0.00928479521934879,0.00688752099561758,0.00841921269728692,0.729665100431533,1.0,1.0,0.4646149359523945
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,16.86872188,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.634728988229636,0.00818072805535472,0.00273349879854757,0.0119346096951512,0.0075308964437597,0.00591367796700706,0.00578329104170321,0.957923297998477,0.213428398303373,0.213428398303373,-0.7486338824280105
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,11.15051107,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.7140245909001735,0.0160361616147136,0.00185083446366488,0.00730973501824061,0.00349956550575257,0.00416153151105757,0.00426975100661699,0.962872420879954,0.319359456002154,0.319359456002154,-0.58524032702172
CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O,DOPE,1,0,0,0,8.327596879,49.0,25.0,24.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ser,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,0.0,4.822697998516666,0.0208671125611406,0.0200298903914976,0.0765668274895919,0.0297655881927753,0.0442427715485906,0.0417155046265625,0.766812305189841,0.0431568482237034,0.0431568482237034,-1.011269549025132
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.548282323781043,0.235642631118293,0.00357683071882224,0.268183756367962,0.0537803810677977,0.0056567696761597,0.00550191880428196,0.427657712246684,1.0,1.0,0.4646149359523945
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.41834022,50.0,7.5,41.5,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.892602227184663,0.0004,0.0007,0.8627,0.1335,0.0019,0.0008,0,0.33,0.33,0.08164550420240263
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.34376213,50.0,29.0,20.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.935911747900319,0.0015,0.0017,0.585,0.3856,0.0215,0.0046,0,0.09,0.09,-0.5587925239809655
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.47881241,45.5,7.5,45.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.657762636107262,0.0008,0.0009,0.9399,0.0565,0.0012,0.0006,0,0.26,0.26,-0.10514892068441307
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.58994389,50.0,17.75,30.25,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.6520537718869415,0.0009,0.0008,0.8853,0.11,0.0021,0.0009,0,0.31,0.31,0.028275668520455245
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.356515817,38.0,30.0,30.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.522874943261261,0.0008,0.0012,0.7508,0.2416,0.0048,0.0008,0,0.12,0.12,-0.4787377704580445
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.211083767,38.0,16.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.802380355275797,0.0003,0.0007,0.8979,0.0985,0.0022,0.0005,0,0.45,0.45,0.40186451829408665
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.891852481,38.0,23.0,38.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.721173861744398,0.0003,0.0009,0.9061,0.0898,0.0024,0.0005,0,0.3,0.3,0.0015907506794815506
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.59856338,45.96,24.83,26.71,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.599152113662528,0.0006,0.0011,0.8386,0.1563,0.0028,0.0007,0,0.36,0.36,0.16170025772532357
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.516252746,44.58,19.33,33.08,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.539030383483547,0.0011,0.0009,0.9163,0.0784,0.0025,0.0008,0,0.24,0.24,-0.15851875636636045
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.79855736,50.0,7.5,39.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.602165676967792,0.0007,0.0007,0.9622,0.0349,0.001,0.0005,0,0.91,0.91,1.6293707389788754
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.789158454,42.5,30.0,24.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.506454213048934,0.0013,0.0022,0.7003,0.2848,0.009,0.0025,0,0.1,0.1,-0.5321076061399918
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.924427289,44.71,13.58,39.21,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.543294782270004,0.0006,0.0008,0.9464,0.0496,0.0015,0.0011,0,0.56,0.56,0.6953986145447971
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.213203287,41.46,24.83,32.21,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.600157644164547,0.0006,0.0011,0.9277,0.0684,0.0014,0.0008,0,0.44,0.44,0.37517960045311294
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.766920469,38.0,14.0,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.380775852772229,0.0005,0.001,0.9807,0.0157,0.0015,0.0006,0,0.46,0.46,0.42854943613506036
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.9150442,50.0,27.0,20.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.490881039585964,0.0013,0.001,0.7257,0.2649,0.0061,0.0009,0,0.13,0.13,-0.4520528526170708
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.33144164,47.24,11.19,38.87,2.71,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.627909672957581,0.0073,0.0639,0.7768,0.1461,0.0042,0.0016,0,1.3,1.3,2.670082534776849
OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.92222847,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.8543712716215905,0.001,0.001,0.8647,0.1302,0.0025,0.0007,0,0.25,0.25,-0.13183383852538677
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.314817884980432,0.0009,0.0007,0.9116,0.0844,0.0018,0.0006,0,1.0,1.0,1.8695349995476385
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.42041204,49.0,7.5,41.5,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.534747721691546,0.0013,0.0021,0.5194,0.4632,0.0111,0.0029,0,0.5,0.5,0.535289107498955
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,15.70987342,34.25,18.75,45.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.191168746857641,0.0011,0.0011,0.7685,0.2222,0.0053,0.0018,0,0.15,0.15,-0.3986830169351235
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,11.2192693,22.0,30.0,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.151039905898646,0.0028,0.0014,0.4022,0.5806,0.0101,0.003,0,0.05,0.05,-0.6655321953448602
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.76101632,49.0,28.0,20.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.154184562578117,0.001,0.0012,0.5862,0.3912,0.0188,0.0017,0,0.16,0.16,-0.37199809909414977
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.31421044,44.61,24.89,27.94,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.155753190350744,0.0041,0.0015,0.5886,0.3825,0.0211,0.0022,0,0.13,0.13,-0.4520528526170708
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,14.60470229,32.11,24.89,40.44,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.104294893075269,0.0017,0.0016,0.5892,0.3913,0.0129,0.0033,0,0.05,0.05,-0.6655321953448602
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.00750041,49.0,18.75,31.25,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.516338972281476,0.0111,0.0048,0.1796,0.7293,0.0671,0.0082,0,0.14,0.14,-0.4253679347760971
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.77390107,42.13,18.75,38.13,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.33204826486764,0.0167,0.0049,0.2598,0.6793,0.0289,0.0104,0,0.15,0.15,-0.3986830169351235
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.21646499,45.61,13.64,38.19,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.365643155423357,0.0042,0.0015,0.3443,0.6172,0.0298,0.003,0,0.2,0.2,-0.2652584277302551
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.27353562,44.5,7.5,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.436751534363128,0.0067,0.0013,0.5909,0.385,0.0142,0.0019,0,0.22,0.22,-0.21188859204830776
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.27759176,49.0,30.0,20.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.151039905898646,0.0122,0.0028,0.2395,0.6818,0.0594,0.0044,0,0.08,0.08,-0.5854774418219391
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,14.75114553,34.5,30.0,32.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.248495242049359,0.0029,0.0024,0.3338,0.6429,0.0151,0.0029,0,0.07,0.07,-0.6121623596629128
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,16.61008,39.36,24.89,34.19,1.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.384523514872469,0.0141,0.0106,0.3243,0.5845,0.0592,0.0073,0,0.14,0.14,-0.4253679347760971
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,12.46688772,24.0,30.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.796616650559047,0.0064,0.0026,0.3777,0.6006,0.0093,0.0034,0,0.1,0.1,-0.5321076061399918
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.37981918,46.5,7.5,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.516338972281476,0.0024,0.0028,0.4642,0.5174,0.0093,0.0039,0,0.81,0.81,1.362521560569139
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,16.04448224,37.36,29.94,31.71,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.370712874773608,0.033,0.008,0.1094,0.8115,0.0325,0.0056,0,0.11,0.11,-0.5054226882990182
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.34728513,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.623010104116422,0.0087,0.0033,0.2348,0.7393,0.011,0.003,0,0.36,0.36,0.16170025772532357
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,14.343031,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.375757021660286,0.0019,0.0023,0.9077,0.0818,0.0033,0.003,0,1.0,1.0,1.8695349995476385
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O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.630330503,34.25,18.75,45.0,2.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.395682961121367,0.03,0.0006,0.0837,0.0261,0.002,0.0013,0.8563,0.78,0.78,0.12527553001915628
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,5.746375559,22.0,30.0,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.264087336809195,0.0156,0.0014,0.0138,0.0104,0.0025,0.0031,0.9532,0.32,0.32,-0.584252318750342
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.15734025,49.0,28.0,20.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,1,0,0,1,0,0,0,,4.513054897080286,,,,,,,,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.812051718,44.61,24.89,27.94,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.470495282661489,0.009,0.0004,0.0178,0.0948,0.0017,0.0003,0.8762,1.05,1.05,0.5417375282099487
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,7.893697629,32.11,24.89,40.44,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.289088639014612,0.0343,0.0003,0.1697,0.027,0.0013,0.0009,0.7666,0.46,0.46,-0.3683090604291903
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.08675917,49.0,18.75,31.25,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.9684234452869465,,,,,,,,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.13512977,42.13,18.75,38.13,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.906015244966153,0.0128,0,0.028,0.0208,0.0006,0,0.9378,0.93,0.93,0.35664330679181877
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.43848511,45.61,13.64,38.19,2.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.525044141508807,0.0635,0.0002,0.2019,0.083,0.0009,0.0003,0.6502,1.5,1.5,1.2358408585279361
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.44748395,44.5,7.5,45.0,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.4520190064939165,0.011,0.0005,0.3972,0.0536,0.0016,0.0009,0.5352,1.45,1.45,1.1587182662703819
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,10.57169095,49.0,30.0,20.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.86830338551846,,,,,,,,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,8.009941019,34.5,30.0,32.5,3.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.3476939555933765,0.0165,0,0.0427,0.0616,0.0035,0.0028,0.8728,0.42,0.42,-0.4300071342352337
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,9.301142352,39.36,24.89,34.19,1.56,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,4.629862798578463,0.0246,0,0.1245,0.0895,0.0015,0.0023,0.7576,0.44,0.44,-0.399158097332212
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,6.525773643,24.0,30.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.732683506287051,0.006,0.0012,0.0205,0.0177,0.0008,0,0.9538,0.44,0.44,-0.399158097332212
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.31765932,46.5,7.5,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.81380905109942,0.073,0,0.0373,0.0149,0,0,0.8748,1.01,1.01,0.4800394544039054
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.01888288,46.37,7.5,44.21,1.92,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.706823839714591,0.0145,0.0004,0.1165,0.019,0.0007,0.0011,0.8477,1.94,1.94,1.9145196703944125
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,11.30562834,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.73795129722191,0.0343,0.0003,0.1697,0.027,0.0013,0.0009,0.7666,1.9,1.9,1.8528215965883692
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO,DSPC,0,0,1,0,9.480986593,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,Crtl,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.302712827954156,0.0455,0,0.324,0.073,0.0011,0.0012,0.5551,1.0,1.0,0.4646149359523945
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,17.88551615,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.763028270603671,0.0253701689981931,0.00985209592098701,0.307949537646453,0.622300893638244,0.0174680522283724,0.0170592515677505,-,0.0,,
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,17.94390528,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.584559232083967,0.00894763570081526,0.00182903773179144,0.430416319953847,0.549730482792046,0.00757886856613304,0.0014976552553668,-,0.0019532059842532,0.0019532059842532,-0.793744670428099
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,18.3291697,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.5827200571505,0.00757568328250189,0.00220510873539676,0.728025615125869,0.236446776884745,0.0226429923353559,0.00310382363613184,-,0.0011482099710543,0.0011482099710543,-0.7958927956755514
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,18.38109198,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.6888677450096585,0.00599960547383456,0.00187471922407934,0.58725363712808,0.393842224090862,0.00908706069367491,0.00194275338946932,-,0.0005585876781053,0.0005585876781053,-0.7974661979200065
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,19.03103458,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.374372415737022,0.0207124354254999,0.00767807173489595,0.560331852523788,0.3797189836544,0.0206003960524344,0.0109582606089812,-,0.0001489580680618,0.0001489580680618,-0.7985592911689305
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,19.07349618,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.567572155572773,0.0084525958204246,0.00170600389954699,0.807774257087237,0.172171860632781,0.00851123850670424,0.00138404405330582,-,0.0052460712339961,0.0052460712339961,-0.7849576865630203
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,17.88551615,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.763028270603671,0.0142965461163966,0.00273099369058116,0.2951874813445,0.196790510597468,0.00567584660232592,0.00900724719724339,0.476311374451485,0.0033203605888808,0.0033203605888808,-1.0727154128818024
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,17.94390528,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.584559232083967,0.0426258503334726,0.000887127042175757,0.102099604743599,0.057196348771858,0.00222434780081794,0.00162961025671667,0.79333711105136,0.0465195426566469,0.0465195426566469,-1.006082754792359
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,18.3291697,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.5827200571505,0.0182648912592805,0.000462867676668248,0.083073077462289,0.0429608616930204,0.00195825764287227,0.000923423624969053,0.852356620640901,0.0509209522037464,0.0509209522037464,-0.9992937925151699
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,18.38109198,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.6888677450096585,0.0068908069603713,0.000629547873998548,0.021394314943629,0.042448777163022,0.00198708372142952,0.00248444060475972,0.92416502873279,0.016201262972428,0.016201262972428,-1.0528472412330891
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1,DSPC,0,0,1,0,19.03103458,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.374372415737022,0.0116932676375475,0.00103739027764326,0.0525071135910941,0.0215477599193875,0.00368874758435242,0.00400972460855577,0.905515996381419,0.006104461793755,0.006104461793755,-1.068421070841257
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1,DSPC,0,0,1,0,19.07349618,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ML,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.567572155572773,0.0237911981258413,0.00067207203055979,0.18334881014348,0.0466442684044473,0.00188246389345958,0.000953648344707904,0.742707539057504,0.0550488822731985,0.0550488822731985,-0.9929266591628888
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.82491214,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GLN,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.572543683160998,0.000714997259249526,0.000661552142657172,0.125943320778554,0.801966162874089,0.0693146503097598,0.00139931663568972,-,0.0127373438778132,0.0127373438778132,-0.764967287060561
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.91081918,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,BIM,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.358502089626924,0.00147233862420237,0.00107405472963131,0.901430168335102,0.0923159134092667,0.00310160866776492,0.000605916234032228,-,0.0763434621140544,0.0763434621140544,-0.5952348831288257
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81357262,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,3FLA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.396299293960601,0.00110223184180453,0.00161797426133587,0.963322201717795,0.0321995776177804,0.00129202117564397,0.000465993385639812,-,0.380376087923258,0.380376087923258,0.21607368094058316
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.58547122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.351438552905858,0.00061802522712851,0.00208191419961706,0.00520107649990865,0.018780252186508,0.966671145724669,0.00664758616216931,-,0.0289886812604962,0.0289886812604962,-0.7216007267742771
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,IZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.544995462952021,0.00423798522906651,0.00360605985882706,0.0132163308359338,0.182768863634774,0.789078621894797,0.00709213854660109,-,0.0033387326299993,0.0033387326299993,-0.7900474039572776
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.80884374,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PY,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.237000862623624,0.0123483310685072,0.00430719249252366,0.0429874465070588,0.751978605237179,0.174073814828135,0.0143046098665965,-,0.0005090956767902,0.0005090956767902,-0.7975982669188943
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.790487251761845,0.00153513483125764,0.00147931904743739,0.82338319944907,0.169033483447006,0.00378262362292623,0.000786239602302501,-,0.306009500746919,0.306009500746919,0.017627054049161966
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,17.10338647,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.842058839093973,0.00164287085070931,0.000659195379539964,0.94017588697419,0.0550751037989028,0.00183173459161262,0.000615208405045708,-,0.504231824712829,0.504231824712829,0.5465816969768794
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.82491214,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,GLN,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.572543683160998,0.0204881792124896,0.00996076677576078,0.024515683125648,0.0206076067733214,0.0213656753332114,0.0146396167476402,0.888422472031929,0.0035574041476412,0.0035574041476412,-1.0723497846072114
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.91081918,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,BIM,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.358502089626924,0.0789442718629389,0.000859220559164078,0.352513414289749,0.0167725689541561,0.00207992092629201,0.000939235620822743,0.547891367786878,0.128034152082589,0.128034152082589,-0.8803503950765449
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81357262,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,3FLA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.396299293960601,0.020589791219893,0.00221295822133462,0.77006639472807,0.0336156368936998,0.00141982059640497,0.000804331444027444,0.17129106689657,0.352623838360951,0.352623838360951,-0.5339316190745824
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.58547122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,1.0,4.351438552905858,0.0518701933925729,0.031230151711712,0.196119602463562,0.0891250765615729,0.225998436967717,0.183312147304902,0.222344391597961,0.0006916766953858,0.0006916766953858,-1.0767700312036428
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,IZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.544995462952021,0.0318134391856252,0.0195739470918212,0.0658637908929555,0.0405146823853727,0.0383355214778253,0.0445803960220688,0.759318222944331,0.0007826107131428,0.0007826107131428,-1.0766297698601666
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.80884374,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PY,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.237000862623624,0.0496007240706346,0.0248050760368446,0.125156740550784,0.0913290655906173,0.0605654916232193,0.0647609529825488,0.583781949145352,0.000319594239126,0.000319594239126,-1.077343950474849
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.790487251761845,0.0660465509749711,0.000704686244275338,0.176882938102508,0.134254150019803,0.00301700767902668,0.00146559050061717,0.617629076478799,0.391796497651864,0.391796497651864,-0.473509678471839
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DOPE,1,0,0,0,17.10338647,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.842058839093973,0.180962520579808,0.000840183131263393,0.0600498448220066,0.0139903797423045,0.00230022430813273,0.00221494849849946,0.739641898917986,0.515169720881209,0.515169720881209,-0.2832124226594992
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.07758774,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.48897339158558,0.000136174132145422,0.00212452688507234,0.811633900204502,0.179761878637886,0.00385751556458306,0.00248600457581157,-,0.767759892635294,0.767759892635294,1.24980418110703
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.50454535,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,ALA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.675628649636653,0.00268100351583557,0.00240431632025112,0.142040711181502,0.523320437165769,0.324868931367264,0.00468460044937817,-,0.0241897161135915,0.0241897161135915,-0.7344067258409619
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.59671966,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,SER,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.737600973168581,0.00157432110064945,0.00176844882817444,0.053765469363115,0.438156626388713,0.500533090562106,0.00420204375724176,-,0.0189624719731265,0.0189624719731265,-0.7483555838832638
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.07758774,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OH,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.48897339158558,0.0550309639531662,0.00234353835896855,0.320198252727196,0.282656133384496,0.0064798077198827,0.00202476215621646,0.331266541700075,1.20135127285815,1.20135127285815,0.775189578295967
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.50454535,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,ALA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.675628649636653,0.0418659426619505,0.0219153925677162,0.21668759621254,0.199875450362037,0.113029824089051,0.0495629458661235,0.357062848240582,0.0027707272238572,0.0027707272238572,-1.0735631958798397
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.59671966,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,SER,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.737600973168581,0.0234118812216689,0.0071462713755353,0.0426958781226752,0.0464078935005845,0.0346044033846598,0.0235967118628926,0.822136960531984,0.0055457738057274,0.0055457738057274,-1.0692828201592537
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.16930088,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,TZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,5.001930853466109,0.00767358537807448,0.00233215653996207,0.0713684727707158,0.307444763898641,0.0172788380976704,0.00511228295653041,0.588789900358405,0.0063917829512014,0.0063917829512014,-1.0679778917918028
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.579236803961587,0.00833063062779389,0.00173987762429209,0.156651961849343,0.112205138324295,0.00895304009765426,0.00427289873828259,0.707846452738339,0.269390835357988,0.269390835357988,-0.6623145181339684
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.15847938,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,3F,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.484131857611035,0.0158311033527607,0.00109353847138243,0.0200990623529318,0.00589717673503959,0.00332080816189693,0.00297802720282806,0.95078028372316,0.0070114291767852,0.0070114291767852,-1.06702211732781
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81395289,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PYR,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,1,0,1,0,0,0,0.0,5.0755487449389,0.0138253404297663,0.00670375922221507,0.064918033729737,0.0310082272870404,0.0307691214666871,0.0156091189056244,0.83716639895893,0.0111434256880136,0.0111434256880136,-1.060648711684908
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.402809173856411,0.0144051248882893,0.000525788660297221,0.125667067331117,0.214373546599095,0.00410880851120861,0.00177167337754258,0.639147990632451,0.176512628889736,0.176512628889736,-0.8055746790752468
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.16930088,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,TZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,5.001930853466109,0.00115119797114568,0.0003959818507672,0.0538124209539168,0.93604524664705,0.00736502972190904,0.00123012285521143,-,0.0261518819859255,0.0261518819859255,-0.7291707023316024
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.0054786,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.579236803961587,0.0010942059599737,0.000714578151988552,0.367034511120116,0.62078160479883,0.0079478856978032,0.00242721427128835,-,0.970510173989973,0.970510173989973,1.7908416411254202
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,17.15847938,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,3F,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.484131857611035,0.0376230130625874,0.00236009027623813,0.247039705692743,0.697452972603375,0.0104681865382628,0.00505603182679352,-,0.0013884403431976,0.0013884403431976,-0.7952517429011965
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.81395289,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PYR,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,5.0755487449389,0.00873826813676438,0.00145112475939544,0.193065080283125,0.778197018798523,0.014433213681334,0.00411529434085825,-,0.165721665234437,0.165721665234437,-0.35672988242469916
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.99522451,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.402809173856411,0.00532422079532615,0.00061084449763591,0.522469676271313,0.459778984209221,0.00966894873803684,0.00214732548846694,-,0.161020662402855,0.161020662402855,-0.3692744698577941
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.36945365,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.584763376210429,0.0318391346416656,0.000341552225113717,0.113678281409446,0.242279767731552,0.00387550619454475,0.000871625110337537,0.60711413268734,0.649833386251602,0.649833386251602,-0.07550020353412855
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.746322465743975,0.0548193142492001,0.000263362025026913,0.0902956804122817,0.160837629010128,0.00315355508353847,0.000739500993108033,0.689890958226717,1.16375238999006,1.16375238999006,0.7171951120404622
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O,DSPC,0,0,1,0,16.87346518,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,HIS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,0,1,0,0,0.0,4.651385609785055,0.0172566765287249,0.00318344365411915,0.0712890876960715,0.171965068058214,0.0218135302099503,0.0115493777455846,0.702942816107335,0.00327405282427,0.00327405282427,-1.0727868403787713
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.36945365,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.584763376210429,0.000599963927151076,0.000397997752734626,0.420976508827142,0.560178394908249,0.017044159994242,0.000802974590480822,-,0.25255828640642,0.25255828640642,-0.1250070722684871
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.746322465743975,0.000524374578838527,0.00061514916196369,0.547432124587029,0.435435317287124,0.015309113403191,0.000683920981854007,-,0.568394489552276,0.568394489552276,0.7177992409467366
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O,DSPC,0,0,1,0,16.87346518,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,HIS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.651385609785055,0.00171983501988967,0.00189561016704693,0.0120716635806003,0.711278646835123,0.270438826106656,0.00259541829068387,-,0.0112897234542117,0.0112897234542117,-0.7688302502674332
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.36945365,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.484733632866144,0.0047850951415261,0.000675911772575438,0.46069265034102,0.522359359837259,0.0109775121699624,0.00050947073765779,-,0.773205414607926,0.773205414607926,1.2643355117511204
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.633757642840004,0.00198911414189635,0.00126811595413123,0.543867583730296,0.438842770521552,0.0129988635137729,0.00103355213835123,-,1.98493053910539,1.98493053910539,4.497814051056962
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.0333911,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.609759638321899,0.00125031423153586,0.0004860362025215,0.538249539726811,0.445414640899446,0.0137801694455006,0.000819299494184621,-,0.291137444797345,0.291137444797345,-0.022058905064912687
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=O,DSPC,0,0,1,0,16.68738808,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,CYS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.392884144674663,0.00226285185388551,0.000562872305858137,0.731364439797527,0.256932619347553,0.00825451238600619,0.000622704309170273,-,1.82872279459479,1.82872279459479,4.080974968218046
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O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.35889865,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.633757642840004,0.0374610013402809,0.0005350551106764,0.260855439538844,0.469905543128085,0.00469334055693451,0.000912093945676405,0.225637526379503,1.69276100831231,1.69276100831231,1.5331654314724417
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.0333911,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,OZ,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.609759638321899,0.0836645231428707,0.000419599806684375,0.0235684307001288,0.0712275212970175,0.00119681308497475,0.00178295859414992,0.818140153374174,0.426058290183635,0.426058290183635,-0.4206625133630252
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O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,18.71419039,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.904756125442696,0.0248552898268163,0.0125192728735768,0.0725307642598596,0.0355254691282667,0.0214395648154144,0.0248745799236939,0.808255059172372,0.0741845243461588,0.0741845243461588,-0.9634108527393006
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,19.34728513,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.733211535868976,0.0883917007893502,0.00174599838911923,0.0536405332414895,0.100118671210748,0.00771990063396103,0.00639776118235737,0.741985434552974,0.528035509086713,0.528035509086713,-0.2633675639025965
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,18.70678989,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intramuscular,0,1,0,0,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular,0,0,1,1,0,0,0,0.0,4.858726543710496,0.0175679405294797,0.00960173891174304,0.0903179131752613,0.0388184937379254,0.0182497546285787,0.0249045868533177,0.800539572163694,0.125181510399577,0.125181510399577,-0.8847504575040614
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O,DSPC,0,0,1,0,17.62870578,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,DOP,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.765586907393996,0.00159278655447388,0.00186611160196327,0.488795918944862,0.485247409700546,0.018616198181097,0.00388157501705755,-,0.352570746370957,0.352570746370957,0.14187535545424673
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O,DSPC,0,0,1,0,17.61880246,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PBA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,1,0,1,0,0,0,0.0,4.82374330878754,0.000875415234709484,0.00127375854285246,0.683377837104949,0.304003257921165,0.00820355561270421,0.00226617558361995,-,0.943420561172443,0.943420561172443,1.7185532318874628
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O,DSPC,0,0,1,0,16.58547122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.433313679041901,0.000602190120987361,0.000576528881915898,0.00566197423128506,0.0161763859347042,0.971683265119797,0.00529965571131053,-,0.0305789310371634,0.0305789310371634,-0.7173571583105779
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O,DSPC,0,0,1,0,17.70929826,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.356324137321509,0.00187378052819512,0.00157654975652554,0.0163863796216318,0.0648246159165097,0.905280007427939,0.0100586667491993,-,0.003875136361479,0.003875136361479,-0.7886160150068647
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O,DSPC,0,0,1,0,18.17273956,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.440767129696482,0.00301049906217731,9.21592223531261e-05,0.00380096827414773,0.0130323481002541,0.97657327492354,0.00349075041752818,-,0.0274401441027376,0.0274401441027376,-0.7257329854571254
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=O,DSPC,0,0,1,0,18.38469122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.349632566862877,0.00273989274094748,0.00161018393061426,0.0112824839963327,0.0583352940699212,0.919247401685963,0.00678474357622127,-,0.0081601896883771,0.0081601896883771,-0.7771813854096181
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=O,DSPC,0,0,1,0,18.90345652,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.662778498608405,0.00349315451118928,0.00171298178399312,0.037797325974731,0.242816837972913,0.706569889763285,0.00760980999388795,-,0.0136767051395404,0.0136767051395404,-0.7624606092513427
O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCN,DSPC,0,0,1,0,18.38469122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,1,0,0,0,0,0,1,,4.405498990859024,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=O,DSPC,0,0,1,0,16.89527599,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,GABA,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,,4.815106909815019,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.89527599,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.562053894914463,0.00241700650155169,0.00189161759954923,0.0117804592312353,0.0588098364115177,0.918016488291877,0.0070845919642692,-,0.288385322760908,0.288385322760908,-0.029402920107978105
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.89527599,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.667205576907544,0.00146771264056884,0.000853267380299107,0.00521853383313367,0.0984194458399351,0.890752405611161,0.00328863469490281,-,0.174730948641107,0.174730948641107,-0.3326886836733955
O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,17.94799221,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,1.0,4.701389043728634,0.00256320924432886,0.00193796271600952,0.0128146756680969,0.0418402586947232,0.934553052894321,0.00629084078252029,-,0.0492674291707299,0.0492674291707299,-0.6674870545840368
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,18.38469122,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.460491174618648,0.00101051612937229,0.00153512067382825,0.00950098551353592,0.161931963893941,0.822835993399315,0.00318542039000704,-,0.105055900803977,0.105055900803977,-0.5186159763833679
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O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,17.18453431,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.684905154006945,0.0025903109842197,0.00122267327648511,0.0959380417500791,0.558064631213231,0.339326541744348,0.00285780103163663,-,0.0836567108446898,0.0836567108446898,-0.5757195389760648
O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,18.58497913,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,1.0,4.695924549256556,0.00270162630925447,0.000571977156802491,0.072649821877092,0.283620916967858,0.638520904456637,0.00193475323235631,-,0.108372702997361,0.108372702997361,-0.5097651169808466
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=O,DSPC,0,0,1,0,16.82518306,48.5,10.0,40.0,1.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,LYS,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,1,0,0,0,1,0,0,,4.202899968776446,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,14.52948326,43.25,25.0,30.0,1.75,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,0.0,5.029784112935016,0.000951862951033406,0.000642237882584555,0.00747953132811133,0.295137112679544,0.692754163229738,0.0030350919289883,-,0.19435393861906,0.19435393861906,-0.2803248961378029
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,11.10169345,30.0,25.0,42.5,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.833102254034098,0.00529626249319983,0.00246267213977097,0.0289260006923807,0.563065088278535,0.393847703229461,0.00640227316665243,-,0.049072760763369,0.049072760763369,-0.6680065256297026
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.72804315,38.075,17.975,41.825,2.125,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,,4.93014804318357,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.39261658,37.0,25.0,37.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,5.146912912388804,0.000759366167023555,0.000694817987152034,0.00466364025695932,0.212680085653105,0.777593147751606,0.00360894218415418,-,0.201238755105862,0.201238755105862,-0.2619528199077537
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.51039532,38.5,20.5,38.5,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.684905154006945,0.00157535225652128,0.00592927130077556,0.00900517890128691,0.366135503933579,0.613833328839362,0.00352136476847493,-,0.149329656900936,0.149329656900936,-0.40047182198750214
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.48290639,45.0,9.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.869839484130799,0.00147117555088917,0.000927103843315829,0.00585237061645294,0.136146016514374,0.851575135737455,0.00402819773751327,-,0.31219703699332,0.31219703699332,0.034138443686487704
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,14.13138042,41.2,22.35,34.325,2.125,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,0.0,4.901564199041894,0.00315707422768752,0.0025689389054212,0.0146712017391132,0.327849346901905,0.646061693847123,0.0056917443787501,-,0.158541375998041,0.158541375998041,-0.3758904252594646
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.11942242,41.825,14.975,41.825,1.375,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,,5.039546637590676,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,14.79492927,45.0,22.5,30.0,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.9141243937154115,0.00113350028034128,0.000566939752127873,0.00680706926467914,0.502661298625749,0.486733894218144,0.00209729785895866,-,0.145448415448628,0.145448415448628,-0.4108288829150842
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,12.55393718,34.325,21.725,41.825,2.125,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,0,1,0,0.0,4.814620410170298,0.001692878443667,0.000820135726038303,0.00868136575507882,0.408928448915581,0.577101122031978,0.00277604912765729,-,0.113760366510672,0.113760366510672,-0.495388181160095
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.93959861,45.0,7.5,45.0,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.527640983478854,0.00506334343919377,0.004281344333051,0.0165771717732586,0.226890591170162,0.736348900590883,0.0108386486934518,-,0.0547343765642327,0.0547343765642327,-0.6528985503803821
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.59337013,45.0,15.75,37.5,1.75,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.810557015713042,0.00141112235558708,0.000749767156842064,0.00637541161251223,0.138880841494329,0.847648476304751,0.00493438107597822,-,0.294154433878409,0.294154433878409,-0.0140080944893819
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,11.66031337,30.0,24.0,45.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,5.167639042905921,0.00199236267032557,0.000827577235394216,0.008719084857644,0.192132365846187,0.792330257640873,0.0039983517495764,-,0.151793984465988,0.151793984465988,-0.3938957841268362
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,13.66358165,37.5,15.0,45.0,2.5,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,0.0,4.618086411254637,0.00271480786609193,0.00181664538344774,0.00938513027274936,0.132547184736695,0.849509595736892,0.0040266360041233,-,0.0950036114384557,0.0950036114384557,-0.5454404279666308
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.26186294,45.0,24.0,30.0,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,0,1,0,0,,5.098035484377089,-,-,-,-,-,-,-,0.0,,
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.27611859,45.0,11.382,42.618,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.680277658474897,0.00152924607683628,0.00192508702614222,0.0105762053188716,0.167270255683968,0.810875386281306,0.00782381961287527,-,0.278754923842637,0.278754923842637,-0.05510156049896443
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,16.11001923,45.0,13.445,40.445,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.924350925499243,0.000999438616070677,0.00125158481927741,0.00771842730472846,0.249469737208587,0.735450494958472,0.00511031709286499,-,0.286455906115286,0.286455906115286,-0.03455155257492116
O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O,DSPC,0,0,1,0,15.85662691,45.0,16.405,37.595,1.0,Pure,Microfluidic,mRNA,1,0,0,FFL,Mouse,0,0,0,0,0,0,0,1,0,body,1,0,0,0,0,0,0,0,0,intravenous,0,0,0,1,Individual,0,1,luminescence,,,,,,PRE,,,Chinese_Academy_of_Sciences,Chinese_Academy_of_Sciences,ccchina,,max,Chinese_Academy_of_Sciences,internal,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous,0,0,1,1,0,0,0,0.0,4.924350925499243,0.00141338619768439,0.00124322063420737,0.0100450891793794,0.235894751086175,0.745556785166654,0.00584676773589971,-,0.264336417833639,0.264336417833639,-0.09357722532293417
1 smiles Helper_lipid_ID Helper_lipid_ID_DOPE Helper_lipid_ID_DOTAP Helper_lipid_ID_DSPC Helper_lipid_ID_MDOA Cationic_Lipid_to_mRNA_weight_ratio Cationic_Lipid_Mol_Ratio Phospholipid_Mol_Ratio Cholesterol_Mol_Ratio PEG_Lipid_Mol_Ratio Purity Mix_type Cargo_type Cargo_type_mRNA Cargo_type_pDNA Cargo_type_siRNA Target_or_delivered_gene Model_type Model_type_A549 Model_type_BDMC Model_type_BMDM Model_type_HBEC_ALI Model_type_HEK293T Model_type_HeLa Model_type_IGROV1 Model_type_Mouse Model_type_RAW264p7 Delivery_target Delivery_target_body Delivery_target_dendritic_cell Delivery_target_generic_cell Delivery_target_liver Delivery_target_lung Delivery_target_lung_epithelium Delivery_target_macrophage Delivery_target_muscle Delivery_target_spleen Route_of_administration Route_of_administration_in_vitro Route_of_administration_intramuscular Route_of_administration_intratracheal Route_of_administration_intravenous Batch_or_individual_or_barcoded Batch_or_individual_or_barcoded_Barcoded Batch_or_individual_or_barcoded_Individual Value_name Formulation_ID Cationic_Lipid_Mass_Ratio Phospholipid_Mass_Ratio Cholesterol_Mass_Ratio PEG_Lipid_Mass_Ratio Amine Tail Lipid_name Library_ID Experiment_ID Experimenter_ID Experiment_weight Goal screen_id Source Sample_weight Comment Amine_number Full_SMILES Amine_SMILES Tail_length Num_tails Ketone Isocyanide Is_cyclic Formulation Batch_or_individual Random_id 4CR_Lipid_name Aldehyde Carboxylic_acid Amine_name Tail_name Linker MolWt Tail_count Num tails Common_name Ester Disulfide Total_radiance Form_comment molecular_weight split_name_for_normalization Encapsulation_Efficiency_EE<50 Encapsulation_Efficiency_50<=EE<80 Encapsulation_Efficiency_80<EE<=100 PDI_0_0to0_2 PDI_0_2to0_3 PDI_0_3to0_4 PDI_0_4to0_5 toxic size Biodistribution_lymph_nodes Biodistribution_heart Biodistribution_liver Biodistribution_spleen Biodistribution_lung Biodistribution_kidney Biodistribution_muscle quantified_total_luminescence unnormalized_delivery quantified_delivery
2 OC(CC(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)(CC(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)C(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O DSPC 0 0 1 0 19.35326347 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence citric acid Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 5.01396308418893 - 0.141974553073968 0.351788837480042 0.21590174472742 0.201831859522378 0.0885030051961923 77.5%? 0.148451427756917 0.148451427756917 -0.8488577305397192
3 OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O DSPC 0 0 1 0 19.19352646 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence citric acid Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.346658490836091 - 0.118429962362459 0.359442163877919 0.207462553548735 0.206757503800386 0.107907816410501 77.5%? 0.141461295642972 0.141461295642972 -0.8596396727167236
4 O=C(CN(CCCCCCCCCCCC)CCCCCCCCCCCC)NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.44559484 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 6.892641641172089 - - - - - - - 0.0
5 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCCCC DSPC 0 0 1 0 15.24245185 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 5.2699178920263385 - 0.124916929794055 0.369468729447656 0.195055730208631 0.225094433177121 0.0854641773725367 77.5%? 0.156358397802496 0.156358397802496 -0.8366616100033615
6 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCCCC DSPC 0 0 1 0 15.24245185 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.345103280569283 - - - - - - - 0.0
7 O=C(CN(CCCCCCCC)CCCCCCCC)NCCCN(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.38607591 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.281930018135596 - 0.150136519605605 0.355001041089 0.229550847405215 0.174081272090009 0.0912303198101713 77.5%? 0.152341943264804 0.152341943264804 -0.8428567977159901
8 CCCCCCCCN([C@H](C(NCCCN(CCCCCCCC)CCCCCCCC)=O)CO)CCCCCCCC DSPC 0 0 1 0 13.70858688 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.6061696863211745 - 0.135258733819858 0.336501144772348 0.220509705752364 0.219041309358291 0.0886891062971386 77.5%? 0.158669313943658 0.158669313943658 -0.8330971331374368
9 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.40770989 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.60816569496789 - 0.104670582084173 0.315839166696278 0.253250862525529 0.232520638852651 0.0937187498413698 77.5%? 0.159094240395848 0.159094240395848 -0.8324417045472029
10 CCCCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CO)CCCCCCCCCCCC DSPC 0 0 1 0 15.96782216 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.378645926514404 - 0.12522501256674 0.335948007662315 0.256499891314685 0.184909383618406 0.0974177048378551 77.5%? 0.158517890991896 0.158517890991896 -0.8333306957487803
11 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.6210435351443815 - 0.018637540697442 0.856266507625458 0.0685481607764484 0.037483843171047 0.0190639477296046 77.5%? 1.0 1.0 0.4646149359523945
12 O=C(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.2554924 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.310127759130018 - - - - - - - 0.0
13 O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O DSPC 0 0 1 0 16.95535314 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.35696520407851 - - - - - - - 0.0
14 O=C(CN(CCCCCCCCCC)CCCCCCCCCC)NCCCN(CCCCCCCCCC)CCCCCCCCCC DSPC 0 0 1 0 14.51030189 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.175309921045206 - - - - - - - 0.0
15 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.11860943 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.447697327163527 - - - - - - - 0.0
16 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 16.80841018 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.381651564343798 - - - - - - - 0.0
17 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCC DSPC 0 0 1 0 14.7769988 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.250350662548819 - - - - - - - 0.0
18 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.33731463 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.386765389021055 - - - - - - - 0.0
19 O=C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H](C)N(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.55151343 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.391729410135267 - - - - - - - 0.0
20 O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O DSPC 0 0 1 0 16.95535314 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.844974178195408 - 0.00630203002731954 0.185980624705068 0.790574355089574 0.0148193516556036 0.00232363852243453 77.5%? 2.42642874788244 2.42642874788244 2.664812590100213
21 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.11860943 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 5.19295685089021 - 0.00474168484136008 0.800367351971756 0.180650022354306 0.00984951126906641 0.00439142956351233 77.5%? 0.287207020238001 0.287207020238001 -0.6348339108922395
22 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 16.80841018 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 5.394990253808298 - 0.00302211757671521 0.318679912693443 0.664215585884173 0.0128029348785811 0.00127944896708776 77.5%? 0.514539131213174 0.514539131213174 -0.28418507685649314
23 CCCCCCCCCCN([C@H](C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCC DSPC 0 0 1 0 14.7769988 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.509649984130679 - 0.00312543572304221 0.147942119682821 0.821649165313096 0.0234407679228166 0.00384251135822455 77.5%? 0.239971111848379 0.239971111848379 -0.7076930249451995
24 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.33731463 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 5.12455904041457 - 0.0210297731298931 0.658450324145507 0.200900368909969 0.111879408982101 0.00774012483253011 77.5%? 0.0342179895228306 0.0342179895228306 -1.0250573081218382
25 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 5.112590016619249 - 0.00128819081649658 0.393692319023747 0.589452131076946 0.0101812483827002 0.00538611070010966 77.5%? 1.0 1.0 0.4646149359523945
26 O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H](C)N(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.85660447 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.114394528387108 - - - - - - - 0.0
27 O=C(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)NCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.63293083 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 5.272999558563747 - - - - - - - 0.0
28 O=C(CN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O DSPC 0 0 1 0 16.2856483 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.28978103552575 - - - - - - - 0.0
29 O=C(CN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)NCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC DSPC 0 0 1 0 16.23582504 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.260615499364025 - - - - - - - 0.0
30 O=C(NCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)CN(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.75702627 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.9788005705762375 - - - - - - - 0.0
31 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)=O)CO)CCCCCCOC(CCCCC)=O)CCCCC DSPC 0 0 1 0 16.47477668 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.68213122712422 - - - - - - - 0.0
32 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.686750172980514 - - - - - - - 1.0 1.0 0.4646149359523945
33 CCCCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 19.33366115 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 - - - - - - - 0.0
34 CCCCCCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.98780245 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.9473404437239425 - - - - - - - 0.0
35 CCCCCCCCCCCCCCN(CCCNC([C@@H](N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)CO)=O)CCCCCCCCCCCCCC DSPC 0 0 1 0 16.42695266 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.545101659521972 - 0.00318490682025255 0.0608074236431031 0.251089505980848 0.00892095913117615 0.00601048706680474 0.669986717357815 0.0815243428420059 0.0815243428420059 -0.9520895361573071
36 CCCCCCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)=O)CO)CCCCCCCCCCCCCC DSPC 0 0 1 0 16.68206611 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.844974178195408 - - - - - - - 0.0
37 O=C(NCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)[C@H]([C@H](O)C)N(CCCCCCCCCCCC)CCCCCCCCCCCC DSPC 0 0 1 0 15.77114057 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence thr Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.331522502500114 - 0.0131160505661734 0.0817206877958181 0.209957462105326 0.0363069917919837 0.0161572104727098 0.642741597267989 0.0248953087459781 0.0248953087459781 -1.0394370942878488
38 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.4135253017332525 - 0.00151329913495755 0.0471551068594211 0.0476760649180962 0.00182335320536251 0.00763287581452213 0.89419930006764 0.35502103370942 0.35502103370942 -0.5302340606861489
39 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.509649984130679 - 0.00235961766437825 0.513627015742916 0.0879412499947796 0.00175822838354556 0.00311254749811917 0.391201340716262 1.0 1.0 0.4646149359523945
40 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.496359280129911 - - - - - - - 0.0
41 CCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCC)CCCCCCCC)=O)CO)CCCCCCCC DSPC 0 0 1 0 14.13296737 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.170425586627436 - - - - - - - 0.0
42 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.445353484534206 - - - - - - - 0.0
43 CCCCCCCCCCN([C@H](C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)=O)CO)CCCCCCCCCC DSPC 0 0 1 0 15.1299087 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.166510173022286 - - - - - - - 0.0
44 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 17.04310679 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.673109168996284 - - - - - - - 0.0
45 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCC)=O)CCCCCCOC(CCCCC)=O)=O)CO)CCCCCCOC(CCCCC)=O)CCCCC DSPC 0 0 1 0 16.72728505 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.7572902340489245 - - - - - - - 0.0
46 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.332573750954351 - 0.000230328920605394 0.0259372790881254 0.0734981485145439 0.000576894596302152 0.000867946038939987 0.898889402841483 0.486446282346577 0.486446282346577 -0.32751694342632615
47 O=C(CCN(CCCNC([C@@H](NCCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.332573750954351 - 0.00183814880222334 0.508470854676458 0.479298868566087 0.00664368457868438 0.00374844337654761 - 0.0806697533656258 0.0806697533656258 -0.5836902104683951
48 O=C(CCN(CCCNC([C@@H](NCCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 14.7050121 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.577079305821566 - 0.00446051681777838 0.0286140231457339 0.01484311836534 0.00629790100652696 0.01599114503205 0.929793295632571 0.0275210452544693 0.0275210452544693 -1.035387022165446
49 OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O DSPC 0 0 1 0 14.7050121 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.577079305821566 - 0.0104002218216073 0.139229779861971 0.807246421461676 0.041233674188 0.00188990266674509 - 0.0040656278842911 0.0040656278842911 -0.7881076899433005
50 O=C(CCN([C@H](C(NCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 16.11494914 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.7535901911063645 - 0.00711911642710361 0.153280595121264 0.136743424441396 0.0628412485834964 0.0734141937722642 0.566601421654476 0.0027486514420013 0.0027486514420013 -1.0735972467102965
51 O=C(CCN([C@H](C(NCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 16.11494914 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.7535901911063645 - 0.106975953776871 0.247623902989694 0.292657465739291 0.229416263063982 0.123326414430162 - 0.001042320755636 0.001042320755636 -0.7961753601769197
52 O=C(CN(CC(O)CCCCCC)CC(O)CCCCCC)NCCCN(CC(O)CCCCCC)CC(O)CCCCCC DSPC 0 0 1 0 14.05354178 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.789157022101107 - 0.0386975655052687 0.153034034478582 0.0799184464451532 0.0414429326981307 0.0607210626185958 0.626185958254269 0.0073827728841294 0.0073827728841294 -1.0664493375412318
53 O=C(CN(CC(O)CCCCCC)CC(O)CCCCCC)NCCCN(CC(O)CCCCCC)CC(O)CCCCCC DSPC 0 0 1 0 14.05354178 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 1 0 0 0 0.0 4.639571612705423 - 0.135531713474282 0.541180183023036 0.178510571158094 0.0949195329757021 0.0498579993688861 - 0.004009461265808 0.004009461265808 -0.7882575701032632
54 O=C(CN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 15.91058453 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.639571612705423 - - - - - - - 0.0
55 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.391357962102766 - 0.000231298468169262 0.195828728849491 0.0126185833117857 0.000504922171493209 0.00109315352063243 0.789723313678428 1.0 1.0 0.4646149359523945
56 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.391357962102766 - 0.00515447939315304 0.962574355010024 0.0304157301451643 0.000918038843316605 0.000937396608342438 - 1.0 1.0 1.8695349995476385
57 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.45295097301058 - - - - - - - 0.0
58 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 4.45295097301058 - - - - - - - 0.0
59 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.508769411701737 0.0963955724315343 0.000259669027359828 0.0209585518067849 0.0324510369422159 0.00191021824445882 0.00526970020363582 0.84275525134401 0.95415067884307 0.95415067884307 0.3938945659349633
60 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.508769411701737 - 0.00301852406237983 0.561715155652109 0.427466534539213 0.00675382930885143 0.00104595643744612 - 0.469108231863161 0.469108231863161 0.4528546780295592
61 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.424367475163407 0.00431198097235812 0.000818950238891083 0.0696322838846972 0.0220758004851341 0.00177157151502323 0.00255208415951453 0.898837328744382 0.673380628639453 0.673380628639453 -0.039179716064767986
62 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCC)=O)CCCCCCCC DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.424367475163407 - 0.00336772556852765 0.856457049453334 0.133858740361315 0.00483749939645135 0.00147898522037143 - 0.274077344076178 0.274077344076178 -0.06758364367522034
63 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.570475216191205 0.0465123735855303 0.000498926332937811 0.165458883776434 0.0565565738614754 0.00106294680997165 0.00247840641808945 0.727431889215561 1.0 1.0 0.4646149359523945
64 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.570475216191205 - 0.00167236193574396 0.848665421605967 0.144098339320739 0.00370843762360476 0.00185543951394526 - 1.0 1.0 1.8695349995476385
65 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.570268133978827 0.0297656858896609 0.000244336475601744 0.00951547807887942 0.00817695885320599 0.000472306069630483 0.00458791238707824 0.947237322245943 0.549425262386022 0.549425262386022 -0.23037489945875103
66 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.570268133978827 - 0.00411439872497652 0.670601694270008 0.311096989874152 0.00850379747404768 0.00568311965681539 - 0.0620258136097327 0.0620258136097327 -0.6334414105302022
67 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCC)=O)CCCCCCC DSPC 0 0 1 0 17.33731463 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 - - - - - - - 0.0
68 O=C(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CO)CCCCCCOC(CCCCCC)=O)CCCCCC DSPC 0 0 1 0 17.04310679 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.311727053457954 - - - - - - - 0.0
69 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.9082333604781745 0.00523681863830338 0.000823668079767528 0.00977318183991921 0.0124596675509096 0.00267973433328739 0.00363617950788083 0.965390750049932 0.316498770359056 0.316498770359056 -0.5896527968703137
70 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.33700102 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.9082333604781745 - 0.010109099822305 0.45796731805265 0.507501663530466 0.0194068402228631 0.00501507837171616 - 0.0817828774610745 0.0817828774610745 -0.5807198479650095
71 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.590361070334383 0.00631834763893091 0.000504819647616299 0.140779687268235 0.0297514168337676 0.000617892126006545 0.0011394500617625 0.820888386423681 1.0 1.0 0.4646149359523945
72 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.590361070334383 - 0.00283873189227405 0.901276452952094 0.0938738308613158 0.00141019974741145 0.000600784546904834 - 1.0 1.0 1.8695349995476385
73 O=C(NCCCN(CCCCCCCCCC)CCCCCCCCCC)[C@H](C)N(CCCCCCCCCC)CCCCCCCCCC DSPC 0 0 1 0 14.63651378 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.442651256490317 - - - - - - - 0.0
74 O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.97521151 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.530769863411841 - - - - - - - 0.0
75 O=C(NCCCCCCN(CCCCCCCCCC)CCCCCCCCCC)CN(CCCCCCCCCC)CCCCCCCCCC DSPC 0 0 1 0 14.88045619 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.48874872297084 - - - - - - - 0.0
76 O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)CN(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.83327693 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.343844382133684 - - - - - - - 0.0
77 O=C(NCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.53889564 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.301494223781961 - - - - - - - 0.0
78 O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.27376909 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.596939379038152 - - - - - - - 0.0
79 O=C(CN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.27376909 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 1 0 0 5.596939379038152 - - - - - - - 0.0
80 O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC DSPC 0 0 1 0 15.06368788 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.403665809777363 0.0159262664008309 0.00726471746994425 0.0644691443511897 0.0154248397225439 0.00666778094817397 0.00618426236554005 0.884062988741777 0.163983867672707 0.163983867672707 -0.8248996899319107
81 O=C(CN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC DSPC 0 0 1 0 15.06368788 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.403665809777363 - 0.0110768066820314 0.679238145596264 0.289982439081482 0.0151104362851107 0.00459217235511197 - 0.0864824917721372 0.0864824917721372 -0.5681789657875123
82 O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC DSPC 0 0 1 0 15.91176651 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.285378059618076 0.00952025723585679 0.00424787112198889 0.0270494802958792 0.00951147065788185 0.00569809581675416 0.00864159943836194 0.935331225433277 0.22281247574214 0.22281247574214 -0.7341593948675438
83 O=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC DSPC 0 0 1 0 15.91176651 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.285378059618076 - 0.00577401787332259 0.781123329740865 0.202386288853494 0.00852464019685452 0.00219172333546338 - 0.23688698835255 0.23688698835255 -0.16682580237138014
84 CCCCCCCCCCCCCCOC(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.11033537 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.0106352940962555 - - - - - - - 0.0
85 CCCCCCCCCCCCCCOC(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.11033537 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 1 0 0 5.0106352940962555 - - - - - - - 0.0
86 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.49121730591206 0.0307690543253117 0.000803846893528031 0.00327375890943859 0.00440309874760962 0.00131506681420977 0.00341198428561488 0.956023190024287 1.14370500641117 1.14370500641117 0.6862729882487519
87 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.49121730591206 - 0.0103006057269574 0.229208194092422 0.735779643429865 0.0182228400970524 0.00648871665370264 - 0.146101132843469 0.146101132843469 -0.40908711190961344
88 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.573885895948325 0.00305704097815131 0.00100491779320209 0.0165773259574103 0.0117710271412967 0.00208697129856503 0.00287252217431477 0.96263019465706 1.0 1.0 0.4646149359523945
89 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.573885895948325 - 0.00330040832612047 0.545398801975274 0.446192251044312 0.00323782528214899 0.00187071337214386 - 1.0 1.0 1.8695349995476385
90 O=C(CN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.79756457 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.789042318607025 - - - - - - - 0.0
91 CCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.40770989 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.168208681201016 - - - - - - - 0.0
92 CCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.93089479 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.697749367281185 - - - - - - - 0.0
93 O=C(CCN(CCCCCCNC([C@@H](N(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CO)=O)CCC(OCCCCCCCC)=O)OCCCCCCCC DSPC 0 0 1 0 16.38737682 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.2112383136936 - - - - - - - 0.0
94 CCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.61200662 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.27999390910873 - - - - - - - 0.0
95 O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.2554924 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.611152257665639 - - - - - - - 0.0
96 CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.391561 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.1422481808981475 - - - - - - - 0.0
97 O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC DSPC 0 0 1 0 16.63400342 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.515354881665727 - - - - - - - 0.0
98 O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC DSPC 0 0 1 0 17.25637024 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.57532934397707 - - - - - - - 0.0
99 O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC DSPC 0 0 1 0 17.79833258 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.451896454476337 - - - - - - - 0.0
100 O=C(CN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.2554924 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.925077405734609 - - - - - - - 0.0
101 CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.391561 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.829912458665998 - - - - - - - 0.0
102 O=C(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC DSPC 0 0 1 0 16.63400342 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.421728001525434 - - - - - - - 0.0
103 O=C(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC DSPC 0 0 1 0 17.25637024 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.775756486563625 - - - - - - - 0.0
104 O=C(CN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC)NCCCN(CC(O)CCCCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCCCC DSPC 0 0 1 0 17.79833258 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 8.862341963516347 - - - - - - - 0.0
105 CCCCCCCCCCCCCCCCOC(CCN([C@H](C(NCCCCCCN(CCC(OCCCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCCCC)=O)=O)CO)CCC(OCCCCCCCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.55042057 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 5.5506312951620265 - - - - - - - 0.0
106 OC[C@@H](C(NCCCN(CC(CCCCCC)O)CC(CCCCCC)O)=O)N(CC(CCCCCC)O)CC(CCCCCC)O DSPC 0 0 1 0 14.34229222 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.47597224751641 - - - - - - - 0.0
107 CCCCCCCCC(CN(CCCNC([C@@H](N(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CO)=O)CC(CCCCCCCC)O)O DSPC 0 0 1 0 15.30473405 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.563722996073918 - - - - - - - 0.0
108 CCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCC)O)O DSPC 0 0 1 0 16.11614863 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.275554390163365 - - - - - - - 0.0
109 CCCCCCCCCCCCC(CN([C@H](C(NCCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CO)CC(CCCCCCCCCCCC)O)O DSPC 0 0 1 0 16.80938411 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.35709336812867 - - - - - - - 0.0
110 O=C(CCCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.32727581 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.473579765600494 - - - - - - - 0.0
111 O=C(CCCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)=O)CCCCCCOC(CCCCCCC)=O DSPC 0 0 1 0 17.03239796 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.5612182984589085 - - - - - - - 0.0
112 O=C(CCCCCC)OCCCCCCN(CCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.71577453 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.695924549256556 - - - - - - - 0.0
113 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCC)CC(O)CCCCCC)=O)N(CC(CCCCCC)O)CC(CCCCCC)O DSPC 0 0 1 0 14.72351388 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.857484114602081 - - - - - - - 0.0
114 CCCCCCCCC(CN([C@H](C(NCCCCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CO)CC(CCCCCCCC)O)O DSPC 0 0 1 0 15.6246954 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.483228515182849 - - - - - - - 0.0
115 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)=O)N(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O DSPC 0 0 1 0 16.38850868 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.426521874560433 - - - - - - - 0.0
116 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O DSPC 0 0 1 0 17.04402965 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.412919498116252 - - - - - - - 0.0
117 O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.53558149 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.69866052907543 - - - - - - - 0.0
118 O=C(CCCCCC)OCCCCCCN(CCCCCCNC([C@H](C)N(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.95535314 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.9459189793765646 - - - - - - - 0.0
119 O=C(NCCCCCCN(CCCCCCCC)CCCCCCCC)[C@H](C)N(CCCCCCCC)CCCCCCCC DSPC 0 0 1 0 13.97521151 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ala Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.450269224770129 - - - - - - - 0.0
120 O=C(CCCCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCCCC)=O)CCCCCCOC(CCCCCCCC)=O)=O)CCCCCCOC(CCCCCCCC)=O DSPC 0 0 1 0 17.46731585 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.659658371272161 - - - - - - - 0.0
121 O=C(CCCCCC)OCCCCCCN(CCCCCCNC(CN(CCCCCCOC(CCCCCC)=O)CCCCCCOC(CCCCCC)=O)=O)CCCCCCOC(CCCCCC)=O DSPC 0 0 1 0 16.8769168 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.139321635057579 - - - - - - - 0.0
122 O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O DSPC 0 0 1 0 18.04309994 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.283448621312786 - - - - - - - 0.0
123 O=C(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O DSPC 0 0 1 0 17.76093253 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence gly Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.1455128487965 - - - - - - - 0.0
124 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 18.07661492 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.3551691805039985 - - - - - - - 0.0
125 O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCC DSPC 0 0 1 0 18.15212729 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 6.632923618509176 - - - - - - - 0.0
126 O=C(C(CCCCCCCC)CCCCCC)OCCCCCC[N+](CC)(CC)CC.[Br-] DSPC 0 0 1 0 12.69438691 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence TEA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.762173934797756 - - - - - - - 0.0
127 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.240751047315928 0.0111914004572023 0.00227125491616379 0.00877931935589419 0.0082437061808303 0.00401873844514775 0.00849693826019724 0.956998642384564 0.596141429580998 0.596141429580998 -0.1583174611704737
128 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.240751047315928 - 0.00531733106486159 0.69156525750989 0.28508003495893 0.0160312488066627 0.00200612765965623 - 0.176602424488684 0.176602424488684 -0.3276946657499996
129 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.253340627045836 0.0210584248832937 0.000931640117614886 0.0300315170504259 0.0160360600660287 0.002060495753182 0.00519348457253804 0.924688377556917 0.507741968135695 0.507741968135695 -0.2946693735871433
130 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.89554445 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.253340627045836 - 0.00533934786984105 0.597844801683409 0.374278985337898 0.0199301473078145 0.00260671780103763 - 0.177860137006811 0.177860137006811 -0.3243384702286213
131 O=C(NCCCCCCN([C@H](C(NCCCN(CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCNC(CCCCCCCCCCC)=O)=O)CO)CCCCCCNC(CCCCCCCCCCC)=O)CCCCCCCCCCC DSPC 0 0 1 0 18.15212729 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 8.664405571096625 - - - - - - - 0.0
132 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.498141613229568 0.00224222740615835 0.000962422246665562 0.00287219892799367 0.00322451176864607 0.00206661890626862 0.00333409585594076 0.985297924888327 0.792858557060483 0.792858557060483 0.14510923508307877
133 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.498141613229568 - 0.00657230701947091 0.556297397905001 0.404138164228711 0.0296624454205942 0.00332968542622302 - 0.20948041157182 0.20948041157182 -0.2399600273409918
134 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.462799844696365 0.0122002332749747 0.000591091003585345 0.00113975593374826 0.00176766182040017 0.00118628775621157 0.000814512180559894 0.98230045803052 1.58712844716331 1.58712844716331 1.3702322926201322
135 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.462799844696365 - 0.0055909076747788 0.864547542326111 0.121503978921508 0.00729914012568763 0.00105843095191469 - 0.762385942529413 0.762385942529413 1.2354638394013375
136 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.196600262926448 0.0390763854278316 0.00164994009844252 0.0661192424915616 0.0206209930549816 0.00197347693054232 0.00160454285244798 0.868955419144192 1.0 1.0 0.4646149359523945
137 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.196600262926448 - 0.00384316363496011 0.851255867494199 0.137210400166604 0.00701109092659647 0.000679477777641109 - 1.0 1.0 1.8695349995476385
138 O=C(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCC)=O)CCCCCCCCC DSPC 0 0 1 0 17.67788651 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.401951803481151 - - - - - - - 0.0
139 O=C(CCCCCCCCC)OCCCCCCN(CCCCCCOC(CCCCCCCCC)=O)CCCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC)=O)CCCCCCOC(CCCCCCCCC)=O)CO)=O DSPC 0 0 1 0 17.86915095 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.421487703554795 - - - - - - - 0.0
140 OC[C@@H](C(NCCCCCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)=O)N(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)O DSPC 0 0 1 0 17.61285873 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.577593418217857 - - - - - - - 0.0
141 OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=O DSPC 0 0 1 0 15.66191374 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DBU Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.647271362006727 - - - - - - - 0.0
142 OC(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(CC(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C(NCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.541058240520847 0.0155523974922323 0.00129152518305059 0.446962380102849 0.0407067099579296 0.00170625578284345 0.00421830607343662 0.489562425407659 1.0 1.0 0.4646149359523945
143 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.379899373657707 0.0165979002447495 0.00361970146585138 0.310566371988181 0.0118953898978584 0.00727497963461814 0.00647222326114303 0.643573433507598 1.0 1.0 0.4646149359523945
144 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.83323084 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.1751562049585145 0.127270779777207 0.0355651632001246 0.0965373529640882 0.0454740204097531 0.0338026797538366 0.0465840928565864 0.614765911038405 0.0505010966098528 0.0505010966098528 -0.999941399550668
145 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.95682792 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.416186486320586 0.0275897803818406 0.0140220813902507 0.0611423332934752 0.0248626002542061 0.0133347505104052 0.0187510241318683 0.840297430037954 0.11103838626238 0.11103838626238 -0.9065655454256818
146 C=CCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)=O DSPC 0 0 1 0 18.01719192 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.445588116163626 0.0250376334304389 0.00337885545037859 0.0517009582142691 0.0430146012578083 0.00350252056656834 0.00406753936383155 0.869297891716705 0.594087846809013 0.594087846809013 -0.1614850137062924
147 CCCCCCCCCCCC(OCCCCCCN(CCCCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.28161356 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.381026134340298 0.00774884428490629 0.00205921183588078 0.0366644403250292 0.0113925424121347 0.00225130046176364 0.00414541402825956 0.935738246652026 0.903691788703443 0.903691788703443 0.31606415773481983
148 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.382151626862033 0.0281381236661192 0.00268792352252722 0.218417144486954 0.0369503427520482 0.00199553488006137 0.00289937744032574 0.708911553251965 1.0 1.0 0.4646149359523945
149 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.83044719 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.199605072879594 0.0747106900577881 0.0465999615731367 0.107994265529626 0.0501322770872438 0.0448116344718523 0.0485065251769853 0.627244646103368 0.0685266977729659 0.0685266977729659 -0.9721377777766667
150 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.94795095 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.333755086000182 0.0109650973341036 0.00500301836333305 0.0209516607489436 0.00928876974106986 0.00498354505150691 0.00613733877720584 0.942670569983837 0.624112412102086 0.624112412102086 -0.11517356757013285
151 CCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.64728116 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.333098961050458 0.0312031939311219 0.00665572714585857 0.0303955096845431 0.016483404133503 0.00703656560389733 0.0108270584446455 0.897398541056431 0.396247798437663 0.396247798437663 -0.4666437613614608
152 O=C([C@H](CO)N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 15.21401022 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 0.0 4.865224091322398 0.113993758795815 0.073640090558649 0.155999510493789 0.089181912745518 0.0778008933488344 0.0854800220277795 0.403903812029615 0.0331042054271613 0.0331042054271613 -1.0267752664553031
153 O=C([C@H](CO)N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.964966 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.177279038170981 - - - - - - - 0.0
154 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.327834405590455 0.0791681309989092 0.00438236238399703 0.207450725009039 0.0200057324176319 0.00435501692886232 0.00687586277442937 0.677762169487131 1.0 1.0 0.4646149359523945
155 O=C(CN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.01143435 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.826712455935327 0.051854991416453 0.0528002488161413 0.131177333337399 0.0608349367134925 0.0676316423389937 0.091080124286102 0.544620723091419 0.0058976768275302 0.0058976768275302 -1.06874002669396
156 O=C(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.98131005 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.613138355637268 0.0349404656939791 0.032170759570341 0.107989787547248 0.0410644871922655 0.0376181677387698 0.0487295770112475 0.697486755246149 0.0093821747742871 0.0093821747742871 -1.0633653564065595
157 O=C([C@H](CO)N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 13.72220648 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.45318382899021 - - - - - - - 0.0
158 O=C(CCCN(CCCCCCOC(CCCCCCC)=O)CCCCCCOC(CCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 14.27012616 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 5.256453162449338 - - - - - - - 0.0
159 O=C(CCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)N(CC1)CCN1C2=NC=CC=N2 DSPC 0 0 1 0 15.19898065 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence pp Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.86830338551846 0.0353281775739917 0.00307182736960491 0.034716407488313 0.0124183147896963 0.00493000176115631 0.00714349716206655 0.902391773855171 0.291015633780908 0.291015633780908 -0.6289593079055151
160 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.260282639765531 0.0263012913083446 0.00104221918552839 0.17396331575752 0.0231252484593015 0.00218421226891195 0.00250493797184971 0.770878775048544 1.0 1.0 0.4646149359523945
161 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.400848388914469 0.142104027989206 0.00287714799265922 0.215134204863943 0.0243152184566193 0.00619704480449007 0.00405451457231669 0.605317841320765 1.0 1.0 0.4646149359523945
162 CCCCCCCCCCCC(OCCCCCCN(CCN(C)CCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.06597416 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.3551691805039985 0.0696417285874694 0.0029599268608454 0.0569405498935433 0.0189535946790038 0.00628554949471398 0.00620455647115851 0.839014094013266 1.46543205325214 1.46543205325214 1.1825214652836151
163 O=C(OCCCCCCN([C@H](C(NCCN(C)CCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.80021894 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.318154558079471 0.0260251149767627 0.00751090805185066 0.0532899531021804 0.0511794000344704 0.0152455710134586 0.0158624088727893 0.830886643948488 0.594741863231617 0.594741863231617 -0.16047622486848778
164 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.518849479521564 0.235642631118293 0.00357683071882224 0.268183756367962 0.0537803810677977 0.0056567696761597 0.00550191880428196 0.427657712246684 1.0 1.0 0.4646149359523945
165 CCCCCCCCCCCC(OCCCCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCOC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)=O DSPC 0 0 1 0 17.89376817 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.605170185988092 0.00991904799330563 0.00800736011391533 0.0452217049389508 0.0197202047147262 0.0164331186633441 0.0158205463682553 0.884878017207502 0.0777961107519447 0.0777961107519447 -0.9578401546237735
166 O=C(OCCCCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCOC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.61561565 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.886582645426277 - - - - - - - 0.0
167 CCCCCCCCCCCC(OCCCCCCN(CCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.01340623 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.190175207928333 - - - - - - - 0.0
168 O=C(OCCCCCCN([C@H](C(NCCOCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.7439276 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.2694176902912275 0.0273933363293668 0.0025481137083807 0.0489889660247262 0.00910395259986531 0.00553863037137659 0.00570731639004281 0.900719684576242 0.282511511559215 0.282511511559215 -0.6420765069177559
169 O=C(CCCCCCCCCCC)OCCCCCCN(CCOCCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)CCCCCCOC(CCCCCCCCCCC)=O DSPC 0 0 1 0 18.18802872 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.561949483533528 0.0107761878140537 0.0018907931479914 0.00906874325536026 0.00817364202148832 0.00369121050409089 0.00412231341943734 0.962277109837578 1.03869430459932 1.03869430459932 0.5242990374784536
170 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.77912349311153 0.0897266059620516 0.00139613482527267 0.256772056278909 0.191186512263101 0.00338160925528312 0.00297344390156773 0.454563637513815 1.0 1.0 0.4646149359523945
171 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 17.8896653 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.422808628394115 - 0.00393259539867672 0.698404256940233 0.29082082024119 0.00482745799593445 0.00201486942396601 - 0.150267764477171 0.150267764477171 -0.3979684896277195
172 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 0 1 0 0 0.0 4.24735173134728 - 0.0193985055782088 0.642311593152982 0.297952931923085 0.0232690994142363 0.0170678699314884 - 0.0138284395356039 0.0138284395356039 -0.7620557072620823
173 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.776599301615622 - 0.00374237304524464 0.388696129733584 0.542462789676973 0.0600826887673663 0.00501601877683173 - 0.0757788640374704 0.0757788640374704 -0.5967415084575073
174 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.59784341060163 - 0.00454633850545055 0.547957057084188 0.42844914578143 0.0150324705651762 0.00401498806375593 - 0.0747683143174281 0.0747683143174281 -0.5994381520828621
175 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.37981918 46.5 7.5 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.784988612563928 - 0.00648649184357099 0.353238786148937 0.611732175774514 0.0204133713900616 0.00812917484291689 - 0.231046253558505 0.231046253558505 -0.18241175518238087
176 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.684905154006945 - 0.00209231248329155 0.858334702447977 0.133879376324869 0.0038743559198132 0.0018192528240494 - 1.0 1.0 1.8695349995476385
177 CC(CNC([C@@H](N(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CO)=O)(CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)C DSPC 0 0 1 0 18.00540724 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.583231278469338 - - - - - - - 0.0
178 CC(CNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)(CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)C DSPC 0 0 1 0 17.73535311 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.224056168743758 - - - - - - - 0.0
179 O=C(CCCCC(OCCCCCCN(CCCNC([C@@H](N(CCCCCCOC(CCCCC(OCCCC(F)(F)F)=O)=O)CCCCCCOC(CCCCC(OCCCC(F)(F)F)=O)=O)CO)=O)CCCCCCOC(CCCCC(OCCCC(F)(F)F)=O)=O)=O)OCCCC(F)(F)F DSPC 0 0 1 0 18.72527826 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.972587226458726 - - - - - - - 0.0
180 O=C(OCCCCCCCCN(CCCNC([C@@H](N(CCCCCCCCOC(CCCCCCCCC)=O)CCCCCCCCOC(CCCCCCCCC)=O)CO)=O)CCCCCCCCOC(CCCCCCCCC)=O)CCCCCCCCC DSPC 0 0 1 0 17.8896653 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.363226005210164 0.0302618004269707 0.0170318389360463 0.0852511261606349 0.0321310738618372 0.020553836096385 0.0249767617646758 0.78979356275345 0.103578477209434 0.103578477209434 -0.9180720959090577
181 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.3651347670036635 0.0896852170263435 0.00316402812450449 0.145700011838927 0.0181473232698177 0.0048727657230144 0.00676784889254742 0.731662805124845 1.0 1.0 0.4646149359523945
182 O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCCCCCC DSPC 0 0 1 0 17.93964861 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.27430221608671 0.0441668582339066 0.00173504332049564 0.0552287456296669 0.0103338721124601 0.00424436496446174 0.00798306414101548 0.876308051597994 0.118006736161235 0.118006736161235 -0.8958172012665345
183 O=C(OCCCCCCN([C@H](C(NC/C=C/CN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCCCC=C DSPC 0 0 1 0 17.66483929 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.322011202263895 0.014374943627672 0.00199135248489222 0.0891563599260395 0.0109943655858212 0.00408170887074953 0.00721565797781185 0.872185611527014 0.120117219447052 0.120117219447052 -0.8925618824281657
184 C=CCCCCCCCCC(OCCCCCCN(CCOCCOCCNC([C@@H](N(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)CO)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O DSPC 0 0 1 0 17.93091393 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.589955020181611 0.159505299591344 0.00863892692709962 0.059163494819016 0.0251436766117119 0.0207012928199433 0.0319161553971728 0.694931153833713 0.19624671777719 0.19624671777719 -0.775135797258418
185 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.461068842013835 0.18227458966528 0.00260059752378256 0.10140002712747 0.0194272464327483 0.00394998811850684 0.00708234329707097 0.683265207835141 1.0 1.0 0.4646149359523945
186 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 18.16832078 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.897839799950911 - - - - - - - 0.0
187 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.87291972 32.96703297 21.97802198 43.95604396 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.667205576907544 - - - - - - - 0.0
188 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.34369997 41.32231405 16.52892562 41.32231405 0.826446281 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.786658062033468 - - - - - - - 0.0
189 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.12329906 27.02702703 32.43243243 37.83783784 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.520374534283375 - - - - - - - 0.0
190 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.602904588 25.0 40.0 30.0 5.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.2162671661789055 - - - - - - - 0.0
191 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.22342652 38.46153846 21.97802198 38.46153846 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 4.634728988229636 - - - - - - - 0.0
192 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.21412129 40.0 34.28571429 22.85714286 2.857142857 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.378896741664954 - - - - - - - 0.0
193 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.29890072 34.65346535 39.6039604 24.75247525 0.99009901 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.661550519424199 - - - - - - - 0.0
194 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.62419529 41.86046512 37.20930233 18.60465116 2.325581395 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.552612935249416 - - - - - - - 0.0
195 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 5.021245473208271 0.0189024787568605 0.00542838949966448 0.0161874266221436 0.00564673685028802 0.0063903753402389 0.0111802988958026 0.936264294035002 0.0913658402077254 0.0913658402077254 -0.9369095003865034
196 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.59373115 37.83783784 37.83783784 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.484470400750307 0.220192249542946 0.000764987158036526 0.00117389921248248 0.000355328494502401 0.000727082388944626 0.00146163086877099 0.775324822334317 0.909323670538887 0.909323670538887 0.3247510642635732
197 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.02523135 35.8974359 41.02564103 20.51282051 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.474947598938117 0.0634606467339624 0.00208550415241484 0.000693953783467295 0.000703971489002912 0.00107462659382075 0.00306678394465369 0.928914513302678 0.68813569412733 0.68813569412733 -0.016420738077667085
198 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.01459482 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.414493824811383 0.0115671522937999 0.000329262998462127 0.000782715410474643 0.000454168201139608 0.00050928396392566 0.0365052454816706 0.949852171650527 1.45919493888772 1.45919493888772 1.172901016723797
199 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.50825332 52.83018868 26.41509434 18.86792453 1.886792453 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.573163389853005 0.0289504727873473 0.000587630380490671 0.00098172979734669 0.000247631664832521 0.000530890620697785 0.00148666967519347 0.967214975074092 1.18732779204068 1.18732779204068 0.7535590344336197
200 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.02959744 50.90909091 29.09090909 18.18181818 1.818181818 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.424367475163407 0.01918176556647 0.0010650954164724 0.0022206234626453 0.00126505200881015 0.0010329415925789 0.00258134917445057 0.972653172778573 0.519739549496667 0.519739549496667 -0.2761636820795619
201 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.0526464 43.24324324 32.43243243 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.646312129319266 0.0173760673957131 0.000550323482827711 0.00231355504088989 0.000799250291024724 0.00171157517792979 0.00187915335599706 0.975370075255618 0.641975082983608 0.641975082983608 -0.08762125790960282
202 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.87880561 39.02439024 39.02439024 19.51219512 2.43902439 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.627909672957581 0.031425165165133 0.00121897501467252 0.00336392108926765 0.00273184674446895 0.00365496097119473 0.00253008289994281 0.95507504811532 0.292484943880311 0.292484943880311 -0.6266929678315919
203 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.72896002 41.02564103 30.76923077 25.64102564 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.6141299273595635 0.00243290161785256 0.00374029360494432 0.00771109158226845 0.00256075951190699 0.0024473081411263 0.00398520450059787 0.977122441041304 0.29000081469118 0.29000081469118 -0.6305246174829606
204 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.2936051730729785 0.0291199872991734 0.000702410023626044 0.0253755412996204 0.0176881988849176 0.000962484515645204 0.00126799370807735 0.92488338426894 1.0 1.0 0.4646149359523945
205 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.596835549198034 0.0642873127295256 0.000194616801396495 0.00548703707264694 0.0163820187916684 0.000849254927099769 0.000518055392084143 0.912281704285579 0.772854925639995 0.772854925639995 0.11425459688882487
206 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.26769266 37.83783784 37.83783784 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.284827171296749 0.000820324065776298 6.77505055763446e-05 0.00130838737685328 0.00203458073148474 0.00044026025400656 0.00179231955954145 0.993536377506761 0.647354606156059 0.647354606156059 -0.07932360246622268
207 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 12.69845587 35.8974359 41.02564103 20.51282051 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.355939299910563 0.000606683031689403 0.000350488437662207 0.00200552330636915 0.00341592792036262 0.00135658595795651 0.00484812686613966 0.98741666447982 0.429472560198128 0.429472560198128 -0.4153961662793264
208 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.73864775 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.210051369934071 0.0506054803736383 0.000934742670841204 0.00195746112246746 0.00131704918881155 0.00229254534633995 0.00362188526923176 0.93927083602867 0.295296757118666 0.295296757118666 -0.622355881313871
209 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.22254695 52.83018868 26.41509434 18.86792453 1.886792453 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.19614876167715 0.000394517913167851 0.000925918583325644 0.00219111536287718 0.00192843383777798 0.00141208216065332 0.00279803133939282 0.990349900802805 0.423957111788814 0.423957111788814 -0.4239034798551084
210 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 16.73562869 50.90909091 29.09090909 18.18181818 1.818181818 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.324000197151533 0.0149763371723649 9.09516394922477e-05 0.00865819492777344 0.00337158611087041 0.000870833891384162 0.00234291805381448 0.9696891782043 0.799987755503576 0.799987755503576 0.1561056803760758
211 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.73441264 43.24324324 32.43243243 21.62162162 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.638604962074329 0.00412763242238728 0.000587351434637121 0.00125519721482213 0.00156835329887146 0.00151910105091065 0.00332452673735467 0.987617837841017 0.519710678404319 0.519710678404319 -0.27620821434922566
212 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.55362203 39.02439024 39.02439024 19.51219512 2.43902439 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.465448242812954 0.001908149535057 0.00051106883667359 0.00195557181028906 0.00222543526142979 0.00102554934782431 0.0036709617373884 0.988703263471338 0.559906246507883 0.559906246507883 -0.21420848616098725
213 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.4082575 41.02564103 30.76923077 25.64102564 2.564102564 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.439351701293151 0.0164941051995163 0.00133624924425635 0.0136411729141475 0.0068725438331318 0.00281561744256348 0.00565863059250302 0.953181680773882 0.404416041627467 0.404416041627467 -0.4540446395817048
214 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.348211286179151 0.25310386523031 0.000588156076259717 0.140706646889545 0.17621759673582 0.00218337900345845 0.000839731767209391 0.426360624297398 1.0 1.0 0.4646149359523945
215 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 17.98993052 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.574298522321004 0.0173152888243317 0.00170643426094864 0.0181271736370668 0.0103847448319841 0.00234708518590686 0.00464250497463967 0.945476768285122 0.880302275630684 0.880302275630684 0.27998696013855723
216 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.54771521 32.96703297 21.97802198 43.95604396 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.530015512387331 0.0022188818222417 0.00151967168045253 0.0265741083102934 0.00935341146520975 0.00161955884356527 0.00594450434134348 0.952769863536894 0.693395601815244 0.693395601815244 -0.008307583759119837
217 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 16.03951812 41.32231405 16.52892562 41.32231405 0.826446281 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.640537329825382 0.0191565810814788 0.00120917820488213 0.00564887782228727 0.00368324602436162 0.00270413188019715 0.00625226385441887 0.961345721132374 0.702078866162311 0.702078866162311 0.005085933354948288
218 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 10.8033785 27.02702703 32.43243243 37.83783784 2.702702703 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.2431955089544555 0.0191175904912105 0.0046774627841674 0.0253721583259607 0.0153479247605493 0.0105242912643767 0.0240873946993884 0.900873177674347 0.168910555827937 0.168910555827937 -0.8173005106963921
219 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 9.298704135 25.0 40.0 30.0 5.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.822697998516666 0.00783638212803346 0.00315432464612104 0.0156004284210389 0.0122536904537434 0.00649575798551451 0.014293561001533 0.940365855364016 0.26946434750834 0.26946434750834 -0.6622011291820169
220 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.90666525 38.46153846 21.97802198 38.46153846 1.098901099 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 5.291292751611072 - - - - - - - 0.0
221 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 13.89035919 40.0 34.28571429 22.85714286 2.857142857 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.388753955423308 0.0457836478243602 0.00256820195313693 0.0933595380902435 0.040121791020458 0.00303459231576053 0.00719748271402532 0.807934746082015 0.638042293066864 0.638042293066864 -0.09368739697327609
222 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 12.97231927 34.65346535 39.6039604 24.75247525 0.99009901 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.500031867864786 0.00367784574047392 0.00111977791364668 0.0109807451773001 0.00533981749985873 0.0035253353907892 0.00945759694134628 0.965898881336585 0.664597706735618 0.664597706735618 -0.05272695016115616
223 C=CCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCC=C)=O)CCCCCCOC(CCCCCCCCC=C)=O)=O)CO)CCCCCCOC(CCCCCCCCC=C)=O)=O DOPE 1 0 0 0 14.30278396 41.86046512 37.20930233 18.60465116 2.325581395 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.578518154990665 0.00602415700375336 0.00352191807012307 0.0129438874596237 0.0112365957475355 0.00705054455561779 0.0163551166761144 0.942867780487232 0.387412476367661 0.387412476367661 -0.48027182019083947
224 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DOPE 1 0 0 0 14.78083639 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.373742415086184 0.00132025329631253 0.000860633620224201 0.00503931327076771 0.0029913613071963 0.00270028184029275 0.0088532339643477 0.978234922700859 1.0 1.0 0.4646149359523945
225 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.434619084793052 0.00770185399584477 0.00244833711322221 0.0462111239750686 0.0198642411939162 0.00381226904350308 0.00922041774380283 0.910741756934642 1.0 1.0 0.4646149359523945
226 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DSPC 0 0 1 0 11.7812451 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.485936098064394 0.00448668985970796 0.00155299888410839 0.00808200908228358 0.00771278024096098 0.00385266053622471 0.00536687174407294 0.968945989652641 1.22295554827804 1.22295554827804 0.8085131327805288
227 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.01459482 54.90196078 23.52941176 19.60784314 1.960784314 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.73444252169223 0.00221922165343577 0.00134658478491355 0.00928071520245763 0.0103471897935628 0.00308928870366618 0.00305991935175966 0.970657080510204 2.4848301850992 2.4848301850992 2.75489399469468
228 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.67100244 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.379899373657707 0.0165979002447495 0.00361970146585138 0.310566371988181 0.0118953898978584 0.00727497963461814 0.00647222326114303 0.643573433507598 1.0 1.0 0.4646149359523945
229 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 18.26075368 50.0 10.0 38.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.7140245909001735 - - - - - - - 0.0
230 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.85564 30.9 36.3 25.9 6.9 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.002960000420248 - - - - - - - 0.0
231 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 12.10629825 33.7 32.2 28.8 5.4 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 3.9917579734469997 - - - - - - - 0.0
232 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 8.076607527 21.5 44.3 27.4 6.7 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 4.150252194160397 - - - - - - - 0.0
233 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.262126773 28.5 36.9 23.3 11.4 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 3.9384701754429945 - - - - - - - 0.0
234 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.14390228 47.0 40.4 5.7 6.8 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 4.139158578011894 - - - - - - - 0.0
235 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.465333240800292 0.0929588198875335 0.00109661539851913 0.0103406974639253 0.00262333547972377 0.00257373980843396 0.00319533888859958 0.887211453073265 2.49616154919077 2.49616154919077 2.7723720781458008
236 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.95064466 41.0 39.5 16.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.25063580654847 0.00217929592656579 0.00233573351378476 0.00718449647353577 0.00718369422949875 0.00471157922942054 0.00408542775852615 0.972319772868668 1.71461830076508 1.71461830076508 1.5668792525462236
237 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.40653622 31.3333 31.3333 31.3333 6.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.188896879163323 0.0142737392382439 0.00348189340868737 0.00880858320276677 0.0038525568856599 0.00593274588142816 0.00610316587084082 0.957547315512373 0.645718762121967 0.645718762121967 -0.08184681311498729
238 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.77836699 50.0 23.5 23.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.343935283551159 0.0065593281978378 0.00138907609400551 0.00613919753007927 0.00613411120238244 0.00366825953495706 0.00406194129869205 0.972048086142046 1.35219591573978 1.35219591573978 1.0078601760398935
239 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.200348974 22.0 22.0 50.0 6.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.057161771094385 - - - - - - - 0.0
240 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.72417162 27.0 27.0 41.0 5.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 0 1 0 0 4.102973888920155 - - - - - - - 0.0
241 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.092439729 16.0 39.5 41.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.127940511650616 0.0097349353786325 0.00823434520879355 0.0380775286515883 0.0189007253206434 0.0281939358827934 0.0273826912679074 0.869475838289641 0.161929321885153 0.161929321885153 -0.8280687278728707
242 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.93804335 39.5 16.0 41.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.116269119637892 0.00176070173692806 0.00134882241229812 0.00721447825021801 0.00277771416530431 0.00258248336542972 0.00338400053115958 0.980931799538662 0.834918279031508 0.834918279031508 0.2099843308438277
243 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.312676556539088 0.0122849683487715 0.00187692747865846 0.313004652084084 0.0267625511357853 0.00478000951875277 0.00400214034383056 0.637288751090117 1.0 1.0 0.4646149359523945
244 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.5612182984589085 0.00230427148121394 0.00151653786120671 0.00981883965091339 0.0195498469521307 0.00278714514326426 0.00256552165624032 0.961457837255031 3.54213716664653 3.54213716664653 4.385739099273481
245 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 13.95064466 41.0 39.5 16.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.2756934238792645 0.00339636246099529 0.00439836397767252 0.00922438120812044 0.0070906355917358 0.00777777401057153 0.0070228258793507 0.961089656871554 1.60048193764837 1.60048193764837 1.3908294086580206
246 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.77836699 50.0 23.5 23.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.300138475201197 0.0251900613139205 0.0263858529561065 0.0690244086529141 0.0290319859464883 0.0512059292322219 0.0395084822769767 0.759653279621372 0.244442812501583 0.244442812501583 -0.7007956420217016
247 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.93804335 39.5 16.0 41.0 3.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.035478809355064 - - - - - - - 0.0
248 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.07835597 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.314416735011824 0.00832740543716945 0.00279899792781369 0.0133506530995165 0.00590470004845411 0.00800781451355169 0.00611088774111073 0.955499541232384 1.4036171732161 1.4036171732161 1.0871749895142324
249 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 12.46964291 32.3 32.3 32.3 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.122932019074013 0.00935369123549862 0.00681432683334856 0.0266295187790274 0.0091342786879667 0.0148394527045059 0.0109795829907811 0.922249148768872 0.807897092094877 0.807897092094877 0.168305451195249
250 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 0 1 0 0 0.0 4.214347354616797 0.00175971204953205 0.0023945553766021 0.00864096914216858 0.00287247113967731 0.00354165273920712 0.00438932700137801 0.976401312551435 2.1807873939408 2.1807873939408 2.28592263046752
251 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.297557478047431 0.0163588203416613 0.0050349858804786 0.141665503002976 0.0268932928836599 0.0108166459136593 0.00842178986187252 0.790808962115693 1.0 1.0 0.4646149359523945
252 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.623991940228679 0.0114998638575461 0.00130788860611426 0.00505223783079306 0.0046933168158669 0.00183202266239377 0.00287251942980201 0.972742150797484 1.19732008331576 1.19732008331576 0.768971662548154
253 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.47398367 41.5 40.5 16.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.261975403606051 0.0120973279883405 0.00779128029381303 0.0260350268299895 0.0160802201335602 0.0156019499205845 0.0170739234476819 0.90532027138603 0.213285375768679 0.213285375768679 -0.7488544878005475
254 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.72570651 40.5 16.0 41.5 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.168678699274804 0.00644850088058007 0.00798921970887525 0.0221223520376599 0.0111631004951633 0.0106463671035197 0.00996963598739929 0.931660823786802 0.29077874869216 0.29077874869216 -0.6293246917477433
255 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.63764671 41.5 40.5 16.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.40562108352751 0.0088141667427258 0.00585903666298478 0.0157870816204507 0.010986042994209 0.00978368783097364 0.0102623946891479 0.938507589459508 0.370029347989408 0.370029347989408 -0.507084458632374
256 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.89020107 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.402441819416474 0.154933534385178 0.00229861102597737 0.00525615721273492 0.00408539799683711 0.0022876287732977 0.00287249757879639 0.828266173027179 1.34933481107146 1.34933481107146 1.003447059865073
257 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.91076362 42.0 40.5 16.5 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.607168188650764 0.0408588610755303 0.0177373482989948 0.0425327283385076 0.0277718677406049 0.0276871974121274 0.0218927074965806 0.821519289637654 0.158736230637426 0.158736230637426 -0.8329939173596629
258 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.86872188 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.4277167605909975 0.00307921600642319 0.00224989559352084 0.00599370029233814 0.00443157985269048 0.00263031532778781 0.00293093049696406 0.978684362430275 1.27822314397057 1.27822314397057 0.8937607377335357
259 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.444179499895966 0.0412236553892641 0.00390663231476925 0.121517080143859 0.0188177267921366 0.00482332620655526 0.0073631886059774 0.802348390547439 1.0 1.0 0.4646149359523945
260 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 17.98206341 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.573473099244837 0.00689869445402741 0.00600089779665737 0.0191135089301672 0.00620664286397134 0.00981653359048003 0.0097967903769499 0.942166931987747 0.749333285576466 0.749333285576466 0.07797359977185479
261 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.88644869 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.688591794127164 0.00886147101476089 0.00436553876298869 0.0150948084008648 0.00476112441477112 0.00826588994437132 0.00836456609804533 0.950286601364198 0.883781845590108 0.883781845590108 0.28535402924280306
262 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 8.877221176 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.829113417472866 0.00517423746484337 0.00420818785762778 0.0136338012801862 0.00389526355348657 0.0081026937251479 0.00825574629036951 0.956730069828339 1.02766134878372 1.02766134878372 0.5072812344232112
263 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 14.07835597 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.4595662121293 0.025369932029363 0.00629969301959379 0.0185849502075566 0.00668329267445478 0.00984673129800659 0.00995848867776924 0.923256912093256 0.773367707896157 0.773367707896157 0.11504553882600273
264 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 9.306031912 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.528073135603124 0.00974026247143072 0.00459547921939943 0.0155882894773368 0.00424301614179951 0.00735125258984654 0.00918675243548622 0.949294947664701 0.925634770529548 0.925634770529548 0.34991015054061214
265 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 6.950074466 41.0 40.0 16.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.730921391293652 0.0307398296858454 0.00502448817507942 0.0144391987292623 0.00475975114719379 0.00732990645958348 0.00864531856689022 0.929061507236145 0.282355212986546 0.282355212986546 -0.6423175899395637
266 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.3578620076745835 0.0575651939642587 0.00224327504140443 0.293214190330324 0.103801109257072 0.00316596887134689 0.00243404296405076 0.537576219571543 1.0 1.0 0.4646149359523945
267 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.1515122352784415 - - - - - - - 0.0
268 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.0693509 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.2656332579940335 - - - - - - - 0.0
269 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.52014814 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.431173877940127 - - - - - - - 0.0
270 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.89020107 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.436396441739405 - - - - - - - 0.0
271 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.50369223 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.5666372362713075 - - - - - - - 0.0
272 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.844529643 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 4.765586907393996 - - - - - - - 0.0
273 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.23312059 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.149936935645806 0.0412282002133458 0.00282906106065428 0.0100452919302821 0.00294646346634102 0.0035555046437446 0.00510039590268196 0.93429508278295 2.31132936702855 2.31132936702855 2.4872773377263835
274 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.0693509 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.244200317766478 0.0307672106546614 0.0492440442693678 0.143087600825361 0.0409904333145751 0.0410729694241231 0.0628737572688051 0.631963984243106 0.159668526820479 0.159668526820479 -0.8315558953918857
275 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.52014814 40.0 16.0 41.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.430459592195472 0.0144382835185698 0.030629687100469 0.0904231657039977 0.0327120644783899 0.0374915496460484 0.0408664371206098 0.753438812431916 0.342029093157046 0.342029093157046 -0.5502735033632513
276 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 15.89020107 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.560277417097355 0.064087583051715 0.00731756531038673 0.0186036957891068 0.0053871458118381 0.00655845861152129 0.0086069303650773 0.889438621060355 2.14638048731397 2.14638048731397 2.232851633855025
277 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 10.50369223 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.667205576907544 0.00310349569550498 0.00416831577034203 0.0115025538737423 0.00349250282837259 0.00500126547712412 0.00690260249517487 0.965829263859739 3.35844880423818 3.35844880423818 4.1024086457439415
278 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 7.844529643 40.5 16.5 41.5 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.713127327493184 0.00089376253365906 0.00183788568066981 0.0054363636464257 0.00195410248071216 0.00225811087193407 0.00383533887250888 0.98378443591409 3.24722414573894 3.24722414573894 3.9308499660154896
279 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.359653205696989 0.0828383439279835 0.00565653685524585 0.157248489872984 0.00928479521934879 0.00688752099561758 0.00841921269728692 0.729665100431533 1.0 1.0 0.4646149359523945
280 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 16.86872188 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.634728988229636 0.00818072805535472 0.00273349879854757 0.0119346096951512 0.0075308964437597 0.00591367796700706 0.00578329104170321 0.957923297998477 0.213428398303373 0.213428398303373 -0.7486338824280105
281 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 11.15051107 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.7140245909001735 0.0160361616147136 0.00185083446366488 0.00730973501824061 0.00349956550575257 0.00416153151105757 0.00426975100661699 0.962872420879954 0.319359456002154 0.319359456002154 -0.58524032702172
282 CCCCCCCCCCCC(OCCCCCCN([C@H](C(NCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)=O)CO)CCCCCCOC(CCCCCCCCCCC)=O)=O DOPE 1 0 0 0 8.327596879 49.0 25.0 24.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ser Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 0.0 4.822697998516666 0.0208671125611406 0.0200298903914976 0.0765668274895919 0.0297655881927753 0.0442427715485906 0.0417155046265625 0.766812305189841 0.0431568482237034 0.0431568482237034 -1.011269549025132
283 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.548282323781043 0.235642631118293 0.00357683071882224 0.268183756367962 0.0537803810677977 0.0056567696761597 0.00550191880428196 0.427657712246684 1.0 1.0 0.4646149359523945
284 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.41834022 50.0 7.5 41.5 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.892602227184663 0.0004 0.0007 0.8627 0.1335 0.0019 0.0008 0 0.33 0.33 0.08164550420240263
285 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.34376213 50.0 29.0 20.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.935911747900319 0.0015 0.0017 0.585 0.3856 0.0215 0.0046 0 0.09 0.09 -0.5587925239809655
286 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.47881241 45.5 7.5 45.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.657762636107262 0.0008 0.0009 0.9399 0.0565 0.0012 0.0006 0 0.26 0.26 -0.10514892068441307
287 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.58994389 50.0 17.75 30.25 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.6520537718869415 0.0009 0.0008 0.8853 0.11 0.0021 0.0009 0 0.31 0.31 0.028275668520455245
288 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.356515817 38.0 30.0 30.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.522874943261261 0.0008 0.0012 0.7508 0.2416 0.0048 0.0008 0 0.12 0.12 -0.4787377704580445
289 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.211083767 38.0 16.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.802380355275797 0.0003 0.0007 0.8979 0.0985 0.0022 0.0005 0 0.45 0.45 0.40186451829408665
290 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.891852481 38.0 23.0 38.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.721173861744398 0.0003 0.0009 0.9061 0.0898 0.0024 0.0005 0 0.3 0.3 0.0015907506794815506
291 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.59856338 45.96 24.83 26.71 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.599152113662528 0.0006 0.0011 0.8386 0.1563 0.0028 0.0007 0 0.36 0.36 0.16170025772532357
292 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.516252746 44.58 19.33 33.08 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.539030383483547 0.0011 0.0009 0.9163 0.0784 0.0025 0.0008 0 0.24 0.24 -0.15851875636636045
293 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.79855736 50.0 7.5 39.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.602165676967792 0.0007 0.0007 0.9622 0.0349 0.001 0.0005 0 0.91 0.91 1.6293707389788754
294 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.789158454 42.5 30.0 24.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.506454213048934 0.0013 0.0022 0.7003 0.2848 0.009 0.0025 0 0.1 0.1 -0.5321076061399918
295 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.924427289 44.71 13.58 39.21 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.543294782270004 0.0006 0.0008 0.9464 0.0496 0.0015 0.0011 0 0.56 0.56 0.6953986145447971
296 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.213203287 41.46 24.83 32.21 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.600157644164547 0.0006 0.0011 0.9277 0.0684 0.0014 0.0008 0 0.44 0.44 0.37517960045311294
297 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.766920469 38.0 14.0 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.380775852772229 0.0005 0.001 0.9807 0.0157 0.0015 0.0006 0 0.46 0.46 0.42854943613506036
298 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.9150442 50.0 27.0 20.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.490881039585964 0.0013 0.001 0.7257 0.2649 0.0061 0.0009 0 0.13 0.13 -0.4520528526170708
299 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.33144164 47.24 11.19 38.87 2.71 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.627909672957581 0.0073 0.0639 0.7768 0.1461 0.0042 0.0016 0 1.3 1.3 2.670082534776849
300 OCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.92222847 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.8543712716215905 0.001 0.001 0.8647 0.1302 0.0025 0.0007 0 0.25 0.25 -0.13183383852538677
301 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.314817884980432 0.0009 0.0007 0.9116 0.0844 0.0018 0.0006 0 1.0 1.0 1.8695349995476385
302 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.42041204 49.0 7.5 41.5 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.534747721691546 0.0013 0.0021 0.5194 0.4632 0.0111 0.0029 0 0.5 0.5 0.535289107498955
303 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 15.70987342 34.25 18.75 45.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.191168746857641 0.0011 0.0011 0.7685 0.2222 0.0053 0.0018 0 0.15 0.15 -0.3986830169351235
304 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 11.2192693 22.0 30.0 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.151039905898646 0.0028 0.0014 0.4022 0.5806 0.0101 0.003 0 0.05 0.05 -0.6655321953448602
305 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.76101632 49.0 28.0 20.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.154184562578117 0.001 0.0012 0.5862 0.3912 0.0188 0.0017 0 0.16 0.16 -0.37199809909414977
306 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.31421044 44.61 24.89 27.94 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.155753190350744 0.0041 0.0015 0.5886 0.3825 0.0211 0.0022 0 0.13 0.13 -0.4520528526170708
307 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 14.60470229 32.11 24.89 40.44 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.104294893075269 0.0017 0.0016 0.5892 0.3913 0.0129 0.0033 0 0.05 0.05 -0.6655321953448602
308 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.00750041 49.0 18.75 31.25 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.516338972281476 0.0111 0.0048 0.1796 0.7293 0.0671 0.0082 0 0.14 0.14 -0.4253679347760971
309 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.77390107 42.13 18.75 38.13 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.33204826486764 0.0167 0.0049 0.2598 0.6793 0.0289 0.0104 0 0.15 0.15 -0.3986830169351235
310 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.21646499 45.61 13.64 38.19 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.365643155423357 0.0042 0.0015 0.3443 0.6172 0.0298 0.003 0 0.2 0.2 -0.2652584277302551
311 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.27353562 44.5 7.5 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.436751534363128 0.0067 0.0013 0.5909 0.385 0.0142 0.0019 0 0.22 0.22 -0.21188859204830776
312 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.27759176 49.0 30.0 20.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.151039905898646 0.0122 0.0028 0.2395 0.6818 0.0594 0.0044 0 0.08 0.08 -0.5854774418219391
313 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 14.75114553 34.5 30.0 32.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.248495242049359 0.0029 0.0024 0.3338 0.6429 0.0151 0.0029 0 0.07 0.07 -0.6121623596629128
314 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 16.61008 39.36 24.89 34.19 1.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.384523514872469 0.0141 0.0106 0.3243 0.5845 0.0592 0.0073 0 0.14 0.14 -0.4253679347760971
315 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 12.46688772 24.0 30.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.796616650559047 0.0064 0.0026 0.3777 0.6006 0.0093 0.0034 0 0.1 0.1 -0.5321076061399918
316 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.37981918 46.5 7.5 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.516338972281476 0.0024 0.0028 0.4642 0.5174 0.0093 0.0039 0 0.81 0.81 1.362521560569139
317 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 16.04448224 37.36 29.94 31.71 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.370712874773608 0.033 0.008 0.1094 0.8115 0.0325 0.0056 0 0.11 0.11 -0.5054226882990182
318 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.623010104116422 0.0087 0.0033 0.2348 0.7393 0.011 0.003 0 0.36 0.36 0.16170025772532357
319 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 14.343031 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.375757021660286 0.0019 0.0023 0.9077 0.0818 0.0033 0.003 0 1.0 1.0 1.8695349995476385
320 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.34776106 49.0 7.5 41.5 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.943782987108415 0.0542 0.0001 0.3146 0.0378 0.0014 0.0006 0.5913 1.14 1.14 0.680558194273546
321 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.630330503 34.25 18.75 45.0 2.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.395682961121367 0.03 0.0006 0.0837 0.0261 0.002 0.0013 0.8563 0.78 0.78 0.12527553001915628
322 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 5.746375559 22.0 30.0 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.264087336809195 0.0156 0.0014 0.0138 0.0104 0.0025 0.0031 0.9532 0.32 0.32 -0.584252318750342
323 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.15734025 49.0 28.0 20.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 1 0 0 1 0 0 0 4.513054897080286 0.0
324 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.812051718 44.61 24.89 27.94 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.470495282661489 0.009 0.0004 0.0178 0.0948 0.0017 0.0003 0.8762 1.05 1.05 0.5417375282099487
325 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 7.893697629 32.11 24.89 40.44 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.289088639014612 0.0343 0.0003 0.1697 0.027 0.0013 0.0009 0.7666 0.46 0.46 -0.3683090604291903
326 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.08675917 49.0 18.75 31.25 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.9684234452869465 0.0
327 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.13512977 42.13 18.75 38.13 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.906015244966153 0.0128 0 0.028 0.0208 0.0006 0 0.9378 0.93 0.93 0.35664330679181877
328 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.43848511 45.61 13.64 38.19 2.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.525044141508807 0.0635 0.0002 0.2019 0.083 0.0009 0.0003 0.6502 1.5 1.5 1.2358408585279361
329 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.44748395 44.5 7.5 45.0 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.4520190064939165 0.011 0.0005 0.3972 0.0536 0.0016 0.0009 0.5352 1.45 1.45 1.1587182662703819
330 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 10.57169095 49.0 30.0 20.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.86830338551846 0.0
331 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 8.009941019 34.5 30.0 32.5 3.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.3476939555933765 0.0165 0 0.0427 0.0616 0.0035 0.0028 0.8728 0.42 0.42 -0.4300071342352337
332 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 9.301142352 39.36 24.89 34.19 1.56 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 4.629862798578463 0.0246 0 0.1245 0.0895 0.0015 0.0023 0.7576 0.44 0.44 -0.399158097332212
333 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 6.525773643 24.0 30.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.732683506287051 0.006 0.0012 0.0205 0.0177 0.0008 0 0.9538 0.44 0.44 -0.399158097332212
334 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.31765932 46.5 7.5 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.81380905109942 0.073 0 0.0373 0.0149 0 0 0.8748 1.01 1.01 0.4800394544039054
335 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.01888288 46.37 7.5 44.21 1.92 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.706823839714591 0.0145 0.0004 0.1165 0.019 0.0007 0.0011 0.8477 1.94 1.94 1.9145196703944125
336 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 11.30562834 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.73795129722191 0.0343 0.0003 0.1697 0.027 0.0013 0.0009 0.7666 1.9 1.9 1.8528215965883692
337 O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCO DSPC 0 0 1 0 9.480986593 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence Crtl Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.302712827954156 0.0455 0 0.324 0.073 0.0011 0.0012 0.5551 1.0 1.0 0.4646149359523945
338 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 17.88551615 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.763028270603671 0.0253701689981931 0.00985209592098701 0.307949537646453 0.622300893638244 0.0174680522283724 0.0170592515677505 - 0.0
339 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 17.94390528 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.584559232083967 0.00894763570081526 0.00182903773179144 0.430416319953847 0.549730482792046 0.00757886856613304 0.0014976552553668 - 0.0019532059842532 0.0019532059842532 -0.793744670428099
340 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 18.3291697 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.5827200571505 0.00757568328250189 0.00220510873539676 0.728025615125869 0.236446776884745 0.0226429923353559 0.00310382363613184 - 0.0011482099710543 0.0011482099710543 -0.7958927956755514
341 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 18.38109198 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.6888677450096585 0.00599960547383456 0.00187471922407934 0.58725363712808 0.393842224090862 0.00908706069367491 0.00194275338946932 - 0.0005585876781053 0.0005585876781053 -0.7974661979200065
342 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 19.03103458 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.374372415737022 0.0207124354254999 0.00767807173489595 0.560331852523788 0.3797189836544 0.0206003960524344 0.0109582606089812 - 0.0001489580680618 0.0001489580680618 -0.7985592911689305
343 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 19.07349618 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.567572155572773 0.0084525958204246 0.00170600389954699 0.807774257087237 0.172171860632781 0.00851123850670424 0.00138404405330582 - 0.0052460712339961 0.0052460712339961 -0.7849576865630203
344 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 17.88551615 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.763028270603671 0.0142965461163966 0.00273099369058116 0.2951874813445 0.196790510597468 0.00567584660232592 0.00900724719724339 0.476311374451485 0.0033203605888808 0.0033203605888808 -1.0727154128818024
345 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 17.94390528 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.584559232083967 0.0426258503334726 0.000887127042175757 0.102099604743599 0.057196348771858 0.00222434780081794 0.00162961025671667 0.79333711105136 0.0465195426566469 0.0465195426566469 -1.006082754792359
346 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 18.3291697 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.5827200571505 0.0182648912592805 0.000462867676668248 0.083073077462289 0.0429608616930204 0.00195825764287227 0.000923423624969053 0.852356620640901 0.0509209522037464 0.0509209522037464 -0.9992937925151699
347 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 18.38109198 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.6888677450096585 0.0068908069603713 0.000629547873998548 0.021394314943629 0.042448777163022 0.00198708372142952 0.00248444060475972 0.92416502873279 0.016201262972428 0.016201262972428 -1.0528472412330891
348 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCN1CCOCC1 DSPC 0 0 1 0 19.03103458 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.374372415737022 0.0116932676375475 0.00103739027764326 0.0525071135910941 0.0215477599193875 0.00368874758435242 0.00400972460855577 0.905515996381419 0.006104461793755 0.006104461793755 -1.068421070841257
349 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCN1CCOCC1 DSPC 0 0 1 0 19.07349618 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ML Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.567572155572773 0.0237911981258413 0.00067207203055979 0.18334881014348 0.0466442684044473 0.00188246389345958 0.000953648344707904 0.742707539057504 0.0550488822731985 0.0550488822731985 -0.9929266591628888
350 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.82491214 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GLN Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.572543683160998 0.000714997259249526 0.000661552142657172 0.125943320778554 0.801966162874089 0.0693146503097598 0.00139931663568972 - 0.0127373438778132 0.0127373438778132 -0.764967287060561
351 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.91081918 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence BIM Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.358502089626924 0.00147233862420237 0.00107405472963131 0.901430168335102 0.0923159134092667 0.00310160866776492 0.000605916234032228 - 0.0763434621140544 0.0763434621140544 -0.5952348831288257
352 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81357262 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence 3FLA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.396299293960601 0.00110223184180453 0.00161797426133587 0.963322201717795 0.0321995776177804 0.00129202117564397 0.000465993385639812 - 0.380376087923258 0.380376087923258 0.21607368094058316
353 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.58547122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.351438552905858 0.00061802522712851 0.00208191419961706 0.00520107649990865 0.018780252186508 0.966671145724669 0.00664758616216931 - 0.0289886812604962 0.0289886812604962 -0.7216007267742771
354 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2 DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence IZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.544995462952021 0.00423798522906651 0.00360605985882706 0.0132163308359338 0.182768863634774 0.789078621894797 0.00709213854660109 - 0.0033387326299993 0.0033387326299993 -0.7900474039572776
355 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.80884374 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PY Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.237000862623624 0.0123483310685072 0.00430719249252366 0.0429874465070588 0.751978605237179 0.174073814828135 0.0143046098665965 - 0.0005090956767902 0.0005090956767902 -0.7975982669188943
356 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.790487251761845 0.00153513483125764 0.00147931904743739 0.82338319944907 0.169033483447006 0.00378262362292623 0.000786239602302501 - 0.306009500746919 0.306009500746919 0.017627054049161966
357 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 17.10338647 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.842058839093973 0.00164287085070931 0.000659195379539964 0.94017588697419 0.0550751037989028 0.00183173459161262 0.000615208405045708 - 0.504231824712829 0.504231824712829 0.5465816969768794
358 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CCC(N)=O)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.82491214 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence GLN Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.572543683160998 0.0204881792124896 0.00996076677576078 0.024515683125648 0.0206076067733214 0.0213656753332114 0.0146396167476402 0.888422472031929 0.0035574041476412 0.0035574041476412 -1.0723497846072114
359 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C1=CC=CC2=C1N=CN2)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.91081918 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence BIM Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.358502089626924 0.0789442718629389 0.000859220559164078 0.352513414289749 0.0167725689541561 0.00207992092629201 0.000939235620822743 0.547891367786878 0.128034152082589 0.128034152082589 -0.8803503950765449
360 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(C(O)C(F)(F)F)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81357262 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence 3FLA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.396299293960601 0.020589791219893 0.00221295822133462 0.77006639472807 0.0336156368936998 0.00141982059640497 0.000804331444027444 0.17129106689657 0.352623838360951 0.352623838360951 -0.5339316190745824
361 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.58547122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 1.0 4.351438552905858 0.0518701933925729 0.031230151711712 0.196119602463562 0.0891250765615729 0.225998436967717 0.183312147304902 0.222344391597961 0.0006916766953858 0.0006916766953858 -1.0767700312036428
362 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCN(CC1=CN=CN1)CC2=CN=CN2 DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence IZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.544995462952021 0.0318134391856252 0.0195739470918212 0.0658637908929555 0.0405146823853727 0.0383355214778253 0.0445803960220688 0.759318222944331 0.0007826107131428 0.0007826107131428 -1.0766297698601666
363 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCN1CCCC1)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.80884374 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PY Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.237000862623624 0.0496007240706346 0.0248050760368446 0.125156740550784 0.0913290655906173 0.0605654916232193 0.0647609529825488 0.583781949145352 0.000319594239126 0.000319594239126 -1.077343950474849
364 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.790487251761845 0.0660465509749711 0.000704686244275338 0.176882938102508 0.134254150019803 0.00301700767902668 0.00146559050061717 0.617629076478799 0.391796497651864 0.391796497651864 -0.473509678471839
365 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DOPE 1 0 0 0 17.10338647 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.842058839093973 0.180962520579808 0.000840183131263393 0.0600498448220066 0.0139903797423045 0.00230022430813273 0.00221494849849946 0.739641898917986 0.515169720881209 0.515169720881209 -0.2832124226594992
366 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.07758774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.48897339158558 0.000136174132145422 0.00212452688507234 0.811633900204502 0.179761878637886 0.00385751556458306 0.00248600457581157 - 0.767759892635294 0.767759892635294 1.24980418110703
367 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.50454535 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence ALA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.675628649636653 0.00268100351583557 0.00240431632025112 0.142040711181502 0.523320437165769 0.324868931367264 0.00468460044937817 - 0.0241897161135915 0.0241897161135915 -0.7344067258409619
368 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.59671966 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence SER Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.737600973168581 0.00157432110064945 0.00176844882817444 0.053765469363115 0.438156626388713 0.500533090562106 0.00420204375724176 - 0.0189624719731265 0.0189624719731265 -0.7483555838832638
369 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCO)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.07758774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OH Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.48897339158558 0.0550309639531662 0.00234353835896855 0.320198252727196 0.282656133384496 0.0064798077198827 0.00202476215621646 0.331266541700075 1.20135127285815 1.20135127285815 0.775189578295967
370 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)C)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.50454535 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence ALA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.675628649636653 0.0418659426619505 0.0219153925677162 0.21668759621254 0.199875450362037 0.113029824089051 0.0495629458661235 0.357062848240582 0.0027707272238572 0.0027707272238572 -1.0735631958798397
371 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC([C@@H](N)CO)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.59671966 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence SER Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.737600973168581 0.0234118812216689 0.0071462713755353 0.0426958781226752 0.0464078935005845 0.0346044033846598 0.0235967118628926 0.822136960531984 0.0055457738057274 0.0055457738057274 -1.0692828201592537
372 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.16930088 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence TZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 5.001930853466109 0.00767358537807448 0.00233215653996207 0.0713684727707158 0.307444763898641 0.0172788380976704 0.00511228295653041 0.588789900358405 0.0063917829512014 0.0063917829512014 -1.0679778917918028
373 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.579236803961587 0.00833063062779389 0.00173987762429209 0.156651961849343 0.112205138324295 0.00895304009765426 0.00427289873828259 0.707846452738339 0.269390835357988 0.269390835357988 -0.6623145181339684
374 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.15847938 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence 3F Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.484131857611035 0.0158311033527607 0.00109353847138243 0.0200990623529318 0.00589717673503959 0.00332080816189693 0.00297802720282806 0.95078028372316 0.0070114291767852 0.0070114291767852 -1.06702211732781
375 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81395289 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PYR Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 1 0 1 0 0 0 0.0 5.0755487449389 0.0138253404297663 0.00670375922221507 0.064918033729737 0.0310082272870404 0.0307691214666871 0.0156091189056244 0.83716639895893 0.0111434256880136 0.0111434256880136 -1.060648711684908
376 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.402809173856411 0.0144051248882893 0.000525788660297221 0.125667067331117 0.214373546599095 0.00410880851120861 0.00177167337754258 0.639147990632451 0.176512628889736 0.176512628889736 -0.8055746790752468
377 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=NC=CS1)CC2=NC=CS2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.16930088 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence TZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 5.001930853466109 0.00115119797114568 0.0003959818507672 0.0538124209539168 0.93604524664705 0.00736502972190904 0.00123012285521143 - 0.0261518819859255 0.0261518819859255 -0.7291707023316024
378 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.0054786 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.579236803961587 0.0010942059599737 0.000714578151988552 0.367034511120116 0.62078160479883 0.0079478856978032 0.00242721427128835 - 0.970510173989973 0.970510173989973 1.7908416411254202
379 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CCC(F)(F)F)CCC(F)(F)F)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 17.15847938 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence 3F Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.484131857611035 0.0376230130625874 0.00236009027623813 0.247039705692743 0.697452972603375 0.0104681865382628 0.00505603182679352 - 0.0013884403431976 0.0013884403431976 -0.7952517429011965
380 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN1CC(C(OC)=O)CC1=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.81395289 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PYR Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 5.0755487449389 0.00873826813676438 0.00145112475939544 0.193065080283125 0.778197018798523 0.014433213681334 0.00411529434085825 - 0.165721665234437 0.165721665234437 -0.35672988242469916
381 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCN(CC1=CNN=C1)CC2=CNN=C2)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.99522451 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.402809173856411 0.00532422079532615 0.00061084449763591 0.522469676271313 0.459778984209221 0.00966894873803684 0.00214732548846694 - 0.161020662402855 0.161020662402855 -0.3692744698577941
382 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.584763376210429 0.0318391346416656 0.000341552225113717 0.113678281409446 0.242279767731552 0.00387550619454475 0.000871625110337537 0.60711413268734 0.649833386251602 0.649833386251602 -0.07550020353412855
383 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.746322465743975 0.0548193142492001 0.000263362025026913 0.0902956804122817 0.160837629010128 0.00315355508353847 0.000739500993108033 0.689890958226717 1.16375238999006 1.16375238999006 0.7171951120404622
384 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O DSPC 0 0 1 0 16.87346518 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence HIS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 0 1 0 0 0.0 4.651385609785055 0.0172566765287249 0.00318344365411915 0.0712890876960715 0.171965068058214 0.0218135302099503 0.0115493777455846 0.702942816107335 0.00327405282427 0.00327405282427 -1.0727868403787713
385 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.584763376210429 0.000599963927151076 0.000397997752734626 0.420976508827142 0.560178394908249 0.017044159994242 0.000802974590480822 - 0.25255828640642 0.25255828640642 -0.1250070722684871
386 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.746322465743975 0.000524374578838527 0.00061514916196369 0.547432124587029 0.435435317287124 0.015309113403191 0.000683920981854007 - 0.568394489552276 0.568394489552276 0.7177992409467366
387 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CC1=CN=CN1)=O DSPC 0 0 1 0 16.87346518 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence HIS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.651385609785055 0.00171983501988967 0.00189561016704693 0.0120716635806003 0.711278646835123 0.270438826106656 0.00259541829068387 - 0.0112897234542117 0.0112897234542117 -0.7688302502674332
388 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.484733632866144 0.0047850951415261 0.000675911772575438 0.46069265034102 0.522359359837259 0.0109775121699624 0.00050947073765779 - 0.773205414607926 0.773205414607926 1.2643355117511204
389 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.633757642840004 0.00198911414189635 0.00126811595413123 0.543867583730296 0.438842770521552 0.0129988635137729 0.00103355213835123 - 1.98493053910539 1.98493053910539 4.497814051056962
390 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.0333911 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.609759638321899 0.00125031423153586 0.0004860362025215 0.538249539726811 0.445414640899446 0.0137801694455006 0.000819299494184621 - 0.291137444797345 0.291137444797345 -0.022058905064912687
391 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=O DSPC 0 0 1 0 16.68738808 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence CYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.392884144674663 0.00226285185388551 0.000562872305858137 0.731364439797527 0.256932619347553 0.00825451238600619 0.000622704309170273 - 1.82872279459479 1.82872279459479 4.080974968218046
392 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.36945365 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.484733632866144 0.0442923458834068 0.00055452650331333 0.106459881295074 0.192526940733964 0.00311682882196998 0.000623042068808978 0.652426434693463 0.672431538902446 0.672431538902446 -0.04064364128082843
393 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.35889865 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.633757642840004 0.0374610013402809 0.0005350551106764 0.260855439538844 0.469905543128085 0.00469334055693451 0.000912093945676405 0.225637526379503 1.69276100831231 1.69276100831231 1.5331654314724417
394 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCN(CC1=COC=N1)CC2=COC=N2)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.0333911 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence OZ Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.609759638321899 0.0836645231428707 0.000419599806684375 0.0235684307001288 0.0712275212970175 0.00119681308497475 0.00178295859414992 0.818140153374174 0.426058290183635 0.426058290183635 -0.4206625133630252
395 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CS)=O DSPC 0 0 1 0 16.68738808 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence CYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.392884144674663 0.0512990735432809 0.000672189655491244 0.187343972483681 0.232187436433234 0.00314791870850824 0.00146679734452725 0.523882611831278 1.30784095113947 1.30784095113947 0.9394447790505344
396 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC([C@@H](N)CS)=O DSPC 0 0 1 0 17.78759767 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence CYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.751259891859986 0.00405799702984203 0.00225047224182105 0.719270208750414 0.257208699720685 0.0138718178214465 0.00334080443579049 - 1.25160610942024 1.25160610942024 2.540943835364252
397 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.31729774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.666265285347902 0.00272982965803786 0.000172365352517303 0.498048022051036 0.479137442306018 0.0180316959727267 0.00188064465966415 - 0.155537169131505 0.155537169131505 -0.3839071266005448
398 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.71419039 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.904756125442696 0.00273286200255075 0.00260055069792003 0.431146257918051 0.50349018951458 0.0550138028095967 0.00501633705730229 - 0.021985308799366 0.021985308799366 -0.7402891686477768
399 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.733211535868976 0.00166528576158017 0.000176886038620712 0.205207225042143 0.750916028545382 0.0392720451710516 0.00276252944122191 - 0.120096690961961 0.120096690961961 -0.478479751420455
400 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 18.70678989 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.858726543710496 0.00383743159330312 0.00248950729214128 0.555903422423481 0.380445635709031 0.0515668712566801 0.00575713172536402 - 0.0526538412251038 0.0526538412251038 -0.6584504418393717
401 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.31729774 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.666265285347902 0.0567289157085495 0.00653348267008008 0.064839577285576 0.335055277453961 0.0144955694225392 0.0143736618741762 0.507973515585118 0.268311366051918 0.268311366051918 -0.6639795475568999
402 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 18.71419039 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.904756125442696 0.0248552898268163 0.0125192728735768 0.0725307642598596 0.0355254691282667 0.0214395648154144 0.0248745799236939 0.808255059172372 0.0741845243461588 0.0741845243461588 -0.9634108527393006
403 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 19.34728513 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.733211535868976 0.0883917007893502 0.00174599838911923 0.0536405332414895 0.100118671210748 0.00771990063396103 0.00639776118235737 0.741985434552974 0.528035509086713 0.528035509086713 -0.2633675639025965
404 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 18.70678989 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intramuscular 0 1 0 0 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intramuscular 0 0 1 1 0 0 0 0.0 4.858726543710496 0.0175679405294797 0.00960173891174304 0.0903179131752613 0.0388184937379254 0.0182497546285787 0.0249045868533177 0.800539572163694 0.125181510399577 0.125181510399577 -0.8847504575040614
405 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCCC1=CC=C(O)C(O)=C1)=O)=O DSPC 0 0 1 0 17.62870578 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence DOP Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.765586907393996 0.00159278655447388 0.00186611160196327 0.488795918944862 0.485247409700546 0.018616198181097 0.00388157501705755 - 0.352570746370957 0.352570746370957 0.14187535545424673
406 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCC(NCC1=CC=C(B(O)O)C=C1)=O)=O DSPC 0 0 1 0 17.61880246 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PBA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 1 0 1 0 0 0 0.0 4.82374330878754 0.000875415234709484 0.00127375854285246 0.683377837104949 0.304003257921165 0.00820355561270421 0.00226617558361995 - 0.943420561172443 0.943420561172443 1.7185532318874628
407 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O DSPC 0 0 1 0 16.58547122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.433313679041901 0.000602190120987361 0.000576528881915898 0.00566197423128506 0.0161763859347042 0.971683265119797 0.00529965571131053 - 0.0305789310371634 0.0305789310371634 -0.7173571583105779
408 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O DSPC 0 0 1 0 17.70929826 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.356324137321509 0.00187378052819512 0.00157654975652554 0.0163863796216318 0.0648246159165097 0.905280007427939 0.0100586667491993 - 0.003875136361479 0.003875136361479 -0.7886160150068647
409 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCNC(CCCN)=O)CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O DSPC 0 0 1 0 18.17273956 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.440767129696482 0.00301049906217731 9.21592223531261e-05 0.00380096827414773 0.0130323481002541 0.97657327492354 0.00349075041752818 - 0.0274401441027376 0.0274401441027376 -0.7257329854571254
410 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(CCCN)=O DSPC 0 0 1 0 18.38469122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.349632566862877 0.00273989274094748 0.00161018393061426 0.0112824839963327 0.0583352940699212 0.919247401685963 0.00678474357622127 - 0.0081601896883771 0.0081601896883771 -0.7771813854096181
411 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(CCCN)=O DSPC 0 0 1 0 18.90345652 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.662778498608405 0.00349315451118928 0.00171298178399312 0.037797325974731 0.242816837972913 0.706569889763285 0.00760980999388795 - 0.0136767051395404 0.0136767051395404 -0.7624606092513427
412 O=C(NCCN(CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCCN(CCCCCCOC(CCCCCCCCCCC)=O)CCCCCCOC(CCCCCCCCCCC)=O)CCCN DSPC 0 0 1 0 18.38469122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 0 0 1 4.405498990859024 - - - - - - - 0.0
413 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(CCCN)=O DSPC 0 0 1 0 16.89527599 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence GABA Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 4.815106909815019 - - - - - - - 0.0
414 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.89527599 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.562053894914463 0.00241700650155169 0.00189161759954923 0.0117804592312353 0.0588098364115177 0.918016488291877 0.0070845919642692 - 0.288385322760908 0.288385322760908 -0.029402920107978105
415 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.89527599 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.667205576907544 0.00146771264056884 0.000853267380299107 0.00521853383313367 0.0984194458399351 0.890752405611161 0.00328863469490281 - 0.174730948641107 0.174730948641107 -0.3326886836733955
416 O=C(OCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 17.94799221 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 1.0 4.701389043728634 0.00256320924432886 0.00193796271600952 0.0128146756680969 0.0418402586947232 0.934553052894321 0.00629084078252029 - 0.0492674291707299 0.0492674291707299 -0.6674870545840368
417 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 18.38469122 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.460491174618648 0.00101051612937229 0.00153512067382825 0.00950098551353592 0.161931963893941 0.822835993399315 0.00318542039000704 - 0.105055900803977 0.105055900803977 -0.5186159763833679
418 O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 19.0764718 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.505460341839079 0.00282763425766742 0.00135220428389579 0.101550310310828 0.701364372579719 0.18950529802972 0.00340018053817036 - 0.0700302222351868 0.0700302222351868 -0.6120817118766197
419 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 17.18453431 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.684905154006945 0.0025903109842197 0.00122267327648511 0.0959380417500791 0.558064631213231 0.339326541744348 0.00285780103163663 - 0.0836567108446898 0.0836567108446898 -0.5757195389760648
420 O=C(OCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCCCCN(CCCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 18.58497913 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 1.0 4.695924549256556 0.00270162630925447 0.000571977156802491 0.072649821877092 0.283620916967858 0.638520904456637 0.00193475323235631 - 0.108372702997361 0.108372702997361 -0.5097651169808466
421 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC([C@@H](N)CCCCN)=O DSPC 0 0 1 0 16.82518306 48.5 10.0 40.0 1.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence LYS Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 1 0 0 0 1 0 0 4.202899968776446 - - - - - - - 0.0
422 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 14.52948326 43.25 25.0 30.0 1.75 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 0.0 5.029784112935016 0.000951862951033406 0.000642237882584555 0.00747953132811133 0.295137112679544 0.692754163229738 0.0030350919289883 - 0.19435393861906 0.19435393861906 -0.2803248961378029
423 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 11.10169345 30.0 25.0 42.5 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.833102254034098 0.00529626249319983 0.00246267213977097 0.0289260006923807 0.563065088278535 0.393847703229461 0.00640227316665243 - 0.049072760763369 0.049072760763369 -0.6680065256297026
424 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.72804315 38.075 17.975 41.825 2.125 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 4.93014804318357 - - - - - - - 0.0
425 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.39261658 37.0 25.0 37.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 5.146912912388804 0.000759366167023555 0.000694817987152034 0.00466364025695932 0.212680085653105 0.777593147751606 0.00360894218415418 - 0.201238755105862 0.201238755105862 -0.2619528199077537
426 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.51039532 38.5 20.5 38.5 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.684905154006945 0.00157535225652128 0.00592927130077556 0.00900517890128691 0.366135503933579 0.613833328839362 0.00352136476847493 - 0.149329656900936 0.149329656900936 -0.40047182198750214
427 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.48290639 45.0 9.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.869839484130799 0.00147117555088917 0.000927103843315829 0.00585237061645294 0.136146016514374 0.851575135737455 0.00402819773751327 - 0.31219703699332 0.31219703699332 0.034138443686487704
428 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 14.13138042 41.2 22.35 34.325 2.125 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 0.0 4.901564199041894 0.00315707422768752 0.0025689389054212 0.0146712017391132 0.327849346901905 0.646061693847123 0.0056917443787501 - 0.158541375998041 0.158541375998041 -0.3758904252594646
429 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.11942242 41.825 14.975 41.825 1.375 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 5.039546637590676 - - - - - - - 0.0
430 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 14.79492927 45.0 22.5 30.0 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.9141243937154115 0.00113350028034128 0.000566939752127873 0.00680706926467914 0.502661298625749 0.486733894218144 0.00209729785895866 - 0.145448415448628 0.145448415448628 -0.4108288829150842
431 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 12.55393718 34.325 21.725 41.825 2.125 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 0 1 0 0.0 4.814620410170298 0.001692878443667 0.000820135726038303 0.00868136575507882 0.408928448915581 0.577101122031978 0.00277604912765729 - 0.113760366510672 0.113760366510672 -0.495388181160095
432 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.93959861 45.0 7.5 45.0 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.527640983478854 0.00506334343919377 0.004281344333051 0.0165771717732586 0.226890591170162 0.736348900590883 0.0108386486934518 - 0.0547343765642327 0.0547343765642327 -0.6528985503803821
433 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.59337013 45.0 15.75 37.5 1.75 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.810557015713042 0.00141112235558708 0.000749767156842064 0.00637541161251223 0.138880841494329 0.847648476304751 0.00493438107597822 - 0.294154433878409 0.294154433878409 -0.0140080944893819
434 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 11.66031337 30.0 24.0 45.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 5.167639042905921 0.00199236267032557 0.000827577235394216 0.008719084857644 0.192132365846187 0.792330257640873 0.0039983517495764 - 0.151793984465988 0.151793984465988 -0.3938957841268362
435 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 13.66358165 37.5 15.0 45.0 2.5 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 0.0 4.618086411254637 0.00271480786609193 0.00181664538344774 0.00938513027274936 0.132547184736695 0.849509595736892 0.0040266360041233 - 0.0950036114384557 0.0950036114384557 -0.5454404279666308
436 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.26186294 45.0 24.0 30.0 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 0 1 0 0 5.098035484377089 - - - - - - - 0.0
437 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.27611859 45.0 11.382 42.618 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.680277658474897 0.00152924607683628 0.00192508702614222 0.0105762053188716 0.167270255683968 0.810875386281306 0.00782381961287527 - 0.278754923842637 0.278754923842637 -0.05510156049896443
438 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 16.11001923 45.0 13.445 40.445 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.924350925499243 0.000999438616070677 0.00125158481927741 0.00771842730472846 0.249469737208587 0.735450494958472 0.00511031709286499 - 0.286455906115286 0.286455906115286 -0.03455155257492116
439 O=C(OCCCCCCCC)CCN(CCC(OCCCCCCCC)=O)CCCCN(CCCCN(CCC(OCCCCCCCC)=O)CCC(OCCCCCCCC)=O)CCNC(C[C@@H](CN)CC(C)C)=O DSPC 0 0 1 0 15.85662691 45.0 16.405 37.595 1.0 Pure Microfluidic mRNA 1 0 0 FFL Mouse 0 0 0 0 0 0 0 1 0 body 1 0 0 0 0 0 0 0 0 intravenous 0 0 0 1 Individual 0 1 luminescence PRE Chinese_Academy_of_Sciences Chinese_Academy_of_Sciences ccchina max Chinese_Academy_of_Sciences internal Chinese_Academy_of_Sciences_Chinese_Academy_of_Sciences_body_Mouse_intravenous 0 0 1 1 0 0 0 0.0 4.924350925499243 0.00141338619768439 0.00124322063420737 0.0100450891793794 0.235894751086175 0.745556785166654 0.00584676773589971 - 0.264336417833639 0.264336417833639 -0.09357722532293417

25
lnp_ml/featurization/smiles.py
View File

@ -1,5 +1,7 @@
"""SMILES 分子特征提取器""" """SMILES 分子特征提取器"""
import logging
import warnings
from dataclasses import dataclass, field from dataclasses import dataclass, field
from typing import List, Optional, Dict from typing import List, Optional, Dict
import numpy as np import numpy as np
@ -15,6 +17,9 @@ import torch
from chemprop.utils import load_checkpoint from chemprop.utils import load_checkpoint
from chemprop.features import mol2graph from chemprop.features import mol2graph
_chemprop_logger = logging.getLogger("chemprop.load_checkpoint")
_chemprop_logger.setLevel(logging.WARNING)
@dataclass @dataclass
class RDKitFeaturizer: class RDKitFeaturizer:
@ -97,16 +102,16 @@ class MPNNFeaturizer:
device = torch.device(self.device) device = torch.device(self.device)
paths = self.ensemble_paths or [self.checkpoint_path] paths = self.ensemble_paths or [self.checkpoint_path]
for path in paths: with warnings.catch_warnings():
model = load_checkpoint(path, device=device) warnings.filterwarnings("ignore", category=FutureWarning)
model.eval() for path in paths:
# 提取 MPNEncoder（D-MPNN 核心部分） model = load_checkpoint(path, device=device, logger=_chemprop_logger)
encoder = model.encoder.encoder[0] model.eval()
# 冻结参数 encoder = model.encoder.encoder[0]
for param in encoder.parameters(): for param in encoder.parameters():
param.requires_grad = False param.requires_grad = False
self._encoders.append(encoder) self._encoders.append(encoder)
self._hidden_size = encoder.hidden_size self._hidden_size = encoder.hidden_size
self._initialized = True self._initialized = True

16
lnp_ml/modeling/benchmark.py
View File

@ -372,6 +372,8 @@ def main(
df = pd.read_parquet(fold_dir / f"{split}.parquet") df = pd.read_parquet(fold_dir / f"{split}.parquet")
all_smiles.update(df["smiles"].tolist()) all_smiles.update(df["smiles"].tolist())
rdkit_cache = None # 跨 fold 共享 RDKit 特征缓存
for fold_dir in fold_dirs: for fold_dir in fold_dirs:
fold_idx = int(fold_dir.name.split("_")[1]) fold_idx = int(fold_dir.name.split("_")[1])
@ -406,11 +408,17 @@ def main(
) )
model = model.to(device) model = model.to(device)
# 第一个 fold 时做 cache warmup # 第一个 fold 时做 cache warmup，之后复用缓存
if fold_idx == 0: if rdkit_cache is None:
warmup_cache(model, list(all_smiles), batch_size=256) warmup_cache(model, list(all_smiles), batch_size=256)
rdkit_cache = model.rdkit_encoder._cache
else:
model.rdkit_encoder._cache = rdkit_cache
logger.info(f"Reusing RDKit cache with {len(rdkit_cache)} entries")
logger.info(f"Model parameters: {sum(p.numel() for p in model.parameters()):,}") n_params_total = sum(p.numel() for p in model.parameters())
n_params_trainable = sum(p.numel() for p in model.parameters() if p.requires_grad)
logger.info(f"Model parameters: {n_params_total:,} total, {n_params_trainable:,} trainable")
# 训练 # 训练
result = train_fold( result = train_fold(
@ -515,7 +523,7 @@ def test(
continue continue
# 加载模型 # 加载模型
checkpoint = torch.load(model_path, map_location=device) checkpoint = torch.load(model_path, map_location=device, weights_only=False)
config = checkpoint["config"] config = checkpoint["config"]
use_mpnn = config.get("use_mpnn", False) use_mpnn = config.get("use_mpnn", False)

36
lnp_ml/modeling/final_train_optuna_cv.py
View File

@ -41,7 +41,10 @@ from lnp_ml.dataset import (
TARGET_CLASSIFICATION_EE, TARGET_CLASSIFICATION_EE,
TARGET_TOXIC, TARGET_TOXIC,
) )
from tqdm import tqdm
from lnp_ml.modeling.models import LNPModel, LNPModelWithoutMPNN from lnp_ml.modeling.models import LNPModel, LNPModelWithoutMPNN
from lnp_ml.modeling.encoders.rdkit_encoder import CachedRDKitEncoder
from lnp_ml.modeling.trainer_balanced import ( from lnp_ml.modeling.trainer_balanced import (
ClassWeights, ClassWeights,
LossWeightsBalanced, LossWeightsBalanced,
@ -140,6 +143,20 @@ def build_composite_strata(
return encoded.astype(np.int64), strata_info return encoded.astype(np.int64), strata_info
# ============ RDKit 缓存预热 ============
def warmup_rdkit_cache(smiles_list: List[str], batch_size: int = 256) -> Dict:
"""预热 RDKit 特征缓存，返回可跨模型共享的缓存字典。"""
encoder = CachedRDKitEncoder()
unique_smiles = list(set(smiles_list))
logger.info(f"Warming up RDKit cache for {len(unique_smiles)} unique SMILES...")
for i in tqdm(range(0, len(unique_smiles), batch_size), desc="Cache warmup"):
batch = unique_smiles[i:i + batch_size]
encoder(batch)
logger.success(f"Cache warmup complete. Cached {len(encoder._cache)} SMILES.")
return encoder._cache
# ============ 模型创建 ============ # ============ 模型创建 ============
def find_mpnn_ensemble_paths(base_dir: Path = DEFAULT_MPNN_ENSEMBLE_DIR) -> List[str]: def find_mpnn_ensemble_paths(base_dir: Path = DEFAULT_MPNN_ENSEMBLE_DIR) -> List[str]:
@ -231,6 +248,7 @@ def run_optuna_cv(
pretrain_state_dict: Optional[Dict] = None, pretrain_state_dict: Optional[Dict] = None,
pretrain_config: Optional[Dict] = None, pretrain_config: Optional[Dict] = None,
load_delivery_head: bool = True, load_delivery_head: bool = True,
rdkit_cache: Optional[Dict] = None,
) -> Tuple[Dict, int, optuna.Study]: ) -> Tuple[Dict, int, optuna.Study]:
""" """
使用全量数据做 3-fold CV Optuna 超参搜索。 使用全量数据做 3-fold CV Optuna 超参搜索。
@ -282,8 +300,9 @@ def run_optuna_cv(
# 搜索训练超参数 # 搜索训练超参数
dropout = trial.suggest_float("dropout", 0.1, 0.5) dropout = trial.suggest_float("dropout", 0.1, 0.5)
lr = trial.suggest_float("lr", 1e-5, 3e-4, log=True) lr = trial.suggest_float("lr", 1e-5, 1e-3, log=True)
weight_decay = trial.suggest_float("weight_decay", 1e-5, 1e-3, log=True) weight_decay = trial.suggest_float("weight_decay", 1e-5, 1e-1, log=True)
backbone_lr_ratio = trial.suggest_float("backbone_lr_ratio", 0.01, 1.0, log=True)
# 3-fold CV # 3-fold CV
cv = StratifiedKFold(n_splits=n_folds, shuffle=True, random_state=seed) cv = StratifiedKFold(n_splits=n_folds, shuffle=True, random_state=seed)
@ -317,6 +336,8 @@ def run_optuna_cv(
use_mpnn=use_mpnn, use_mpnn=use_mpnn,
mpnn_device=device.type, mpnn_device=device.type,
) )
if rdkit_cache is not None:
model.rdkit_encoder._cache = rdkit_cache
# 加载预训练权重 # 加载预训练权重
if pretrain_state_dict is not None and pretrain_config is not None: if pretrain_state_dict is not None and pretrain_config is not None:
@ -335,6 +356,7 @@ def run_optuna_cv(
epochs=epochs_per_trial, epochs=epochs_per_trial,
patience=patience, patience=patience,
class_weights=class_weights, class_weights=class_weights,
backbone_lr_ratio=backbone_lr_ratio,
) )
fold_val_losses.append(result["best_val_loss"]) fold_val_losses.append(result["best_val_loss"])
@ -402,7 +424,7 @@ def main(
swa_start_ratio: float = 0.75, swa_start_ratio: float = 0.75,
# 预训练权重 # 预训练权重
init_from_pretrain: Optional[Path] = None, init_from_pretrain: Optional[Path] = None,
load_delivery_head: bool = True, load_delivery_head: bool = False,
# MPNN # MPNN
use_mpnn: bool = False, use_mpnn: bool = False,
# 设备 # 设备
@ -431,7 +453,7 @@ def main(
if init_from_pretrain is not None: if init_from_pretrain is not None:
if init_from_pretrain.exists(): if init_from_pretrain.exists():
logger.info(f"Loading pretrain weights from {init_from_pretrain}") logger.info(f"Loading pretrain weights from {init_from_pretrain}")
checkpoint = torch.load(init_from_pretrain, map_location="cpu") checkpoint = torch.load(init_from_pretrain, map_location="cpu", weights_only=False)
pretrain_state_dict = checkpoint["model_state_dict"] pretrain_state_dict = checkpoint["model_state_dict"]
pretrain_config = checkpoint.get("config", {}) pretrain_config = checkpoint.get("config", {})
logger.success(f"Loaded pretrain checkpoint (d_model={pretrain_config.get('d_model')})") logger.success(f"Loaded pretrain checkpoint (d_model={pretrain_config.get('d_model')})")
@ -462,6 +484,9 @@ def main(
# 创建完整数据集 # 创建完整数据集
full_dataset = LNPDataset(df) full_dataset = LNPDataset(df)
# 预热 RDKit 缓存（在整个训练流程中共享）
rdkit_cache = warmup_rdkit_cache(full_dataset.smiles)
# 运行 Optuna 调参 # 运行 Optuna 调参
logger.info(f"\nRunning {n_folds}-fold Optuna with {n_trials} trials...") logger.info(f"\nRunning {n_folds}-fold Optuna with {n_trials} trials...")
study_path = output_dir / "optuna_study.sqlite3" study_path = output_dir / "optuna_study.sqlite3"
@ -481,6 +506,7 @@ def main(
pretrain_state_dict=pretrain_state_dict, pretrain_state_dict=pretrain_state_dict,
pretrain_config=pretrain_config, pretrain_config=pretrain_config,
load_delivery_head=load_delivery_head, load_delivery_head=load_delivery_head,
rdkit_cache=rdkit_cache,
) )
# 保存最佳参数 # 保存最佳参数
@ -539,6 +565,7 @@ def main(
use_mpnn=use_mpnn, use_mpnn=use_mpnn,
mpnn_device=device.type, mpnn_device=device.type,
) )
model.rdkit_encoder._cache = rdkit_cache
# 加载预训练权重 # 加载预训练权重
if pretrain_state_dict is not None and pretrain_config is not None: if pretrain_state_dict is not None and pretrain_config is not None:
@ -569,6 +596,7 @@ def main(
use_cosine_annealing=True, use_cosine_annealing=True,
use_swa=use_swa, use_swa=use_swa,
swa_start_epoch=swa_start, swa_start_epoch=swa_start,
backbone_lr_ratio=best_params.get("backbone_lr_ratio", 1.0),
) )
# 加载最终权重 # 加载最终权重

377
lnp_ml/modeling/nested_cv_optuna.py
View File

@ -41,7 +41,10 @@ from lnp_ml.dataset import (
TARGET_CLASSIFICATION_EE, TARGET_CLASSIFICATION_EE,
TARGET_TOXIC, TARGET_TOXIC,
) )
from tqdm import tqdm
from lnp_ml.modeling.models import LNPModel, LNPModelWithoutMPNN from lnp_ml.modeling.models import LNPModel, LNPModelWithoutMPNN
from lnp_ml.modeling.encoders.rdkit_encoder import CachedRDKitEncoder
from lnp_ml.modeling.trainer_balanced import ( from lnp_ml.modeling.trainer_balanced import (
ClassWeights, ClassWeights,
LossWeightsBalanced, LossWeightsBalanced,
@ -142,6 +145,20 @@ def build_composite_strata(
return encoded.astype(np.int64), strata_info return encoded.astype(np.int64), strata_info
# ============ RDKit 缓存预热 ============
def warmup_rdkit_cache(smiles_list: List[str], batch_size: int = 256) -> Dict:
"""预热 RDKit 特征缓存，返回可跨模型共享的缓存字典。"""
encoder = CachedRDKitEncoder()
unique_smiles = list(set(smiles_list))
logger.info(f"Warming up RDKit cache for {len(unique_smiles)} unique SMILES...")
for i in tqdm(range(0, len(unique_smiles), batch_size), desc="Cache warmup"):
batch = unique_smiles[i:i + batch_size]
encoder(batch)
logger.success(f"Cache warmup complete. Cached {len(encoder._cache)} SMILES.")
return encoder._cache
# ============ 模型创建 ============ # ============ 模型创建 ============
def find_mpnn_ensemble_paths(base_dir: Path = DEFAULT_MPNN_ENSEMBLE_DIR) -> List[str]: def find_mpnn_ensemble_paths(base_dir: Path = DEFAULT_MPNN_ENSEMBLE_DIR) -> List[str]:
@ -344,6 +361,7 @@ def run_inner_optuna(
pretrain_state_dict: Optional[Dict] = None, pretrain_state_dict: Optional[Dict] = None,
pretrain_config: Optional[Dict] = None, pretrain_config: Optional[Dict] = None,
load_delivery_head: bool = True, load_delivery_head: bool = True,
rdkit_cache: Optional[Dict] = None,
) -> Tuple[Dict, int, optuna.Study]: ) -> Tuple[Dict, int, optuna.Study]:
""" """
在内层数据上运行 Optuna 超参搜索。 在内层数据上运行 Optuna 超参搜索。
@ -395,8 +413,9 @@ def run_inner_optuna(
# 搜索训练超参数 # 搜索训练超参数
dropout = trial.suggest_float("dropout", 0.1, 0.5) dropout = trial.suggest_float("dropout", 0.1, 0.5)
lr = trial.suggest_float("lr", 1e-5, 3e-4, log=True) lr = trial.suggest_float("lr", 1e-5, 1e-3, log=True)
weight_decay = trial.suggest_float("weight_decay", 1e-5, 1e-3, log=True) weight_decay = trial.suggest_float("weight_decay", 1e-5, 1e-1, log=True)
backbone_lr_ratio = trial.suggest_float("backbone_lr_ratio", 0.01, 1.0, log=True)
# 内层 3-fold CV # 内层 3-fold CV
inner_cv = StratifiedKFold( inner_cv = StratifiedKFold(
@ -438,6 +457,8 @@ def run_inner_optuna(
use_mpnn=use_mpnn, use_mpnn=use_mpnn,
mpnn_device=device.type, mpnn_device=device.type,
) )
if rdkit_cache is not None:
model.rdkit_encoder._cache = rdkit_cache
# 加载预训练权重 # 加载预训练权重
if pretrain_state_dict is not None and pretrain_config is not None: if pretrain_state_dict is not None and pretrain_config is not None:
@ -456,6 +477,7 @@ def run_inner_optuna(
epochs=epochs_per_trial, epochs=epochs_per_trial,
patience=patience, patience=patience,
class_weights=class_weights, class_weights=class_weights,
backbone_lr_ratio=backbone_lr_ratio,
) )
fold_val_losses.append(result["best_val_loss"]) fold_val_losses.append(result["best_val_loss"])
@ -501,6 +523,178 @@ def run_inner_optuna(
return best_params, epoch_mean, study return best_params, epoch_mean, study
# ============ 单 fold 执行（可跨进程调用） ============
def _run_single_outer_fold(
outer_fold: int,
outer_train_idx: np.ndarray,
outer_test_idx: np.ndarray,
df: pd.DataFrame,
strata: np.ndarray,
fold_dir: Path,
n_trials: int,
epochs_per_trial: int,
inner_patience: int,
batch_size: int,
n_inner_folds: int,
use_mpnn: bool,
seed: int,
pretrain_state_dict: Optional[Dict],
pretrain_config: Optional[Dict],
load_delivery_head: bool,
device_str: str,
) -> Dict:
"""
执行单个外层 fold 的完整流程（内层调参 + 外层训练 + 评估）。
所有参数均为可序列化类型，以支持 spawn 多进程。
"""
device = torch.device(device_str)
fold_dir = Path(fold_dir)
fold_dir.mkdir(parents=True, exist_ok=True)
full_dataset = LNPDataset(df)
logger.info(f"\n{'='*60}")
logger.info(f"OUTER FOLD {outer_fold}")
logger.info(f"{'='*60}")
logger.info(f"Train: {len(outer_train_idx)}, Test: {len(outer_test_idx)}")
# 预热 RDKit 缓存（在整个 fold 内共享）
rdkit_cache = warmup_rdkit_cache(full_dataset.smiles)
# 保存 split indices
with open(fold_dir / "splits.json", "w") as f:
json.dump({
"outer_train_idx": outer_train_idx.tolist(),
"outer_test_idx": outer_test_idx.tolist(),
}, f)
# 内层 Optuna 调参
logger.info(f"\nRunning inner Optuna with {n_trials} trials...")
study_path = fold_dir / "optuna_study.sqlite3"
best_params, epoch_mean, study = run_inner_optuna(
full_dataset=full_dataset,
inner_train_indices=outer_train_idx,
strata=strata,
device=device,
n_trials=n_trials,
epochs_per_trial=epochs_per_trial,
patience=inner_patience,
batch_size=batch_size,
n_inner_folds=n_inner_folds,
use_mpnn=use_mpnn,
seed=seed + outer_fold,
study_path=study_path,
pretrain_state_dict=pretrain_state_dict,
pretrain_config=pretrain_config,
load_delivery_head=load_delivery_head,
rdkit_cache=rdkit_cache,
)
# 保存最佳参数
with open(fold_dir / "best_params.json", "w") as f:
json.dump(best_params, f, indent=2)
with open(fold_dir / "epoch_mean.json", "w") as f:
json.dump({"epoch_mean": epoch_mean}, f)
# 外层训练（使用最优超参，固定 epoch 数，不 early-stop）
logger.info(f"\nTraining outer fold with best params, epochs={epoch_mean}...")
train_subset = Subset(full_dataset, outer_train_idx.tolist())
test_subset = Subset(full_dataset, outer_test_idx.tolist())
train_loader = DataLoader(
train_subset, batch_size=batch_size, shuffle=True, collate_fn=collate_fn
)
test_loader = DataLoader(
test_subset, batch_size=batch_size, shuffle=False, collate_fn=collate_fn
)
class_weights = compute_class_weights_from_loader(train_loader)
model = create_model(
d_model=best_params["d_model"],
num_heads=best_params["num_heads"],
n_attn_layers=best_params["n_attn_layers"],
fusion_strategy=best_params["fusion_strategy"],
head_hidden_dim=best_params["head_hidden_dim"],
dropout=best_params["dropout"],
use_mpnn=use_mpnn,
mpnn_device=device.type,
)
model.rdkit_encoder._cache = rdkit_cache
if pretrain_state_dict is not None and pretrain_config is not None:
loaded = load_pretrain_weights_to_model(
model, pretrain_state_dict, best_params["d_model"],
pretrain_config, load_delivery_head
)
if loaded:
logger.info(f"Loaded pretrain weights for outer fold {outer_fold}")
train_result = train_fixed_epochs(
model=model,
train_loader=train_loader,
val_loader=None,
device=device,
lr=best_params["lr"],
weight_decay=best_params["weight_decay"],
epochs=epoch_mean,
class_weights=class_weights,
use_cosine_annealing=True,
backbone_lr_ratio=best_params.get("backbone_lr_ratio", 1.0),
)
model.load_state_dict(train_result["final_state"])
model = model.to(device)
config = {
"d_model": best_params["d_model"],
"num_heads": best_params["num_heads"],
"n_attn_layers": best_params["n_attn_layers"],
"fusion_strategy": best_params["fusion_strategy"],
"head_hidden_dim": best_params["head_hidden_dim"],
"dropout": best_params["dropout"],
"use_mpnn": use_mpnn,
}
torch.save({
"model_state_dict": train_result["final_state"],
"config": config,
"epoch_mean": epoch_mean,
"best_params": best_params,
}, fold_dir / "model.pt")
with open(fold_dir / "history.json", "w") as f:
json.dump(train_result["history"], f, indent=2)
# 在测试集上评估
logger.info("Evaluating on outer test set...")
test_metrics = evaluate_on_test(model, test_loader, device)
with open(fold_dir / "test_metrics.json", "w") as f:
json.dump(test_metrics, f, indent=2)
logger.info(f"\nOuter Fold {outer_fold} Test Results:")
for task, metrics in test_metrics.items():
if "rmse" in metrics:
logger.info(f" {task}: RMSE={metrics['rmse']:.4f}, R²={metrics['r2']:.4f}")
elif "accuracy" in metrics:
logger.info(f" {task}: Acc={metrics['accuracy']:.4f}, F1={metrics['f1']:.4f}")
elif "kl_divergence" in metrics:
logger.info(f" {task}: KL={metrics['kl_divergence']:.4f}, JS={metrics['js_divergence']:.4f}")
return {
"fold": outer_fold,
"best_params": best_params,
"epoch_mean": epoch_mean,
"test_metrics": test_metrics,
}
# ============ 主流程 ============ # ============ 主流程 ============
@app.command() @app.command()
@ -520,9 +714,11 @@ def main(
batch_size: int = 32, batch_size: int = 32,
# 预训练权重 # 预训练权重
init_from_pretrain: Optional[Path] = None, init_from_pretrain: Optional[Path] = None,
load_delivery_head: bool = True, load_delivery_head: bool = False,
# MPNN # MPNN
use_mpnn: bool = False, use_mpnn: bool = False,
# 并行
parallel: bool = False,
# 设备 # 设备
device: str = "cuda" if torch.cuda.is_available() else "cpu", device: str = "cuda" if torch.cuda.is_available() else "cpu",
): ):
@ -533,6 +729,7 @@ def main(
外层训练不使用 early-stopping，epoch 数使用内层 best trial 的 epoch_mean。 外层训练不使用 early-stopping，epoch 数使用内层 best trial 的 epoch_mean。
使用 --init-from-pretrain 从预训练 checkpoint 初始化模型权重。 使用 --init-from-pretrain 从预训练 checkpoint 初始化模型权重。
使用 --parallel 同时运行所有外层 fold（需要足够 GPU 显存）。
""" """
if optuna is None: if optuna is None:
logger.error("Optuna not installed. Run: pip install optuna") logger.error("Optuna not installed. Run: pip install optuna")
@ -547,7 +744,7 @@ def main(
if init_from_pretrain is not None: if init_from_pretrain is not None:
if init_from_pretrain.exists(): if init_from_pretrain.exists():
logger.info(f"Loading pretrain weights from {init_from_pretrain}") logger.info(f"Loading pretrain weights from {init_from_pretrain}")
checkpoint = torch.load(init_from_pretrain, map_location="cpu") checkpoint = torch.load(init_from_pretrain, map_location="cpu", weights_only=False)
pretrain_state_dict = checkpoint["model_state_dict"] pretrain_state_dict = checkpoint["model_state_dict"]
pretrain_config = checkpoint.get("config", {}) pretrain_config = checkpoint.get("config", {})
logger.success(f"Loaded pretrain checkpoint (d_model={pretrain_config.get('d_model')})") logger.success(f"Loaded pretrain checkpoint (d_model={pretrain_config.get('d_model')})")
@ -577,165 +774,55 @@ def main(
with open(run_dir / "strata_info.json", "w") as f: with open(run_dir / "strata_info.json", "w") as f:
json.dump(strata_info, f, indent=2, default=str) json.dump(strata_info, f, indent=2, default=str)
# 创建完整数据集 # 创建完整数据集（仅用于获取样本数做 split）
full_dataset = LNPDataset(df) n_samples = len(LNPDataset(df))
n_samples = len(full_dataset)
# 外层 CV # 外层 CV split
outer_cv = StratifiedKFold( outer_cv = StratifiedKFold(
n_splits=n_outer_folds, shuffle=True, random_state=seed n_splits=n_outer_folds, shuffle=True, random_state=seed
) )
outer_results = [] device_str = str(device)
fold_args = []
for outer_fold, (outer_train_idx, outer_test_idx) in enumerate( for outer_fold, (outer_train_idx, outer_test_idx) in enumerate(
outer_cv.split(np.arange(n_samples), strata) outer_cv.split(np.arange(n_samples), strata)
): ):
logger.info(f"\n{'='*60}") fold_args.append(dict(
logger.info(f"OUTER FOLD {outer_fold}") outer_fold=outer_fold,
logger.info(f"{'='*60}") outer_train_idx=outer_train_idx,
logger.info(f"Train: {len(outer_train_idx)}, Test: {len(outer_test_idx)}") outer_test_idx=outer_test_idx,
df=df,
fold_dir = run_dir / f"outer_fold_{outer_fold}"
fold_dir.mkdir(parents=True, exist_ok=True)
# 保存 split indices
splits = {
"outer_train_idx": outer_train_idx.tolist(),
"outer_test_idx": outer_test_idx.tolist(),
}
with open(fold_dir / "splits.json", "w") as f:
json.dump(splits, f)
# 内层 Optuna 调参
logger.info(f"\nRunning inner Optuna with {n_trials} trials...")
study_path = fold_dir / "optuna_study.sqlite3"
best_params, epoch_mean, study = run_inner_optuna(
full_dataset=full_dataset,
inner_train_indices=outer_train_idx,
strata=strata, strata=strata,
device=device, fold_dir=run_dir / f"outer_fold_{outer_fold}",
n_trials=n_trials, n_trials=n_trials,
epochs_per_trial=epochs_per_trial, epochs_per_trial=epochs_per_trial,
patience=inner_patience, inner_patience=inner_patience,
batch_size=batch_size, batch_size=batch_size,
n_inner_folds=n_inner_folds, n_inner_folds=n_inner_folds,
use_mpnn=use_mpnn, use_mpnn=use_mpnn,
seed=seed + outer_fold, seed=seed,
study_path=study_path,
pretrain_state_dict=pretrain_state_dict, pretrain_state_dict=pretrain_state_dict,
pretrain_config=pretrain_config, pretrain_config=pretrain_config,
load_delivery_head=load_delivery_head, load_delivery_head=load_delivery_head,
) device_str=device_str,
))
if parallel:
import multiprocessing as mp
from concurrent.futures import ProcessPoolExecutor
# 保存最佳参数 ctx = mp.get_context("spawn")
with open(fold_dir / "best_params.json", "w") as f: logger.info(f"Running {n_outer_folds} outer folds in PARALLEL (spawn)")
json.dump(best_params, f, indent=2) with ProcessPoolExecutor(max_workers=n_outer_folds, mp_context=ctx) as executor:
futures = [executor.submit(_run_single_outer_fold, **args) for args in fold_args]
with open(fold_dir / "epoch_mean.json", "w") as f: outer_results = [f.result() for f in futures]
json.dump({"epoch_mean": epoch_mean}, f) outer_results.sort(key=lambda r: r["fold"])
else:
# 外层训练（使用最优超参，固定 epoch 数，不 early-stop） logger.info(f"Running {n_outer_folds} outer folds SEQUENTIALLY")
logger.info(f"\nTraining outer fold with best params, epochs={epoch_mean}...") outer_results = []
for args in fold_args:
# 创建 DataLoader result = _run_single_outer_fold(**args)
train_subset = Subset(full_dataset, outer_train_idx.tolist()) outer_results.append(result)
test_subset = Subset(full_dataset, outer_test_idx.tolist())
train_loader = DataLoader(
train_subset, batch_size=batch_size, shuffle=True, collate_fn=collate_fn
)
test_loader = DataLoader(
test_subset, batch_size=batch_size, shuffle=False, collate_fn=collate_fn
)
# 计算类权重
class_weights = compute_class_weights_from_loader(train_loader)
# 创建模型
model = create_model(
d_model=best_params["d_model"],
num_heads=best_params["num_heads"],
n_attn_layers=best_params["n_attn_layers"],
fusion_strategy=best_params["fusion_strategy"],
head_hidden_dim=best_params["head_hidden_dim"],
dropout=best_params["dropout"],
use_mpnn=use_mpnn,
mpnn_device=device.type,
)
# 加载预训练权重
if pretrain_state_dict is not None and pretrain_config is not None:
loaded = load_pretrain_weights_to_model(
model, pretrain_state_dict, best_params["d_model"],
pretrain_config, load_delivery_head
)
if loaded:
logger.info(f"Loaded pretrain weights for outer fold {outer_fold}")
# 训练（固定 epoch，不 early-stop）
train_result = train_fixed_epochs(
model=model,
train_loader=train_loader,
val_loader=None, # 外层不用验证集
device=device,
lr=best_params["lr"],
weight_decay=best_params["weight_decay"],
epochs=epoch_mean,
class_weights=class_weights,
use_cosine_annealing=True,
)
# 加载最终权重
model.load_state_dict(train_result["final_state"])
model = model.to(device)
# 保存模型
config = {
"d_model": best_params["d_model"],
"num_heads": best_params["num_heads"],
"n_attn_layers": best_params["n_attn_layers"],
"fusion_strategy": best_params["fusion_strategy"],
"head_hidden_dim": best_params["head_hidden_dim"],
"dropout": best_params["dropout"],
"use_mpnn": use_mpnn,
}
torch.save({
"model_state_dict": train_result["final_state"],
"config": config,
"epoch_mean": epoch_mean,
"best_params": best_params,
}, fold_dir / "model.pt")
# 保存训练历史
with open(fold_dir / "history.json", "w") as f:
json.dump(train_result["history"], f, indent=2)
# 在测试集上评估
logger.info("Evaluating on outer test set...")
test_metrics = evaluate_on_test(model, test_loader, device)
with open(fold_dir / "test_metrics.json", "w") as f:
json.dump(test_metrics, f, indent=2)
# 打印测试结果
logger.info(f"\nOuter Fold {outer_fold} Test Results:")
for task, metrics in test_metrics.items():
if "rmse" in metrics:
logger.info(f" {task}: RMSE={metrics['rmse']:.4f}, R²={metrics['r2']:.4f}")
elif "accuracy" in metrics:
logger.info(f" {task}: Acc={metrics['accuracy']:.4f}, F1={metrics['f1']:.4f}")
elif "kl_divergence" in metrics:
logger.info(f" {task}: KL={metrics['kl_divergence']:.4f}, JS={metrics['js_divergence']:.4f}")
outer_results.append({
"fold": outer_fold,
"best_params": best_params,
"epoch_mean": epoch_mean,
"test_metrics": test_metrics,
})
# 汇总结果 # 汇总结果
logger.info("\n" + "=" * 60) logger.info("\n" + "=" * 60)

2
lnp_ml/modeling/predict.py
View File

@ -38,7 +38,7 @@ def load_model(
自动根据 checkpoint 的 config.use_mpnn 选择模型类型。 自动根据 checkpoint 的 config.use_mpnn 选择模型类型。
""" """
checkpoint = torch.load(model_path, map_location=device) checkpoint = torch.load(model_path, map_location=device, weights_only=False)
config = checkpoint["config"] config = checkpoint["config"]
use_mpnn = config.get("use_mpnn", False) use_mpnn = config.get("use_mpnn", False)

9
lnp_ml/modeling/pretrain.py
View File

@ -158,7 +158,7 @@ def pretrain(
model = model.to(device) model = model.to(device)
optimizer = torch.optim.AdamW(model.parameters(), lr=lr, weight_decay=weight_decay) optimizer = torch.optim.AdamW(model.parameters(), lr=lr, weight_decay=weight_decay)
scheduler = torch.optim.lr_scheduler.ReduceLROnPlateau( scheduler = torch.optim.lr_scheduler.ReduceLROnPlateau(
optimizer, mode="min", factor=0.5, patience=5, verbose=True optimizer, mode="min", factor=0.5, patience=5
) )
early_stopping = EarlyStopping(patience=patience) early_stopping = EarlyStopping(patience=patience)
@ -303,8 +303,9 @@ def main(
dropout=dropout, dropout=dropout,
) )
n_params = sum(p.numel() for p in model.parameters() if p.requires_grad) n_params_total = sum(p.numel() for p in model.parameters())
logger.info(f"Model parameters: {n_params:,}") n_params_trainable = sum(p.numel() for p in model.parameters() if p.requires_grad)
logger.info(f"Model parameters: {n_params_total:,} total, {n_params_trainable:,} trainable")
# 预热 RDKit 缓存（避免训练时阻塞） # 预热 RDKit 缓存（避免训练时阻塞）
all_smiles = train_df["smiles"].tolist() + val_df["smiles"].tolist() all_smiles = train_df["smiles"].tolist() + val_df["smiles"].tolist()
@ -392,7 +393,7 @@ def test(
# 加载模型 # 加载模型
logger.info(f"Loading pretrain model from {model_path}") logger.info(f"Loading pretrain model from {model_path}")
checkpoint = torch.load(model_path, map_location=device_obj) checkpoint = torch.load(model_path, map_location=device_obj, weights_only=False)
config = checkpoint["config"] config = checkpoint["config"]
# 解析 MPNN 配置 # 解析 MPNN 配置

44
lnp_ml/modeling/trainer_balanced.py
View File

@ -286,6 +286,43 @@ def validate_balanced(
return metrics return metrics
BACKBONE_PREFIXES = ("token_projector.", "cross_attention.", "fusion.")
def build_optimizer(
model: nn.Module,
lr: float,
weight_decay: float,
backbone_lr_ratio: float = 1.0,
) -> torch.optim.AdamW:
"""
构建 AdamW 优化器，支持分层学习率。
当 backbone_lr_ratio < 1.0 时，backbone 参数使用 lr * backbone_lr_ratio，
其余参数（task heads 等）使用 lr。backbone_lr_ratio = 1.0 等价于统一学习率。
"""
if backbone_lr_ratio >= 1.0:
return torch.optim.AdamW(model.parameters(), lr=lr, weight_decay=weight_decay)
backbone_params = []
head_params = []
for name, param in model.named_parameters():
if not param.requires_grad:
continue
if name.startswith(BACKBONE_PREFIXES):
backbone_params.append(param)
else:
head_params.append(param)
return torch.optim.AdamW(
[
{"params": backbone_params, "lr": lr * backbone_lr_ratio},
{"params": head_params, "lr": lr},
],
weight_decay=weight_decay,
)
class EarlyStoppingBalanced: class EarlyStoppingBalanced:
"""早停机制（与 trainer.py 的 EarlyStopping 兼容）""" """早停机制（与 trainer.py 的 EarlyStopping 兼容）"""
@ -324,6 +361,7 @@ def train_with_early_stopping(
patience: int = 15, patience: int = 15,
task_weights: Optional[LossWeightsBalanced] = None, task_weights: Optional[LossWeightsBalanced] = None,
class_weights: Optional[ClassWeights] = None, class_weights: Optional[ClassWeights] = None,
backbone_lr_ratio: float = 1.0,
) -> Dict: ) -> Dict:
""" """
带早停的完整训练流程。 带早停的完整训练流程。
@ -332,7 +370,7 @@ def train_with_early_stopping(
Dict with keys: history, best_val_loss, best_epoch, best_state Dict with keys: history, best_val_loss, best_epoch, best_state
""" """
model = model.to(device) model = model.to(device)
optimizer = torch.optim.AdamW(model.parameters(), lr=lr, weight_decay=weight_decay) optimizer = build_optimizer(model, lr, weight_decay, backbone_lr_ratio)
scheduler = torch.optim.lr_scheduler.ReduceLROnPlateau( scheduler = torch.optim.lr_scheduler.ReduceLROnPlateau(
optimizer, mode="min", factor=0.5, patience=5 optimizer, mode="min", factor=0.5, patience=5
) )
@ -394,6 +432,7 @@ def train_fixed_epochs(
use_cosine_annealing: bool = True, use_cosine_annealing: bool = True,
use_swa: bool = False, use_swa: bool = False,
swa_start_epoch: Optional[int] = None, swa_start_epoch: Optional[int] = None,
backbone_lr_ratio: float = 1.0,
) -> Dict: ) -> Dict:
""" """
固定 epoch 数的训练（不使用 early stopping）。 固定 epoch 数的训练（不使用 early stopping）。
@ -413,12 +452,13 @@ def train_fixed_epochs(
use_cosine_annealing: 是否使用 CosineAnnealingLR use_cosine_annealing: 是否使用 CosineAnnealingLR
use_swa: 是否使用 SWA use_swa: 是否使用 SWA
swa_start_epoch: SWA 开始的 epoch（默认为 epochs * 0.75） swa_start_epoch: SWA 开始的 epoch（默认为 epochs * 0.75）
backbone_lr_ratio: backbone 学习率相对于 head 的比例（1.0 = 统一学习率）
Returns: Returns:
Dict with keys: history, final_state Dict with keys: history, final_state
""" """
model = model.to(device) model = model.to(device)
optimizer = torch.optim.AdamW(model.parameters(), lr=lr, weight_decay=weight_decay) optimizer = build_optimizer(model, lr, weight_decay, backbone_lr_ratio)
if use_cosine_annealing: if use_cosine_annealing:
scheduler = torch.optim.lr_scheduler.CosineAnnealingLR(optimizer, T_max=epochs) scheduler = torch.optim.lr_scheduler.CosineAnnealingLR(optimizer, T_max=epochs)

4
scripts/preprocess_internal.py
View File

@ -37,10 +37,6 @@ def main(
.transform(lambda x: (x - x.mean()) / x.std()) .transform(lambda x: (x - x.mean()) / x.std())
) )
# 将 Cationic_Lipid_Mol_Ratio,Phospholipid_Mol_Ratio,Cholesterol_Mol_Ratio,PEG_Lipid_Mol_Ratio 四列的百分数转换为小数
logger.info("Converting percentage columns to decimal...")
df[["Cationic_Lipid_Mol_Ratio", "Phospholipid_Mol_Ratio", "Cholesterol_Mol_Ratio", "PEG_Lipid_Mol_Ratio"]] = df[["Cationic_Lipid_Mol_Ratio", "Phospholipid_Mol_Ratio", "Cholesterol_Mol_Ratio", "PEG_Lipid_Mol_Ratio"]] / 100
# 对 size 列取 log # 对 size 列取 log
logger.info("Log-transforming size column...") logger.info("Log-transforming size column...")
df["size"] = pd.to_numeric(df["size"], errors="coerce") df["size"] = pd.to_numeric(df["size"], errors="coerce")